AAPS PHARMSCITECH
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2018
·Vol. 19
·期 5
·2395-2406
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IF 2.666
Xiao Yu,Wang Shuang,Zong Qingyu,Yin Zongning
Single chemotherapeutic agent like paclitaxel (PTX) has shown some limitations in anti-tumor treatment, such as undesirable side effects, multidrug resistance, and high toxicity. In order to reduce the toxicity of PTX and increase the anti-tumor effect, folate-modified amphiphilic and biodegradable biomaterial was developed to co-deliver PTX and metformin (MET) for exerting the synergistic effect. PTX was physically entrapped in the hydrophobic inner core of the amphiphilic block copolymer by a solvent evaporation method, whereas MET was chemically conjugated to the hydrophilic terminals of copolymer via a pH-sensitive cis -aconityl linkage (Cis). The in vitro release behaviors of the drugs were analyzed by high-performance liquid chromatography (HPLC), and the synergistic effect of the drugs was evaluated by a Q value method. Results showed that drug-loaded micelles with an average size about 100 nm were successfully constructed. In acidic environments, the chemically conjugated MET was rapidly released after the breakage of sensitive bond between drug and copolymer. In vitro anti-tumor studies demonstrated that MET and PTX had a synergistic effect and co-delivery micelles induced higher cytotoxicity and apoptosis against 4T1 breast cancer cells than free drugs. Furthermore, folate-targeted co-delivery micelles increased the cellular uptake of drugs and were found to be effective for the treatment of solid tumor in vivo . These findings indicated that co-delivery of MET and PTX through the polymeric micelles is a promising strategy for cancer therapy.
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高影响因子
ACS Sustainable Chemistry & Engineering
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2015
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IF 4.642
Chen Feng,Shaoyu Lü,Chunmei Gao,Xinggang Wang,Xiubin Xu,Xiao Bai,Nannan Gao,Mingzhu Liu,Lan Wu
With the fast development of sustainable modern agriculture, there has been a shift toward the development of controlled/slow release fertilizers (CSRFs) that can overcome current limitations of conventional fertilizers. Ideally, CSRFs would release nutrient matching plants demands, even when environmental conditions fluctuate. However, no current CSRFs meet this ideal, especially as nutrient release is affected by temperature and pH. In this study, a “smart” fertilizer with polymer brushes of poly(N,N-dimethylaminoethyl methacrylate) grafting from polydopamine-coated ammonium zinc phosphate via surface-initiated atom-transfer radical polymerization is reported. The structure and morphology of the fertilizer were measured by transmission electron microscopy (TEM); the composition of the product was determined with Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and inductively coupled plasma (ICP) emission spectrometer. Dual-responsive controlled-release behaviors were characterized in water by spectrophotometry and ICP, and results demonstrate the “smart” fertilizer shows excellent temperature- and pH-responsive behavior to release nutrients according to the ambient environment. The nutrients release rate can be obviously accelerated in an acidic pH (below pKa) medium at a definite temperature. In addition, low temperature (below LCST) can accelerate the nutrients release rate in a basic medium (above pKa), which is contrasting to the reduction of nutrients release rate at high temperature (above LCST) in the same medium. The pH- and temperature-responsive “smart” fertilizer will improve nutrients availability and avoid excessive release of nutrients causing damage to plant roots at high temperature, which indicating that the stimuli-responsive system has potential application in sustainable modern agriculture.
