JOURNAL OF SOLID STATE CHEMISTRY
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2022
·
IF 3.656
Meng Chen,Chao Wang,Lei Wang,Jixiang Xu
In this work, carbon quantum dots@In 2 S 3 hollow tube (CQDs@In 2 S 3 ) with sheet-like hierarchical structure was synthesized by sulfidation CQDs@In-MIL-68. The CQDs@In 2 S 3 -2 exhibited the optimal Cr(VI) reductive ratio of nearly 100% after 45 min light irradiation in solution with pH of 4. The enhanced Cr(VI) reduction activity was ascribed to the efficient separation of electrons and holes after coupling of CQDs. The ·O 2 − was the dominant active specie to reduce Cr(VI), and possible mechanism was proposed. This work provides thought for design of high-performance photocatalysts by loading electron-collecting species to remove environmental pollutants .
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Nature Communications
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2022
·Vol. 13
·期 1
·1-12
·
IF 17.694
Mu Zhangyan,Han Na,Xu Dan,Tian Bailin,Wang Fangyuan,Wang Yiqi,Sun Yamei,Liu Cheng,Zhang Panke,Wu Xuejun,Li Yanguang,Ding Mengning
Precise understanding of interfacial metal−hydrogen interactions, especially under in operando conditions, is crucial to advancing the application of metal catalysts in clean energy technologies. To this end, while Pd-based catalysts are widely utilized for electrochemical hydrogen production and hydrogenation, the interaction of Pd with hydrogen during active electrochemical processes is complex, distinct from most other metals, and yet to be clarified. In this report, the hydrogen surface adsorption and sub-surface absorption (phase transition) features of Pd and its alloy nanocatalysts are identified and quantified under operando electrocatalytic conditions via on-chip electrical transport measurements, and the competitive relationship between electrochemical carbon dioxide reduction (CO 2 RR) and hydrogen sorption kinetics is investigated. Systematic dynamic and steady-state evaluations reveal the key impacts of local electrolyte environment (such as proton donors with different p K a ) on the hydrogen sorption kinetics during CO 2 RR, which offer additional insights into the electrochemical interfaces and optimization of the catalytic systems.
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ACS Applied Materials & Interfaces
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2022
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IF 10.383
Guoliang Tong,Yue Chen,Xingfu Xiao,Junjie Tang,Biqi He,Sheng Cao,Mingkai Li,Yunbin He,Junnian Chen
Two-dimensional (2D) Dion-Jacobson (DJ) perovskites are drawing significant attention in optoelectronic fields because of their enhanced out-of-plane electron coupling and improved structure stability. However, the structural effects of organic cations on the in-plane charge transport properties of 2D DJ lead bromide perovskites have remained less explored. Herein, we adopt asymmetric 3-(dimethylamino)-1-propylammonium (DMPD) and symmetric butane-1,4-diammonium (BDA) to systematically investigate the influence of organic cations on the structural, optical, and in-plane charge transport properties of 2D lead bromide perovskites. The large penetration depth of DMPD2+ induces a decreased perovskite layer distortion and a lower bandgap in DMPDPbBr4, compared with that of BDAPbBr4. Moreover, DMPDPbBr4 is shown to possess a low exciton binding energy, a low defect density, and a low ion migration activation energy, thereby yielding a more efficient in-plane charge collection efficiency than BDAPbBr4. Density functional theory calculations suggest that the improved in-plane charge transport can be traced to the enlarged antibonding coupling between Pb–6s and Br–4p orbitals that enables a high band dispersion and a low carrier effective mass in the in-plane direction of DMPDPbBr4. Finally, the planar Ag/DMPDPbBr4/Ag photodetector delivers a satisfying detectivity of 1.73 × 1012 Jones under an incident power intensity of 0.16 mW cm–2 and a high on/off ratio of 5.3 × 103. The above findings offer novel insight for the design of 2D DJ lead bromide perovskites for optoelectronic devices.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2022
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IF 5.062
Wantong Zhao,Lin Ma,Song Guo,Jia Yan Liu,Jingshu Piao,Mingguan Piao
Domperidone (DMP) is an effective peripheral D2 dopamine receptor antagonist . It is commonly used in the treatment of nausea and vomiting caused by Parkinson's disease . An oral preparation, which is rapidly absorbed after administration, and reaches a peak plasma concentration within 15–30 min, is commonly used. However, owing to the “first-pass effect” of liver metabolism and intestinal wall metabolism, the oral bioavailability of domperidone is low, and the action period is long. Therefore, in the present study, spray drying and emulsion solvent evaporation were combined to prepare a coated microsphere preparation with sustained release effect, and a gel matrix was selected to prepare a sustained-release coated microsphere gel for transdermal drug delivery. The pharmacokinetic results showed that the transdermal sustained-release coated microsphere gel effectively increased the Tmax, Cmax, T 1/2 , and AUC compared with those of an oral DMP group ( P < 0.05), and the relative bioavailability was 3.2 times that of the oral DMP group. This indicates that the preparation was able to ameliorate the problems associated with a traditional oral DMP formulation. Therefore, the present study may provide a theoretical basis for the transdermal delivery of DMP sustained-release microspheres.
