JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 29
·期 11
·9613-9620
·
IF 2.324
Zhang Jun,Kong Wenwen,Chang Aimin
The [Mn 1.56 Co 0.96 Ni 0.48 O 4 ] 1−x [SrMnO 3 ] x ((MCN) 1−x (SM) x , 0 ≤ x ≤ 0.5) ceramic thin composite films were grown on SiO 2 /Si (100) substrates by the chemical solution deposition (CSD) method. The results of X-ray diffraction showed that the (MCN) 1−x (SM) x (0 < x ≤ 0.5) films were a resemblance of the spinel–perovskite composite structure. The field emission scanning electron microscope analyses presented a considerable improvement in relative density with the increasing of the SM contents. In particular, the thermal constant of (MCN) 1−x (SM) x ceramic film increased from 3289 to 5390 K with the increasing of the SM contents (x) from 0 to 0.5. This feature was attributed to the increase in the grain boundary resistance and the increase in Mn 3+ /Mn 4+ pairs as the SM contents increased. From the spectroscopic ellipsometer spectroscopy results, it was found that the (MCN) 0.5 (SM) 0.5 film had the biggest refractive index n value of 2.36 at 1.5 eV and a strong absorption peak at 4.0 eV. The sensitivity of MCN spinel ceramic film was enhanced by the compounding of SM. It was a significant disposition in the study of negative temperature coefficient thermistors.
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ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Jiaxin Zheng,Xiaolun Peng,Yijia Wang,Ting Bao,Wei Wen,Xiuhua Zhang,Shengfu Wang
The development of some sensitive methods for MUC1 is critical for preclinical diagnosis of tumors. In this experiment, we built a triple-amplified electrochemical aptasensor to achieve sensitive detection of MUC1, which was based on exonuclease III (Exo III)-assisted with strand displacement reaction and enzyme catalytic strategy. Firstly, with the help of Exo III, MUC1 and aptamer could be recycled during the cycle I, the single stranded DNA-1 (S-1) was produced during the process and was introduced to the hybride reaction on the electrode. Secondly, during the cycle II, strand displacement reaction was triggered on the electrode with the adding of hairpin DNA-2 (H-2). Thirdly, after the gold nanoparticles (AuNPs)-DNA-enzyme conjugates hybrided with the H-2 on the electrode, the AuNPs-DNA-enzyme conjugates could act as signal probe to produce electrochemical catalytic signal. We used the fabricated triple-amplified electrochemical aptasensor that could detect MUC1 from 0.1 pg mL −1 to 10 ng mL −1 with the detection limit of 0.04 pg mL −1 under the optimized experimental conditions. The constructed triple-amplified electrochemical aptasensor could be applied in real samples determination. Besides, the strategy can be applied to detect other proteins for health monitoring.
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DRUG DELIVERY
·
2017
·
IF 6.402
Zhaoming Guo,Wenqing Li,Yue Yuan,Kun Zheng,Yu Tang,Kun Ma,Changhao Cui,Li Wang,Bing He,Qiang Zhang
How to overcome drug resistance and prevent tumor metastasis is key to the success of malignant tumor therapy. In this paper, ADH-1 peptide-modified liposomes (A-LP) have been successfully constructed for restoring chemosensitivity and suppressing cancer cell migration. With a particle size of about 90 nm, this functionalized nanocarrier was loaded with fluorescent probe or paclitaxel (PTX). Cellular uptake studies showed that A-LP facilitated the delivery of anticancer drug to tumor cells undergoing EMT. Interestingly, this nanocarrier enhanced chemosensitivity by assessing the cell activity using CCK-8 assay. Further, the results of Wound scratch assay and Transwell migration assay showed the inhibition effect of this nanocarrier on tumor cell migration. Moreover, this nanocarrier exhibited significant tumor-targeting ability and anti-tumor efficacy in vivo. Collectively, A-LP might be a novel targeted drug delivery system to enhance the efficacy of chemotherapy and prevent tumor metastasis.
