JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2024
·
IF 2.6
Li Gang,Ren Haifang,Geng Chunping,Wu Xiang
Electrical energy storage devices (EES) play an important role in the development of portable electronic devices, power grids, and electric vehicles. Supercapacitors (SCs) become the focus of the EES field due to their high power density and high energy density. ZnCo 2 O 4 ternary metal oxides show considerable potential as electrodes for SCs. In this work, Ni(OH) 2 and PPy materials are combined on the surface of ZnCo 2 O 4 samples. The synthesized products possess a specific capacitance of 1256 C/g at 1 A/g and an energy density of 69 Wh/kg at 1350 W/kg. Moreover, the assembled device retains 81% of its capacity after being fully charged and discharged 10,000 times.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Wang Xiaochen,Zhang Ning,Shang Huishan,Duan Haojie,Sun Zhiyi,Zhang Lili,Lei Yuanting,Luo Xuan,Zhang Liang,Zhang Bing,Chen Wenxing
Owing to their synergistic interactions, dual-atom catalysts (DACs) with well-defined active sites are attracting increasing attention. However, more experimental research and theoretical investigations are needed to further construct explicit dual-atom sites and understand the synergy that facilitates multistep catalytic reactions. Herein, we precisely design a series of asymmetric selenium-based dual-atom catalysts that comprise heteronuclear SeN 2 –MN 2 (M = Fe, Mn, Co, Ni, Cu, Mo, etc.) active sites for the efficient oxygen reduction reaction (ORR). Spectroscopic characterisation and theoretical calculations revealed that heteronuclear selenium atoms can efficiently polarise the charge distribution of other metal atoms through short-range regulation. In addition, compared with the Se or Fe single-atom sites, the SeFe dual-atom sites facilitate a reduction in the conversion energy barrier from *O to *OH via the coadsorption of *O intermediates. Among these designed selenium-based dual-atom catalysts, selenium-iron dual-atom catalysts achieves superior alkaline ORR performance, with a half-wave potential of 0.926 V vs. a reversible hydrogen electrode. In addition, the SeN 2 –FeN 2 -based Zn–air battery has a high specific capacity (764.8 mAh g −1 ) and a maximum power density (287.2 mW cm −2 ). This work may provide a good perspective for designing heteronuclear DACs to improve ORR efficiency.
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HEREDITAS
·
2024
·Vol. 161
·期 1
·1-17
·
IF 2.1
Zheng Jianxiu,Wang Liyan,Liu Ahui,Shen Haofei,Wang Bin,Jiang Yanbiao,Jing Panpan,Guan Defeng,Yu Liulin,Zhang Xuehong
Background Indole-3-acetic acid (IAA), an indole analog produced by intestinal microorganisms metabolizing tryptophan, has anti-inflammatory and antioxidant properties and thus has potential applications in ovarian protection, although the exact mechanism is unknown. The present study preliminarily investigated the pharmacological mechanism of IAA in alleviating diminished ovarian reserve (DOR) by network pharmacology and molecular docking. Methods Relevant target proteins of IAA were searched in SwissTargetPrediction, PharmMapper, TargetNet, BATMAN-TCM, and SuperPred databases. The potential targets of DOR were obtained from GeneCards, DisGenet, OMIM, and Drugbank databases. Both common targets were then imported into the String website to construct a PPI network, and these targets were analyzed for GO and KEGG enrichment. Finally, we utilized molecular docking to validate the possible binding conformations between IAA and the candidate targets. We used in vitro experiments to preliminarily investigate the effects of IAA on DOR. Results We obtained 88 potential targets for IAA and DOR interaction. We received 16 pivotal targets by constructed protein interaction screening. KEGG enrichment analysis mainly included the AGE-RAGE signaling pathway, IL-17 signaling pathway, Chemical carcinogenesis—reactive oxygen species in diabetic complications, etc. GO functional analysis showed that IAA treatment of DOR may involve biological processes such as response to external stimuli, hypoxia, gene expression, and regulation of enzyme activity. Molecular docking and in vitro experiments further revealed the potential effects of IAA on MMP2, TNF-α, AKT1, HSP90AA1, and NF-κ B. Conclusion We preliminarily revealed the potential protective effects of IAA against DOR through multiple targets and pathways, which provides a new research strategy for the molecular mechanism of IAA to alleviate DOR in the future. However, further studies need to demonstrate whether IAA can be used as a compound to prevent and treat DOR.
