INDUSTRIAL CROPS AND PRODUCTS
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2025
·
IF 6.2
Hui Kong,Xiaoqian Chen,Shuzhen Ni,Yongchao Zhang,Menghua Qin,Yingjuan Fu,Chuanling Si
Structural change, reduced reactivity, and deepened color of lignin caused by uncontrollable reaction in the process of separation are the main problems that hinder its effective utilization. Based on lignin-first strategy, nucleophilic phenol (PH) or syringol (SL) in conjunction with hydrotrope p -toluenesulfonic acid ( p -TsOH) was employed to separate phenolated and light-colored lignin from pine under mild conditions. It was found that the quick and targeted reaction of the nucleophilic PH or SL with lignin at the sidechain C α position inhibited the cleavage of β-O-4 bonds thus reduced the intermolecular condensation of lignin and the formation of chromophoric groups. The introduction of phenolic hydroxyl groups and low condensation degree enhanced the solubility of lignin in p -TsOH solution, resulting in a high extract yield of lignin. The separated lignin had a lighter color, more phenolic hydroxyl and methoxyl groups, abundant β-O-4 bond and more uniform molecular distribution and exhibited an exceptional UV shielding and antioxidant activity. The phenolated lignins were easily self-assembled into regular spherical nanoparticles by anti-solvent method, which had good mixing effect with face cream to prepare sunscreen with adjustable sun protection factor (SPF) value.
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FOOD AND CHEMICAL TOXICOLOGY
·
2025
·
IF 3.5
Yongjun Tang,Zhengning Feng,Chenlu Ma,Nian Jang,Xiaolong Chen,Yingxu He,Francis L. Martin,Hui Liu,Weiyi Pang
Breast cancer has a high global incidence, and benzo[ a ]pyrene (B[ a ]P) is considered a contributing factor that increases carcinogenic risk. This study examined B[ a ]P's oncogenic mechanisms in mammary epithelial cells. Chronic B[ a ]P exposure induced morphological changes and enhanced proliferative/clonogenic capacity in MCF-10A cells. Chronic B[ a ]P exposure altered gene expression in MCF-10A cells, revealing differential levels of circRNAs, lncRNAs, miRNAs, and mRNAs. qRT-PCR validation demonstrated strong alignment with RNA-seq results, ensuring sequencing reliability. Additionally, chronic B[ a ]P exposure upregulated the protein expression of AhR and ARNT, as well as TGF- β , pSmad2/3, and KRT14 , while increasing Vimentin expression and decreasing E-cadherin expression. Notably, treatment with the TGF- β inhibitor SB431542 reversed these protein expression changes in transformed cells. These results show that exposure to Chronic B[ a ]P induces MCF-10A cell transformation. The underlying mechanisms involve significant transcriptional alterations, AhR/ARNT expression regulation, TGF- β signaling pathway activation, KRT14 protein modulation, and EMT. Furthermore, Chronic B[ a ]P exposure may drive transformation through TGF- β modulation. Chronic B[ a ]P exposure promotes breast carcinogenesis, revealing mechanistic insights and potential preventive biomarkers.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Feng Wang,Yimin Zhang,Xinyu Xu,Yunxiang Nie,Binbin He,Yi Mei,Yun Zu
Low-valuable utilization and a massive accumulation of yellow phosphorus slag (YPS) have caused severe pollution in surrounding environments. Among numerous implementation strategies, the conversion of YPS into phosphorus-containing zeolites represents a promising approach for high value-added utilization. Herein, we report that P-ZSM-5 zeolites were successfully prepared from acid-leaching YPS in one step using a hydrothermal synthesis method. The obtained P-ZSM-5 zeolites exhibited high crystallinity, uniform crystal size (200–400 nm), and a large BET surface area (>400 m2/g). Accordingly, a nonclassical crystallization mechanism of P-ZSM-5 zeolites from the YPS was proposed by multiple