LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
·
IF 6.6
Guoying Fu,Lei Cai,Peihang He,Yan Wang,Yingqi Zhang,Enxue Xie,Liang Li,Zedong Zhang,Guoqiang Wu
A series of Candida antarctica lipase B (CALB) catalysts immobilized on two-dimensional planar ZSM-5 zeolite (denoted as x CAL/ZSM-5-P) were developed for the efficient and green esterification of capric acid (CA) and glycerol (Gly) to synthesize medium-chain glycerides (MCGs). Comprehensive characterizations, including X-ray diffraction, Fourier-transform infrared, scanning electron microscopy, transmission electron microscopy, N 2 physisorption, and thermogravimetric analysis, confirmed the successful immobilization and uniform dispersion of lipase of CALB on ZSM-5-P via sulfhydryl modification. The framework structure of ZSM-5-P remained structurally intact after immobilization. The CAL/ZSM-5-P catalysts exhibited outstanding catalytic performance in the esterification reaction. Notably, the 9CAL/ZSM-5-P catalyst achieved the highest CA conversion of 66.94 %, with nearly 100 % selectivity toward MCGs—substantially outperforming bare ZSM-5-P (without immobilized lipase), which showed only 0.19 % conversion. Additionally, 9CAL/ZSM-5-P demonstrated excellent catalytic stability and chemical robustness. A possible mechanism for the CALB/ZSM-5-P-catalyzed esterification of CA to MCGs was also proposed. This approach provides both theoretical insight and practical guidance for developing MCGs as food emulsifiers and functional oils via heterogeneous catalytic esterification using immobilized lipase in the food industry.
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JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 3.6
Zefeng Li,Jing Xu,Pingbo Zhang,Mingming Fan,Pingping Jiang,Shijun Chen,Xunxun Sheng
Conventional food packaging plastics are difficult to degrade under natural conditions, causing long-lasting environmental harm. With the aim of addressing this problem, this study develops a novel biodegradable composite food packaging film based on polybutylene adipate-terephthalate (PBAT) and polyurethane (PU). MOF-5 nanoparticles are prepared via the ambient temperature precipitation method and modified with gallic acid (GA). PBAT/PU/GA@MOF-5 composite films are fabricated by the solvent casting method. The findings demonstrate that the introduction of GA@MOF-5 enhances the compatibility between PBAT and PU and reduces phase separation; therefore, it augments the mechanical performance of the resultant composite films. These composite films manifest excellent mechanical, thermal degradation, and antioxidant properties, performing remarkably in apple freshness tests. Furthermore, the incorporation of GA@MOF-5 endows the films with significant antimicrobial activity, showing restraint on the proliferation of both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). This study offers an innovative idea for biodegradable food packaging materials design and expands the application prospect of the PBAT/PU composite system in the food packaging field. Graphical Multifunctional degradable food packaging film based on PBAT/PU/GA@MOF-5.
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CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
Maolin Li,Quanxi Lu,Zhichao Dong,Sijie Liu,Rong Tan
5-Hydroxymethylfurfural (HMF), which is obtained from fructose dehydration, can be oxidized to valuable biomass-based platform chemicals, such as 2,5-furandicarboxylic acid (FDCA), 2,5-dicarbonylfuran (DFF) and 5-formyl-2-furancarboxylic acid (FFCA). However, the complex reactions of dehydration and oxidations make it is still challenging to obtain these chemicals from fructose. Herein, a dual single-atomic Fe/Co composed of isolated FeN 6 and CoN 5 sites supported on N-doped carbon (Fe/Co-NC) was constructed to efficient conversion of fructose to FDCA, DFF or FFCA through a two-step strategy. Owing to the Lewis acid sites in Fe/Co-NC, fructose can efficiently convert to HMF with an isolated yield of 91.70 % at 145 °C in dimethyl sulfoxide (DMSO). Furthermore, synergistic effect between Fe and Co atoms, which results in charge redistribution, can also promote the adsorption and activation of HMF and O 2 for efficient oxidation. Attributing to the various ability of Fe/Co-NC to activate O 2 in different solvents, superoxide radicals (·O 2 − ) generated in MeCN result in 97.70 % yield of DFF, while peroxyl radicals (·OOH) generated in water lead to 97.29 % yield of FDCA. Adding DMSO in aqueous system seriously hinders the reaction rate (rate constant from 0.0022 to 0.0008 min −1 ) due to solvation of HMF by DMSO, resulting in high yield of FFCA (81.56 %) at 4 h. Therefore, controllable conversion of FDCA, DFF or FFCA from fructose is achieved over Fe/Co-NC, and the readily recovered method and good stability of the catalyst also indicate the prospect for continuous production of the above chemicals from fructose in the future.