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Acta Biomaterialia
·
2024
·
IF 9.4
Cheng Lu,Miao Chen,Yuanyuan Zhao,Yongxin Zhan,Xin Wei,Laijin Lu,Mingxi Yang,Xu Gong
Avoiding ischemic necrosis after flap transplantation remains a significant clinical challenge. Developing an effective pretreatment method to promote flap survival postoperatively is crucial. Cobalt chloride (CoCl 2 ) can increase cell tolerance to ischemia and hypoxia condition by stimulating hypoxia-inducible factor-1 (HIF-1) expression. However, the considerable toxic effects severely limit the clinical application of CoCl 2 . In this study, cobalt-based metal-organic frameworks (Co-MOF) encapsulated in a microneedle patch (Co-MOF@MN) was developed to facilitate the transdermal sustained release of Co 2+ for rapid, minimally invasive rapid pretreatment of flap transplantation. The MN patch was composed of a fully methanol-based two-component cross-linked polymer formula, with a pyramid structure and high mechanical strength, which satisfied the purpose of penetrating the skin stratum corneum of rat back to achieve subcutaneous vascular area administration. Benefiting from the water-triggered disintegration of Co-MOF and the transdermal delivery via the MN patch, preoperative damage and side effects were effectively mitigated. Moreover, in both the oxygen-glucose deprivation/recovery (OGD/R) cell model and the rat dorsal perforator flap model, Co-MOF@MN activated the HIF-1α pathway and its associated downstream proteins, which reduced reperfusion oxidative damage, improved blood supply in choke areas, and increased flap survival rates post-transplantation. This preprotection strategy, combining MOF nanoparticles and the MN patch, meets the clinical demands for trauma minimization and uniform administration in flap transplantation. Statement of significance Cobalt chloride (CoCl 2 ) can stimulate the expression of hypoxia-inducible factor (HIF-1) and improve the tolerance of cells to ischemia and hypoxia conditions. However, the toxicity and narrow therapeutic window of CoCl 2 severely limit its clinical application. Herein, we explored the role of Co-MOF as a biocompatible nanocage for sustained release of Co 2+ , showing the protective effect on vascular endothelial cells in the stress model of oxygen-glucose deprivation. To fit the clinical needs of minimal trauma in flap transplantation, a Co-MOF@MN system was developed to achieve local transdermal delivery at the choke area, significantly improving blood supply opening and flap survival rate. This strategy of two-step delivery of Co 2+ realized the enhancement of biological functions while ensuring the biosafety.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jingjie Gao,Shaowei Bai,Fan Wang,Liangzhen Yang,Yufeng Hu,Yuhuan Yang,Bing Bai,Zuoming Zhang
Enzymatic glycosylation is an efficient and biocompatible approach to enhance natural product bioavailability. Cellobiose phosphorylase, a novel glycosyltransferase, utilizes 1-phospho-glucose (1-p-Glc) as a glycosyl donor for regioselective glycosylation of various natural substrates. However, the high cost of 1-p-Glc limits the economic feasibility of the process. Thus, a dual-enzyme cascade system involving cellulase Ac Cel9A and cellobiose phosphorylase Cb CBP using a co-immobilization strategy was developed to overcome this challenge. The system utilizes low-cost carboxymethyl cellulose (CMC) for continuous 1-p-Glc production, which was then used in the fluorodeoxy glucose (FDG) glycosylation to generate fluorodeoxy cellobiose (FDC), which potentially traces fungal infections. The compartmentalized co-immobilization of the two enzymes within the internal and external regions of a porous zeolitic imidazolate framework-8 (ZIF-8) carrier enhanced the overall stability of the dual-enzyme system. The immobilized enzymes retained approximately 63.3 % activity after seven reuse cycles and 74 % catalytic efficiency after 12 days of storage at room temperature. Therefore, the developed co-immobilized multi-enzyme system holds significant potential for industrial biocatalysis applications.
