Journal of Materials Chemistry B
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2023
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IF 7
Bin Zhu,Yu Liu,Yanlei Zhao,Xinyu Dou,Linbang Wang,Shuyuan Min,Xiaoguang Liu,Dong Qiu
The ideal skull defect repairing material should have good biocompatibility, mechanical properties, and contribute to osteogenesis. In this study, we designed and fabricated biodegradable, bioactive and mechanically robust porous scaffolds composed completely of biological materials. We used gelatin-chitosan blend as the matrix, sodium phytate instead of toxic glutaraldehyde for cross-linking, and the pH-neutral bioactive glass (PSC) to improve biological activity and mechanical properties. The chitosan-gelatin-30%PSC/sodium phytate composite scaffold avoided the problems of high toxicity in conventional cross-linking agents with glutaraldehyde, the poor mechanical support of pure chitosan or gelatin scaffold, and the mismatch of degradation rate with bone repair, being promising as a new candidate for skull defect repair.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Huanyang Yu,Yuan Ge,Huanqi Ding,Yongtai Yan,Liyan Wang
Cross-linking is the most promising method for preparing high-performance chitosan/gelatin bio-polymer film. In this work, vanillin cross-linked chitosan/gelatin bio-polymer (CGGV) film with good mechanics, water resistance, antioxidant and ultraviolet-proof property was prepared. The micro-structure, physical and functional properties of CGGV film were studied. Results showed that vanillin as a cross-linking agent provided a compact inner micro-structure through Schiff base and hydrogen bond interaction. Moderate cross-linking significantly improved mechanical strength, thermal ability, hydrophobicity of the films and reduced the water vapor permeability, swelling ratio and water solubility. Especially, CGGV films showed stronger ultraviolet-proof properties and possessed potent radical scavenging activity. Therefore, CGGV film is suitable to protect per-mature fruits and could be used as novel multifunctional packaging in the agriculture and foods industry.
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CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Binbin Zhang,Xuelin Dong,Qi Zhou,Shan Lu,Xinwei Zhang,Yonggui Liao,Yajiang Yang,Hong Wang
In this work, the luminescence of lanthanide supramolecular metallogel formed by the self-assembly of 5,5′,5″-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl)triisophthalate (H 6 L) and Tb 3+ was efficiently promoted by carboxymethyl chitosan (CMCS). The total quantum yield of the resultant metallogel (denoted as H 6 L/Tb 3+ /CMCS gel) was 9 times higher than the gel without CMCS. The average lifetime of H 6 L/Tb 3+ /CMCS gel increased from 0.51 ms to 1.20 ms. More importantly, the aqueous dispersion of H 6 L/Tb 3+ /CMCS xerogels showed a stable and pH-dependent luminescence. Based on the selective affinity of CMCS to different metal ions as well as with the aid of principal component analysis, H 6 L/Tb 3+ /CMCS can be used as a sensor array to distinguish 11 metal ions ( P < 0.05). This work provides a new strategy for the design and development of bio-based functional luminescent lanthanide supramolecular metallogels.
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CARBOHYDRATE POLYMERS
·
2021
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IF 9.381
Panxianzhi Ni,Renpeng Li,Sheng Ye,Jing Shan,Tun Yuan,Jie Liang,Yujiang Fan,Xingdong Zhang
To develop a biomaterial to lift the lesion and promote wound healing in endoscopic submucosal dissection (ESD), we used lactobionic acid (LA) to improve the water solubility of chitosan (CS) and prepared a new three-phase hydrogel system with lactobionic acid-modified chitosan/chitosan/β-glycerophosphate (CSLA/CS/GP). The results indicated that the hydrogel retains temperature-sensitive properties, and CSLA obviously improved the low-temperature fluidity of the hydrogel precursor solution, enabling injection of the hydrogel by endoscopic needle. The mechanical strength and bio-adhesion of the hydrogels were also improved by the addition of CSLA and the hydrogels could be maintained in acidic environment for a few days and exhibit greater protection of cells. The CSLA/CS/GP hydrogels show good cytocompatibility. The heights of cushions elevated by CSLA/CS/GP hydrogels remained ∼ 60 % 2 h post-injection in porcine stomach models. Given the unique characteristics of these materials, the CSLA/CS/GP thermo-sensitive hydrogel is a promising intraoperative biomaterial in ESD.