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MOLECULES
·
2025
·Vol. 30
·期 12
·2478
·
IF 4.6
Shiluo Chen,Jinxin Wang,Yuteng Cao,Kangcai Wang,Haijun Yang,Tianlin Liu
Energetic metal–organic frameworks (E-MOFs) have recently emerged as a promising strategy to address the long-standing challenge of reconciling energy and sensitivity in energetic materials. Nitrogen-rich compounds, with their abundant nitrogen atoms and superior enthalpy of formation, are particularly beneficial for forming multiple coordination bonds while simultaneously elevating the energy content. This makes them ideal ligand molecules for constructing E-MOFs. In this work, we report the synthesis and structural design of a novel series of E-MOFs, constructed from the nitrogen-rich energetic ligand BNTA and a range of alkali metals (Na–Rb, compounds2–5). The research indicates that the synthesized E-MOFs exhibit high thermal stability and low sensitivity. Specifically, Compound3displays a high decomposition temperature of 285 °C, with impact sensitivity and friction sensitivity values exceeding 40 J and 360 N, respectively. Moreover, Compound3also exhibits excellent computational detonation performance. Significantly, this study demonstrates how the aromatic character, coordination chemistry, and intermolecular interactions work synergistically to enhance the stability and safety of E-MOFs, thereby establishing fundamental criteria for engineering the next generation of energetic frameworks.
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RSC Advances
·
2026
·Vol. 16
·期 15
·13320-13331
·
IF 6.1
Muhammad S. Mustafa,Wrya O. Karim
Tetracycline (TC) is an efficient antibiotic used for curing different bacterial infections in both humans and animals. Accurate and precise detection of TC is a requisite for quality control of pharmaceutical productions and patient safety using a reliable method. This study presents a highly sensitive and selective strategy based on utilizing 1,4-di-2-(5-phenyloxazolyl)-benzene (POB) as a molecular fluorescence sensor for detecting TC. POB displays an optimal excitation and a high-intensity emission at 355 nm and 418 nm, respectively. The TC–POB interaction leads to a remarkable quenching of the fluorescence, allowing fluorometric detection of TC. A linear calibration curve in a range of 0.5–40 µM along with a limit of detection (LOD) of 0.143 µM was established. The analytical applicability of the developed method was estimated for measuring TC within pharmaceutical formulations and human serum samples, revealing high accuracy and precision. Ultimately, the greenness of the proposed method was inspected via the Analytical Greenness Metrics for Sample Preparation (AGREEprep) and the Analytical Greenness Index (BAGI), emphasizing the eco-friendly feature with respect to sample preparation steps, applicability, and practicability.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Ye-Fei Ruan,Jin-Hui Wang,Wen-Da Zhong,Lin Qiu
Targeting mitochondrial dysfunction in inflamed lung vessels addresses a key challenge in acute lung injury treatment, where current therapies lack precision and efficacy. • We develop smart nanoparticles that actively seek out injured blood vessels and release medicine only where oxidative stress is high, enabling enhanced mitochondrial repair. • This strategy markedly improves lung function and survival in mice with acute lung injury, demonstrating a promising approach for treating severe pulmonary inflammation. Acute lung injury (ALI) is a life-threatening condition with complex pathogenesis. Mitochondrial dysfunction in pulmonary vascular endothelial cells serves as a central hub, driving oxidative stress, inflammation, and barrier disruption. Existing treatments are limited by poor targeting and insufficient efficacy. To address this, we engineered a novel dual-targeting nanoplatform, P-selectin-directed and ROS-responsive fucoidan micelles loaded with the mitochondrial modulator Mitochonic Acid 5 (Fuc-TP@MA-5). Here we show that this system actively homes to inflamed lung endothelium via fucoidan-P-selectin binding and selectively releases MA-5 within the high-ROS microenvironment via thioketal linker cleavage. This enhanced delivery potently restores mitochondrial membrane potential and ATP production, scavenges excess ROS, and inhibits endothelial apoptosis. Consequently, Fuc-TP@MA-5 significantly attenuates pulmonary edema, vascular hyperpermeability, and inflammatory cytokine storm in a murine model of LPS-induced ALI, outperforming free MA-5. Our work establishes a targeted mitochondrial functional improvement strategy, offering a promising and intelligent nanotherapeutic paradigm for treating ALI and other vascular inflammatory disorders. Download: Download high-res image (166KB) Download: Download full-size image