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MOLECULAR NEUROBIOLOGY
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2024
·
IF 4.6
Chen Jinglin,Wei Yumeng,Li Nong,Pi Chao,Zhao Wenmei,Zhong Yueting,Li Wen,Shen Hongping,Yang Yan,Zheng Wenwu,Jiang Jun,Liu Zerong,Liu Kezhi,Zhao Ling
The aim of this study was to develop a novel antidepressant with high activity. Based on the findings of molecular docking, eight novel curcumin analogues were evaluated in vitro to check for antidepressant efficacy. Among them, CACN136 had the strongest antidepressant effect. Firstly, CACN136 had a stronger 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonate) radical ion scavenging ability (IC 50 : 17.500 ± 0.267 μg/mL) compared to ascorbic acid (IC 50 : 38.858 ± 0.263 μg/mL) and curcumin (27.189 ± 0.192 μg/mL). Secondly, only CACN136 demonstrated clear protective effects on cells damaged by glutamate and oxidative stress at all concentrations. Finally, only CACN136 showed ASP + inhibition and was more effective than fluoxetine hydrochloride (FLU) at low concentrations. To further confirm the antidepressant effect of CACN136 in vivo, the CUMS model was established. Following 28 days of oral administration of CUMS mice, CACN136 increased the central area residence time in the open-field test, significantly increased the sucrose preference rate in the sucrose preference test ( P < 0.001) and significantly reduced the immobility period in the tail suspension test ( P < 0.0001), all of which were more effective than those of FLU. Subsequent research indicated that the antidepressant properties of CACN136 were linked to a decrease in the metabolism of 5-HT and the modulation of oxidative stress levels in vivo. In particular, the activation of the Keap1-Nrf2/BDNF-TrkB signaling pathway by CACN136 resulted in elevated levels of antioxidant enzymes, enhancing the antioxidant capability in mice subjected to CUMS. In conclusion, CACN136 has the potential to treat depression and could be an effective antidepressant. Graphical Abstract
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JOURNAL OF PLANT GROWTH REGULATION
·
2025
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IF 4.4
Zheng Ying,Han Xiaohuan,Zhang Yang,Qiu Weiwen,Tao Tao,Xu Yuting,Li Mohan,Xie Xingbin,Sun Peipei,Zheng Guanghui,Fang Congbing,Zhao Jing
Strawberry fruits are among the popular berries due to their bright colour and desirable flavour. However, their rapid quality loss results in a short shelf life and low economic value. This study aimed to comprehensively examine the effects of preharvest spraying at small green (SG), large green (LG), white (W), and red-turning (RT) fruit stages, along with postharvest treatments using γ -aminobutyric acid (GABA) and its synthesis inhibitor, 3-mercaptopropionic acid (3-MP), on fruit quality and shelf life. Preharvest application of 10 mM GABA at RT stage significantly enhanced the fruit colour, weight, firmness, soluble solids content (SSC), and the contents of GABA, citric acid, Vc, and soluble sugars at harvest. Postharvest treatment with 10 mM GABA notably delayed the decreases in organic acids, soluble sugars, firmness, colour, and SSC. In addition, postharvest 10 mM GABA treatment reduced the decay incidence and weight loss, while 0.2 mM 3-MP had opposite effects in both preharvest and postharvest treatments. GABA partially induced or inhibited the expression of genes involved in citrate metabolism. Overall, GABA demonstrates effectiveness in improving fruit quality (e.g., increase in organic acids, soluble sugars, firmness, colour, and SSC after preharvest treatment or delaying the decrease of these indices) and extending shelf life by modulating the transcripts of genes related to citrate metabolism.