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CHEMISTRY OF MATERIALS
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2022
·
IF 10.508
Han Lin,Hideyuki Mitomo,Yusuke Yonamine,Zhiyong Guo,Kuniharu Ijiro
The emerging concept of tunable plasmonic chirality is mostly observed as a reconfigurable behavior or a feature of complex chiral plasmonic assemblies. For discrete colloidal particles, it is challenging to achieve reversible tunability or a transient response with regard to chiroptical activities, particularly in the visible or near-infrared region. Herein, we demonstrate a stimulus-responsive system based on chiral molecule–achiral plasmonic nanoparticles coated with polyaniline (PANI) as a variable dielectric layer, in which l-/d-cysteine molecules are introduced between the gold core and the shell as a static chiral source, allowing the chiral transfer effect to be greatly amplified by the hotspot gap of sub-monomolecular thickness. By taking advantage of the responsive properties to either pH or the electric potential dual stimuli of PANI, which also provides a stable and real-time switchable dielectric environment for the whole system, dynamic tuning of the plasmon and its induced chiroptical activities of core–gap–shell nanoparticles@PANI were precisely obtained. This well-defined design provides an open platform for flexible and rational tailoring of plasmonic cores, chiral molecules, and variable dielectrics to chiroptical needs, which is important for realizing applications in chemical sensing, chiral nanocatalysis, enantioselective separations, and novel optical devices.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Chen-Yan Hu,Xin-Yu Yang,Li-Li Hu,Hao Liu,Jia-Nan Chen,Ling-Mei Gao,Zheng-Yu Dong
The enhanced degradation mechanism of micropollutants by sulfite (S(IV)) activated permanganate (Mn(VII)/S(IV)) process under different pH conditions were investigated in this study. The Mn(VII)/S(IV) process can significantly promote the degradation of sulfamethoxazole (SMX), ibuprofen (IBU), iohexol (IOX) and acetochlor (ACE). Compared with the permanganate (Mn(VII)) process alone, the degradation efficiency of SMX, IBU, IOX, and ACE in the Mn(VII)/S(IV) process increased by 51.6 %, 38.9 %, 43 % and 78.7 %, respectively. The pH value has a significant impact on the degradation of the four target pollutants. The mechanism of the Mn(VII)/S(IV) process was further explored using SMX as a model pollutant. Hydroxyl radicals (HO•), sulfate radicals (SO 4 •− ), and reactive manganese species (RMnS, Mn(III), and Mn(V)) were detected in the process. HO• plays an important role in the degradation of SMX under acidic conditions. At pH= 7, RMnS is the main reactive species. Under alkaline conditions, SO 4 •− plays an important role in the process. Mn(III) and Mn(V) can also be converted into other manganese species. In addition, the possible degradation pathway of SMX was proposed. This work reveals the important role of pH in the generation and transformation of reactive species, and demonstrates the enormous potential of the Mn(VII)/S(IV) process in controlling micropollutants. Considering the complexity of water matrix, future studies can explore the application of the Mn(VII)/S(IV) process in practical water treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Yongjie Zhou,Jiamin Liang,Yan Zhang,Huijuan Zhang,Sam K.C. Chang,Hui Hong,Yongkang Luo,Yuqing Tan
Deep eutectic solvents (DESs) are renowned in chemical and food industries for their eco-friendly extraction efficacy. Silver carp swim bladders, a collagen-rich byproduct of surimi production, are underutilized, resulting in considerable protein waste. Traditionally, collagen extraction has relied on harsh acids, contributing to environmental pollution and producing collagens with limited solubility, thus constraining their applications. This study evaluated DESs compared to conventional acids in extracting collagen, focusing on structural and solubility variations. Notably, urea-based DESs (urea-lactic acid: U-LA, 1:10, w/v) achieved the highest hydroxyproline recovery rates (∼ 94 %), comparable to acetic acid (AA, 1:20, w/v), but with half the solid-liquid ratio. Unlike acid-extracted collagen, which preserved the triple-helical structure, urea-based DESs partially disrupted this configuration by reducing intramolecular hydrogen bonding within collagen. However, these solvents simultaneously increased intermolecular hydrogen bonding. This alteration significantly enhanced collagen's solubility, maintaining over 60 % across a broad pH range (1−10) and various NaCl concentrations (0–6 %, w/v). Furthermore, urea-acetic acid (U-AA) extracted collagen exhibited the highest maximum transition temperature (solid state, T max = 101.94 °C) and gel strength (165 g). The findings suggest that urea-based DESs not only enhance collagen recovery rates but also its solubility and gelation properties, broadening its potential applications in cosmetics, food products, and biomaterials.
