MOLECULAR PHARMACEUTICS
·
2025
·
IF 4.5
Hongyu Zhu,Sen Yang,Jingyang Zhao,Liuyang Wang,Chenghao Gao,Yanan Sheng,Xuan Lin,Zhiguo Su,Kiichi Sato,Zhongyu Hu,Songping Zhang
All-trans retinoic acid (Ra) has been demonstrated to enhance the establishment of systemic and intestinal immunity for codelivered antigens; however, the extremely poor water solubility of Ra significantly limits its application in vaccines. Herein, leveraging the advantages of ionic liquids in modifying the physicochemical properties of small-molecule drugs, we synthesized a novel ionic liquid composed of choline and retinoic acid ([Cho][Ra]). Compared to Ra, [Cho][Ra] exhibited an 18165-fold increase in solubility at pH 7.4 and an acid-responsive Ra release behavior. The [Cho][Ra] was then formulated with the SARS-CoV-2 RBD antigen, and its adjuvant effects were comprehensively evaluated. The in vitro cellular studies indicated that at 50 μg Ra equivalent dose, the [Cho][Ra]@RBD showed significantly higher than RBD along in activation of BMDC and the expression of gut homing molecules, including C–C motif chemokine receptor 9 (CCR9, 10.55 folds), α4β7 integrin (13.29 folds), and lymph node migration molecule CCR7 (82.68 folds). Animal experiments showed that compared to RBD alone, [Cho][Ra]@RBD promoted the establishment of mucosal immunity in the intestines in mice at the early stage following subcutaneous immunization and elicited higher serum antibody levels. Furthermore, compared to RBD and Alum@RBD, [Cho][Ra]@RBD enhanced the formation of CD4+ TCM and CD8+ TCM cells, indicating stronger cellular immune responses. In summary, [Cho][Ra] showed potential adjuvant effects in enhancing the humoral and cellular immune responses, as well as in the establishment of intestinal mucosal immunity for RBD antigen without the need for delivery system, thereby offering promising prospects for applying Ra in vaccines.
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高影响因子
LANGMUIR
·
2026
·
IF 3.9
Shisong Yang,Mingyang Lin,Zili Wang,E Yang,Yangyang Luo,Ran Zhu,Zheng Chen,Qian Lin,Hongyan Pan
Selective oxidation of methane to methanol by in situ-generated hydrogen peroxide (H2O2) from H2 and O2 is a promising alternative to the current industrial methods. However, it still faces the dilemma that the slow formation of the hydroxyl radical (•OH) leads to a low efficiency of partial oxidation of methane to methanol. In order to solve this problem, we constructed an Fe–Pd/SIL–NH2 composite catalyst synergistically modified by amino and [BMIM]PF6. Comprehensive characterization and experimental results show that the electron transfer path between Pd and Fe is regulated. Fe2+ and Pd2+ species are mainly distributed in Fe–Pd alloy catalysts. The Fe–Pd/SIL–NH2 catalyst not only successfully coupled the in situ synthesis and efficient decomposition of H2O2 to produce •OH radicals but also changed the local hydrophobic microenvironment of the active sites, thereby promoting the rapid desorption of hydrophilic products. These factors work together to weaken the adsorption energy of HOOH* (from 0.78 to 0.49 eV) and greatly promote the dissociation of HOOH*, thereby greatly improving the efficiency of generation of •OH radicals, which lays a foundation for the efficient synthesis of methanol. The final CH3OH yield and selectivity were as high as 73.42 mmol gFePd–1 h–1 and 87.4%, respectively, which were 2.52 and 1.67 times those of of Fe–Pd/SBA-15–NH2 and 4.87 and 2.11 times those of Fe–Pd/SIL, respectively. This study highlights the surface modification of Fe–Pd alloy catalysts for bimetallic catalysis.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Xiaoli Zhou,Xinyue Yan,Xiaofeng Liang,Ziyi Zhao,Yong Huang,Kun Hu