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FIBERS AND POLYMERS
·
2024
·Vol. 25
·期 11
·4149-4160
·
IF 2.2
Hu Ke,Chen Hongxuan,Lin Yihui,Han Shitong,Wang Qi,Peng Houqian,Wang Ying,Zhao Jiwu,Xi Hailing,Wen Na,Long Jinlin
Abstract Polypropylene (PP) nonwovens have been widely used in disposable protective masks and protective clothing, which are essential to protect healthcare workers from highly infectious diseases such as COVID-19. However, realizing the disinfection reusable function of PP nonwovens to reduce carbon emission or white waste pollution after extensive use has been still a great challenge. Herein, Durable Antimicrobial and Anti-fungal Post-disinfection polypropylene nonwovens were developed by co-grafting of Triclosan and Chitosan. The antibacterial performance test results showed that the as-prepared co-grafted polypropylene nonwoven has a > 99.9% of antimicrobial efficiency against E. coli , S. aureus as well as multi-drug-resistant P. aeruginosa , and the excellent anti-fungal performance against fungus ( C. albicans ) and mold ( A. niger ). Moreover, it retained excellent Antimicrobial and Anti-fungal Properties after disinfection 3 times with boiling water, 40 × diluted 84 disinfectant and 75% alcohol for 5 min. This work provided ideas for developing more effective pathogen protection and longer-lasting personal protective equipment to reduce the environmental impact of medical masks and personal protective equipment in terms of energy consumption, carbon emissions and waste generation. Graphical Abstract Polypropylene (PP) nonwovens have been widely used in disposable protective masks and protective clothing, which are essential to protect healthcare workers from highly infectious diseases such as COVID-19. The as-prepared PP-AA-CS-TCL nonwovens exhibited an antibacterial efficiency of > 99.9% against E. coli , S. aureus , and P. aeruginosa as well as the excellent anti-fungal properties against C. albicans and A. niger. And the antimicrobial and anti-fungal activities were maintained even after disinfection 3 times with boiling water, 40x diluted 84 disinfectant and 75% alcohol for 5 minutes each. This provides a new way of thinking about reusing disposable surgical products with polypropylene nonwoven and reducing environmental pollution.
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Nano Research
·
2024
·
IF 9.5
Li Qingqing,Sun Chang,Sun Xiaolei,Yin Zijun,Du Yaping,Liu Jin-Cheng,Luo Feng
Direct ethanol fuel cells (DEFCs) have drawn attention for their simplicity, rapid start-up, high power density and environmental friendliness. Despite these advantages, the widespread application of DEFCs faces challenges, primarily due to the inadequate performance of anode and cathode catalysts. Pd-based materials have shown exceptional catalytic activity for both the ethanol oxidation reaction (EOR) and the oxygen reduction reaction (ORR). Alloying noble metals with rare earth elements has emerged as an effective strategy to further enhance the catalytic activity by modulating the electronic structure. In this study, we synthesized a series of palladium-rare earth (Pd 3 RE) alloys supported on carbon to serve as bifunctional catalysts that efficiently promote both ORR and EOR. Compared to Pd/C, the Pd 3 Tb/C catalyst exhibits 3.1-fold and 1.8-fold enhancement in activity for ORR and EOR, respectively. The charge transfer in the Pd 3 Tb/C results in an electron-rich Pd component, thereby weakening the binding energy with oxygen species and facilitating the two reactions.