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PubMed
高影响因子
FOOD CONTROL
·
2024
·
IF 5.6
Xiaojia Wang,Jizhong Yuan,Nana Sun,Yaohuang Jiang,Yanchun Yu,Guoqiao Lai,Xiongfa Yang
Antibacterial and pH−sensitive eugenol functionalized chitosan−polyurethane hydrogels (UV−EBs) for shelf−life extension of chicken were prepared from thiol−modified chitosan (CS) and UV−curable polyurethanes grafted with eugenol and bromocresol green by UV−curable method. The antibacterial efficiency of UV−EBs is about 55% and 86% respectively after 8 h co−cultured against S. aureus and E. coli . Therefore, a contact−kill mechanism was proposed. Despite the toxicity of UV−EBs against L929 cells increased with the increment of the amount of eugenol groups, the UV−EBs prepared still have potential application in food packing and coatings. Shelf−life extension study for chicken breast demonstrated the UV−EBs can be utilized for packaging materials to extend the shelf−life of high−quality protein food such as chicken breast. The thermal stability of UV−EBs is better than eugenol because the initiate decomposition temperature ( T d5 ) of the former is in the range of 154–175 °C while that of the latter is about 134 °C. Therefore, UV−EBs have potential application in package some food that still has a high residual temperature after being cooked or heated. The UV−EBs demonstrate superior mechanical performance with tensile strength in the range of 0.77–4.90 MPa and the elongation at break in the range of 135–196%, respectively. The UV−EBs also show naked eyes visible color variation from yellow to green and finally to be Prussian blue when the pH values varied from 2 to 14. This work supplied a feasible method to develop antibacterial hydrogels for packaging materials to extend the shelf−life of high−quality protein food.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
·
IF 8.1
Xiang Li,Zhan Zhao,Kelei Huang,Xiangchao Meng,Zizhen Li
The design of highly efficient catalysts applied in a wide pH range for hydrogen evolution reaction (HER) is still very challengeable. Herein, a rapid Joule heating method has been applied to deposit Ru nanoparticles onto carbon nanotubes (Ru/CNTs). Owing to the rapid heating and cooling processes during the Joule heating treatment, the lattice was disordered with exposure of massive reactive sites for HER. As tested, Ru/CNTs showed outstanding activity in HER in a wide pH range. It only required an overpotential of 21 mV and 9 mV at 10 mA cm −2 for HER in 0.5 M H 2 SO 4 and 1 M KOH, specifically. The overpotential required to achieve a current density of 1 A cm −2 in 0.5 M H 2 SO 4 and 1 M KOH was 162 mV and 360 mV, respectively. The excellent performance of Ru/CNTs was comparable to commercial Pt/C catalyst. Furthermore, using the manufactured Ru/CNTs, a homemade anion-exchange membrane AEM electrolyzer was assembled. It only required 1.87 V to reach 100 mA cm −2 with nearly 100% Faraday efficiency. This work provided a novel method to prepare Ru nanoparticles onto carbon nanotubes by a rapid Joule heating treatment for advanced HER activity in a wide pH range.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Mingxue Xia,Xiao Meng,Limin Lin,Ang Gao,Yunhe Diao,Xuying Liu,Huige Yang
Hydrogel-based flexible electronic devices have garnered significant attention due to their excellent mechanical properties, high electrical conductivity, and signal sensitivity. Nevertheless, internal water molecules crystallize inevitably at low temperatures, impairing the performance of hydrogels. Designing anti-freezing and tough hydrogels to meet long-term stability requirements is extremely challenging. A double physically crosslinked PVA/SA-g-DA/Fe 3+ hydrogel was fabricated using a two-step method. The coordination mode between catechol groups and ferric ions was modified by adjusting pH of soaking solution, subsequently regulating antifreeze performance and mechanical properties of the hydrogels. The obtained PVA/SA-g-DA/Fe 3+ hydrogel is stretchable, tough, and has a remarkable freeze tolerance (−42.21 °C). The hydrogels can be assembled into a strain sensor to monitor various human activities accurately at normal and low temperatures. This study proposes a strategy for designing hydrogels for supporting signal detection in cold environments.
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Jiabo Shi,Li Sheng,Meng Chen,Xiaoyi Wu,Xiaojie Li,Yan Qin Tan
Sustainable and intelligent packaging systems, utilizing biomass-derived matrix and bioactive indicators represent promising approaches for real-time detection and monitoring of freshness of food, as well as prolonging the shelf-life and improving the quality and safety of food products. Herein, we reported pH-responsive collagen nanocomposite films reinforced by curcumin-loaded Laponite nanoplatelets which could act as smart indicators for monitoring the freshness of shrimps. Caffeic acid, as a bio-based modifier, was covalently grafted onto the surfaces of the nanoplatelets loaded with curcumin . The collagen nanocomposite films were fabricated by the incorporation of functionalized nanoplatelets through all-aqueous casting-evaporation approach. The triple-helical structure of collagen molecules was stabilized by the functionalized nanoplatelets mainly through hydrogen bonding and electrostatic interactions with uniform distribution into the film matrix. Moreover, the resultant nanocomposite films not only demonstrated favorable hydrophobicity and water vapor barrier properties, but also exhibited effective antioxidant activity and anticipated color responsiveness to pH changes and NH 3 presence. The consistent changes in color of the nanocomposite film with the shrimps following days of storage supported its feasibility and potential for monitoring the freshness of shrimps. Therefore, we envision that the developed collagen-based nanocomposite films showcase great potential in the application of sustainable and intelligent packaging system for dynamic visualization of seafood freshness.