Background The overuse of nonsteroidal anti-inflammatory drugs (NSAIDs) has raised public health and environmental concerns, and their concentrations are low in environmental and biological samples, where complex sample matrices can interfere with analytical accuracy, creating an urgent need for a simple, effective, and sensitive method to detect NSAIDs in complex samples. Covalent organic frameworks (COFs) have emerged as promising adsorbents owing to their tunable pore structures and abundant functional groups. Nevertheless, synthesizing COFs that simultaneously exhibit high adsorption performance and enable sensitive detection of NSAIDs remains a remarkable challenge. Results To address this, we synthesized triazine COFs with the assistance of an ionic liquid (IL), termed T-IL-COFs, and employed them as adsorbents for enriching and detecting various NSAIDs. For comparison, W-COFs (lacking IL assistance and triazine units) and T-COFs (containing triazine groups but synthesized without IL) were also prepared. Compared with these two COFs, T-IL-COFs contained triazine units and exhibited larger specific surface areas and pore sizes, enhancing their adsorption performance and selectivity. Adsorption mechanisms were examined using multiple spectroscopic techniques, revealing that interactions were driven by π–π stacking, hydrophobic, electrostatic, and hydrogen-bonding forces. A T-IL–COF–based high-performance liquid chromatography–ultraviolet (HPLC–UV) method was then developed for dispersive solid–phase extraction of NSAIDs. The proposed method exhibited excellent linear ranges (ibuprofen: 1–800 ng/mL; flurbiprofen and ketoprofen: 0.5–800 ng/mL), high enrichment factors (50–81), low limits of detection (0.12–0.33 ng/mL), and excellent recoveries (80.51%–104.70%) in urine and river water samples. Significance This study presents an alternative strategy to enhance the adsorption performance and selectivity of COFs for NSAIDs by introducing functional groups and increasing the specific surface area and pore size. Moreover, it offers an efficient HPLC–UV method for the selective enrichment and sensitive detection of NSAIDs in environmental and biological samples.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Nguyen Dao Anh Le,Mai Duy Quoc,Le Mai Ngoc Thi,Nguyen Trinh Hao,Le Diep Dinh,Tran Phuong Hoang
To contribute to alleviating the
depletion of fossil fuel resources
and address environmental issues, renewable biomass is being studied
in depth for the synthesis of valuable petroleum derivatives. The
direct transformation of abundant glucose resources into 2,5-diformylfuran
(DFF) is a promising route for producing an alternative candidate
on an industrial scale. In this work, we developed a practical approach
for preparing various molybdate-based acidic ionic liquid systems
for the “one-pot, one-step” production of DFF from glucose,
yielding approximately 40% in an acceptable time frame of 3 h through
an approachable procedure. The results indicated the high catalytic
performance of multifunctional ionic liquid catalysts bearing Lewis
acid, Brönsted acid, and oxidation sites to promote DFF production.
Therefore, the findings of this work highlight the potential application
of molybdate-based acidic ionic liquids as a sustainable strategy
for synthesizing high-value chemicals on a large scale.
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JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Xuemeng Xu,Xiaxing Feng,Shuang Wang,Yuhong Lin,Bing Wang,Yaming Sun,Chenchen Song,Lijun He,Ke Zhang
Aflatoxin B 1 (AFB 1 ) and its biosynthetic precursors usually coexist and pose a significant risk to food safety, but the simultaneous and accurate detection remains challenging due to their diverse structures and trace levels as well as complex food matrix. Herein, we proposed a novel triphenyl ionic liquid-modified multipods periodic mesoporous organosilica (mp-PMO-IL(ph) 3 ) with controllable pods, serving as an adsorbent of dispersive solid-phase extraction (DSPE), and then combined with high performance liquid chromatography for simultaneous and accurate determination of AFB 1 and its two typical biosynthetic precursors with varied structures and polarity. The multipods and hierarchical pore structure as well as multifunctional groups endowed mp-PMO-IL(ph) 3 with excellent extraction recovery of above 90.6% and satisfactory extraction selectivity for three analytes from different cereals. Under optimal conditions, the developed method was validated and showed wide linearity of 0.9-120 ng g -1 (r 2 ≥ 0.9974) and low limits of detection of 0.18-0.30 ng g -1 . The recoveries of three analytes in seven cereal samples spiked at three different concentrations (1.0, 5.0 and 25.0 ng g -1 ) were 93.1% to 106.9% with relative standard deviations ≤ 6.9%. This study introduces a promising and novel approach for accurate determination of trace AFB 1 and its precursors in complex food matrix.
