MOLECULAR PHARMACEUTICS
·
2025
·
IF 4.5
Hao Zhang,Dan Xie,Meng Chen,Qiangqiang Yin,Guangyue Shi,Jialong He,Xiaoyang Yu,Qian Lu,Zhengji Wang,Jing Dong,Liguo Hao
Chemotherapy is a widely used cancer treatment modality, while the complex tumor microenvironment (TME) significantly impedes drug delivery and deep tissue penetration. An MR molecular imaging drug-loaded nanomotor has been developed to achieve deep tumor tissue penetration and imaging-guided drug delivery, enabling combined photothermal and chemotherapeutic treatment of pancreatic cancer. A Janus-type nanomotor (Au@H-MP NMs) was fabricated via magnetron sputtering for application in photothermal therapy. Doxorubicin (DOX) was loaded onto one hemisphere of the nanomotor, achieving combined photothermal and chemotherapeutic treatment. Additionally, the nanomotor exhibits dual responsiveness to pH and glutathione (GSH), facilitating the controlled release of DOX within deep tumor tissues. Studies confirmed the nanomotors excellent biosafety, strong photothermal conversion capability, and effective induction of apoptosis. Tumor tissue penetration was validated through in vitro migration and infiltration assays, while in vivo experiments demonstrated significant tumor suppression and enhanced drug accumulation. Moreover, MR imaging technology enables real-time monitoring of nanomotor dynamics. These findings suggest that the synthesized Janus-type MR molecular imaging nanomotor offers a promising strategy for multimodal treatment of pancreatic cancer with significant clinical potential.
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Xu He,Xiaobo Zhang,Qiuyue Zheng,Jingli Yuan,Jijuan Cao
Staphylococcus aureus ( S. aureus ), a prevalent foodborne pathogen, poses a significant threat to public health. Rapid, specific, and sensitive on-site pathogen detection methods are crucial for food safety. In this study, a ternary MXene/WS 2 /Au NPs composite was synthesized via a solvothermal and in situ growth method. This composite serves dual purposes as a photoactive material for photoelectrochemical (PEC) aptasensing and as an effective antibacterial catalyst. A PEC aptasensor was developed using MXene/WS 2 /Au NPs as the substrate and a ferrocene-modified aptamer as the recognition probe, enabling quantitative detection of S. aureus . The sensor exhibits a wide linear range (1.0 × 10–1.0 × 10 7 CFU/mL) and an ultra-low detection limit (3.0 CFU/mL). Additionally, the nanocomposite demonstrates strong peroxidase-like activity, efficiently catalyzing H 2 O 2 to generate ·OH, offering broad-spectrum antibacterial properties for pathogen control in food safety monitoring.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Yongjiao Sun,Jun Li,Yuchen Hou,Bingliang Wang,Wendong Zhang,Koichi Suematsu,Lin Chen,Jie Hu
Electrically conductive metal-organic frameworks (EC-MOFs) exhibit significant potential application as sensing materials for chemical resistance gas sensors. Herein, we developed a flexible gas sensor based on Ni 3 (HITP) 2 nanosheets co-functionalized with noble metal nanoparticles (NPs) and WS 2 quantum dots (QDs) for NO 2 detection at room temperature. The gas sensing performance was regulated by optimizing the metal species and loading ratios of WS 2 QDs. The measured results revealed that Au NPs and 2 mol% WS 2 achieved the most effective enhancement for NO 2 sensing performance. Therefore, Au NPs was selected to optimize WS 2 -2/Ni 3 (HITP) 2 sensor for further improving the sensing properties. A unique hierarchical structure based on gas sensor (Au 3 @WS 2 -2/Ni 3 (HITP) 2 sensor) enables high response (14.73 % to 5 ppm NO 2 ), rapid response/recovery time (97 s/110 s), good selectivity, anti-humidity, repeatability, long-term stability as well as flexibility at room temperature. Furthermore, density functional theory (DFT) and band theory were employed to comprehend adsorption energies and the electronic structures at atomic scale, elucidating the intrinsic correlation between NO 2 adsorption behavior and Ni 3 (HITP) 2 surface and the sensitization mechanism of heterostructures. These findings provide novel insights for designing high-performance NO 2 gas sensors worked at room temperature and guidance for EC-MOFs sensing mechanism.
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高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 6
·3825-3831
·
IF 1.354
Chen Jian,Wang Jun-Feng,Wu Xue-Zhong,Rong Zhen,Dong Pei-Tao,Xiao Rui
We developed a high-performance surface-enhanced Raman scattering (SERS) sensing platform that can be used for specific and sensitive DNA detection. The SERS platform combines the advantages of Au film over nanosphere (AuFON) substrate and Ag@PATP@SiO2 SERS tag. SERS tag-on-AuFON
is a sensing system that operates by the self-assembly of SERS tag onto an AuFON substrate in the presence of target DNAs. The SERS signals can be dramatically enhanced by the formation of “hot spots” in the interstices between the assembled nanostructures, as confirmed by finite-difference
time-domain (FDTD) simulation. As a new sensing platform, SERS tag-on-AuFON was utilized to detect Staphylococcus aureus (S. aureus) DNA with a limit of detection at 1 nM. A linear relationship was also observed between the SERS intensity at Raman peak 1439 cm−1 and
the logarithm of target DNA concentrations ranging from 1 μM to 1 nM. Besides, the sensing platform showed good homogeneity, with a relative standard deviation of about 1%. The sensitive SERS platform created in this study is a promising tool for detecting trace biochemical molecules
because of its relatively simple and effective fabrication procedure, high sensitivity, and high reproducibility of the SERS effect.