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IONICS
·
2022
·Vol. 29
·期 1
·419-427
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IF 2.961
Zhao Jiang,Zhang Da,Wang Shumeng,Wang Zhitong,Xu Rongqing
Laser direct writing of polyimide (PI) film to induce porous graphene as a flexible electrode facilitates the development of efficient, low-cost, and large-scale preparation of flexible planar micro-supercapacitors (MSCs). Nevertheless, current flexible MSCs based on laser-induced graphene (LIG) face bottlenecks such as poor LIG electrode wettability, inhomogeneous doping of heterogeneous components, and limited electrochemical performance. In view of this, a simple and effective process for in situ fabrication of flexible FeO x nanoparticles embedded N-doped LIG (FeO x @NLIG) electrode is developed by laser direct writing in this study. The as-assembled in-plane FeO x @NLIG MSCs exhibit an excellent areal specific capacitance of 13.82 mF cm −2 , a remarkable energy density of 1.228 mW h cm −2 at a high power density of 0.024 mW cm −2 , good flexibility, and conspicuous cycling stability. Besides, these high-performance in-plane FeO x @NLIG MSCs as a vital micro-energy storage component can be easily miniaturized, modularized, and integrated to suit customized needs of wearable electronics due to great advantages in terms of identicality and stability of the as-fabricated FeO x @NLIG. Graphical abstract
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CNS Neuroscience & Therapeutics
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2022
·Vol. 29
·期 1
·306-316
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IF 7.035
Ayang Zhao,Hongjiang Jin,Guibo Fan,Yan Li,Chenglong Li,Qi Li,Xiaofei Ma,Tianyang Zhao,Siqi Sun,Shuai Liu,Yueyue Gao,Sihua Qi
Background Exposure to anesthesia leads to extensive neurodegeneration and long-term cognitive deficits in the developing brain. Caenorhabditis elegans also shows persistent behavioral changes during development after exposure to anesthetics. Clinical and rodent studies have confirmed that altered expression of the regulators of G protein signaling (RGS) in the nervous system is a factor contributing to neurodegenerative and psychological diseases. Evidence from preclinical studies has suggested that RGS controls drug-induced plasticity, including morphine tolerance and addiction. This study aimed to observe the effect of propofol exposure in the neurodevelopmental stage on learning and memory in the L4 stage and to study whether this effect is related to changes in rgs-3 expression. Methods Caenorhabditis elegans were exposed to propofol at the L1 stage, and learning and memory abilities were observed at the L4 stage. The expression of rgs-3 and the nuclear distribution of EGL-4 were determined to study the relevant mechanisms. Finally, RNA interference was performed on rgs-3 -expressing cells after propofol exposure. Then, we observed their learning and memory abilities. Results Propofol time- and dose-dependently impaired the learning capacity. Propofol induced a decline in non-associative and associative long-term memory, rgs-3 upregulation, and a failure of nuclear accumulation of EGL-4/PKG in AWC neurons. Inhibition of rgs-3 could alleviate the propofol-induced changes. Conclusion Inhibition of the expression of rgs-3 alleviated propofol-induced learning and memory deficits in Caenorhabditis elegans .