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ACS Applied Nano Materials
·
2021
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IF 5.097
Bin Zuo,Qinyue Deng,Han Shao,Bingbing Cao,Yunhui Fan,Wanfang Li,Mingxian Huang
In this work, we designed the Fe3O4@mesoporous-SiO2@chitosan@polyaniline core–shell nanoparticles (Fe3O4@mSiO2@CS@PANI, hence abbr. FSCP), which can be used to capture Cr(VI) in wastewater. Rapid adsorption behavior and high removal capability (249.6 mg Cr(VI) per gram of FSCP) were exhibited by this material. X-ray photoelectron spectroscopy (XPS) analysis demonstrates that Cr(VI) was adsorbed and in situ reduced on FSCP at pH 2. Adsorption was facilitated by the electrostatic attraction of HCrO4– and −N+═C–/–N+H–, while the active −NH–/–N+H– sparked the reduction of Cr(VI) to Cr(III). Moreover, the coordination of the resulting Cr(III) with the amino group promoted adsorption, thus achieving detoxification of Cr(VI) in wastewater. After eight recycling experiments, the Cr(VI) removal efficiency of this material is still more than 90%, indicating that this material has excellent stability and good application potential. Therefore, this magnetic adsorbent offers a potential solution for the successful handling of chromium-containing wastewater.
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Nanoscale Research Letters
·
2021
·Vol. 16
·期 1
·1-12
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IF 4.703
Shu Mengjun,Gao Feng,Zeng Min,Yu Chulang,Wang Xue,Huang Renhua,Yang Jianhua,Su Yanjie,Hu Nantao,Zhou Zhihua,Liu Ke,Yang Zhi,Tan Hongtao,Xu Lin
To achieve better antitumour efficacy, it is urgent to improve anticancer drug delivery efficiency in targeting cancer cells. In this work, chitosan-functionalized graphene oxide (ChrGO) nanosheets were fabricated via microwave-assisted reduction, which were employed to the intracellular delivery nanosystem for anticancer drug agent in breast cancer cells. Drug loading and release research indicated that adriamycin can be efficiently loaded on and released from the ChrGO nanosheets. Less drug release during delivery and better biocompatibility of ChrGO/adriamycin significantly improve its safety and therapeutic efficacy in HER2-overexpressing BT-474 cells. Furthermore, ChrGO/adriamycin in combination with trastuzumab exhibited synergistic antitumour activity in BT-474 cells, which demonstrated superior therapeutic efficacy compared with each drug alone. Cells treated with trastuzumab (5 μg/mL) or equivalent ChrGO/adriamycin (5 μg/mL) each elicited 54.5% and 59.5% cell death, respectively, while the combination treatment with trastuzumab and ChrGO/adriamycin resulted in a dramatic 88.5% cell death. The dual-targeted therapy displayed higher apoptosis, indicating superior therapeutic efficacy due to the presence of different mechanisms of action. The combined treatment of ChrGO/adriamycin and trastuzumab in BT-474 cells induced cell cycle arrest and apoptosis, which ultimately led to the death of augmented cancer cells. This work has provided a facile microwave-assisted fabrication of ChrGO as a controlled and targeted intracellular drug delivery nanosystem, which is expected to be a novel promising therapy for treating HER2-overexpressing breast cancer cells.
