COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Yuan Chen,Yanchen Sun,Gaojie Fang,Wenyao Huang,Quan Wang
The performance of energetic hydrogels—a promising class of water-resistant explosives—is often related to the internal microstructure and chemical reactivity. This study introduces a modification strategy employing copper (II) nitrate trihydrate (Cu(NO 3 ) 2 ·3H 2 O) to simultaneously tailor the hydrogel’s microstructure and enhance its chemical reactivity. The additive functions dually: by acidifying the system, it accelerates cross-linking kinetics and refines sensitized microbubbles; concurrently, it lowers the thermal decomposition barrier of the gel matrix. At an optimal content of 0.75 wt%, the proportion of effective microbubbles (diameter ≤ 100 µm) is maximized to 42.2 %, establishing a dense hotspot network. This microstructural and chemical optimization synergistically boosts detonation performance, increasing velocity by 15.34 % to 4610 m·s⁻¹ and reducing the minimum initiation charge from 50 g to 30 g. Thermal analysis confirms a reduced apparent activation energy and reveals a possible low-temperature exothermic pathway, providing direct evidence for the enhanced reactivity. Crucially, this enhancement does not compromise handling safety, as the initial decomposition temperature remains above 244 °C for all formulations. This work establishes additive-mediated modification as an effective route to engineer energetic materials by concurrently optimizing the microstructure and accelerating the reaction kinetics.
✓ 已验证
产品关联
DOI
高影响因子
Pharmaceutics
·
2026
·Vol. 18
·期 8
·1010
·
IF 6.9
Zeyu Wen,Xilu Sun,Sumeng Chen,Jinyan Meng,Runlin Yu,Shuyan Guo,Xingyuan Cao
Background: The Biopharmaceutics Classification System (BCS) classifies drug substances according to their aqueous solubility and intestinal permeability; however, its application to veterinary drugs should account for species-specific gastrointestinal physiology. Grapiprant is a selective prostaglandin E2receptor subtype 4 (EP4) antagonist approved as an oral tablet to control pain and inflammation associated with osteoarthritis in dogs, but its properties within the BCS framework remain unclear.Methods: This study evaluated the equilibrium solubility of grapiprant across pH conditions relevant to the canine gastrointestinal tract and calculated the dose number (D0) based on different gastric fluid volumes. A Caco-2 cell monolayer model was used to assess grapiprant intestinal permeability and the effects of time, concentration, pH, and efflux transporter inhibitors on its transepithelial transport.Results: Grapiprant showed relatively small changes in solubility across the tested pH range. D0varied with pH and gastric fluid volume and approached or fell below 1 at larger fluid volumes. In the Caco-2 model, grapiprant showed generally limited apparent absorptive permeability, with permeability varying with pH. Efflux ratios were greater than 1, and verapamil reduced the efflux ratio, suggesting possible P-glycoprotein (P-gp) involvement.Conclusions: These findings suggest that both solubility and apparent intestinal permeability may limit the oral absorption of grapiprant under certain canine-relevant conditions. Accordingly, this study provides a biopharmaceutical characterization of grapiprant within the BCS framework rather than a definitive canine BCS classification, highlighting the importance of considering canine gastrointestinal conditions when interpreting its solubility and permeability. The results may support future optimization of dosing conditions and oral formulations.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Yaozhi Zhang,Menglu Jiang,Shiqi Zhang,Aimeng Dong,Fenghua Zhang,Yanju Liu,Huiping Yuan,Jinsong Leng
Traditional hydrogel-based drug delivery systems face critical limitations, including poor toughness and adhesion, and low drug utilization efficiency, which collectively limit their efficacy in glaucoma treatment. Deep eutectic solvents (DESs) can effectively address these limitations because they are structurally tunable and exhibit high rates of drug dissolution. Herein, we apply β-cyclodextrin and phytic acid to prepare a novel DES, which was used to fabricate a deep eutectic smart gel drug delivery system (DSGS). The DES establish multi-hydrogen-bonded shielding networks with polymer chains, endowing the DSGS with an ocular tissue-matched modulus and a high toughness of 5.94 MJ·m − 3 . Notably, the DSGS enables precise drug release in response to dual stimuli: matrix metalloproteinase-2 and temperature. We employ 4D printing technology to engineer a novel glaucoma drainage device (GDD) from the DSGS loaded with an antifibrotic drug for glaucoma treatment. Based on the synergistic effect of DSGS and the drug, the GDD regulates intraocular pressure (IOP), suppresses fibrosis, and restructures the extracellular matrix collagen architecture in vivo. Furthermore, the DSGS is injectable and exhibits strong tissue adhesion. Following minimally invasive implantation into the conjunctiva, a stable IOP was maintained for 30 days. This innovative design represents a promising direction for future drug delivery.
