Inorganic Chemistry Frontiers
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2021
·Vol. 8
·期 24
·5270-5276
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IF 6.569
Shiwei Liu,Jiale Chen,Hongping Wu,Hongwei Yu,Zhanggui Hu,Jiyang Wang,Yicheng Wu
The dimensional reduction theory is applied to an A2O–P2O5–Bi2O3 system where P2O5 serves as a binary parent while A2O and Bi2O3 are regarded as dimensional reduction agents. Thus, three novel phosphates ACs5Bi4(PO4)2(P2O7)3 (A = K, Rb and Cs) have been prepared through the high-temperature solution method. Single-crystal X-ray diffraction measurements reveal that they all crystallize in the monoclinic space group P21/c (no. 14) and in their structures, two different kinds of P–O units, i.e. isolated PO4 tetrahedra and P2O7 dimers, are interconnected by Bi–O groups to construct a 3∞[Bi4(PO4)2(P2O7)36−] framework. Note that with the change of cationic size in their structures, the Bi3+ cations also exhibit flexible coordination, i.e. BiO5 and BiO6 polyhedra in KCs5Bi4(PO4)2(P2O7)3 and only BiO6 polyhedra in Cs6Bi4(PO4)2(P2O7)3, suggesting that combining the flexible coordination of Bi3+ cations with phosphates based on dimensional reduction theory is an effective strategy to guide the synthesis of new compounds.
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Bioresources and Bioprocessing
·
2021
·Vol. 8
·期 1
·1-9
·
IF 4.578
Ma Jun,Zeng Xiankun,Zhou Min,Cheng Le,Ren Difeng
Spirulina platensis protein hydrolysates were prepared by digesting protein extracts with papain, and the hydrolysates were separated into 30, 10, and 3 kDa weights using membrane ultrafiltration. The 0–3 kDa low-molecular-weight Spirulina peptides (LMWSPs) proved the highest chemical antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging ability, hydroxyl radical (·OH) scavenging activities and total antioxidant capacity. Cellular antioxidant ability of LMWPs fractions against 2000 μg/mL H2O2 induced oxidative damage of L02 cells were investigated. The MTT assay results displayed that LMWSPs at different concentrations (0–1000 μg/mL) had proliferation effect on the L02 cells and that treatment of the L02 cells with the 1000 μg/mL LMWSPs (0–3 kDa) significantly prevented H2O2-induced oxidative damage compared with control cells. Moreover, the 2′,7′-dichlorofluorescein diacetate (DCFH-DA) fluorescent probe assay showed that the levels of ROS and NO were significantly lower in the experimental group that was treated with the peptides for 24 h than in the control group. Furthermore, using the corresponding kits, the treatment inhibited the reduction of SOD activity and the increase of MDA contents in the L02 cells. Therefore, LMWSPs (0–3 kDa) may have potential applications in antioxidant and liver health products.
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Bioengineered
·
2021
·
IF 3.269
Yan Wang,Zhiqiang Cheng,Jing Xu,Meina Lai,Liming Liu,Min Zuo,Lin Dang
Excessive activation of signal transducer and activator of transcription 3 (STAT3) is implicated in breast cancer (BC) chemoresistance, but its underlying mechanism is not fully understood. There are STAT3 binding sites in fat mass and obesity-associated protein (FTO) promoter region, thus STAT3 may regulate the transcription of FTO. This study aimed to investigate the correlation between FTO and STAT3 in BC chemoresistance. Herein, FTO and STAT3 were highly expressed in doxorubicin-resistant BC (BC-DoxR) cells. CHIP assay verified the binding between STAT3 and FTO promoter in BC-DoxR cells. Dual luciferase reporter assay showed that FTO promoter activity was inhibited by S3I-201 (STAT3 inhibitor) but enhanced by epidermal growth factor (EGF, STAT3 activator) in BC-DoxR and BC cells. FTO mRNA and protein expression were suppressed by S3I-201 in BC-DoxR cells and EGF-stimulated BC cells. Notably, FTO regulated total N6-methyladenosine (m6A) levels in BC-DoxR and BC cells but could not affect STAT3 mRNA expression, indicating that FTO was not involved in the m6A modification of STAT3. However, FTO could activate STAT3 signaling in BC-DoxR and BC cells. Besides, FTO knockdown inhibited the doxorubicin resistance of BC-DoxR cells, while FTO overexpression enhanced the doxorubicin resistance and weakened the doxorubicin sensitivity of BC cells. Moreover, decreased doxorubicin resistance by STAT3 knockdown was abolished by FTO overexpression and decreased doxorubicin sensitivity by STAT3 overexpression was reversed by FTO knockdown, indicating that FTO was implicated in STAT3-mediated doxorubicin resistance and impairment of doxorubicin sensitivity of BC cells. Altogether, our findings provide a mechanism underlying BC doxorubicin resistance.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2020
