CELLULOSE
·
2022
·Vol. 30
·期 3
·1533-1542
·
IF 6.123
Lou Jiayu,Wang Meiyi,Liu Yang,Wang Huashan
T 1 –T 2 multi-modality submicron particles were widely used in clinic imaging, biochemical analysis and biosensor. Here, we prepared a new magnetic submicron particle through the spatial-gap of cellulose nanocrystal (CNC) dispersion as a template.The obtained submicron particles were ellipsoid and had a better magnetic response and relaxation effects. By varying the Fe(acac) 3 to Gd(acac) 3 ratio, it was possible to tune the surface morphology, crystal structure and T 1 –T 2 relaxation effect. More importantly, the pre-drying and burning process had influence on the polycrystalline growth process of Fe(acac) 3 and Gd(acac) 3 mixture, and the slow removal process for the CNC template could endow the compounds with different relaxation effects. By using the spatial-gap of the cellulose nanocrystal dispersion as a template makes it possible to fabricate T 1 –T 2 multi-modality crystalline submicron particles directly and is promising for preparing other CNC-templating based functional materials.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 190
·期 1
·1-10
·
IF 6.408
Wang Zhongrui,Ji Xinxin,Zhao Jingying,Ji Jie,Li Guangyao,Yang Guang,Xia Hongyan,Hou Juan
Fluorescein-functionalized fluorescent polymer dots (F-PDs) were prepared by a facile one-pot method by magnetic stirring under mild conditions based on carboxymethylcellulose (CMC) and fluorescein as the precursors. The obtained F-PDs exhibited a nanoscale size of 3.2 ± 1.1 nm, excellent water solubility, and bright yellow fluorescence emission with a fluorescence quantum yield of 12.0%. The fluorescent probe displays rapid and sensitive chiral discrimination for lysine focused on different complexation abilities between lysine enantiomers and Cu 2+ . The concentration of L-lysine in the range 4 to 14 mM ( R 2 = 0.997) was measured by the fluorescence intensity ratio ( I 513 / I 429 ); the exitation wavelength was set to λ ex = 365 nm. The detection limit was 0.28 mM (3 σ /slope). Importantly, this sensor accurately predicted the enantiomeric excess (ee) of lysine enantiomers at the designed concentration (lysine: 20 mM; Cu 2+ : 10 mM) ranges. The proposed sensor was successfully applied to determine L-lys (recovery: 95.8–101%; RSD: 0.465–3.34%) and ee values (recovery: 98.5–102%; RSD: 2.61–3.21%) in human urine samples using the standard addition method. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
·
2022
·Vol. 233
·期 11
·1-12
·
IF 2.984
Wang Xuejia,Yan Peng,Yang Xue,He Mingqi
Anionic surfactant wastewater has an irreversible effect on aquatic animals and plants. In this paper, the oxidation of sodium dodecylbenzene sulfonate (SDBS) by electro-Fenton system was researched. The results demonstrated that HO 2 · had a weak ability to oxidize SDBS; ·OH was the primary active substance for oxidizing SDBS. The broken bond sites of SDBS molecules oxidized by the active substances were analyzed by using the concept density functional theory. The calculation results indicated that ·OH initially attacked the C3-C11 bond in the SDBS molecule, and then ·OH underwent addition reactions, forming two typical structures: aromatic sodium p-hydroxybenzene sulfonate and aliphatic linear alkanes. Phenol and sodium dodecyl sulfate (SDS) were selected to study their oxidation behaviors in the electro-Fenton system. It can reflect the oxidation process of the products after the SDBS molecule was broken. The main active substance for oxidizing phenol in the electro-Fenton cathode chamber was ·OH, but the main active substance for oxidizing SDS was HO 2 ·. Unlike the ·OH produced by the cathode, the Pt(·OH) produced by the anode had no effect on the removal of SDBS. Nevertheless, Pt(·OH) exhibited an excellent oxidation effect on SDBS bond-breaking products. The research results clarified the mechanisms of SDBS oxidation in electro-Fenton system and the direction of regulation for the reaction path. It is believed that promoting the ·OH generated at the cathode makes SDBS bond breakage a key step in the electro-Fenton oxidation of SDBS. It provided a theoretical basis for enhancing the current efficiency of the system.