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Yong Zheng,Haobin Wu,Shouchao Zhong,Xun Kan,Ye Song,Fujian Liu,Wei Lin,Jianchun Wang,Lilong Jiang
The development of efficient and reusable sorbents for SO 2 removal from flue gas has attracted considerable attention. Herein, we report a “chainmail” structured Ca-based SO 2 sorbent by encapsulating Ca species within ordered mesoporous carbon (OMC), denoted as Ca(OH) 2 @OMC- x , where x denotes the Ca(OH) 2 mass fraction (wt%). The OMC was prepared via a one-step solvent-free mechanochemical assembly: the precursors and a block copolymer template (Pluronic F127) were ground to form a preorganized composite, followed by solidothermal treatment and calcination to remove the template and carbonize the polymer. The obtained OMC was then impregnated with a Ca precursor and calcined to strengthen interfacial interactions, encapsulating the Ca species within the OMC framework. Finally, steam treatment converted the confined Ca species into finely dispersed Ca(OH) 2 active domains. The resulting Ca(OH) 2 @OMC- x exhibits a large BET surface area (169.4–290.3 m 2 /g), long-range ordered mesoporosity with a narrow pore size distribution (∼5.5 nm), and well-dispersed Ca active phases with enhanced stability. Consequently, Ca(OH) 2 @OMC- x serves as an efficient and reusable solid sorbent for SO 2 capture, exhibiting a high SO 2 adsorption capacity of 11.24 mmol/g and maintaining 98.6% of its initial capacity after five adsorption–desorption cycles. This study provides an effective “chainmail encapsulation” materials design strategy for scalable SO 2 abatement under complex flue gas conditions.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
·
2026
·
IF 4.4
Fuyu Song,Jiaxi Liu,Qi Wu,Aiqin Diao,Yinhu Jiang,Xin Yan,Na Li,Jian He,Jiguo Qiu
An efficient Rhodococcus sp. YQ-4 strain degraded 98% of 2-ABT within 24 h. • A new intermediate metabolite (2-hydroxybenzothiazole) was identified. • A novel 2-ABT biotransformation pathway was proposed. • Biodegradation of 2-ABT was a detoxification process. 2-Aminobenzothiazole (2-ABT), a representative heterocyclic compound originating from tire wear particles, was widely detected in diverse environmental matrices. Due to its persistence and potential toxicity, the removal of 2-ABT from contaminated environments has become an increasing environmental concern. However, studies on the efficient biodegradation of 2-ABT by pure cultures remain limited. In this study, the abundance of Rhodococcus increased significantly following enrichment and acclimation. Subsequently, a 2-ABT-degrading pure culture, designated Rhodococcus sp. YQ-4, was isolated. Under the optimal conditions of pH 7.0, 1% NaCl, and 30 °C, strain YQ-4 achieved a removal rate of 98% for 50 μM 2-ABT within 24 h. A key metabolic intermediate, 2-hydroxybenzothiazole (2-OBT), was identified by liquid chromatography-time-of-flight mass spectrometry (LC-TOF-MS). Based on these results, a possible initial biotransformation pathway involving deamination and hydroxylation at the C2 position of the thiazole ring was proposed. Furthermore, toxicity bioassays involving the green alga Chlamydomonas ellipsoidea and mung bean ( Vigna radiata ) demonstrated that the biodegradation of 2-ABT by strain YQ-4 significantly alleviated its phytotoxicity, thereby restoring the growth and physiological vigor of the test species. Collectively, this study provided a novel bacterial resource for the bioremediation of 2-ABT-contaminated environments and offered new insights into the catabolic pathway associated with emerging pollutants.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF THERMOPHYSICS
·
2026
·Vol. 47
·期 7
·112
·
IF 3.6
Shi Jiahao,Wang Jianan,Feng Junyu,Zhang Ke,Bi Shengshan
This study presents an investigation into the liquid density of isobutanol and 2-butanol at selected temperatures from 303.15 K to 383.15 K and pressures up to 200 MPa using a variable-volume high-pressure system. The apparatus was validated with n -decane, and the measured densities agreed with literature values within 0.2 %. The expanded relative uncertainty of density was estimated to be 0.27 % with a coverage factor of k = 2. The experimental data were correlated with the Tammann–Tait equation, yielding average absolute deviations below 0.05 % for both butanol isomers. The isothermal compressibility and isobaric thermal expansivity were derived from the fitted correlations to characterize the pressure and temperature dependence of the volumetric properties. In addition, the pure-component parameters for the perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state were optimized using the 2B association scheme. The optimized PC-SAFT model reproduced the measured densities with average absolute deviations lower than 0.2 %. The results expand the available high-pressure density database for these two butanol isomers and may be useful for thermodynamic modeling and engineering calculations within the investigated temperature and pressure ranges.