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CELLULOSE
·
2021
·Vol. 28
·期 18
·11429-11450
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IF 5.044
Zhao Yali,Lu Wenxi,Shen Shangzhu,Wei Li
The hydrogel wound dressings are mostly sheet-like and do not possess adhesive properties, so it is often difficult for them to adhere well to the skin tissues and fit completely with the irregularly shaped wounds or deep wounds, thereby affecting their therapeutic effects. Herein, the chitosan derivative-based mussel-inspired hydrogels have been developed to overcome these obstacles. Specifically, the principle of adhesion of marine mussel was imitated to synthesize catechol-modified chitosan (CMC), which was potentially used as the raw material to prepare the mussel-inspired hydrogels, that can contribute to the excellent adhesive property and make the hydrogels adhere well to the wound sites. The o-diphenyl groups in CMC could be easily oxidized to form o-diquinone to further form a covalent binding with amino groups (–NH2), or can directly form coordination binding with Fe 3+ .This strong covalent and coordination binding causes the hydrogels to possess a complex spatial structure, which facilitates the hydrogels to display good swelling properties, drug loading and release properties. Furthermore, the total saponins of Panax notoginseng were loaded in the hydrogels and the therapeutic effects of drug-loaded hydrogel were investigated in the model of full-thickness skin injury in mice. The wound healing rate was observed to be as high as 92.5% without exhibiting any scarring. Overall, our findings provided a novel strategy for the preparation of hydrogels for therapeutic applications.
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JOURNAL OF HAZARDOUS MATERIALS
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2021
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IF 10.588
Guang Yang,Xin Hu,Jie Liang,Qiang Huang,Jibo Dou,Jianwen Tian,Fengjie Deng,Meiying Liu,Xiaoyong Zhang,Yen Wei
In this work, a novel imidazoles-MXene hybrid composite, namely polyimidazoles chain overlaying on the surface of MXene (Ti 3 C 2 @IMIZ), was prepared by a simple method. Through this strategy, imidazoles can be in situ growth on the surface of MXenes via a facile multicomponent reaction using chitosan as a renewable reactant. Based on the characterization results, we demonstrated that a thin layer imidazoles with an ordered chain structure was embedded on the surface of Ti 3 C 2 , which resulted in the formation of a novel imidazoles-MXene hybrid composite. The adsorption performance of Ti 3 C 2 @IMIZ for removal environmental pollutants was evaluated using heavy metal ions of Cr(Ⅵ) as adsorbate. Detailed adsorption characteristics of Ti 3 C 2 @IMIZ including operational factors, adsorption kinetics and isotherms models were investigated. XPS analysis showed that Cr(VI) was converted to Cr(III) with low toxicity during the adsorption process . The adsorption of Cr(VI) and reduction of Cr(VI) to Cr(III) contribute to elimination of Cr(VI) species. The adsorption behavior and process analysis show that the adsorption mechanism is mainly physical adsorption through electrostatic interaction. The excellent reproducibility suggests that Ti 3 C 2 @IMIZ may be a potential candidate for remove of Cr(Ⅵ) in actual sewage treatment .
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CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Kun Gao,Jiang Zhan,Yukun Qin,Song Liu,Ronge Xing,HuaHua Yu,Xiaolin Chen,Pengcheng Li
Plant fungal diseases can lead to yield reduction and quality degradation in crops, which usually cause serious economic losses. Additionally, chemical fungicides used in the prevention and control of plant diseases are increasingly restricted due to resistance development and high toxicity. Therefore, biogenic fungicides such as chitosan with low toxicity and good biocompatibility are receiving increasing attention. This study found that the acid swelling chitosan pretreatment method can accelerate the rate of the specific oxidation of chitosan catalyzed by the TEMPO-NaBr-NaOCl system. This study proved that OCTS induces plant disease resistance, and the control efficiencies achieved in protection and treatment experiments against Botrytis cinerea were 80.6 % and 83.4 %, respectively, at 400 μg/mL OCTS. In addition, OCTS can promote plant growth and enhance plant defense enzyme activities. This research has realized a forward-looking exploration of the application of OCTS in the agricultural field.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