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SCIENCE OF THE TOTAL ENVIRONMENT
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2022
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IF 10.753
Zhen Pang,Peifeng Zhang,Xinyi Chen,Feilong Dong,Jing Deng,Cong Li,Junping Liu,Xiaoyan Ma,Andrea M. Dietrich
Disinfection byproducts (DBPs) are initially formed in the process of chlorination in the drinking water treatment plants (DWTPs), then further formed in the distribution system due to the presence of residual chlorine and reactive organic matters. However, in China, DBPs are monitored in the effluent from the DWTPs, but less is known about concentrations of DBPs in tap water since they are usually monitored once per half a year. The smart water service system is establishing real-time monitoring of water indices, although DBPs are an urgent need, they are difficult to monitor in real-time due to their diversity and complicated detection methods. If the correlation between DBP concentration and routinely real-time monitored water quality parameters (e.g., pH value, residual chlorine, ammonia) can be evaluated, the concentration of DBPs can be predicted, which will strengthen the control of tap water safety. This article comprehensively assessed the physicochemical parameters and the occurrence of DBP formation in the tap water with an 18-month investigation in Z city (China). DBP formation in tap water of different seasons and different water sources were compared. Based on the relationship between DBPs and physicochemical parameters, linear prediction and nonlinear prediction models of trihalomethanes (THMs), haloacetonitriles (HANs) and haloacetic acids (HAAs) were established, and the accuracy of these models was verified by measured data. Finally, the toxicity and carcinogenic and non-carcinogenic health risk assessment of DBPs in tap water were analyzed.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Minbo Li,Wanzhen Zhang,Chaofan Guo,Xiaosong Hu,Junjie Yi
“High-pressure processing (HPP) plus” combined technologies are applied to overcome the limitation of single HPP and to produce juices with more stable quality during storage. This research explored the potential of HPP in combination with centrifugation to produce cloud stable orange juice during refrigerated storage. The results indicated that HPP combined processing technology significantly improved the cloud stability of orange juice, which was related to removed large particles, reduced viscosity, decreased protein contents, and inactivated pectin methylesterase activity induced by centrifugation ( P < 0.05). Besides, chelator solubilized pectin (CSP) decreased but water solubilized pectin (WSP) maintained in the juice after centrifugation. During storage, the conversion of pectin fraction from WSP to CSP, resulting in sedimentation appeared in centrifugation treated orange juice when stored for 28 days. In general, pectin characteristics changes and pectin fractions conversion were the main driving forces affecting cloud stability of orange juice pasteurized by HPP in combination with centrifugation and during chilled storage.
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Nano Research
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2022
·Vol. 16
·期 4
·4908-4916
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IF 10.269
Ban Jinjin,Wen Xiaohan,Lei Honghong,Cao Guoqin,Liu Xinhong,Niu Chunyao,Shao Guosheng,Hu Junhua
Domain boundaries are regarded as the effective active sites for electrochemical energy storage materials due to defects enrichment therein. However, layered double hydroxides (LDHs) tend to grow into single crystalline nano sheets due to their unique two-dimentional (2D) lattice structure. Previously, much efforts were made on the designing hierarchical structure to provide more exposed electroactive sites as well as accelerate the mass transfer. Herein, we demonstrate a strategy to introduce low angle grain boundary (LAGB) in the flakes of Ni/Co layered double hydroxides (NiCo-LDHs). These defect-rich nano flakes were self-assembled into hydrangea-like spheres that further constructed hollow cage structure. Both the formation of hierarchical structure and grain boundaries are interpreted with the synergistic effect of Ni 2+ /Co 2+ ratio in an “etching-growth” process. The domain boundary defect also results in the preferential formation of oxygen vacancy (Vo). Additionally, density functional theory (DFT) calculation reveals that Co substitution is a critical factor for the formation of adjacent lattice defects, which contributes to the formation of domains boundary. The fabricated battery-type Faradaic NiCo-LDH-2 electrode material exhibits significantly enhanced specific capacitance of 899 C·g −1 at a current density of 1 A·g −1 . NiCo-LDH-2//AC asymmetric capacitor shows a maximum energy density of 101.1 Wh·kg −1 at the power density of 1.5 kW·kg −1 .