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Jiawen Li,Junhong Ran,Chaoyong Deng,Min Zhang
Eu 3+ -doped La 7 O 6 (BO 3 )(PO 4 ) 2 phosphors were synthesized using a high-temperature solid-state method. The phosphors with the optimal doping concentration ( x = 0.4 mol) exhibited strong red emission at 616 nm, demonstrating good thermal stability (70% at 398 K) under 465 nm excitation. Furthermore, tunable correlated color temperature (CCT) was achieved, and the fabricated red LEDs showed satisfactory CCT stability, with standard deviations of 0.00451 and 0.00447 for CIE x and CIE y , respectively. White LEDs made from this phosphor exhibited a good color rendering index R a = 92.6 and a high color temperature CCT = 5612 K. In addition, this phosphor can be used to display invisible anti-counterfeiting patterns, fingerprint visualization, and light-controlled encryption, demonstrating its multifunctional potential in solid-state lighting and security applications.
✓ 已验证
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2026
·
IF 7.1
Qingqing Xu,Qian Zou,Lei Zheng,Dongming Lan,Menglei Yan,Weifei Wang,Yonghua Wang
A rapid, reduced-error sn -2 fatty acid determination method is vital. • A separation-free method for sn -2 fatty acid composition was built. • Validation for new method was done by comparison with conventional method. Positional distribution of fatty acids determines the nutritional value of edible oils, and can be reflected by the sn -2 fatty acid composition. Traditional determination methods generally involve three steps: hydrolysis, separation, and gas chromatography analysis. The separation process is complex and consumes large amounts of organic solvents. To address this issue, we developed a separation-free method. In this approach, triacylglycerol oils were first hydrolyzed by a sn -1,3 regioselective lipase, which retains the first step of the traditional method. The fatty acids originally esterified at the sn -2 position are retained and form 2-monoacylglycerol, and the 2-monoacylglycerol composition has conventionally been considered as the sn -2 fatty acid composition. However, we also took into account that the majority of 1-monoacylglycerol in the hydrolysate actually originate from acyl migration of 2-monoacylglycerol. We propose that the fatty acid composition of monoacylglycerols in the hydrolysate directly represents the sn -2 fatty acid composition. A UPLC-Q-TOF-MS-based method for directly determining the composition of monoacylglycerols was developed, with mass spectrometry parameters and formic acid concentration in the mobile phase optimized, followed by method validation. Finally, the new method was applied to various triacylglycerol oils and compared with the traditional method to confirm its validity.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Liao Zixin,Zhong Rui,Li Wan jing,Wong Yee Shan,Liu Jiaxin,Venkatraman Subbu S.,Wang Hong,Cao Ye
Triple-negative breast cancer (TNBC) bone metastasis remains a significant clinical challenge owing to limited drug across the blood - bone marrow barrier as well as the chemotherapy resistance. Overexpression of the anti-apoptosis protein B-cell lymphoma-2 (Bcl-2) and activation of ATP-binding cassette transporter-mediated drug efflux pathway contribute substantially to paclitaxel (PTX) resistance, leading to poor therapeutic outcomes. Herein, we developed a biomimetic bone-targeted nanotherapeutic by integrating neutrophil “hitchhiking” technology with hyaluronic acid (HA)-modified lipid nanoparticles co-loaded with PTX and Bcl-2 small interfering RNA (siRNA) (BP-HLNP@NEs) for the therapy of TNBC bone metastasis. Leveraging neutrophil-mediated bone marrow homing and HA-CD44 receptor-mediated active targeting, BP-HLNP@NEs efficiently traversed the blood-bone marrow barrier, enhanced accumulation within metastatic bone lesions, and reduced off-target toxicity in the liver and spleen. Following cellular internalization, the co-delivered PTX and Bcl-2 siRNA synergistically suppressed tumor growth by silencing Bcl-2 expression, inhibiting the NF-κB/P-glycoprotein resistance pathway, restoring chemosensitivity, and activating caspase-mediated apoptosis. In orthotopic bone metastatic TNBC models, BP-HLNP@NEs markedly inhibited tumor progression, reduced secondary lung metastasis, preserved bone architecture, and elicited antitumor immune responses. Collectively, this biomimetic delivery platform overcomes both biological delivery barriers and chemoresistance, providing a promising therapeutic strategy for the treatment of TNBC bone metastasis. Graphical
✓ 已验证
DOI
高影响因子
Chinese Physics B
·
2026
·Vol. 35
·期 1
·017801
·
IF 1.6
Mengyu Zhang,Shujing Pan,Haitang Hu,Wenzhi Su,Yong Zou,Shoujun Ding,Qingli Zhang
Conventional Tb3+-doped phosphors typically suffer from concentration quenching once the doping level exceeds a critical threshold. Consequently, the development of Tb3+ phosphors with intrinsic resistance to concentration quenching has become a key research focus. In this work, we successfully synthesized KBi(MoO4)2: xTb3+ (x = 0–100 at%) (denoted as KBM: xTb3+) phosphors via a high-temperature solid-state reaction. Remarkably, no concentration quenching was observed across the entire doping range. This anti-quenching behavior originates from the large Tb3+–Tb3+ interionic distance (> 5 Å) inherent to the quasi-layered crystal structure, which effectively suppresses multipole-interaction-mediated energy migration. At full Tb3+ substitution (x = 100 at%), the material undergoes a structural phase transition from the monoclinic KBM phase to the triclinic α-KTb(MoO4)2 (α-KTM) phase. The α-KTM phosphor exhibits excellent thermal stability (activation energy = 0.6129 eV) and a single-exponential decay profile, whereas KBM: xTb3+ (x < 100%) display double-exponential decay behaviors, attributed to dual energy transfer pathways. These findings provide new insights into the luminescence mechanisms of high-concentration rare-earth-doped systems and offer guidance for designing next-generation anti-quenching phosphors.