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DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 45
·17441-17453
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IF 4.569
Yuewen Shao,Mingzhu Guo,Mengjiao Fan,Kai Sun,Guoming Gao,Chao Li,Félix Mérimé Bkangmo Kontchouo,Lijun Zhang,Shu Zhang,Xun Hu
One-pot conversion of furfural, a biomass-derived platform chemical, to gamma-valerolactone (GVL), a fuel additive and green solvent, involves multiple steps of hydrogenation. Among these reactions, the deep hydrogenation of the furan ring in furfural interrupts GVL formation over Ni or Co-based catalysts. In this study, a method of alloying Ni and Co with Fe over a ZSM-5 support was proposed for tackling excessive activity of the catalyst for hydrogenation. The results indicated that the formation of binary NiFe and CoFe alloys in Ni–Co–Fe/ZSM-5 enhanced the dispersion of metallic species, reduction of metal oxides, formation of more Lewis acidic sites, and the adsorption of the C–O functionality of the furan ring, while lowering the capability for adsorption/activation of H2 and the adsorption of the CC group of the furan ring. These factors together reduced the activity for the hydrogenation of the furan ring in furfural, but enhanced the hydrogenation of the CO in ethyl levulinate (EL). The kinetic study confirmed that the hydrogenation of EL was the rate-determining step. The coordination of the dual alloys, NiFe and CoFe, in the bifunctional Ni–Co–Fe/ZSM-5 catalyst rendered superior activity for selective one-pot conversion of furfural to GVL with a yield of 85.7%.
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Molecular Catalysis
·
2023
·
IF 4.6
Shuxing Zhang,Jiali Zheng,Zhihui Li,Xiaoshu Ding,Yanji Wang
Herein, we reported a green catalytic reaction system for the synthesis of 5-amino-1-pentanol with furfural and ionic liquid hydroxylamine salt as the initial raw material. In addition, the method can obtain 2-furonitrile and furfurylamine in high yields. The reaction system comprises three new reactions, including the reaction of furfural with ionic liquid hydroxylamine salt to synthesize 2-furonitrile, the hydrogenation of 2-furonitrile to prepare furfurylamine, and the hydrogenolysis of furfurylamine to prepare 5-amino-1-pentanol. For the synthesis of 2-furonitrile, ionic liquid hydroxylamine salt (NH 2 OH) 2 ·[HSO 3 - b - mim ]·HSO 4 was prepared. The ionic liquid as co-solvents, catalysts, and hydroxylamine stabilizer has recovery and reusability. For the hydrogenation of 2-furonitrile to furfurylamine, high-efficiency Ru/g-C 3 N 4 catalyst was prepared. For the hydrogenolysis of furfurylamine to 5-amino-1-pentanol, high-efficiency Pt/ZrO 2 catalyst was prepared. Finally, the yield of 5-amino-1-pentanol based on furfural was 48.7%. A potential pathway for preparing drugs from biomass has been identified in this work.
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ACS ES&T Engineering
·
2022
·
IF 0
Yaoyu Zhang,Yuxiong Wang,Yue Liu,Huimin Xu,Qingji Ying,Zhongbiao Wu
Cerium-modified Cu/ZSM-5 catalysts were employed for the selective catalytic combustion of acetonitrile. It was obtained that cerium addition effectively improved the mineralization rate of acetonitrile and nitrogen selectivity as well. The optimal Cu5Ce8/ZSM-5 sample exhibited 100% mineralization rate and higher than 95% nitrogen selectivity within 325–500 °C. The strong interaction between Cu and Ce species was induced in a core–shell-like structure of Cu–Ce/ZSM-5 samples, where the Cu–Ce/ZSM-5 core was wrapped with a Cu–Ce mixed oxide layer. The external mixed oxides exhibited enhanced reducibility and increased active oxygen species. In situ diffuse reflectance infrared Fourier transform spectroscopy and density functional theory simulations revealed that surface cerium species strengthened the hydrolysis reaction path of acetonitrile as ceria could effectively promote the dissociation of water and the hydrolysis of cyano groups, thereby generating a sufficient amount of NHx species. As a result, the NOx from acetonitrile overoxidation would be eliminated through internal selectivity catalytic reduction over the Cu–Ce/ZSM-5 core.