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TOXICOLOGY LETTERS
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2022
·
IF 4.271
Shiqi Duan,Yan Jia,Zhihang Zhu,Lancheng Wang,Peng Xu,Youmei Wang,Bin Di,Chi Hu
Information regarding the metabolism of illicit drugs is under urgent need for toxicological assessment . Its development, however, is limited by the currently available animal models. To this end, we proposed three-dimensional (3D) HepaRG spheroids as an in vitro model to study the effects of illicit drugs on hepatic cytochrome P450 (CYP450) enzymes and potential drug-drug interactions (DDIs). By comparing the results from animal and cell experiments, we confirmed the significant impact of heroin, morphine, tetrahydrocannabinol , and fentanyl on CYP450 enzymes, and the 3D spheroids results were in good agreement with the animal results for 2B6, 2C19, 2D6. Using 3D HepaRG spheroids, we demonstrated DDIs between heroin as a 2B6 perpetrator and clinical medicine for cancer, depression, and illicit drug withdrawal. Specifically, the clearance rate of 5.4 μM bupropion was increased by 214 % under DDI with 5 µM heroin, highlighting the importance of DDI pre-screening and individualized medication guidance for illicit drug users. This research contributes to the growing body of evidence regarding the metabolic toxicity of illicit drugs and suggests 3D HepaRG spheroids as a high-throughput and cost-efficient platform for DDI analysis.
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MOLECULES
·
2022
·Vol. 27
·期 11
·3582
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IF 4.927
Yinping Zhao,Yawei Kong,Liwen Chen,Han Sheng,Yiyan Fei,Lan Mi,Bei Li,Jiong Ma
With the development of precision medicine, antigen/antibody-targeted therapy has brought great hope to tumor patients; however, the migration of tumor cells, especially a small number of cells flowing into blood or other tissues, remains a clinical challenge. In particular, it is difficult to use functional gold nanomaterials for targeted clinical tumor diagnosis while simultaneously obtaining stable and highly sensitive Raman signals. Therefore, we developed a detection method for functional Au Nanostars (AuNSs) with dual signal enhancement that can specifically track location and obtain high-intensity surface-enhanced Raman scattering (SERS) signals. First, AuNSs with specific optical properties were synthesized and functionalized. The Raman dye 4-mercapto-hydroxybenzoic acid and polyethylene glycol were coupled with the tumor marker, epidermal growth factor receptor, to obtain the targeted SERS probes. In addition, a detection chip was prepared for Raman detection with physical enhancement, exhibiting a 40-times higher signal intensity than that of quartz glass. This study combines physical enhancement and SERS enhancement technologies to achieve dual enhancement, enabling the detection of a highly sensitive and stable Raman signal; this has potential clinical value for antigen/antibody-targeted tumor diagnosis and treatment.Keywords:SERS probe;dual enhancement;stable and highly sensitive;Raman signals;A549 cell
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2022
·Vol. 29
·期 49
·74306-74318
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IF 5.19
Chen Aixia,Zhang Yixuan,Wei Xiao,Pang Jiaju,Hu Ruirui,Guan Juanjuan
Porous carbon is an excellent absorbent for pollutants in water. Here, we report a breakthrough in performance of porous carbon based on lignin prepared using sodium lignosulfonate (SLS), potassium carbonate and melamine as precursor, activator and nitrogen source, respectively. A series of characterization tests confirmed that in-situ nitrogen doping greatly enhanced porous structure, resulting in a specific surface area of 2567.9 m 2 g −1 and total pore volume of 1.499 cm 3 g −1 , which is nearly twice that of non-nitrogen-doped porous carbon. Moreover, adsorption experiments revealed that at 303 K, the saturated adsorption capacity of chloramphenicol was as high as 713.7 mg g −1 , corresponding to an improvement of 33.7%. Further, the prepared porous carbon exhibited a strong anti-interference against metal ions and humic acid. The adsorption process was confirmed to be an endothermic reaction dominated by physical adsorption, indicating that an increase in temperature is conducive to adsorption. The results of this study show that nitrogen-doped lignin-based porous carbon prepared by in-situ doping is a promising material to significantly alleviate water pollution owing to its low cost, excellent pore structure and good adsorption properties.
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