·Vol. 18
·期 1
·1-15
·
IF 6.518
Zhang Man,Ye Lili,Huang Hao,Cheng Dandan,Liu Kaixin,Wu Wenbo,Shen Fukui,Jiang Zhihong,Hou Yuanyuan,Bai Gang
Background Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. They exhibit significant advantages compared to traditional pulmonary drug delivery systems. However, developing the formulation of each drug is a time-consuming and laborious task.Results In this study, a universal lung-targeting nanoparticle was designed and constructed. The self-assembled micelles were composed of a platycodon secondary saponin, 3-O-β-d-glucopyranosyl platycodigenin 682 (GP-682), based on its specific amphiphilic structure. The GP-682 micelles exhibited a relatively stable zeta potential with a particle size between 60 and 90 nm, and the critical micelle concentration (CMC) value was approximately 42.3 μg/mL. Preincubation of GP-682 micelles markedly enhanced their cell membrane permeability and improved drug uptake in vitro. The results were visualized using fluorescent dye tracing, transmission electron microscopy (TEM) observations and the lactate dehydrogenase (LDH) release assay. The obtained benefits enhanced the distribution of levofloxacin (Lev) in mouse lung tissue and reduced antibiotics overdosing. The acute lung injury mouse model induced by the Pseudomonas aeruginosa PA 14 strain demonstrated that preinjection of GP-682 micelles before antibiotic administration resulted in a higher survival rate and anti-infective efficacy in vivo. It also caused reductions in pulmonary injury, bacterial invasion and cytokine expression compared with treatment with Lev alone.Conclusion sGP-682 micelles are another nanoparticle-based pulmonary drug delivery system and provide a new lung-targeting therapy option.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2020
·Vol. 27
·期 32
·40346-40354
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IF 3.056
Liao Taiwan,Huang Pengwei,Song Huiyu,Guo Jia,Fu Xionghui,Yu Xiang,Peng Liang,Han Boping,Zhu Yi,Zhang Yuanming
In this study, La(OH) 3 -modified magnetic sodium carboxymethyl cellulose (La-MC) was prepared as adsorbents for phosphate, which exhibited excellent adsorption performance up to 62.98 mg P/g and magnetic property for easy recovery. The recovered adsorbents after phosphate sorption were subsequently used for photocatalytic reduction of Cr(VI) and possessed good photocatalytic activity. This work provided an excellent reference for developing a new way of extending life cycle of adsorbents by combining phosphate adsorption with photocatalysis for sequential removal of pollutants from water in the future.
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Nanomaterials
·
2020
·Vol. 10
·期 4
·808
·
IF 4.324
Yuhao Liu,Xiaoxiao Qu,Guangxu Huang,Baolin Xing,Fengmei Zhang,Binbin Li,Chuanxiang Zhang,Yijun Cao
Three-dimensional porous carbon is considered as an ideal electrode material for supercapacitors (SCs) applications owing to its good conductivity, developed pore structure, and excellent connectivity. Herein, using longan shell as precursor, 3-dimensional porous carbon with abundant and interconnected pores and moderate heteroatoms were obtained via simple carbonization and potassium hydroxide (KOH) activation treatment. The electrochemical performances of obtained 3-dimensional porous carbon were investigated as electrode materials in symmetric SCs with aqueous and solid electrolytes. The optimized material that is named after longan shell 3-dimensional porous carbon 800 (LSPC800) possesses high porosity (1.644 cm3g−1) and N content (1.14 at %). In the three-electrode measurement, the LSPC800 displays an excellent capacitance value of 359 F g−1. Besides, the LSPC800 also achieves splendid specific capacitance (254 F g−1) in the two electrode system, while the fabricated SC employing 1 M Li2SO4as electrolyte acquires ultrahigh power density (15930.38 W kg−1). Most importantly, LSPC800 electrodes are further applied into the SC adopting the KOH/polyvinyl alcohol (PVA) gel electrolyte, which reaches up to an outstanding capacitance of 313 F g−1at 0.5 A g−1. In addition, for the all-solid-state SC, its rate capability at 50 A g−1is 72.73% and retention at the 10,000th run is 93.64%. Evidently, this work is of great significance to the simple fabrication of 3-dimensional porous carbon and further opens up a way of improving the value-added utilization of biomass materials, as well as proving that the biomass porous carbons have immense potential for high-performance SCs application.Keywords:3-dimensional porous carbon;biomass;high nitrogen content;all-solid-state supercapacitors