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Research
·
2022
·Vol. 26
·期 1
·1-21
·
IF 15.863
Wu Hao,Wei Guoli,Luo Lixia,Li Lingchang,Gao Yibo,Tan Xiaobin,Wang Sen,Chang Haoxiao,Liu Yuxi,Wei Yingjie,Song Jie,Zhang Zhenhai,Huo Jiege
Background Combination of chemotherapy and immune checkpoint inhibitor therapy has greatly improved the anticancer effect on multiple malignancies. However, the efficiency on triple-negative breast cancer (TNBC) is limited, since most patients bear “cold” tumors with low tumor immunogenicity. Doxorubicin (DOX), one of the most effective chemotherapy agents, can induce immunogenic cell death (ICD) and thus initiating immune response.Methods In this study, to maximize the ICD effect induced by DOX, chitosan and cell-penetrating peptide (R6F3)-modified nanoparticles (PNPs) loaded with ginsenoside Rg3 (Rg3) were fabricated using the self-assembly technique, followed by co-encapsulation with DOX based on thermo-sensitive hydrogel. Orthotopic tumor model and contralateral tumor model were established to observe the antitumor efficacy of the thermo-sensitive hydrogel combined with anti-PD-L1 immunotherapy, besides, the biocompatibility was also evaluated by histopathological.Results Rg3-PNPs strengthened the immunogenic cell death (ICD) effect induced by DOX. Moreover, the hydrogel co-loading Rg3-PNPs and DOX provoked stronger immune response in originally nonimmunogenic 4T1 tumors than DOX monotherapy. Following combination with PD-L1 blocking, substantial antitumor effect was achieved due to the recruitment of memory T cells and the decline of adaptive PD-L1 enrichment.Conclusion The hydrogel encapsulating DOX and highly permeable Rg3-PNPs provided an efficient strategy for remodeling immunosuppressive tumor microenvironment and converting immune “cold” 4T1 into “hot” tumors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RARE METALS
·
2022
·Vol. 42
·期 2
·558-571
·
IF 6.318
Hu Qing-Qing,Chai Liang,Liang Ke,Jiang Yan-Xin,Yang Guang,Zhang Lin-Bo,Yin Liang-Jun,Wang Xin,Liu Tao,Lu Hai-Peng,Deng Long-Jiang
Carbonyl iron (CI) particles as magnetic microwave absorption material often suffer from serious corrosion under corrosive environment which leads to performance deterioration. In this study, fluorin-containing acrylate type polymer network layers with thickness ranging from tens of nanometers to around one hundred nanometers were formed continuously around CI. The crosslinked coating layer (named FT) effectively increases CI’s thermal decomposition temperature by at least 34%. The FT-coated CI (named CI-FT) was able to resist both inorganic and organic corrosive media attacking efficiently compared with bare CI. The surface polymer network could also help CI withstand organic medium dissolution which proved the firmness of coating. Cyclic voltammetry (CV) test revealed that the coating layer could significantly reduce maximum oxidation current density of CI by more than 45 times. Tafel polarization study during CV tests also confirmed that thicker FT coating layer could help CI sample stabilize corrosion current density. Meanwhile, the surface coating also enhanced the impedance matching properties of CI as microwave absorber and the CI-FT samples demonstrated improved microwave absorption properties which degenerated little after corrosive medium soaking compared with that of CI. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2022
·Vol. 30
·期 1
·141-152
·
IF 6.123
Chang Longjun,Sun Yong,Gan Linhuo
To clarify the formation of pseudo-lignin during pretreatment is vital to high-value utilization of lignocellulose. In this study, hydrothermally treated bamboo and α -cellulose were employed to investigate the generation of pseudo-lignin during deep eutectic solvent (DES) treatment. It is found that pseudo-lignin not only contains some characteristic substructures of natural lignin, but also has the structural characteristics of phenol-type oxygenated and furan-type compounds. It is proposed that chloride anion probably stimulates the deconstruction of crystalline cellulose to form pseudo-lignin. Besides, it’s suggested that the change in lignin content can be reflected from the viewpoint of acid-soluble lignin to minimize the interference from pseudo-lignin, and there may exist a competition between 5-chloromethylfurfural production and pseudo-lignin formation. This study provides a feasible route to produce pseudo-lignin from α -cellulose via DES and contributes to a better understanding of pseudo-lignin formation.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Shi Benbing,Pang Xiao,Li Shunning,Wu Hong,Shen Jianliang,Wang Xiaoyao,Fan Chunyang,Cao Li,Zhu Tianhao,Qiu Ming,Yin Zhuoyu,Kong Yan,Liu Yiqin,Zhang Mingzheng,Liu Yawei,Pan Feng,Jiang Zhongyi