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IF 6.953
Jiying Men,Hongxing Shi,Chengya Dong,Yuanyuan Yang,Yuanrui Han,Ruixin Wang,Yiqing Zhang,Ting Zhao,Jun Li
A novel adsorbent with high adsorption capacity to remove cationic dyes was synthesized. Sodium 4-styrene sulfonate (SSS) was grafted polymerization on the surface of magnetic chitosan microspheres via -NH 2 /S 2 O 8 2− surface initiating system, obtaining MCS-g-PSSS microspheres. The grafted microsphere was characterized by Fourier transforms infrared spectroscopy , X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, vibration sample magnetometer and the Brunauer-Emmett-Teller. Cationic dyes were adsorbed by MCS-g-PSSS and methylene blue(MB) was acted as a typical example. The adsorption performance was explored by varying experimental conditions. The results showed the maximal adsorption capacity was 989 mg/g at pH 1 at 25 °C. The pseudo-second order model was found to be applicable for the adsorption kinetics . The adsorption capacity increased with rising temperature and it decreased owing to adding of ions. The adsorption isotherms were the best fitted by Langmuir. MCS-g-PSSS for MB showed high adsorption capacity due to the strong electrostatic interactions and π-π stacking, which was explained by FTIR and XPS and was verified by DFT calculations. The degree of adsorption spontaneity increased with rising the temperature. The grafted MCS-g-PSSS microspheres had high adsorption capacity for various kinds of cationic dyes and excellent for remove MB in the aqueous solution.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Wenqi Li,Liping Zhang,Die Hu,Ran Yang,Jie Zhang,Ying Guan,Fanxun Lv,Hui Gao
In this study, a novel mesoporous nanocellulose/sodium alginate (SA)/carboxymethyl-chitosan (CMC) aerogel was fabricated using a simple method. The adsorption of Cu 2+ and Pb 2+ on the aerogel in aqueous solutions was investigated. The obtained aerogel was characterized using scanning electron microscopy, fourier-transform infrared spectroscopy, transmission microscope, atomic force microscopy and N 2 adsorption–desorption. Furthermore, the fundamental Cu 2+ and Pb 2+c adsorption behaviours of the mesoporous aerogel, including the effect of pH, adsorption equilibrium and kinetics were investigated. The adsorption isotherms and kinetics of aerogel closely followed the Langmuir model and pseudo-second-order model, respectively, indicating that the adsorption behaviours can be classified as monolayer chemical adsorption. The aerogel exhibited high efficiency for the adsorption of Cu 2+ (169.94 mg/g) and Pb 2+ (472.59 mg/g). The aerogel maintained a high adsorption capacity for Cu 2+ (56 mg/g) and Pb 2+ (245 mg/g) after five adsorption–desorption cycles. Therefore, the as-prepared mesoporous aerogel has great potential in wastewater treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
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IF 6.953
Tao Liao,Chang Liu,Jun Ren,Hui Chen,Ying Kuang,Bingbing Jiang,Jianli Chen,Zhengguang Sun,Cao Li
To enhance drug utilization and reduce their side effects, the strategy of “tumor-triggered targeting” was introduced to fabricate dual-pH-sensitive chitosan (CHI)/mesoporous silica nanoparticle (MSN)-based anticancer drug delivery system (DDS) in this work. Model drug doxorubicin hydrochloride (DOX) was loaded in MSN, which was modified with benzimidazole (Bz) group. Then chitosan- graft - β -cyclodextrin (CHI- g -CD) was applied as the “gatekeeper” to cover MSN through host-guest interaction between β -CD and Bz. After being coated with targeting peptide adamantane-glycine-arginine-glycine-aspartic acid-serine (Ad-GRGDS), methoxy poly(ethylene glycol) benzaldehyde (mPEG-CHO) was finally grafted on CHI through the pH-sensitive benzoic imine bond. Due to the dynamic protection of PEG, the obtained carriers were “stealthy” at pH 7.4, but could reveal the shielded targeting peptide and the positive charge of CHI in the weakly acidic environment achieved a “tumor-triggered targeting”. Inside cancer cells, the interaction between β -CD and Bz group could be destroyed due to the lower pH, resulted in DOX release. Both in vitro and in vivo studies proved the DDS could targeting induce cancer cell apoptosis, inhibit tumor growth, and reduce the cytotoxicity of DOX against normal cells. It is expected that the system named DOX@MSN-CHI-RGD-PEG could be a potential choice for cancer therapy.
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