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高影响因子
MOLECULES
·
2020
·Vol. 25
·期 4
·858
·
IF 3.267
Xiaojuan Liu,Yue Wang,Yezhi Chen,Shuting Xu,Qin Gong,Chenning Zhao,Jinping Cao,Chongde Sun
O-methylation of flavonoids is an important modification reaction that occurs in plants.O-methylation contributes to the structural diversity of flavonoids, which have several biological and pharmacological functions. In this study, anO-methyltransferase gene (CrOMT2) was isolated from the fruit peel ofCitrus reticulata, which encoding a multifunctionalO-methyltransferase and could effectively catalyze the methylation of 3’-, 5’-, and 7-OH of flavonoids with vicinal hydroxyl substitutions. Substrate preference assays indicated that this recombinant enzyme favored polymethoxylated flavones (PMF)-type substrates in vitro, thereby providing biochemical evidence for the potential role of the enzyme in plants. Additionally, the cytotoxicity of the methylated products from the enzymatic catalytic reaction was evaluated in vitro using human gastric cell lines SGC-7901 and BGC-823. The results showed that the in vitro cytotoxicity of the flavonoids with the unsaturated C2-C3 bond was increased after being methylated at position 3’. These combined results provide biochemical insight regarding CrOMT2 in vitro and indicate the in vitro cytotoxicity of the products methylated by its catalytic reaction.Keywords:citrus;flavonoids;O-methyltransferase;bioactivity;cytotoxicity
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
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2020
·Vol. 167
·期 8
·086508
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IF 3.721
Suxia Wang,Min Zhou,Yongxi Zhu,Bo Peng,Jia Yang,Yongjun Ma
In this study, a novel poly(L-citrulline)/lanthanide-containing cyano-bridged heterometallic coordination polymer modified glassy carbon electrode, poly(L-Cit)/(Ho(III)-Fe(III)-WO42− CyHMCP/GCE, was constructed as a sensing platform for the electrochemical detection of 3-nitropropionic acid (3-NPA) using the two-step electrosynthesis method. The surface morphology of materials coated on the chemically modified electrode was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Based on the excellent synergistic electrocatalytic performance for electrochemical reduction of 3-NPA, the voltammetric detection of 3-NPA in real sugarcane juice samples was achieved with a facile sample pretreatment process and less matrix interference. Furthermore, by means of water-phase infrared spectra technique, the electrocatalytic reduction pathway of 3-NPA was preliminarily studied. Under the optimized detection conditions, a good linear relationship was obtained between the reduction peak current of 3-NPA and testing concentration in the range of 40.0–4.00 × 103 μM, with a regression equation of Ip (μA) = −3.126 + 0.08804C3-NPA (μM), R2 = 0.9997. The lower detection limit (LOD) of 3-NPA was estimated to be 16.0 μM (S/N = 3). Therefore, the method had been employed to analyze raw sugarcane samples, with the average recovery of 96.8%–104%, and the actual concentration level of free 3-NPA in the raw sugarcane juices was revealed.
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RSC Advances
·
2020
·Vol. 10
·期 5
·2767-2785
·
IF 3.119
Songfa Qiu,Hongjun Zhou,Zhichuan Shen,Li Hao,Huayao Chen,Xinhua Zhou
Silanized iminodiacetic acid (GLYMO–IDA) modified mesoporous silica (G-SBA) was prepared following a co-condensation method. G-SBA/Cu2+, G–SBA/Zn2+ and G-SBA/Cu2+–Zn2+ were obtained through the impregnation method with coordination by GLYMO–IDA. SBA/CuO, SBA/ZnO, and SBA/CuZnO were generated after calcination of G-SBA/Cu2+, G-SBA/Zn2+ and G-SBA/Cu2+–Zn2+. After modification, the amount of metal ion was 6 to 70 times higher than that of the blank mesoporous silica. The diameter of nano-copper oxide particles in mesoporous silica was 4.8 nm. The bacteriostatic rates of SBA/CuO at a copper oxide concentration of 250 ppm against E. coli and S. aureus were 85.87% and 100%, respectively. SBA/CuO and SBA/CuZnO with {111} lattice planes exhibited better antibacterial effects compared to the commercial-grade nano-zinc oxide and nano-copper oxide. When exposed to ultraviolet light, SBA/CuZnO displayed the highest photocatalytic activity and optimal antimicrobial effect. Therefore, SBA/CuZnO can be an alternative to antibiotics because of its non-toxic nature and good antibacterial properties.
