CHEMICAL PAPERS
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2026
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IF 2.7
Zhong Xiangyan,He Xinye,Long Ruiqing,Qi Linfeng,Zhao Qiang
Efficient utilization of long-wavelength visible light remains a key challenge in developing metal-organic-framework-based photocatalysts for solar-driven pollutant removal. To address this issue, carbon quantum dot (CQD)-modified UiO-66-NH 2 hybrid materials with different nominal CQD loadings were constructed through induced loading and secondary thermal fixation to combine spectral conversion with interfacial photophysical regulation. Structural and textural characterizations showed that CQD incorporation preserved the crystalline and porous framework of UiO-66-NH 2 while modifying its surface composition, pore characteristics, and optical response. The CQDs displayed visible-to-ultraviolet anti-Stokes emission centered at approximately 340 nm under 600 nm excitation. CQD incorporation also enhanced visible-light absorption and induced photoluminescence quenching consistent with interfacial photophysical coupling. Transient-current measurements showed reproducible light-switching responses, while EIS revealed a lower impedance response for CU-3 under illumination; together, these results are consistent with facilitated interfacial charge migration. Under visible-light irradiation in the presence of FeCl 3 as an electron scavenger, CU-3, containing 3 wt% CQDs, achieved a background-corrected net methyl orange removal of 67% within 90 min. Its apparent rate constant was 1.203 × 10 − 2 min − 1 , approximately 6.6 times that of pristine UiO-66-NH 2 . Tert-butanol inhibition and DMPO spin-trapping ESR measurements jointly supported the involvement of hydroxyl radicals, with CU-3 exhibiting a stronger light-induced DMPO–·OH signal than pristine UiO-66-NH 2 . The effect of EDTA-2Na could not be assigned exclusively to photogenerated holes because of its complexation with Fe 3+ . These findings demonstrate the importance of optimizing CQD loading and suggest that spectral conversion and interfacial photophysical coupling contribute to the enhanced apparent visible-light activity.
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高影响因子
Nature Microbiology
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2026
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IF 18.7
Wu Xiaolei,Wang Teng,Jia Chenghao,Zhou Haiyang,Li Yan,Baker Stephen,Yue Min
Understanding the genetic factors facilitating emergence of infectious diseases is critical, however, mechanisms underlying expansion of pathogenic bacterial variants remain unclear. Here we performed a large-scale genomic analysis of 44,597 Salmonella Typhimurium genomes and observe that sequential gene loss in monophasic Salmonella Typhimurium (mSTM) ST34 explains its clonal expansion as an increasingly prevalent zoonotic lineage. Functional and in vivo competition experiments show that a frameshift mutation in dinB , a polymerase for translesion DNA synthesis, leads to transcriptional changes affecting flagellin gene expression and subsequent loss of the flagellin-encoding fljB , altering the requirements for gut infection. Temporal evolutionary modelling supports a role for gene loss events in a specific chronological order for mSTM ST34 expansion. Our findings reveal a stepwise pathoadaptation model underpinning clonal global spread, providing mechanistic insights relevant to forecasting future pandemics.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2026
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IF 1.7
Yu Jiayan,Wang Tao,Li Jiajia,He Zhiyou,Wang Jing,Zhao Peng,Chen Yue,Yang Xia
Antibody-targeted radioimmunotherapy holds significant potential for solid tumor treatment. However, intact antibodies (IgG) and fragments (F(ab’) 2 ) may exhibit distinct pharmacokinetic and radiation delivery properties due to differences in molecular size and Fc functionality. TROP2 is highly overexpressed in most malignant tumors but minimally expressed in normal tissues. Therefore, the anti-TROP2 antibody was selected as the targeting agent in this study. We prepared the F(ab’) 2 antibody fragments of anti-TROP2 antibody and systematically compared the in vitro and in vivo behaviors of [ 177 Lu]Lu-DOTA-anti-TROP2 antibody and [ 177 Lu]Lu-DOTA-anti-TROP2-F(ab’) 2 antibody fragments to optimize radioligand therapy strategies. Cell binding assays were conducted to evaluate their TROP2 antigen binding affinity. In vivo distributions in tumors and normal organs were investigated through Micro-SPECT/CT imaging and biodistribution studies using tumor-bearing mice. The results demonstrated that, compared to the anti-TROP2 antibody, the anti-TROP2-F(ab’) 2 antibody fragments exhibited superior blood clearance kinetics as well as lower accumulation in liver and spleen. This could reduce the radiation side effects of [ 177 Lu]Lu-DOTA-anti-TROP2-F(ab’) 2 antibody fragments on bone marrow or other full-antibody target normal organs. However, cutting Fc from the full anti-TROP2 antibody increased renal accumulation and exhibited shedding phenomena following tumor targeting.