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ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Le-Qing Fan,Qiu-Mei Tu,Cheng-Long Geng,Jian-Ling Huang,Yun Gu,Jian-Ming Lin,Yun-Fang Huang,Ji-Huai Wu
To achieve a quasi-solid-state supercapacitor (SC) with high energy density and low self-discharge, a redox-active poly(vinyl alcohol) (PVA)-based gel polymer electrolyte (GPE) is synthesized by the addition of 1-butyl-3-methylimidazolium bromide (BMIMBr) ionic liquid (IL) and carbon nanotubes (CNTs) into a PVA aqueous solution, followed by the addition of Li 2 SO 4 and then the removal of excess water. The influences of BMIMBr-to-PVA and CNTs-to-PVA mass ratios on the ionic conductivity of GPE are discussed. The maximum ionic conductivity of GPE can reach 61.1 mS cm −1 . A SC consisting of the optimized GPE and a pair of activated carbon (AC) electrodes exhibits a high energy density of 43.1 Wh kg −1 , which can be assigned to the wide working voltage of 1.8 V as a result of the strong solvation effect of Li + cations and SO 4 2− anions, pseudocapacitance contribution from the redox reaction of Br − /Br 3 − at the electrolyte/electrode interface, and the three-dimensional (3D) conductive network of CNTs throughout the PVA matrix providing transport channel to facilitate ion transport. And the self-discharge is greatly suppressed due to the presence of 3D network of CNTs in the GPE. Additionally, the SC presents excellent cyclic stability.
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Theranostics
·
2026
·Vol. 16
·期 4
·1997
·
IF 13.3
Zhaoyan Xu,Jian Chen,Ling Shu,Wanzi Hong,Yuanxi Mo,Jiaqi Wang,Yaoxin Liu,Wing-Tak Wong,Suk-Ying Tsang,Ning Tan,Lei Jiang
Acute myocardial infarction (AMI) remains one of the most severe and life-threatening cardiac diseases, accounting for a substantial proportion of mortality worldwide and necessitating the development of novel treatment approaches for effective myocardial repair. Biocompatible, ionically conductive injectable hydrogel scaffolds have emerged as promising candidates for AMI treatment owing to their prominent electrical conductivity and mechanical compatibility with cardiac tissue. Methods: In the present investigation, a facile ionic-conductive injectable hydrogel was developed by incorporating the conductive polymer PEDOT and boronic acid-functionalized carboxymethyl chitosan (pCMC) with poly-ionic liquid (P-ILs), oxygen-generating calcium peroxide (CaO 2 ) particles, and adipose-derived stem cell exosomes (ADSC-exos) to improve myocardial regeneration via enhancing conductivity and oxygen release. The physiological and mechanical characteristics of the injectable hydrogel were examined through morphological evaluation, oxygen-release profiling, electroactivity, and rheological analysis. In vitro biocompatibility was assessed using rat cardiac fibroblasts (RCF) and H9C2 cells. For in vivo investigation, a rat ischemia-reperfusion model was established, and the developed hydrogels were administered for 28 days to examine cardiac function recovery and myocardial regeneration. Results: The encapsulation of Exo within the hydrogel enhanced its biological performance by promoting antioxidant activity and angiogenesis, while concurrently inhibiting cardiomyocyte (CM) apoptosis and inflammation. Both in vitro and in vivo findings demonstrated that the Exo-loaded ICon-O 2 -hydrogel significantly enhanced reactive oxygen species (ROS) scavenging, cellular proliferation, migration, angiogenesis responses, resulting in effective myocardial repair, accelerated cardiac functional recovery, reduced fibrosis, and increased neovascularization in the rat model. Conclusion: The combined therapeutic model integrating ADSC-exos with an oxygen-generating ionic-conductive hydrogel demonstrates a promising potential for AMI therapy by reducing fibrosis and scar formation while promoting angiogenesis and myocardial regeneration.
