PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
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2024
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IF 2.6
Yun Meng,Ye Cai,Mengyao Cui,Yuhang Xu,Long Wu,Xiang Li,Xiaoqin Chu
The aim of this study was to prepare a solid self-microemulsifying drug delivery system (S-SMEDDS) of cinnamaldehyde (CA) by spray drying technique to improve the oral bioavailability of CA. The preparation of CA S-SMEDDS with maltodextrin as the solid carrier, a core-wall material mass ratio of 1:1, a solid content of 20% (w/v), an inlet air temperature of 150 °C, an injection speed of 5.2 mL/min, and an atomization pressure of 0.1 MPa was determined by using the encapsulation rate as the index of investigation. Differential scanning calorimetry (DSC) revealed the possibility of CA being encapsulated in S-SMEDDS in an amorphous form. The in-vitro release showed that the total amount of CA released by S-SMEDDS was approximately 1.3 times higher than that of the CA suspension. Pharmacokinetic results showed that the relative oral bioavailability of CA S-SMEDDS was also increased to 1.6-fold compared to CA suspension. Additionally, we explored the mechanism of CA uptake and transport of lipid-soluble drugs CA by S-SMEDDS in a Caco-2/HT29 cell co-culture system for the first time. The results showed that CA S-SMEDDS uptake on the co-culture model was mainly an energy-dependent endocytosis mechanism, including lattice protein-mediated endocytosis and vesicle-mediated endocytosis. Transport experiments showed that CA S-SMEDDS significantly increased the permeability of CA in this model. These findings suggested that CA S-SMEDDS is an effective oral solid dosage form for increasing the oral bioavailability of lipid-soluble drug CA.
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Solar RRL
·
2024
·
IF 6
Chenxi Zhao,Bowen Liu,Fuyan Chen,Jiaxin Gao,Xinan Shi,Daocheng Pan
Cu(In, Ga)(S, Se) 2 (CIGSSe) solar cell is one of the most promising thin-film solar cells with a record power conversion efficiency (PCE) of 23.6%. Conventional CIGSSe thin-film solar cells are usually fabricated on Mo-coated soda-lime glass substrate, thereby, the sunlight on the rear side cannot be utilized by the monofacial CIGSSe solar cells owing to the opacity of the Mo electrode. CIGSSe solar cells fabricated on transparent conductive oxide (TCO) electrode enable to fabricate bifacial solar cells, which can generate power on both sides of solar cells, so that bifacial solar cells have a high potential application in building-integrated photovoltaics. However, the PCEs of CIGSSe solar cells fabricated on TCO substrates are significantly lower than those of ones on Mo substrates. In this article, bifacial CIGSSe solar cells on fluorine-doped tin oxide (FTO) substrate are fabricated by using an ionic liquid-assisted solution approach and utilizing a MoO 3 thin film as an interface layer between FTO and CIGSSe absorber layer, yielding a front-side PCE of 9.73% and a back-side PCE of 1.77%.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Xiang Li,Yunyi Wang,Ting Wu,Guigan Fang
The graphitic carbon nitride (g-C 3 N 4 ) photocatalysis has emerged as a clean method for cleaving lignin-linked bonds due to its mild and sunlight-driven reaction conditions. The fast electron–hole pair complex of g-C 3 N 4 constrains its degradation efficiency, making the heterojunction construction a popular solution. The conventional methods of preparing g-C 3 N 4 heterojunctions by physical mixing destroy π-conjugations in g-C 3 N 4 , reducing the adsorption of lignin containing benzene rings. In this study, a novel indium oxide (In 2 O 3 ) quantum dot–g-C 3 N 4 0D/2D heterojunction was prepared through the high-temperature oxidation of pre-prepared indium-doped g-C 3 N 4 . The introduction of In 2 O 3 at the quantum dot level minimizes the interference with lignin adsorption capacity. The strong combination of the two (In 2 O 3 and g-C 3 N 4 ) increases the intersection interface area, promoting the S-scheme transfer route of the photogenerated electrons. Consequently, this enhances the photoelectric conversion efficiency and carrier lifetime of the heterojunction, and inhibits the rapid recombination of photogenerated electron–hole pairs in g-C 3 N 4 . The proposed heterojunction was 3 times more efficient than g-C 3 N 4 alone for selective cleavage of lignin β–O–4 bonds after 2 h of sunlight irradiation. Combined with inhibitor experiments and gas chromatography–mass spectrometry analysis, this paper defines the reactive oxides and proposes a cleavage pathway for the lignin β–O–4 bonds in In 2 O 3 –g-C 3 N 4 heterojunction system.