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BMC MICROBIOLOGY
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2026
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IF 5.4
Ru Yi,Yu Ying,Liu Chuanxin,Liu Yunge,Liu Dongxia,Chen Ruyan,Chen Xiaowan,Bai Xiaoyang,Jiang Tao,Duan Jiajia
Podophyllotoxin (PPT) is a naturally occurring plant-derived insecticide, yet its potent cytotoxicity raises concerns regarding potential neurobehavioral toxicity in non-target organisms. However, the underlying mechanisms remain largely unclear. This study aims to investigate the neurotoxic effects of PPT in zebrafish. Three-day post-fertilization wild-type AB strain zebrafish were exposed to six concentration gradients of PPT (0.997–31.2 µg/mL). Based on the determined LC10 and MNLC values, four concentrations including 0.140, 0.420, 1.26, and 1.57 µg/mL were selected for intestinal-brain toxicity assessments and color preference tests were conducted. Histopathological damage in brain and intestinal tissues were evaluated through hematoxylin-eosin and acridine orange staining techniques. Subsequently, based on the maximum non-lethal concentration of 1.26 µg/mL, the mechanisms were further investigated using 16S rRNA sequencing, HM700 targeted metabolomics, and bulk RNA-seq, with key genes being validated via quantitative PCR. Correlation analysis was employed to elucidate the relationships among gut microbiota, differential metabolites, and gene expression. Our results showed that zebrafish exposed to various concentrations of PPT for 2 days exhibited significant intestinal and neurotoxic effects, including alterations in color preference behavior and structural damage in both the brain and intestinal tissues. 16S rRNA sequencing revealed reduced gut microbial diversity and increased levels of Acinetobacter and Perlucidibaca . Metabolomic profiling revealed that PPT disrupts purine metabolism, significantly reducing neuroprotective metabolites like adenosine and inosine, while increasing neurotoxic compounds such as quinolinic and oxalic acids. Transcriptomic analysis showed that genes associated with neuronal damage and inflammation were affected. qPCR confirmed that PPT exposure suppresses genes crucial for synaptic function (gad1b, drd2b) and upregulates genes related to the complement pathway (c3a.1, c1qc) and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α). Correlation analysis linked changes in gut bacteria, Acinetobacter and Perlucidibaca , to altered purine metabolism and genes involved in synaptic and inflammatory pathways. These findings suggest that PPT-induced neurotoxicity is associated with alterations in gut microbial composition, dysregulation of purine metabolism, and changes in neuroinflammatory and synaptic-related pathways. This study highlights the potential association between microbiota-gut-brain axis disturbances and PPT-induced neurotoxicity and provides new insights for evaluating its environmental health risks. Graphical The alternative text for this image may have been generated using AI.