The idea of spatial confinement has gained widespread interest in myriad applications. Especially, the confined short hydrogen-bond (SHB) network could afford an attractive opportunity to enable proton transfer in a nearly barrierless manner, but its practical implementation has been challenging. Herein, we report a SHB network confined on the surface of ionic covalent organic framework (COF) membranes decorated by densely and uniformly distributed hydrophilic ligands. Combined experimental and theoretical evidences have pointed to the confinement of water molecules allocated to each ligand, achieving the local enrichment of hydronium ions and the concomitant formation of SHBs in water-hydronium domains. These overlapped water-hydronium domains create an interconnected SHB network, which yields an unprecedented ultrahigh proton conductivity of 1389 mS cm −1 at 90 °C, 100% relative humidity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2023
·Vol. 25
·期 2
·1-14
·
IF 2.5
Ding Jianjun,Ye Li,Su Tong,Guo Naiyu,Yu Linbo,Miao Longxin,Cao Mian,Sun Chao
Surface-enhanced Raman scattering (SERS) features a unique fingerprint spectrum for fast and highly sensitive non-destructive detection without sample pretreatment. Aiming at the problem of few “hot spot” and uneven distribution of traditional SERS substrate, in this work, a surface-enhanced Raman substrate of silica/carbon nanotubes/silver nanoparticles (SiO 2 /CNTs/AgNPs) with high on all sides and low in the middle was synthesized by hydrothermal synthesis. The AgNPs were characterized by transmission electron microscopy (TEM), and the average diameter was 38 nm to 63 nm. The substrate exhibited high sensitivity, stability, and uniformity with a detection limit of 10 −12 M for rhodamine 6G (R6G). Furthermore, we conducted an in-depth research on the enhancement contribution of the substrate by finite-difference time-domain (FDTD); the simulation results were in good agreement with the experimental results. Finally, the substrate was used for the detection of phenol red in water; the results showed that the Raman intensity was exponentially related to the concentration of phenol red solution with the coefficient of determination R 2 = 0.99991, which provided a new method for detecting water pollutants. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
Journal of Superconductivity and Novel Magnetism
·
2023
·Vol. 36
·期 2
·711-719
·
IF 1.8
Huang Danqiang,Wen Xinchao,Dai Jianfeng,Wang Qing,Liu Hui,Li Zengpeng
In this study, SrFe 12 O 19 @MFe 2 O 4 (M = Co, Ni, Zn) core–shell nanofibers were fabricated by coaxial electrostatic spinning. The composites obtained at an annealing temperature of 900 °C are composed of SrFe 12 O 19 in pure phase and MFe 2 O 4 (M = Co, Ni, Zn) in different spinels. X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), and transmission electron microscope (TEM) were used to describe the structure and morphology of nanofibers. Magnetic Property Measurement Systems (MPMS) are used to characterize the magnetic properties of nanofibers. Sr@Ni and Sr@Zn fibers all exhibit a unique core–shell structure, while Sr@Co fibers are connected by a lamellar structure. The single-phase hysteresis lines for each composite indicate the presence of exchange coupling effects between the hard/soft magnetic composite phases. The magnetic properties of the composites change as the soft magnetic material in the shell layer changes. Sr@Co has the highest M s (69.43 emu/g) and M r (33.82 emu/g), whereas Sr@Zn has the highest H c (2927 Oe). The switching plant curves indicate that the best exchange coupling of the three groups of samples is for Sr@Co. The magnetic properties of the composites are explained in terms of the nanofiber diameter, the exchange coupling between the two phases, and the nature of the soft magnetic phase itself. It is shown that the exchange coupling of composites is closely related to the type of composite.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-17
·
IF 10.2
Zhao Yading,Shi Dandan,Guo Lu,Shang Mengmeng,Sun Xiao,Meng Dong,Xiao Shan,Wang Xiaoxuan,Li Jie