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·123755
·
IF 7.5
Huiyi Ye,Zhancheng Fan,Wei Ding,Yu Chang,Dayi Deng
Coal tar dense non-aqueous phase liquids (DNAPLs), widespread legacy contaminants at former industrial sites, pose significant environmental challenges due to high viscosity and persistent polycyclic aromatic hydrocarbons (PAHs) content. Conventional cosolvent flushing is hampered by solvent volatility, flammability, and recycling difficulties. We therefore developed a closed-loop system integrating ionic liquid (IL) flushing, electrical resistance heating (ERH), and activated carbon (AC) regeneration. Batch tests showed that 60% v/v 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF 4 ]) mobilized coal tar and solubilized > 60% of total PAH (ΣPAH) within 12 h at ambient temperature. Density functional theory calculations confirmed strong π–π stacking between [BMIM]⁺ and PAHs (e.g., interaction energy (ΔE) = –45.1 kJ/mol for phenanthrene). AC rapidly adsorbed PAHs from [BMIM][BF 4 ] solution with even greater affinity (ΔE = –59.1 kJ/mol for phenanthrene), enabling efficient IL regeneration. Column studies demonstrated enhanced ΣPAH removal at elevated temperature (93.6% at 60 °C vs. 76.8% at 20 °C within 2 h); this is particularly critical for the removal of high-molecular-weight PAHs (HMW PAH), attributed to a reduction in coal tar viscosity that promotes mobilization and intra-tar diffusion. A 2D sand tank experiment demonstrated 93.2% ΣPAH removal at 80 °C within 5 h under continuous AC regeneration and ERH-enhanced circular IL flushing. This innovative IL-ERH-AC system offers a safe, sustainable, and efficient solution for recalcitrant coal tar DNAPL remediation.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Zidan Luo,Mengfei Tian,Naveed Ahmad,Wu Qiu,Yu Zhang,Chunying Li,Chunjian Zhao
In this study, a switchable temperature-responsive ionic liquid-based surfactant-free microemulsion (TRIL-SFME) for extraction and in-situ separation of hydrophilic and lipophilic compounds from Camptotheca acuminata was firstly developed and systematically characterized. This TRIL-SFME was obtained using 1-hexyl-3-methylimidazolium tetrafluoroborate ([HMIM][BF 4 ]), 1,2-propanediol and H 2 O. The prepared TRIL-SFME presented low viscosity and rapid response to temperature. Firstly, the effect of temperatures on TRIL-SFME phase behavior was studied followed by determination of effect of liquid/solid ratio and extraction time on the extraction yields of the targeted compounds. The TRIL-SFME demulsified rapidly by thermal stimulus, resulting in in-situ separation and enrichment of compounds with varying polarity. The results of present study revealed that TRIL-SFME had higher extraction yields (1.50–5.79 folds) compared to traditional solvents and individual components of TRIL-SFME. Besides, in-situ separation and enrichment of hydrophilic compounds (phenolic acids) and lipophilic compounds (alkaloids) was accomplished in short time (within 3 min) by cooling the system to 4 ℃. Furthermore, the mesoscopic behavior between TRIL-SFME and targeted compounds was simulated by dissipative particle dynamics (DPD) to explore the extraction mechanism for the first time. The results illustrated the formation of W/IL structure of TRIL-SFME and clarified solubilization mechanism of TRIL-SFME system for targeted compounds, which is related to its special "water pool" structure. This novel and switchable TRIL-SFME is an environmentally friendly and promising alternative to simultaneously extract, in-situ separate and enrich the natural active compounds with different polarity from plant matrices.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yu Chen,Jiayuan Yu,Yiqian Yang,Feng Huo,Chunshan Li