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POLYMER BULLETIN
·
2024
·
IF 3.1
Chen Yurong,Zhan Xue,Hong Shuo,Yuan Dehui,Liang Jiaming,Li Wenyu,Wang Zefeng
Long afterglow nanoparticles, a type of luminescence material, may gradually release stored light energy even after the excitation light has stopped. The modification of polymer membranes by introducing long afterglow nanoparticles via an inorganic particle mixtures, broaden their uses in biomedicine field. In this study, a new membrane modification approach was employed to reduce the loss of physical–mechanical performance, caused by inherent strontium aluminate inorganic particle aggregation. Moreover, eugenol, a cross-linking agent, was used to interact with acrylate monomers to form locally cross-linked compounds using an ex situ approach that improves strontium aluminate particle dispersion. Furthermore, the soap-free emulsion polymerization method used, regulates the degree of cross-linking in the membrane, hence addressing nanoparticles agglomeration. Results showed that the cross-linked structure of the membrane produced improves the heat stability and the hydrophobicity of the material produced while also increasing the nanoparticles dispersion as evidenced by the XRD study. Nevertheless, membranes with cross-linking agents outperformed in water droplet trials by not breaking or whitening the droplets. Furthermore, the generated membranes exhibit high antibacterial activity, making them attractive for paramedical applications such as protective membranes applied on the top of the skin or on the surface areas of sensors, microneedles and metal fasteners.
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Biomass Conversion and Biorefinery
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2025
·
IF 4.1
Li Wangliang,Fang Yi,Chang Shengqiang,Mi Shuzhen,Zhao Shengyong
Co-gasification of biomass and coal offers a strategic approach to enhance the sustainability of energy resources by exploiting the inherent synergies between various biomass components (cellulose, hemicellulose, and lignin) and coal. This study investigates the co-gasification in a downdraft fixed-bed reactor, focusing on the impacts on gas yield, calorific value, and carbon structure transformations. Thermogravimetric analysis revealed parameter-specific effects of biomass components during gasification. At a 50 wt% blending ratio, cellulose significantly enhances gasification, increasing calorific value and CO production beyond theoretical predictions. In contrast, lignin inclusion at a 70 wt% ratio decreases the calorific value and CO production by 6.44% and 11.21%, respectively. Additionally, hemicellulose is found to catalytically enhance CO 2 conversion, with a maximum increase of 45.99% at a 70 wt% ratio. The study elucidates the differential impacts of each biomass component on the co-gasification process and underscores the potential of optimizing biomass blends to maximize the efficiency and sustainability of energy production.
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JOURNAL OF POLYMER RESEARCH
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2024
·Vol. 31
·期 6
·1-13
·
IF 2.6
Wang Wenheng,Liao Mingyi,Wang Lei
The binary segmented styrene-butadiene rubber (SSBR) have been synthesized using butadiene (Bd) and styrene (St) as monomers through living anionic polymerization. This study investigates the loss peak transition mechanism, phase transition mechanism, and the relationship among structure, phase state, and dynamic mechanical properties of segmented SSBR. The results indicate that the two-segment polymerization method allows for precise control of the sequence structure of binary segmented SSBR. The change in the loss peak of SSBR is continuously observed. The phase structure of SSBR can be altered by adjusting the length ratio of the soft and hard segments, which makes structure transition from phase separation to partial compatibility, and ultimately to full compatibility. Furthermore, the mass ratio of Bd/St within the soft and hard segments can be manipulated to influence the compatibility of the SSBR system. TEM images reveal that the transition from complete phase separation to partial compatibility, and ultimately full compatibility, can be represented by changes in the size and distribution of Bd aggregate particles, transitioning from large-sized, mixed-sized particles to uniformly small-sized particles.