Immunotherapy had demonstrated inspiring effects in tumor treatment, but only a minority of people could benefit owing to the hypoxic and immune-suppressed tumor microenvironment (TME). Therefore, there was an urgent need for a strategy that could relieve hypoxia and increase infiltration of tumor lymphocytes simultaneously. In this study, a novel acidity-responsive nanoscale ultrasound contrast agent (L-Arg@PTX nanodroplets) was constructed to co-deliver paclitaxel (PTX) and L-arginine (L-Arg) using the homogenization/emulsification method. The L-Arg@PTX nanodroplets with uniform size of about 300 nm and high drug loading efficiency displayed good ultrasound diagnostic imaging capability, improved tumor aggregation and achieved ultrasound-triggered drug release, which could prevent the premature leakage of drugs and thus improve biosafety. More critically, L-Arg@PTX nanodroplets in combination with ultrasound targeted microbubble destruction (UTMD) could increase cellular reactive oxygen species (ROS), which exerted an oxidizing effect that converted L-Arg into nitric oxide (NO), thus alleviating hypoxia, sensitizing chemotherapy and increasing the CD8 + cytotoxic T lymphocytes (CTLs) infiltration. Combined with the chemotherapeutic drug PTX-induced immunogenic cell death (ICD), this promising strategy could enhance immunotherapy synergistically and realize powerful tumor treatment effect. Taken together, L-Arg@PTX nanodroplets was a very hopeful vehicle that integrated drug delivery, diagnostic imaging, and chemoimmunotherapy.Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APOPTOSIS
·
2023
·Vol. 28
·期 3
·607-626
·
IF 7.2
Yu Li-Ming,Dong Xue,Huang Tao,Zhao Ji-Kai,Zhou Zi-Jun,Huang Yu-Ting,Xu Yin-Li,Zhao Qiu-Sheng,Wang Zhi-Shang,Jiang Hui,Yin Zong-Tao,Wang Hui-Shan
Ferroptosis contributes to the pathogenesis of atrial fibrillation (AF), although the mechanisms are still largely uncovered. The current study was designed to explore the pharmacological effects of icariin against ethanol-induced atrial remodeling, if any, and the mechanisms involved with a focus on SIRT1 signaling. Excessive ethanol-treated animals were administered with Ferrostatin-1, Erastin or icariin to evaluate the potential effects of icariin or ferroptosis. Then, the underling mechanisms was further explored in the in vitro experiments using HL-1 atrial myocytes. Excessive ethanol administration caused significant atrial damage as evidenced by increased susceptibility to AF, altered atrial conduction pattern, atrial enlargement, and enhanced fibrotic markers. These detrimental effects were reversed by Ferrostatin-1 or icariin treatment, while Erastin co-administration markedly abolished the beneficial actions conferred by icariin. Mechanistically, ethanol-treated atria exhibited markedly up-regulated pro-ferroptotic protein (PTGS2, ACSL4, P53) and suppressed anti-ferroptotic molecules (GPX4, FTH1). Icariin treatment inhibited ethanol-induced atrial ferroptosis by reducing atrial mitochondrial damage, ROS accumulation and iron overload. Interestingly, the in vivo and in vitro data showed that icariin activated atrial SIRT1-Nrf-2-HO-1 signaling pathway, while EX527 not only reversed these effects, but also abolished the therapeutic effects of icariin. Moreover, the stimulatory effects on GPX4, SLC7A11 and the suppressive effects on ACSL4, P53 conferred by icariin were blunted by EX527 treatment. These data demonstrate that ferroptosis plays a causative role in the pathogenesis of ethanol-induced atrial remodeling and susceptibility to AF. Icariin protects against atrial damage by inhibiting ferroptosis via SIRT1 signaling. Its role as a prophylactic/therapeutic drug deserves further clinical study.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 9
·5223-5234
·
IF 6.123
Li Qi,Zhang Yufei,Liu Zengshe,Liu Shilin,Huang Fenghong,Zheng Mingming
Photocatalytic degradation of organic pollutants is an effective, energy-saving and renewable technique. In this study, functional oil/water (O/W) Pickering emulsions with excellent photocatalytic activity were prepared by the adsorption of nano-titanium oxide (TiO 2 ) into bacterial cellulose (BC). The results indicate that the novel hybrid structure enhanced the interfacial diffusion rate of BC-TiO 2 and further improved the mechanical strength of the obtained interfacial layer. Stable medium internal phase emulsions (MIPEs) and high internal phase emulsions (HIPEs) were also obtained by using low-loading hybrid particles. The investigation of morphology and rheological properties indicated that the shear-thinning and solid-like behaviors of the obtained emulsion systems. The photocatalytic degradation of rhodamine B was much faster in the emulsion system than p-TiO 2 suspension, which was stabilized by BC-TiO 2 (45 min, 90%) with respect to the case of TiO 2 (90 min, 90%) and an aqueous system containing TiO 2 (120 min, 53%). Therefore, this paper gives new insights to the application of BC as an efficient scaffold for loading TiO 2 coupling at the oil–water interface, thus paving the way for the development of sustainable catalyst.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）