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JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
·
2015
·
IF 0.606
Haiyan Liu,Yamin Ma,Fengqing Wang,Jiafei Wang,Quanjie Liu
A new poly(1-dodecene-co-trimethylol propane triacrylate-co-ethylene dimethacrylate) [poly(C12-co-TMPTA-co-EDMA)] monolithic column was prepared via in situ free-radical polymerization reaction. Various parameters affecting the polymerization were investigated and optimized. The permeability of the monolithic column was calculated as 2.9098 × 10−14 m2 with methanol as the mobile phase and the surface areas was 73.1 m2/g by the nitrogen adsorption–desorption experiment. The morphologies of the monolith were characterized by scanning electron microscopy (SEM) and the mechanical strength has been studied in detail as well. The prepared monolith was then used as the stationary phase of reversed phase high-performance liquid chromatography (RP-HPLC) to separate small molecule compounds. Column efficiency for chlorobenzene reached 14,340 theoretical plates per meter. The monolith also showed satisfactory reproducibility, based on the retention times of benzene, phenol, chlorobenzene, diphenylamine, and anthracene; the relative standard deviation (RSD) values for run-to-run, column-to-column and batch-to-batch were less than 0.62%, 3.2%, and 5.7%, respectively.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Liming Liu,Junjie Li,Sidra Subhan,Xin Yu,Zhonghe Liu,Rubiao Chen,Jiguang Deng,Hongbing Ji,Zhongxing Zhao,Zhenxia Zhao
A major challenge in utilizing metal–organic frameworks (MOFs) for volatile organic compound (VOC) capture was their inclination for strong adsorption, which consequently impeded desorption and elevated energy demand. To overcome this challenge, the construction of HKUST-1@Cu nanofibers (HK@Cu-NF) with thermal conductive adsorption sites was proposed to synchronous enhance toluene adsorption and desorption efficiency for VOCs capture. In this work, Cu-based HKUST-1 was designed to grow on Cu nanofibers, and formed uniform coverage MOF layer with tight connection via homologous Cu self-transformation growth strategy. The synthesized composite was proved to maintain high surface area (1473 m 2 /g) and generate abundant unsaturated Cu sites on its nanointerface based from the thermally conductive Cu nanofibers. This unique connection structure endowed these adsorption sites with high affinity towards toluene and high thermal conductivity as well, and finally formed thermal conductive adsorption sites. As a result, HK@Cu-NF composite (80 % loading of HKUST-1) exhibited 1.9 times higher of toluene adsorption capacity at P / P 0 = 0.002 and >3 times higher of thermal diffusivity than pure HKUST-1. Furthermore, it achieved enhancement in both adsorption and desorption efficiency for toluene, which reached 4.8 and 6.9 times of pure HKUST-1. Therefore, construction of thermal conductive adsorption sites successfully improved the adsorption efficiency and regeneration efficiency for VOCs capture, and realized the low energy VOCs desorption process.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2017
·Vol. 129
·期 3
·1875-1885
·
IF 1.953
Cheng Jian,Zheng Yu,Li Zhenming,Liu Zuliang,Li Lixia,Zhao Fengqi,Xu Siyu
Abstract The purpose of this work was to study the catalytic reaction and its mechanism of ammonium perchlorate (AP) with cobalt complex of 2,6-diamino-3,5-dinitropyrazine-1-oxide (Co-LLM-105) during thermal decomposition process. At first, the catalytic performance of Co-LLM-105 on the thermal decomposition of AP was investigated by TG–DSC, TG-FTIR, non-isothermal kinetic and α – T kinetic curves analyses. Secondly, the thermal decomposition mechanism of Co-LLM-105 in the absence and presence of AP was proposed based on TG, DTG, DSC and thermolysis/RSFTIR analyses. The results showed that Co-LLM-105 exhibited excellent catalytic activity on the thermal decomposition of AP. Meanwhile, AP also exhibited some catalytic effects on the thermal decomposition of Co-LLM-105. Both of the components had catalytic effects on each other during the process. The formation of active CoCO 3 , Co 3 O 4 , CoO and Co(NH 3 ) 6 (ClO 4 ) 2 in situ in the system accounted for the higher catalytic activity of Co-LLM-105 for the thermal decomposition of AP was deduced. Graphical Abstract Co-LLM-105 exhibited excellent catalytic activity on the thermal decomposition of AP. Meanwhile, AP also exhibited some catalytic effects on the thermal decomposition of Co-LLM-105. Both of the components had catalytic effects on each other during the process.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2017
·
IF 2.323
Jing Zhao,Jianzhou Wu,Yitong Dai,Xinxin Cheng,Haiyun Sun,Yongsheng Guo,Wenjun Fang