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ACTA PHYSICO-CHIMICA SINICA
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2025
·
IF 13.5
Yanyan Zhao,Zhen Wu,Yong Zhang,Bicheng Zhu,Jianjun Zhang
Photocatalytic oxygen reduction reaction (ORR) offers a mild and cost-effective approach for hydrogen peroxide (H 2 O 2 ) production. However, its practical application is significantly hindered by rapid charge carrier recombination and insufficient O 2 adsorption capacity in photocatalysts. To address these limitations, we developed a strategy involving the creation of S-vacancy-rich CdIn 2 S 4 (S v –CIS) to facilitate charge separation and subsequent deposition of Au nanoparticles on its surface (Au–S v –CIS) to strengthen O 2 adsorption. The results suggest that the optimized Au–S v –CIS achieves a significantly increased H 2 O 2 production yield of 2542 μmol·h·g −1 in 10%-ethanol/water solution, which is about 12.8 and 1.7 times higher than that of pure CIS and S v –CIS. Comprehensive characterizations including photoluminescence spectra, time-resolved photoluminescence spectra, transient photocurrent response, electrochemical impedance spectra, and femtosecond transient absorption spectroscopy confirm the improved charge dynamics of Au–S v –CIS. In addition, temperature-programmed desorption of O 2 combined with density functional theory calculations conclusively demonstrates the superior O 2 adsorption capacity of Au–S v –CIS. This work provides a design strategy for efficient solar–to–chemical energy conversion through cooperative photocatalyst engineering.
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ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Xuan Yang,Xueqin Wang,Shenghao Xu,Beili Lu,Biao Huang,Xinyu Zheng,Guanfeng Lin
Hydroquinone (HQ) in wastewater is of great concern, as it is harmful to human health and threatens the ecological environment. However, the existing adsorbents have low adsorption capacity for HQ. To improve the removal of HQ, N,S-codoped activated carbon-ZIF-67 (NSAC-ZIF-67@C) was synthesized in this study by in situ growth of ZIF-67 on N,S-codoped activated carbon (NSAC) and carbonization. The influence of pH, contact time, and initial concentration on the adsorption behaviors of NSAC-ZIF-67@C on HQ were investigated. Owing to the synergistic effect of abundant active sites and well-developed pore structure, the NSAC-ZIF-67@C achieved a prominent adsorption capacity of 962 mg·g–1 and can still retain high adsorption performance after 5 cycles for HQ, which is superior to that of reported other adsorbents. HQ adsorption follows the pseudo-second-order kinetics model (R2 = 0.99999) and the Freundlich isotherm model. X-ray photoelectron spectroscopy (XPS) analysis before and after adsorption as well as density functional theory (DFT) calculation results showed that pyridinic-N-termini were conducive to the π–π interactions and hydrogen-bonding interactions. Therefore, the adsorption mechanisms of NSAC-ZIF-67@C on HQ involve pore filling, electrostatic attraction, π–π interaction, and hydrogen bonding. This study is expected to provide a reference for designing highly effective adsorbents for wastewater treatment.
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Hua Chai,Jun Nan,Wenxing Jin,Fangmin Wu,Bohan Liu,Yan Guo
Hydrogen peroxide (H 2 O 2 ) serves as a critical industrial chemical and potential energy carrier. Photocatalytic synthesis presents a viable alternative to the anthraquinone process, yet existing catalyst systems exhibit restricted sunlight wavelength responses and inadequate activity. In this study, zinc phthalocyanine/polymer carbon nitride (ZnPc/PCN) S-scheme heterojunction formation extends the photocatalyst's light absorption range to the near-infrared region (400–800 nm) and generates an internal electric field at the interface, facilitating photogenerated carrier separation and transfer. ZnPc/PCN exhibits an AQY of 1.11 % for H 2 O 2 production under 800 nm irradiation. The optimized ZnPc/PCN yields 1.87 mM H 2 O 2 , surpassing the original PCN and ZnPc by 1.36 and 93.5 times, respectively·H 2 O 2 production remains above 1.5 mM (80 %) after five cycles, demonstrating ZnPc/PCN stability. Detection of intermediate ·OOH suggests H 2 O 2 production via 2 e - oxygen reduction processes. This research offers novel insights for designing near-infrared absorbing photocatalysts.