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PubMed
高影响因子
Nature Communications
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2026
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IF 18.1
Huang Ju,Zhu Jianqiu,Liu Bowen,Dai Chencheng,Chen Zhimin,Wu Hao,Li Gang,Du Shichao,Wang Jian-Qiang,Ren Zhiyu,Xu Zhichuan J.,Fu Honggang
Achieving high selectivity in the electrocatalytic hydrogenation (ECH) of concentrated 5-hydroxymethylfurfural (HMF) to 2,5-dihydroxymethylfuran (DHMF) remains a challenge due to competitive adsorption at high HMF concentrations, which limits active-site availability and suppresses *H generation. Regulating the balance between *H generation and HMF adsorption is therefore essential for maintaining selectivity under practical conditions. Here we show a surface amide-functionalized copper nitride catalyst (Ami-Cu 3 N) featuring dual-nitrogen active sites. The catalyst achieves >99% DHMF selectivity and >98% Faradaic efficiency, with a production rate of 63.4 mmol cm -2 h -1 at 500 mA cm -2 under concentrated HMF conditions. Mechanistic studies indicate that the combined roles of lattice nitrogen (promoting water dissociation) and amide nitrogen (modulating HMF adsorption) lower the energy barriers for both *H formation and HMF hydrogenation, facilitating high activity and selectivity. In addition, a coupled electrolysis system enables simultaneous production of value-added products at both electrodes. These findings provide design principles for electrocatalysts that enable selective biomass conversion at high reaction rates.
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Nature Nanotechnology
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2026
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IF 37.5
Huang Yuan,Wang Zeyu,Chen Xi,Gu Lin,Xiao Hai,Liu Qingda,Wang Xun
Industrial seawater electrolysis remains constrained in achieving both high catalytic activity and long-term durability, with key limitations including structural degradation and mechanical instability within catalyst layers. Here we show a self-adhesive high-entropy oxide sub-nanowire monolithic catalyst that overcomes both obstacles. The catalyst is synthesized under mild conditions and incorporates 14 metal elements into uniform ~1.2 nm sub-nanowires with strong intrinsic adhesion to conductive substrates, eliminating the need for external binders. It also features unconventional active sites that enable efficient and durable lattice oxygen activation while preserving structural integrity during prolonged operation. It exhibits overpotentials of 129 mV in 1 M KOH and 153 mV in 1 M KOH + seawater at 10 mA cm −2 , and maintains continuous operation at 1,000 mA cm −2 for 4,700 h and 4,400 h, respectively. Integrated into an anion exchange membrane seawater electrolyser, it delivers 3,000 mA cm −2 at 1.70 V (80 °C) and operates continuously for over 3,819 h at 2,000 mA cm −2 under ambient conditions.
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Nature Communications
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2026
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IF 18.1
Ali Mohamed. A.,Mohamed Moushira. A.,Chen Yujie,Ju Zhijie,Deng Renren,Gu Lin,Li Boyuan,Deng Lu,Yang Lei,Gao Lina,Liu Xiaofeng,Yue Yuanzheng,Qiu Jianrong
Vitrification-devitrification process often results in the formation of translucent/transparent bulk glass-ceramics/ceramics with functionalities comparable to their crystalline counterparts. Here we show a significant enhancement and tunability of luminescence in Mg 2 Al 4 Si 5 O 18+1.5 x : x Eu 2+ (MAS: x Eu) powders after being subjected to a vitrification-devitrification protocol. In MAS: x Eu powders, Eu 2+ occupies multiple-sites in MAS hollow channels, demonstrating tunable blue-to-yellow emissions with red-afterglow. After vitrifying-devitrifying MAS: x Eu powders, the derived ceramics showcase red-emissions with a near-unity luminescence efficiency, higher-thermal stability, and longer-persistent luminescence, enabling the fabrication of red-emitting lighting device with an ultrahigh brightness. The luminescence enhancement is ascribed to the increase of oxygen-related defects in the network during vitrification process that facilitates an efficient trapping-detrapping process. From structural analyses, the luminescence tunability can be attributed to the change in the heterogeneous structure of the channel wall, amending the distribution of Eu 2+ multiple-sites. Thus, our approach has opened a new avenue for advancing the design of high-performance luminescent materials.