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高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Runliang Feng,Mingzhu Wang,Zhimei Song,Yunjing Jia,Yuli Li,Qingmin Liu,Fuyou Wang,Guangxi Zhai
A liquid formulation with suitable consistency and sustained release characteristics can improve compliance in users with dysphagia. In the study, we prepared curcumin-loaded lipid nanocapsules (Cur-LNCs) and incorporated it in a mixture of sodium alginate, dextrin, calcium chloride and sodium citrate to form a pH-responsive pre-hydrogel solution (SA-DEX:Cur-LNCs). The SA-DEX:Cur-LNCs exhibited a pH-responsive solution-gel conversion: solubilized at near neutral (pH = 7) and rapidly gelatinized to a strong elastic gel at stomach acid (pH = 2.5). The SA-DEX:Cur-LNCs could effectively improve the thermal and pH stability of Cur, and maintain its antioxidant effect. Interestingly, the bioaccessibility of SA-DEX:Cur-LNCs in gastrointestinal was significantly increased to 37.00% when compared with free Cur. The SA-DEX:Cur-LNCs also significantly improved the small intestinal absorption of Cur, being 16 times higher than that of free Cur. Therefore, incorporating lipid nanocapsule in pH-responsive pre-hydrogel provided a new oral administration platform of hydrophobic bioactive compounds for compliance improvement of users with dysphagia.
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JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Xiao Huang,Shushan Yuan,Haohan Wan,Xiujing Xing,Zhaohuan Mai,Hideto Matsuyama,Gang Zhang
Developing functional membranes with switchable pores for the separation of contaminants with different sizes has been challenging due to the lack of novel materials with adaptable and adjustable structures. Polymers containing the tertiary amine (TA) unit can be transformed via oxidation into amine oxide (AO) structure that can modulate the membrane pore size. In this study, new monomers containing pH-responsive TA units and diacyl chloride containing reducible thioether (-S-) groups were used to yield pore-size-adjustable membrane resin polyarylene sulfide sulfone amide/amide tertiary amine (PASSA/ATA) at room temperature. By varying the polymerization ratio of the reaction solution, membranes could be prepared directly through non-solvent induce phase separation (NIPS) method without extra treatment. By oxidizing the TA units to AO through acid condition (H 2 O 2 /H 2 SO 4 /CH 3 COOH), the PASSA/ATA membrane can be switched from ultrafiltration to loose-nanofiltration with the rejection of RO16 and rhodamine B increased from 18.4% to 34.3 % (pristine membrane) to 91.7 % and 98.5 %. The permeance and rejection rate of the oxidized membrane were found to recover to the initial state after alkali-treatment. The mechanism of the switchable pore size was elucidated by dissipative particle dynamics (DPD) simulations. Interestingly, the oxidized PASSA/ATA membrane showed good organic solvent resistance and in nanofiltration performance, as it was capable of retaining about 95 % of Congo red in N,N-dimethylformamide (DMF) with permeance of about 10 L m −2 h −1 bar −1 . This work presents a facile and low-carbon approach to develop novel membranes with multiple filtration capabilities, potentially applicable in various separation processes.
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高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Sa Liu,Yapeng Chen,XinKuan Li,Yijia Yao,Huashan Wang,Meiyi Wang
Food packaging films containing antimicrobial reagents play a crucial role in preventing bacterial-induced fruit decay. This study proposes a bilayer film consisting of an internal amino-modified starch hydrophilic layer and an external amino-modified polyvinyl alcohol/polylactic acid hydrophobic layer, embedding alliin@MIL-101(Fe) as an antibacterial agent, utilizing the pH reduction of fruit decay sites to achieve pH-responsive release, enhancing antibacterial performance. Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) analyses confirm successful crosslinking between amino and aldehyde groups, resulting in the formation of imine bonds and a mesh-like structure conducive to adsorption. Under acidic conditions, the cumulative release rate of alliin reached 74 % within 36 h. Compared to a simple mixture, the tensile strength of the alliin@MIL/NST-NPVA/PLA film reached 34.771 MPa, and transmittance in the wavelength range of 200–370 nm decreased to 0. The scavenging rate of DPPH free radicals in the film can reach 83 %. In addition, the water vapor permeability and oxygen permeability of the film are approximately 7.62 × 10 −16 [g/ (m 2 ‧24 h‧0.1 mm)] and 6.83 (m 2 ‧24 h‧0.1 MPa), respectively; moisture content and water solubility decreased to 10.99 % and 20.77 %. This composite film extended the shelf life of strawberries from 2 to 7 days, significantly enhancing freshness.
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PubMed
高影响因子
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