advanced characterizations. Importantly, the presence of phosphorus not only induced framework Al sited in the straight/sinusoidal channels and improved the hydrothermal stability of the zeolite framework but also enhanced the Brønsted acidity. Under comparable conditions, the as-prepared P-ZSM-5(75) zeolite catalyst with a higher ratio of Brønsted/Lewis acid sites in the methanol-to-propylene reaction exhibited a considerable catalytic lifetime (30 h, WHSV = 6 h–1), high propylene selectivity (55.1%), and a propylene-to-ethylene ratio of 5.9. The advancement in P-ZSM-5 zeolites paves a novel way for more effective YPS utilization and driving sustainability in phosphorus-based chemical production.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ning Zhang,Yefang Teng,Dong Zhao,Zongsheng Liu,Jian Xu,Meng Ma
As a promising biodegradable alternative to petroleum-based plastics, Polylactic acid (PLA) faces significant challenges in industrial applications due to its inherent flammability and brittleness, necessitating material modifications for expanded utilization. This study addresses the critical challenges of flammability and brittleness in PLA through the development of a novel bio-based anti-dripping flame retardant system. A phosphorus‑nitrogen containing flame retardant (AAPZ), was successfully synthesized and incorporated with ammonium polyphosphate (APP) to create high-performance PLA composites. The optimized PLA/4.5APP/4.5AAPZ composite demonstrated exceptional flame retardancy, passing a UL-94 V-0 rating with complete suppression of melt dripping. Cone calorimetry analysis revealed significant improvements in fire safety, with peak heat release rate (PHRR) and total smoke release (TSR) reduced by 60.2 % and 28.3 %, respectively, compared to neat PLA. Remarkably, the composite maintained excellent mechanical properties, exhibiting a 185 % increase in elongation at break while preserving tensile strength. The synergistic flame-retardant mechanism was systematically investigated, demonstrating effective gas-phase and condensed-phase actions. This bio-based flame-retardant system not only overcomes the inherent limitations of PLA but also provides a sustainable solution for expanding its applications in demanding sectors.
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BIOMATERIALS
·
2011
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IF 7.883
Feihu Wang,Dianrui Zhang,Qiang Zhang,Yuxuan Chen,Dandan Zheng,Leilei Hao,Cunxian Duan,Lejiao Jia,Guangpu Liu,Yue Liu
Multidrug resistance (MDR) in tumor cells is a significant obstacle for successful cancer chemotherapy. Overexpression of drug efflux transporters such as P-glycoprotein (P-gp) is a key factor contributing to the development of tumor drug resistance. Verapamil (VRP), a P-gp inhibitor, has been reported to be able to reverse completely the resistance caused by P-gp. For optimal synergy, the drug and inhibitor combination may need to be temporally colocalized in the tumor cells. Herein, we investigated the effectiveness of simultaneous and targeted delivery of anticancer drug, paclitaxel (PTX), along with VRP, using DOMC-FA micelles to overcome tumor drug resistance. The floate-functionalized dual agent loaded micelles resulted in the similar cytotoxicity to PTX-loaded micelles/free VRP combination and co-administration of two single-agent loaded micelles, which was higher than that of PTX-loaded micelles. Enhanced therapeutic efficacy of dual agent micelles could be ascribe to increased accumulation of PTX in drug-resistant tumor cells. We suggest that the synergistic effect of folate receptor-mediated internalization and VRP-mediated overcoming MDR could be beneficial in treatment of MDR solid tumors by targeting delivery of micellar PTX into tumor cells. As a result, the difunctional micelle systems is a very promising approach to overcome tumor drug resistance.