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Xiaojun Tang,Wenhao Lv,Song Lv
Customized Co(OH) 2 interface layer designed by electrodeposition. • The NF@[Co] 120 /Mn/[Co] 60 composite electrode integrates "conduction-adhesion-protection" functions. • Achieves high volumetric capacitance and excellent cycling stability. • Provide a novel design strategy for next-generation flexible and wearable energy storage devices. The in-situ synthesized nickel foam(NF)/manganese dioxide(MnO 2 ) electrode shows great promise for flexible supercapacitors owing to its high theoretical capacity, abundance, and eco-friendliness. However, the practical application of MnO 2 is hindered by poor conductivity, significant volume expansion, dissolution in electrolytes, and weak adhesion to smooth NF. To address these challenges, this work leverages the advantages of high conductivity and interface modification offered by Co(OH) 2 to precisely construct a sandwich-structured composite electrode(NF@[Co] 120 /Mn/[Co] 60 ) at the MnO 2 interface layer, which integrates conductive, adhesive, and protective functions. Benefiting from the advanced structure, the composite electrode exhibits outstanding electrochemical performance. NF@[Co] 120 /Mn/[Co] 60 achieves a capacitance of 340.31 F g −1 at 1 mA cm −2 , with a capacitance retention of 196.05 F g −1 when the current density increases to 20 mA cm −2 , and a capacity retention rate of 86.68% after 9000 cycles. Moreover, by utilizing the smooth and continuous macroscopic interface of the outermost Co(OH) 2 nanosheets, we integrated it with hydrogel electrolyte to assemble flexible supercapacitor (NF@[Co] 120 /Mn/[Co] 60 //PAA//AC). This device delivers an energy density of 74.95 Wh kg –1 at a power density of 994.94 W kg –1 and demonstrates excellent mechanical flexibility. This novel structural design provides a new electrode system strategy for the development of flexible wearable energy storage systems. Download: Download high-res image (197KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Infectious Diseases and Clinical Microbiology
·
2026
·Vol. 8
·期 2
·165
·
IF 1.1
Jingping Yang,Dan Liu,Xiyuan Xu,Na Meiri,Dezhi Yang
Objective This study aimed to develop a sensitive and reliable method for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various environmental samples using nano–liquid chromatography–tandem mass spectrometry parallel reaction monitoring (nanoLC-MS/MS PRM), targeting sequences of the viral spike (S) and nucleocapsid (N) proteins. Materials and Methods A synthetic peptide screening approach was employed to systematically evaluate candidate sequences as surrogates for protein quantification. The process began with the digestion of purified SARS-CoV-2 proteins. The candidate sequences were then refined to a subset of target peptides, and stable isotope-labeled heavy peptides were used as standards in a PRM workflow. The detection limits were determined using the nanoLC-MS/MS PRM method. Results The developed method achieved limits of detection in the 1 fmol/µL (2–8 × 10-15 viral copies/L) range on-column. This demonstrates high sensitivity for detecting SARS-CoV-2 in environmental samples using the PRM method. Conclusion The study successfully developed a sensitive and reliable peptide probe-based approach for detecting SARS-CoV-2 in various environmental samples. The use of the PRM method targeting the S and N proteins of SARS-CoV-2 provides a robust approach for virus detection, particularly given the potential persistence of the virus on surfaces. Graphic Graphic . Open in a new tab
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）