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Pharmaceutics
·
2024
·Vol. 16
·期 3
·344
·
IF 4.9
Juliana Palungan,Widya Luthfiyah,Apon Zaenal Mustopa,Maritsa Nurfatwa,Latifah Rahman,Risfah Yulianty,Nasrul Wathoni,Jin-Wook Yoo,Nurhasni Hasan
Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. Self-healing hydrogel mechanical properties were improved via polymer blends. Applying this hydrogel to the wound site allows it to self-heal and reattach after mechanical damage. This work evaluated polyvinyl alcohol (PVA)-based self-healing hydrogels with borax as a crosslinking agent and carboxymethyl chitosan as a mechanical property enhancer. Three formulations (F1, F4, and F7) developed self-healing hydrogels. These formulations had borax concentrations of 0.8%, 1.2%, and 1.6%. An FTIR study shows that borate ester crosslinking and hydrogen bonding between polymers generate a self-healing hydrogel. F4 has a highly uniform and regular pore structure, as shown by the scanning electron microscope image. F1 exhibited faster self-healing, taking 13.95 ± 1.45 min compared to other formulations. All preparations had pH values close to neutrality, making them suitable wound dressings. Formula F7 has a high drug content (97.34 ± 1.21%). Good mechanical qualities included high tensile stress–strain intensity and Young’s modulus. After 28 h of storage at −20 °C, 5 °C, and 25 °C, the self-healing hydrogel’s drug content dropped significantly. The Korsmeyer–Peppas release model showed that the release profile of GSNO followed Fickian diffusion. Thus, varying the concentration of crosslinking agent and adding a polymer affects self-healing hydrogels’ physicochemical properties.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Ying Tian,Kunfeng Zhang,Haoran Zhao,Bo Peng,Jinxia Liang,Hongxia Chen,Runfeng Huang,Yuanyuan Wei,Hanyu Chen
Novel 2D/2D TiO 2 /BiOBr (TOB- x , x represented the molar ratio of TiO 2 /BiOBr) heterostructures with dual oxygen vacancies were fabricated via an in-situ hydrothermal approach. Owing to the construction of p-n heterostructure and strong interface interaction, a S-scheme charge transfer path was formed, which facilitated efficiency separation and transfer of charge and retained strong redox capacities of photoexcited electrons and holes. Simultaneously, the introduction of oxygen vacancies induced strong photoabsorption, improving the light harvesting capacity. The oxytetracycline (OTC) degradation efficiencies over TOB-0.05 and TOB-0.1 were significantly improved relative to those of single components. The TOB-0.1 photocatalyst displayed the best photocatalytic activity, which was 3.75 and 1.76 times higher those of TiO 2 -Vo and BiOBr-Vo, respectively. Furthermore, we also examined the effects of pH, ions, and water matrixes on OTC conversion of TOB-0.1, and investigated the photocatalytic degradation mechanism. This work provides a useful guideline for constructing high-efficiency photocatalysts for wastewater treatments by combining 2D/2D heterojunction and dual-defect engineering.
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Sustainability
·
2024
·Vol. 16
·期 20
·9051
·
IF 3.3
Huali Zhang,Kanghui Zhang,Qin Liu,Tongshan Shi,Jiaheng Cui,Jinxiu Li
This study presents a novel Fe-CNs-P/S carbon composite material, synthesized by doping elements P and S into NH2-MIL-101 (Fe) using the carbonization method. The material’s application in sustainable water treatment was evaluated, focusing on its effectiveness in activating persulfate for pollutant degradation. The research thoroughly investigates the synthesis process, structural characteristics, and performance in degrading pollutants. The results indicate that Fe-CNs-P/S-5 with 50% P and S co-doping is higher than that of other samples, where the degradation rate of TC in 30 min is as high as 98.11% under the optimum conditions, that is temperature at 25 °C, 0.05 g/L of catalyst concentration, and 0.2 g/L of PMS concentration. The composite material demonstrates robust versatility and stability, maintaining high degradation efficiency across multiple organic pollutants, with no significant reduction in catalytic performance after four cycles. Furthermore, the free radical quenching experiments display that the singlet oxygen1O2is the main active species. It is demonstrated that the doping of P and S play a role in the enhancement of PMS activation over the Fe-CNs-P/S catalyst. This material demonstrates remarkable efficacy in treating a range of organic contaminants and exhibits excellent reusability, presenting a promising approach for enhancing sustainability in water treatment applications.