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JOURNAL OF POWER SOURCES
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2021
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IF 9.127
Jianfei Xiao,Yuan Wang,Tian C. Zhang,Like Ouyang,Shaojun Yuan
Heteroatom-doped porous carbon materials (HPCMs) have attracted great attention due to their excellent physical and chemical properties and the enhanced performance of multiple heteroatom co-doping. Herein, N, P-co-doped porous carbon materials (NPPCs) are developed via a novel synthesis of the phytic acid-induced self-assembled chitosan aerogel followed by pyrolysis and activation. Phytic acid serves as a P source, acid regulator and structure-directing agent for improved activation efficiency to create more pores. A little of NaNO 3 is used both as a template and activator simultaneously. The porosity and N content of such NPPCs are controlled by rationally tuning the pyrolysis temperature and the mount of NaNO 3 . The NPPC-0.75-600 delivers a good CO 2 adsorption capability of 3.02 and 5.31 mmol g −1 at 100 and 500 kPa, respectively, and has an excellent stability with almost no adsorption capacity decay even after successive 20 cycles. For supercapacitors (SCs), the NPPC-0.75-700 also displays a high capacitance of 231.2 F g −1 at 1 A g −1 and an outstanding stability at circa 96.7% initial capacity after 10000 cycles. These results highlight the great potential of such NPPCs in CO 2 capture and SCs, and the novel synthetical route offers new insights for the readily scalable production of HPCMs.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2018
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IF 6.735
Junyu Fan,Zhaoxia Ding,Zhiwei Zhao,Jie Liu
In this study, potassium ferrate(VI) was employed for the degradation of p-arsanilic acid (p-ASA) and simultaneous removal of the generated arsenic species though in-situ coagulation. The effects of several factors, including ferrate(VI) dosage, initial pH, coexisting anions, and humic acid, on the p-ASA degradation and arsenic species removal were investigated. Under various water quality conditions, an excellent removal of p-ASA could always be achieved with the 20:1 mol radio dosage of ferrate(VI) and p-ASA within 30 min. But the removal of arsenic species is significantly affected by the water quality. It could be inhibited by alkalinity and presence of phosphate and humic acid. The generated ferric oxide was mainly 2-line ferrihydrite according to the XRD and XPS analysis. Based on the HPLC-HG-AFS and GC–MS analysis, the major degradation products were detected and the mechanism of the p-ASA degradation by ferrate(VI) and the released arsenic removal by 2-line ferrihydrite generated from ferrate(VI) was given. Two simultaneous degradation pathways of p-ASA were proposed. The p-ASA in solution attacked by ferrate(VI) in solution would lead cleavage of the As–C bond firstly to generate As(III) and p-aminophenol. On the other hand, small amounts of p-ASA initially absorbed on 2-line ferrihydrite would be firstly converted to 4-nitrophenylarsonic acid through the oxidation of –NH 2 to –NO 2 by ferrate(VI), subsequently transformed to As(III) and p-nitrophenol. Combined with the strong oxidizing and the high removal capacity of released arsenic by its generated product, ferrate(VI) have well potential applications for controlling the risk of p-ASA in wastewater.
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高影响因子
Analytical Methods
·
2021
·Vol. 13
·期 19
·2223-2228
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IF 2.896
Bo-Wen Liu,Peng-Cheng Huang,Fang-Ying Wu
A novel and efficient light-controlled colorimetric assay for the quantification and detection of nitroreductase (NTR) was constructed based on p-aminophenol (pAP)-catalyzed and nicotinamide adenine dinucleotide (NADH)-mediated generation of AgNPs. Due to the hydrolysis of p-nitrophenol by NTR in the presence of NADH, the hydrolysis product can be used as a catalyst to catalyze the reduction of Ag+ by NADH under the light. As the concentration of NTR increases, the value of absorbance at ca. 400 nm (A400) decreases and the color of the solution turns from brown to bright yellow. A linear correlation was obtained between A400 and the NTR concentration in the range from 1–50 μg mL−1 and the limit of detection (LOD) is 0.27 μg mL−1. The detection system does not respond to other common biological molecules due to the specificity of enzymes and the effect of the nitroreductase inhibitor on the NTR activity was also tested. Finally, we applied the assay to determine NTR in human serum samples by spiking different concentrations of NTR with a recovery of 85.2%–92.5%.
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高影响因子
Journal of Materiomics
·
2018
·
IF 0
Lei Wei,Shi-Xi Zhao,Xia Wu,Shu-Jin Zhao,Ce-Wen Nan
Nano-Li 2 Mn 0.5 Fe 0.5 SiO 4 /C cathode material is synthesized by a hydrothermal route and phosphorus substitution is applied to improve structural stability and electrochemical properties. At low substitution content, P element completely enters into the lattice, forms [PO 4 ] tetrahedrons and partially replaces [SiO 4 ] tetrahedrons , which is confirmed by X-ray diffraction and X-ray photoelectron spectroscope measurements. Phosphorus substitution helps to suppress the change of coordination number of Mn and stabilize the material structure to some extent, obtaining better electrochemical performance in the early cycle. With the increase of P content, parts of P element exist in Li 3 PO 4 which distributes uniformly and co-exists with active substance. Electrochemical tests prove that existing Li 3 PO 4 has positive impacts on cycle and rate performance, and the lithium ion diffusion coefficient increases by about 14 times than pristine sample. Under the synergistic effects of phosphate substation and proper Li 3 PO 4 , Li 2 Mn 0.5 Fe 0.5 SiO 4 /C shows enhanced electrochemical performances.