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Nature Communications
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2026
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IF 18.1
Xu Wenzhe,Gao Pengfei,Wu Jianfeng,Du Ran,Li Mengtao,Tang Lingfeng,Li Mingrui,Feng Na,Zhang Baoliang,Lu Zongjing,Zhang Lei
Electrosynthesis of 1,3-butadiene from acetylene offers a promising alternative to energy-intensive industrial processes. Nonetheless, achieving selective hydrodimerization of acetylene remains challenging due to competing side reactions, particularly for dilute coal-derived acetylene. Herein, we synthesize a series of dicopper paddlewheel Cu 2 (LCOO) 4 (L = tert-butyl, isopropyl, ethyl, and methyl), featuring bidentate bridging carboxylate ligands with specific Cu···Cu distances for electrocatalytic hydrodimerization of acetylene to 1,3-butadiene. Through catalyst benchmarking, in situ spectroscopy and computational analysis, we reveal that sequential modulation of carboxylate ligands (methyl → ethyl → isopropyl → tert-butyl) progressively enriches electron density at dicopper sites while strengthening structural robustness across the Cu 2 (LCOO) 4 series. The optimized Cu 2 (tert-butylCOO) 4 exhibits favorable reaction energetics for acetylene dimerization and subsequent hydrogenation, achieving 91% Faradaic efficiency with a 1,3-butadiene formation rate of 0.93 mmol h −1 cm −2 in a flow cell. For simulated production of 1,3-butadiene from coal-derived acetylene (15%) in a membrane electrode assembly system, this catalyst demonstrates 83% Faradaic efficiency at −300 mA. This work highlights an effective coordination modulation strategy for producing 1,3-butadiene via dicopper molecular catalysts.
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高影响因子
JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 5
·205
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IF 3.5
Zhu Yimin,Liu Hanxiao,Wang Ruijie,Ma Ke,Dong Yan,Wang Cuiping
Hydrogel is a kind of three-dimensional network gel with water as its core dispersion medium. It is constructed by complex interactions of covalent bonds and non-covalent bonds. Traditional hydrogels usually exhibit soft and fragile mechanical properties, and are difficult to meet the requirements in a variety of practical application scenarios. In this work, 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS), 2-hydroxyethyl methacrylate, and methacrylamide monomer were synthesized through the “one-pot method”, which simplifies the tedious steps of preparation. Then, the hydrogels’ mechanical modification was carried out by adding different ratios of polyvinyl alcohol (PVA). The tensile strength and load-bearing properties of the prepared hydrogels were significantly enhanced as PVA content increased. Meanwhile, the introduction of crosslinking agent N, N’-methylenebisacrylamide (BIS) resulted in a more compact molecular cross-linking network within the hydrogels. The highest tensile strength of the hydrogels was 0.65 MPa, and the maximum bearing capacity was 8.75 kg. In addition, fluorescent components were observed no effect on the hydrogels’ performances, such as mechanical properties and electrical conductivity. The realization of this multi-color hydrogel has contributed to its application in fields such as biomedical, anti-counterfeiting, flexible devices, and other fields.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 5
·347
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IF 5.4
Li Xiaoming,Mao Qiu,He Lin,Zhang Zhengwei,Liu Dongmei,Liu Lu,Ju Pan,Ding Shijia,Li Siqiao,Luo Rong
Bimetallic Fe/Mo-doped carbon dots (Fe/Mo-CDs) have been developed as a high-performance nanozyme to construct a self-validating dual-mode (colorimetric/fluorometric) platform for hydroquinone (HQ) detection. The Fe/Mo-CDs exhibited strong peroxidase-like activity, catalyzing H 2 O 2 -mediated TMB oxidation to generate oxTMB, which simultaneously yields a colorimetric signal and quenches the fluorescence of Fe/Mo-CDs through a confirmed FRET process. The introduction of HQ competitively scavenges the essential reactive oxygen species, inhibiting oxTMB formation and triggering synchronous signal inversion in both channels. This endogenous self-validating function enables favorable analytical performance, with wide linear ranges and ultralow detection limits (0.03 µM for colorimetric; 0.016 µM for fluorometric). Successful application in commercial creams with satisfactory recoveries underscores its strong potential for accurate and reliable screening in complex samples. This work not only presents a sensitive sensor for HQ but also offers a novel design strategy for developing intelligent, self-validating biosensing systems.