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Molecular & Cellular Toxicology
·
2025
·
IF 1.4
He Chaojie,Fan Hongyan,Zhu Chunyan,Huang Yueqing
Background Ischemia–reperfusion (I/R) injury is a severe disorder during revascularization therapy against acute myocardial infarction. Objective Our study aims to investigate the role and regulation mechanism of Annexin A1 (ANXA1) against I/R injury. Results Western blotting analysis showed that ANXA1 expression in rat cardiomyocytes (H9C2 cells) was notably decreased by oxygen–glucose deprivation/reperfusion (OGD/R) treatment. Meanwhile, the NLRP3 inflammasome activation accompanied by pyroptosis and inflammation was observed in H9c2 cells under OGD/R induction. Besides, overexpression or knockdown of ANXA1 dramatically inhibited or aggravated NLRP3-mediated pyroptosis and inflammation. Further investigations found that the m 6 A level of ANXA1 was upregulated by OGD/R, thus leading to decreased mRNA stability in H9C2 cells. FTO, a N6-methyladenosine (m 6 A) “eraser”, was downregulated in H9C2 cells by OGD/R and shown to increase the ANXA1 protein expression by demethylating mRNA in H9c2 cells under OGD/R induction. Moreover, knockdown FTO reversed the protection of ANXA1 against NLRP3-mediated pyroptosis and inflammation in OGD/R-induced H9C2 cells. Conclusion ANXA1 protects cardiomyocytes against I/R injury by alleviating NLRP3-mediated pyroptosis and inflammation via FTO-mediate demethylation. These findings innovatively suggest the therapeutic potential of ANXA1 for myocardial I/R injury.
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Chinese Medicine
·
2024
·Vol. 19
·期 1
·1-16
·
IF 5.3
Rao Chang,Hu Ruixue,Hu Yongxin,Jiang Yan,Zou Xu,Tang Huilan,Chen Xing,He Xiaoli,Hu Guang
Background Salvia miltiorrhiza (Danshen, DS) and Radix Paeoniae Rubra (Chishao, CS) herbal pair (DS-CS) is a famous traditional Chinese combination which has been used as antithrombotic formular for centuries. However, there is still lack of sufficient scientific evidence to illustrate its underlying mechanisms. The purpose of this study is to investigate the antithrombotic effects of DS-CS extract in zebrafish and explore its possible mechanism of action. Methods The quality of traditional Chinese medicines DS and CS granules was evaluated using High Performance Liquid Chromatography (HPLC). Subsequently, the therapeutic effect of the DS-CS combination and its components, Salvianolic Acid A (SAA) and Paeoniflorin (PF), in various concentrations on thrombosis was experimentally validated. Moreover, the interaction between DS-CS and the thrombosis disease targets was analyzed through network pharmacology, predicting the potential antithrombotic mechanism of DS-CS. Molecular docking and in vivo zebrafish experiments were conducted to validate the predicted targets, with qRT-PCR utilized for target validation. Results DS-CS exhibited anti-thrombotic effect in zebrafish with concentrations ranging from 25 to 300 μg/mL. The co-administration of PF and SAA at 25 μg/mL each revealed a synergistic antithrombotic effect exceeding that of individual components when contrasted with PHZ treatment. Protein–protein interaction (PPI) analysis identified key genes, including Albumin (ALB), Proto-oncogene tyro-sine-protein kinase Src (SRC), Matrix metalloproteinase-9 (MMP9), Caspase-3 (CASP3), Epidermal growth factor receptor (EGFR), Fibroblast growth factor 2 (FGF2), Vascular endothelial growth factor receptor 2 (KDR), Matrix metalloprotein-ase-2(MMP2), Thrombin (F2), and Coagulation factor Xa (F10), associated with the antithrombotic action of PF and SAA. Furthermore, KEGG pathway analysis indicated involvement of lipid metabolism and atherosclerosis pathways. Molecular docking revealed strong binding of PF and SAA to pivotal hub genes, such as SRC, EGFR, and F10. The experimental findings demonstrated that DS-CS could upregulate the mRNA expression levels of EGFR while inhibiting F10 and SRC mRNA levels, thereby ameliorating thrombotic conditions. Conclusion This research provided valuable insights into the potential mechanisms underlying the antithrombotic activity of DS-CS. Our findings suggested that PF and SAA could be the key active ingredients responsible for this activity. The antithrombotic effects of DS-CS appeared to be mediated through the regulation of mRNA expression of SRC, EGFR, and F10. These results enhanced our understanding of DS-CS's therapeutic potential and lay the groundwork for future studies to further elucidate its mechanisms of action.
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