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MARINE POLLUTION BULLETIN
·
2025
·
IF 4.9
Jia Shi,Dan Xu,Qiao Ma
p -Chloro- m -xylenol (PCMX), a widely used antimicrobial agent, poses potential ecological risks due to its ubiquitous distribution and documented toxicity to aquatic vertebrates. Although microbial degradation represents a key natural attenuation pathway, the molecular mechanisms governing PCMX biodegradation remain elusive. Here, we report the isolation of three novel Rhodococcus strains from marine sediments capable of mineralizing PCMX. Among these, strain R. ruber SJ-1 completely metabolized 30 mg/L PCMX within 72 h and maintained significant degradation capacity under high-salinity stress. Integrated genomic and transcriptomic analyses revealed that PCMX exposure triggered extensive transcriptional reprogramming in strain SJ-1, with 1063 genes upregulated and 533 downregulated. PCMX inhibited core cellular functions, including key genes related to cell stress resistance, energy production, central carbon metabolism, fatty acid metabolism, and protein biosynthesis. Concurrently, aromatic catabolism pathways were markedly induced. A highly upregulated gene cluster ( sj4821 - sj4838 ) was identified as pivotal for PCMX metabolism, encompassing a flavin-dependent monooxygenase (NphA1-sj, sj4831 ; 2145.26-fold) and catechol 2,3-dioxygenase (C23O, sj4838 , 2052.43-fold) genes. Quantitative PCR assays further validated the upregulation patterns. Based on bioinformatics and high-resolution mass spectrometry analyses, we proposed that strain SJ-1 converted PCMX to 4-chloro-3,5-dimethylcatechol via ortho -hydroxylation, followed by meta -cleavage of the aromatic ring. This study presents the first documented evidence of PCMX degradation by a marine Rhodococcus isolate. Our findings reveal the molecular mechanisms driving PCMX detoxification and cellular adaptation, establishing a foundation for bioremediation in saline ecosystems.
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ACS Sustainable Chemistry & Engineering
·
2022
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IF 9.224
Tao Ding,Yishuang Wu,Xun Zhu,Guiying Lin,Xun Hu,Hongqi Sun,Yong Huang,Shu Zhang,Hong Zhang
Co-doping of heteroatoms into the support of metal-supported catalysts is a prevalent method to improve the catalytic performance by adjusting metal–support interactions. This paper investigated the catalytic performances of Ru supported on biomass-derived char (Ru@Char), N-doped char (Ru@N-Char), and N,P-co-doped char (Ru@NP-Char) in the emerging lignin-first depolymerization for both poplar (hardwood) and pine (softwood) samples, with an emphasis on the production of phenolic monomers. Various characterizations of the prepared catalysts showed that the codoping of N,P not only facilitated the formation of micropores in the char but also introduced weak and moderate acid sites. Furthermore, the sizes of Ru nanoparticles on the codoped char became smaller, and the proportion of metallic Ru species was increased, resulting from electron transfer from Ru to the codoped char. The yields of the phenolic monomers from poplar and pine over Ru@NP-Char were as high as 57.98 and 17.53 wt % Klason lignin, respectively, which were improved by factors of 1.4–2.5 in comparison to Ru@Char and Ru@N-Char. Full delignification during the depolymerization of both poplar and pine was also achieved over Ru@NP-Char.
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ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Lingling Wang,Hui Huang,Songhua Xiao,Daoping Cai,Yuan Liu,Bin Liu,Dandan Wang,Chenxia Wang,Han Li,Yanrong Wang,Qiuhong Li,Taihong Wang
We report a room-temperature NH3 gas sensor with high response and great long-term stability, including CeO2 NPs conformally coated by cross-linked PANI hydrogel. Such core–shell nanocomposites were prepared by in situ polymerization with different weight ratios of CeO2 NPs and aniline. At room temperature, the nanohybrids showed enhanced response (6.5 to 50 ppm of NH3), which could be attributed to p–n junctions formed by the intimate contact between these two materials. Moreover, the stability was discussed in terms of phytic acid working as a gelator, which helped the PANI sheath accommodate itself and enhance the mechanical strength and chemical stability of the sensors by avoiding “swelling effect” in high relative humidity. The sensors maintained its sensing characteristic (response of ca. 6.5 to 50 ppm of NH3) in 15 days. Herein, the obtained results could help to accelerate the development of ammonia gas sensor.
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