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Acta Biomaterialia
·
2025
·
IF 9.6
Jie Zhang,Yanlong Wang,Yu Sun,Zeyi Zhou,Fengni Liu,Xinyu Zhang,Chuiyu Kong,Jiang Yuan,Meng Yin,Dongjin Wang
Intimal hyperplasia, thrombosis formation, and vascular calcification are the leading causes of failure in small-diameter vascular grafts. In the study, bilayer vascular grafts with separately released nitric oxide (NO) and resveratrol (RESV) were fabricated. S-nitrosated keratin nanoparticles (KNPs) were synthesized and subsequently electrospun with polycaprolactone (PCL) to prolong the NO release for up to 25 d in the presence of ascorbic acid and trypsin, serving as the inner layer of grafts. Additionally, RESV was incorporated into poly(ε-caprolactone-co-L-lactide) (PLCL) fibers to alleviate oxidative stress and inflammation, acting as the outer layer of the grafts. The PCL/KNPs//PLCL/RESV bilayer grafts were capable of promoting endothelial cell proliferation while inhibiting the excessive proliferation of smooth muscle cells. Notably, bilayer grafts could regulate macrophage polarization toward the M2 phenotype. In rat abdominal aorta replacement models, the grafts retained patency for 3 months. These grafts could accelerate endothelialization without apparent intimal hyperplasia, thrombosis, inflammation, and calcification. These bilayer grafts are promising for small-diameter tissue-engineered vascular grafts. Statement of Significance • S-nitrosated keratin nanoparticles (KNPs) were synthesized and subsequently electrospun to prolong the NO release for 25 d. • Resveratrol (RESV) was incorporated into PLCL fibers to alleviate oxidative stress and inflammation. • Bilayer grafts promoted EC proliferation while inhibiting SMC proliferation. • Bilayer grafts accelerated endothelialization without intimal hyperplasia, thrombosis, and calcification in vivo.
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Journal of Materials Chemistry A
·
2025
·
IF 9.5
Yuting Sun,Bin Yao,Yuhong Jiang,Yongfeng Li,Xiaobo Du,Zhanhui Ding,Jiayong Zhang,Chunkai Wang,Ding Ma,Mengge Li,Yan Zhu,Xiaofei Sun,Ning Ding,Liyuan Shi
It is well known that the improvement of crystal quality and photoelectric properties of Cu2ZnSn(S,Se)4 (CZTSSe) is one of the key issues in enhancing power conversion efficiency (PCE). To resolve this problem, we selected Li2CO3 as a Li source to prepare Li-doped CZTSSe by annealing Li-doped Cu2ZnSnS4 (CZTS) precursor films in air, followed by selenization (CZTSSe-Li-A). It is interesting that the air annealing leads to the incorporation of Li and O into CZTSSe in the form of Li-O pairs, which improves the crystal quality and absorption coefficient (α) of CZTSSe-Li-A and decreases its hole concentration and resistivity compared with Li-doped CZTSSe prepared using Li-doped CZTS that is not annealed in air (CZTSSe-Li). By optimizing Li doping concentration, annealing temperature and time, the highest PCE of CZTSSe-Li-A solar cell without MgF anti-reflection layer reaches 11.13%, which is larger than the highest PCE of CZTSSe-Li solar cell (10.21%). Quantitative analysis indicates that the increased PCE of CZTSSe-Li-A solar cell compared to CZTSSe-Li solar cell is mainly attributed to the decrease in reverse saturation current density (J0) and series resistance (Rs) caused by thermal effect of the air annealing, followed by an increase in photogeneration density (JL) and shunt resistance (Rsh). The decreased J0 is due to a reduction in interfacial defect density, increased JL is due to increase in α and depletion region width, and decreased Rs and increased Rsh are due to improve crystal quality. This work offers a route for the improvement of PCE of CZTSSe solar cells.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wei Liu,Heng Zhang,Zhe Zhang,Yali Ji,Tiantian Xu,Xusheng Li,Jiao Chen,Mengyao She,Ping Liu,Shengyong Zhang,Jian-Li Li
Solar-driven photocatalytic CO 2 -to-CH 4 conversion represents a promising strategy to mitigate the energy and climate crisis. However, it is still challenging to achieve efficient CO 2 conversion due to the difficulties of CO 2 activation, sluggish kinetics of water oxidation half-reaction and high cost of sacrificial agents in conventional reaction systems. Herein, by precisely integrating bimetallic sulfide with functionalized UiO-66 to construct a Cu 0.1 Zn 0.9 S/Bim-UiO-66 S-scheme heterojunction photocatalyst, which innovatively accomplished complete CO 2 methanation and benzimidazole synthesis in one redox cycle. Experimental results reveal that the optimized photocatalyst exhibited an exceptional CH 4 production rate of 35.2 μmol h −1 g −1 (selectivity of 100 %) and 92 % benzimidazole conversion under simulated solar irradiation. Mechanistic studies demonstrate that the S-scheme heterojunction significantly enhances photogenerated charge carrier separation efficiency through the establishment of a built-in electric field, while preserving the strongest redox potentials of the two semiconductors. Remarkably, the benzimidazole synthesis process replaced conventional H 2 O oxidation, proving beneficial for CO 2 -to-CH 4 conversion. This work provides new insights into designing high-performance photocatalysts for CO 2 conversion and the synthesis of fine chemicals.
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