Measurements on density and viscosity at T = (293.15, 298.15, 303.15, 308.15 313.15, 318.15, 323.15, 328.15, and 333.15) K and the pressure P = 0.1 MPa for binary mixtures of n-dodecane or methylcyclohexane with 1-heptanol or cyclohexylmethanol have been carried out over the whole composition range. Densities were measured with a vibrating-tube densimeter. Viscosities were determined by an automatic microviscometer based on the rolling-ball principle. The excess molar volumes (VmE) and viscosity deviations (Δη) were calculated with experimental data and fitted to the Redlich–Kister equation. The results of these excess or deviation functions are explained by molecular interactions and structural effects. Freezing points were measured with a differential scanning calorimeter. The fundamental data, VmE and Δη can be used to study the nature of mixing behaviors between new hydrocarbon fuels.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2016
·
IF 2.567
Nan Zhong,Helei Liu,Xiao Luo,Mohammed J. AL-Marri,Abdelbaki Benamor,Raphael Idem,Paitoon Tontiwachwuthikul,Zhiwu Liang
In this work, the reaction kinetics of carbon dioxide (CO2) with diethylenetriamine (DETA) and 1-amino-2-propanol (1-AP) in methanol and ethanol systems were measured using the stopped flow technique over a temperature range of 293–313 K in terms of pseudo-first-order rate constant (k0). Concentration in the range of 10 to 50 mol/m3 for diethylenetriamine, and 20 to 100 mol/m3 for 1-amino-2-propanol were studied. The experimental data show that the pseudo-first-order rate constants (k0) increase with the increase of both amine concentration and temperature. The zwitterion mechanism and the termolecular mechanism were used to represent the data for DETA in methanol and ethanol systems with excellent ADDs of 3.5% and 2.4%, respectively, and 1-AP in methanol and ethanol systems with excellent ADDs of 2.4% and 2.6%, respectively. In comparison with EDA and AEEA in terms of k2, DETA exhibits a better reaction kinetics performance for capturing CO2. Those results will be useful in finding an efficient method for the removal of CO2 from industrial gases.
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Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 34
·7153-7163
·
IF 4.543
Yan Li,Zuyuan Luo,Xiao Xu,Yongliang Li,Siqi Zhang,Ping Zhou,Yi Sui,Minjie Wu,En Luo,Shicheng Wei
Several bone diseases, including arthritis, fracture and osteoporosis, have a pathophysiologically important inflammatory component. Sustained inflammation can result in delayed bone healing. Therefore, to promote bone repair, it is important to inhibit inflammatory bone erosion and suppress pro-inflammatory mediators. In this study, aspirin significantly enhanced immunomodulation and osteogenic differentiation in human mesenchymal stem cells (hMSCs). Additionally, an osteogenic BFP-1 peptide-decorated substrate (PS-PEP) enhanced osteogenic differentiation of aspirin-treated hMSCs compared to a pristine substrate. Alkaline phosphatase assay, quantitative real-time polymerase chain reaction, immunostaining and Alizarin Red S staining revealed that aspirin-treated hMSCs cultured on PS-PEP exhibited enhanced osteogenesis compared with untreated cells. Thus, we report here that the anti-inflammatory and osteogenic effects of aspirin promote the activity and osteogenesis of hMSCs. The combination of aspirin and an osteogenic BFP-1 peptide-decorated substrate suppresses the production of pro-inflammatory mediators and promotes osteogenic differentiation of hMSCs; therefore, this novel strategy has potential for application in cell therapy and bone tissue engineering.
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Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 24
·12144-12148
·
IF 8.867
Qianqian Yang,Jie Zhou,Genqiang Zhang,Cong Guo,Meng Li,Yongchun Zhu,Yitai Qian
Sb nanoparticles encapsulated in 1-D N-doped porous carbon (denoted as Sb/NPC) have been fabricated by an in situ nanoconfined replacement reaction between SbCl3 and the intermediate Ni/NPC, in which Ni/NPC was obtained by annealing the hydrothermally synthesized nickel–nitrilotriacetic acid (Ni–NTA) precursor in an argon atmosphere. The Sb nanoparticles with a size of 10–20 nm were uniformly encapsulated in the 1-D N-doped porous carbon scaffolds. When the Sb/NPC composite was applied as an anode material in the batteries, it exhibited a high reversible capacity of 556 mA h g−1 at 200 mA g−1 after 100 cycles for Li-ion batteries (LIBs) and a reversible capacity of 400.9 mA h g−1 at 100 mA g−1 after 100 cycles for Na-ion batteries (NIBs). Such enhanced electrochemical performance of the designed Sb/NPC can be attributed to the synergistic effect between uniformly dispersed Sb nanoparticles and the 1-D N-doped porous carbon matrices.
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