The reaction of CO 2 and propylene oxide (PO) for the synthesis of propylene carbonate (PC) is an important reaction, but the reaction is generally carried out under high-temperature and high-pressure conditions due to the limitations of reaction kinetics and mass transfer. Here, we propose a novel microreaction system catalyzed by ionic liquids (ILs). The reaction processes (e.g., catalyst, temperature, pressure, gas–liquid flow rate, catalyst concentration, residence time) were optimized within microreactors of different inner diameters. The kinetics for carbonate synthesis with CO 2 catalyzed by ionic liquid (IL-[HMIM]Br) in a microreactor was evaluated, and the activation energy of [HMIM]Br was obtained. Based on the rough numerical estimation of mass transfer characteristics, coupled with the reaction characteristics, the microreactor enhancement can reduce the reaction time for this fast reaction to minutes, typically several hours in conventional reactors. This provides new opportunities for enhancing gas–liquid reactions with typical mass transfer control and for CO 2 utilization to achieve carbon neutrality.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Wenqing Wang,Hao Li,Xinmin Ma,Jianming Pan
The development of environmentally friendly and efficient methods for the removal of Phenolic endocrine disruptors (PEDs) from aqueous is essential to protect the environment and human health. In this work, sol–gel method and emulsion template approach were combined and applied to construct 1-Butyl-3-methylimidazolium hexafluorophosphate ([BMIM]PF 6 ) ionic liquid-filled silica-shell microcapsules (SiO 2 @IL). And amino, halogen and long-chain alkanes surface-functionalized silica-shell encapsulated ionic liquid microcapsules (SiO 2 -NH 2 @IL, SiO 2 -Cl@IL, and SiO 2 -C 16 @IL) were successfully formulated by silica layer modification techniques. The microcapsules have homogeneous dimensions, about 1 µm, and high loading, about 92 wt% of ILs. Four microcapsules showed high adsorption properties and excellent regeneration performance for removing 3,4,5-trichlorophenol (3,4,5-TCP), which benefited from the excellent performance of [BMIM]PF 6 on the extraction of 3,4,5-TCP and the enhanced hydrophobic and electrostatic effects of the surface modified microcapsules. The maximum adsorption capacity of SiO 2 @IL, SiO 2 -NH 2 @IL, SiO 2 -Cl@IL and SiO 2 -C 16 @IL calculated from the Langmuir model was 1047, 1207, 1108 and 1145 mg g −1 at 25 °C, respectively. The main factors affecting the extraction performance were the hydrophobicity and steric hindrance of [BMIM]PF 6 . After three regeneration cycles, the adsorption capacity and desorption efficiency of microcapsules were still above 90 %. The functionalization of the shell layer enhances the hydrophobic and electrostatic effects, which is conducive to the adsorption process, and provides some theoretical and data support for the subsequent construction of ionic liquid encapsulation materials for chlorophenol removal.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Jiabo Cheng,Mengfei Tian,Zarmina Gul,Chunyu Liang,Bin Qiao,Yuan Gao,Chunjian Zhao,Chunying Li
In this study, a functionalized surface active ionic liquid (SAIL) was designed and prepared, which exhibits pH-responsive behavior and high yield for 6 target flavonoids from the leaves of Vitex negundo L.. Firstly, a series of functionalized SAIL [N-C n , N'–CO 2 H-Im]Br (n = 10, 12, 14, 16) were prepared and used for extraction of the target components, [N-C 14 , N'–CO 2 H-Im]Br showed the highest yield. Secondly, optimized extraction conditions obtained by Plackett-Burman design (PBD) and response surface methodology (RSM) were concentration of 45.5 mM, liquid–solid ratio of 11.6 (mL/g), extraction time of 38.5 min, extraction temperature of 40 °C, and ultrasonic power of 400 W. The yield obtained by [N-C 14 , N'–CO 2 H-Im]Br of vitexin, isovitexin, hyperoside, luteolin, quercetin, apigenin is 2.04, 1.81, 1.24, 1.51, 2.47 and 1.21 mg/g, respectively, which is 1.11–1.56 folds higher than non-functionalized SAIL ([C 14 min]Br) and 1.50–5.36 folds higher than traditional solvents. More importantly, the solvent system can realize the in-situ separation of the target compound by adjusting pH. When pH is changed from 6.1 to 4.9, the system is divided into two phases, and the target compounds were separated to the upper phase with a high recovery rate. Finally, molecular simulation was used to reveal the extraction mechanism of functionalized SAIL on target compounds. The results showed that the target flavonoids were compatibilized to the palisade region of micelles, and the weak interaction between the target flavonoids and functionalized SAIL was mainly van der Waals force.
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危险品化学品经营许可证（带存储）