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Nanomaterials
·
2022
·Vol. 12
·期 4
·696
·
IF 5.719
Chao Zhang,Shuangqing Fu,Fanghua Zhang,Mengnan Han,Xuming Wang,Jie Du,Honglei Zhang,Wei Li
Combination chemotherapy is emerging as an important strategy for cancer treatment with decreased side effects. However, chemotherapeutic drugs with different solubility are not easy to realize co-delivery in traditional nanocarriers. Herein, an affibody modified G-quadruplex DNA micellar prodrug (affi-F/GQs) of hydrophilic 5-fluorodeoxyuridine (FUdR) by integrating polymeric FUdRs into DNA strands is developed for the first time. To achieve synergistic efficacy with hydrophobic drugs, curcumin (Cur) is co-loaded into affi-F/GQs micelles to prepare the dual drug-loaded DNA micelles ([email protected]/GQs), in which affibody is employed as a targeting moiety to facilitate HER2 receptor-mediated uptake.[email protected]/GQs have a small size of approximately 130 nm and exhibit excellent stability. The system co-delivers FUdR and Cur in a ratiometric manner, and the drug loading rates are 21.1% and 5.6%, respectively. Compared with the physical combination of FUdR and Cur,[email protected]/GQs show higher cytotoxicity and greater synergistic effect on HER2 positive gastric cancer N87 cells. Surprisingly,[email protected]/GQs significantly enhance the expression and activity of apoptosis-associated proteins in Bcl-2/Bax-caspase 8, 9-caspase 3 apoptotic pathway, which is the main factor in the death of tumor cells induced by FUdR. Overall, this nanoencapsulation is a promising candidate for the targeted co-delivery of drugs with significant differences in solubility.Keywords:G-quadruplex;DNA micelles;affibody;5-fluorodeoxyuridine;curcumin;synergetic therapy
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FUEL
·
2022
·
IF 8.035
Miao Zuo,Xinyu Wang,Wenlong Jia,Yanzhong Zhu,Xianhai Zeng,Lu Lin
As one of the essential building blocks for bio-chemicals and bio-fuels, the 5-Hydroxymethylfurfural (HMF) production is still challenging in a green and cheap way. This work developed a bio-derived aqueous-natural deep eutectic solvent (A-NADES) to synthesize HMF using α-Al 2 O 3 or Al(OH) 3 as robust catalysts, obtaining high yields of 67.1% and 63.6% HMF from glucose under mild reaction reactions, respectively. Different kinds of starches and starchy food waste also exhibited high conversion efficiency in the A-NADES system. The mechanistic study indicated that the in-situ formed Al (III) site of α-Al 2 O 3 during the reaction was critical for converting glucose-based carbohydrates. A-NADES could be effectively reused six times with a more convenient direct reuse method without significant activity loss. This study suggested a novel A-NADES reaction media in the synergistic reaction with robust aluminum-based catalysts for HMF synthesis, and proposed a novel process of food waste utilization in green solvents.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Hengli Qian,Qidong Hou,Weijie Zhang,Yifan Nie,Ruite Lai,Huiru Ren,Guanjie Yu,Xinyu Bai,Haozhi Wang,Meiting Ju
Photocatalytic oxidation is an attractive approach for biomass valorization, but uncontrollable reactive oxygen species (ROS) inevitably initiates over-oxidation of target product, leading to low selectivity. Here we report that combining MnO 2 , WO 3 with carbon nitride (CN) enables the construction of photocatalyst with electron transport channels and oxygen adsorption sites. Owing to the rapid transfer of photo-generated electrons to adsorbed O 2 , CN-WO 3 @MnO 2 exhibited 13.5 and 1.18 times higher 1 O 2 and ∙O 2 - generation capacity than CN-WO 3 with 92.8% lower ∙OH generation capacity, respectively. With the synergistic effect of ∙O 2 - and 1 O 2 , 2,5-diformylfuran (DFF) selectivity up to 79.6% at high 5-hydroxymethylfurfural (HMF) conversion (77.6%) was attained. Both experimental results and density functional theory calculations indicate that the construction of electron transport channels and oxygen adsorption sites can deliberately modulate the generation of ROS with desired oxidation ability, thus facilitating the efficient and selective oxidation of HMF into DFF.
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