Section
Graphical abstract
The alternative text for this image may have been generated using AI.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 22
·15926-15939
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IF 4.4
Feng Yu,Sun Jun,Xu Ruonan,Zhang Wenchao,Liu Baicen,Yue Dong,Yao Yuanhang
The advancement of dielectric capacitors toward achieving high-energy storage density requires polymer-based dielectric materials with both high breakdown strength ( E b ) and high dielectric constant ( ε r ). However, the inherent trade-off between E b and ε r limits further enhancement of energy storage density. In this study, a design approach involving inorganic fillers with gradient dielectric matching is proposed for a double core–shell structure. Barium calcium zirconate titanate (BZCT) nanofibers are utilized as fillers within a double core–shell structure (BT + SiO 2 ), embedded into a polyetherimide (PEI) matrix through electrostatic spinning with an oriented arrangement. This results in the fabrication of BZCT nanofibers PEI-based composite dielectrics with parallel double core–shell structure, demonstrating exceptional energy storage performance. Specifically, the composite dielectric (0.5%-10% BZCT@BT@S/PEI) achieves a charge/discharge efficiency ( η ) of 93.29% and a discharge energy density ( U e ) of 6.97 J/cm 3 with BT and BZCT contents of 0.5% and 10%, respectively. The results show that BZCT enhances the ε r of the composite dielectric, while the double core–shell structure of BT + SiO₂ leads to a gradient change in ε r . This strategy not only can reduce the electric field( E ) distortion caused by the dielectric mismatch between the PEI matrix and BZCT, but also the double core–shell structure shows a relatively significant synergistic effect, successfully increasing the E b of the composite dielectric, with simulation results supporting the design rationale behind the double core–shell structure. This investigation introduces an insight for designing energy storage composite dielectrics. Graphical abstract The alternative text for this image may have been generated using AI.
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COLLOID AND POLYMER SCIENCE
·
2026
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IF 2.9
Sun Zhiguo,Wang Honglong,Wang Xiaoguang,Li Jiali,Lin Qinghua,Tian Fuliang
EB irradiation is widely used for starch modification. Nevertheless, modification mechanism and level are blurry especially at a higher dose irradiation, restraining deep functional material design. In this work, pure corn starch was irradiated by an EB in air with dose up to 500 kGy. Then, microstructural and physicochemical property variations were explored via FT-IR, XPS, 13 C-NMR, GPC, XRD, SEM, whiteness, TGA and viscosity analysis. Later, its post acceleration effect was explored via AA grafting. Main results reveal that irradiation induced severe starch backbone scission. Cleavage mainly occurred at α -1,4 glycosidic bond and the link of C-1 and C-2 atoms within starch glucose unit. Upon 500 kGy irradiation, number-average molecular mass- Mn -decreased from 2.56 × 10 5 to 1.33 × 10 3 Da, conversing macromolecule to small molecule debris. Certain hydroxyls were oxidized to carbonyls. Molecule chain stacking regularity was destroyed. Amorphization occurred shown a crystallinity reduction close to 34%. Synchronously, color be darken, cracks and micropores were generated, thermal-stability and viscosity decreased. In details, whiteness and viscosity decreased from 91.3 ± 0.1 and 1539 ± 5 to 45.3 ± 1.6 and 0 mPas and the fastest speed thermal-decomposition temperature decreased by 6 °C. It seems a dose of 500 kGy EB irradiation deteriorated starch microstructure and physicochemical property sufficiently. However, it promotes post AA grafting efficiently. Via a dose of 100 kGy EB irradiation and certain level AA grafting a QH 2 O as 687.9 ± 19.5 sample was achieved, showing a 1.16 times elevation compared to sample without pre-irradiation, implying sufficient acceleration effect. These findings promote EB irradiation technology use in starch-based functional material design and starch irradiation damage mechanism, sustaining visible use and academic values. In addition, the prepared grafted product possibly sustains a use application in agriculture field, sustaining potential commercial profit, attractive.
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