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MOLECULES
·
2021
·Vol. 26
·期 14
·4361
·
IF 4.412
Ya Wang,Xiao-Jing Shen,Fa-Wu Su,Yin-Rong Xie,Li-Xia Wang,Ning Zhang,Yi-Long Wu,Yun Niu,Dong-Ying Zhang,Cheng-Ting Zi,Xuan-Jun Wang,Jun Sheng
Lung cancer is one of the most commonly occurring cancer mortality worldwide. The epidermal growth factor receptor (EGFR) plays an important role in cellular functions and has become the new promising target. Natural products and their derivatives with various structures, unique biological activities, and specific selectivity have served as lead compounds for EGFR. D-glucose and EGCG were used as starting materials. A series of glucoside derivatives of EGCG (7–12) were synthesized and evaluated for their in vitro anticancer activity against five human cancer cell lines, including HL-60, SMMC-7721, A-549, MCF-7, and SW480. In addition, we investigated the structure-activity relationship and physicochemical property–activity relationship of EGCG derivatives. Compounds11and12showed better growth inhibition than others in four cancer cell lines (HL-60, SMMC-7721, A-549, and MCF), with IC50values in the range of 22.90–37.87 μM. Compounds11and12decreased phosphorylation of EGFR and downstream signaling protein, which also have more hydrophobic interactions than EGCG by docking study. The most active compounds11and12, both having perbutyrylated glucose residue, we found that perbutyrylation of the glucose residue leads to increased cytotoxic activity and suggested that their potential as anticancer agents for further development.Keywords:EGCG;synthesis;cytotoxicity;EGFR;molecular docking
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Yinyin Liao,Haibo Tan,Guotai Jian,Xiaochen Zhou,Luqiong Huo,Yongxia Jia,Lanting Zeng,Ziyin Yang
Tea (Camellia sinensis) is the most popular nonalcoholic beverage worldwide. During cultivation, tea plants are susceptible to herbivores and pathogens, which can seriously affect tea yield and quality. A previous report showed that (Z)-3-hexenol is a potentially efficient defensive substance. However, the molecular mechanism mediating (Z)-3-hexenol signaling in tea plants and the resulting effects on plant defenses remain uncharacterized. To clarify the signaling mechanisms in which (Z)-3-hexenol and light are involved, the gene transcription and metabolite levels were assessed, respectively. This study demonstrated that tea plants rapidly and continuously release (Z)-3-hexen-1-ol in response to an insect infestation. (Z)-3-Hexen-1-ol absorbed by adjacent healthy plants would be converted into three insect defensive compounds: (Z)-3-hexenyl-glucoside, (Z)-3-hexenyl-primeveroside, and (Z)-3-hexenyl-vicianoside identified with laboratory-synthesized standards. Moreover, (Z)-3-hexen-1-ol also activates the synthesis of jasmonic acid to enhance the insect resistance of tea plants. Additionally, a continuous light treatment induces the accumulation of (Z)-3-hexenyl-glycosides. Hence, (Z)-3-hexenol serves as a light-regulated signaling molecule that activates the systemic defenses of adjacent plants. Our study reveals the molecular mechanisms by which biotic and abiotic factors synergistically regulate the signaling functions of herbivore-induced plant volatiles in plants, providing valuable information for future comprehensive analyses of the systemic defense mechanisms in plants.
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Advanced Optical Materials
·
2019
·Vol. 7
·期 23
·1901082
·
IF 7.125
Daqin Chen,Su Zhou,Feifan Tian,Haitao Ke,Naizhong Jiang,Shujin Wang,Yongzhao Peng,Yue Liu
Recently, Mn 2+ -doped CsPb(Cl/Br) 3 perovskite nanocrystals (NCs), showing the advantages of dual-color emissions via exciton-to-dopant energy transfer and reduced usage of toxic Pb 2+ heavy metal ions by nontoxic Mn 2+ substitution, are widely explored. However, photoluminescence quantum yields (PLQYs) for Mn 2+ -doped CsPb(Cl/Br) 3 NCs still need to be further improved. Here, a halogen-hot-injection strategy is developed to prepare Mn:CsPb(Cl 0.6 Br 0.4 ) 3 NCs with the maximal PLQY of 65%. With this method, intense blue narrowband emission from excitonic recombination and orange broadband emission from Mn 2+ 4 T 1 → 6 A 1 transition can be simultaneously achieved. The competitive luminescence between perovskite NCs and Mn 2+ dopants is systematically investigated by controlling the injected halogen types and ratios. As a proof-of-concept experiment, the present Mn 2+ -doped CsPb(Cl/Br) 3 perovskite NCs with highly efficient dual-color emissions are demonstrated to be applicable as color converter in UV-excitable solid-state lighting.
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危险品化学品经营许可证（带存储）