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2022
·
IF 12.545
Hao-Cheng Hu,Shao-Hua Wu,Lei-Xin Jin,Jian-Jun Sun
In this work, a novel “turn-on” mode Au nanocubes (AuNCs) enhanced surface-enhanced Raman scattering (SERS) biosensing platform coupled with heated Au electrode (HAuE) and strand displacement amplification (SDA) strategy was proposed for highly sensitive detection of DNA adenine methylation (Dam) Methyltransferase (MTase) activity. The Dam MTase and Dpn I enzyme activities were significantly increased by elevating the HAuE surface temperature, resulting in the rapid production of template DNA for later SDA. During the SDA process, the released single-stranded DNA (ssDNA) could be amplified exponentially, and its concentration was positively related to the Dam MTase activity. The plasmonic AuNCs in SERS tags could provide significant SERS enhancement due to their “lightning rod” effect resulting from the sharp feature of the edges and corners of AuNCs. Because of these factors, the proposed biosensors exhibited high sensitivity in detecting the Dam MTase activity. The limit of detection was estimated to be 8.65 × 10 −5 U mL −1 , which was lower than that in most of the sensors for detection of Dam MTase activity in the literature. This SERS biosensor could also be used to screen inhibitors of Dam MTase and had the potential for detecting Dam MTase activity in real biological samples.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2022
·
IF 4.598
Ming Yin,Li Zhang,Xiuxia Wei,Yiwei Sun,Shuyan Qi,Yan Chen,Xinxin Tian,Jingxuan Qiu,Dongpo Xu
This work is carried out by the synergy of Co/Ni-Bio-MOF and noble metal Au-doped coral-like ZrO 2 . A novel electrochemical aptamer sensor (aptasensor) for measuring kanamycin (Kan) was developed by using ZrO 2 @Au as an amplification platform for electrochemical aptasensors. ZrO 2 @Au was strategically used to significantly reduce the Differential Pulse Voltammetry (DPV) response by hindering electron transfer at the working electrode surface. When Kan is recognized by the ZrO 2 @Au-linked aptamer, it is disconnected from the complementary sequence attached to the Co/Ni-Bio-MOF due to the applied force, thereby disengaging from the electrode. This results in the removal of obstacles to electron transfer, enabling signal amplification. This electrochemical sensor exhibits good linearity from 10 μM to 1000 μM. It has a detection limit of 0.037 μM and has excellent stability (RSD = 0.14–0.21%), reproducibility (RSD = 0.079–0.63%) and selectivity.
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高影响因子
FOOD CONTROL
·
2021
·
IF 5.548
Peifang Chen,Chenbiao Li,Xiaoyuan Ma,Zhouping Wang,Yin Zhang
Aflatoxin B1 (AFB1) has the strongest carcinogenesis and mutagenesis effects. Herein, a novel ratiometric surface-enhanced Raman scattering (SERS) aptasensor based on graphene oxide (GO) as a corrective internal standard (IS) and signal amplifier was constructed for reliable detection of AFB1. 4-Mercaptobenzoic acid as Raman reporter embedded in [email protected] core-shell nanoparticles and AFB1aptamer conjugated to the Ag shell acted as the signal probes ( [email protected] NPs-AFB1apt). AFB1apt was attached to the surface of GO with Raman signals modified Au NPs/Indium tin oxide glass (GO/Au NPs/ITO) via π–π stacking interaction, facilitating further amplification of the signal. With an increase of AFB1 concentration (0.0001 ng/mL–100 ng/mL), the probes were released owing to the affinity of aptamers, causing the decreased 4-MBA intensity (I 4-MBA ) and unchanged GO intensity (I GO ). Therefore, the quantitative test was achieved based on the ratiometric value (I 4-MBA /I GO ) . A good negative correlation (R 2 = 0.992) was achieved and the limit of detection (LOD) was as low as 0.1 pg/mL, proving the proposed sensor can become an efficient analytical tool and shows a bright application prospect in the food detection field.
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高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 22
·3462-3468
·
IF 0
Yanhu Wang,Jinmeng Xu,Chao Ma,Shuai Li,Jinghua Yu,Shenguang Ge,Mei Yan
In this work, a paper-based chemiluminescence excited photoelectrochemical aptamer device (PPECD) was developed for adenosine triphosphate (ATP) measurement based on a porous Au-paper electrode modified with a tin dioxide quantum dot/reduced graphene oxide nanocomposite (SnO2 QD/RGO) integrated with an all-solid-state paper supercapacitor (PSC) amplifier and a digital multi-meter (DMM). The Au-paper electrode was constructed through the growth of a gold nanoparticle (AuNP) layer on the back of the paper working electrode to improve the electron conduction. Fe3O4@AuNP nanocomposites were used as labels of luminol, glucose oxidase (GOx) and signal aptamer which greatly enhanced the chemiluminescence emission and provided a simple magnetic separation approach to attain interference-free measurement for real detection. GOx was used for the oxidation of glucose to produce H2O2 which was not only used as the co-reactant in the CL system, but also as the electron donors to suppress the corrosion of SnO2 QDs under illumination as well as to facilitate the generation of stable photocurrent. A PSC was constructed and integrated into a PPECD as an effective electrical energy storage unit to collect and store the photocurrents. The stored electrical energy could be released instantaneously through a low cost, portable, and simple DMM to obtain an amplified current for the quantification of ATP.
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PubMed
NANOTECHNOLOGY
·
2018
·Vol. 29
·期 17
·175203
·
IF 3.404
Yan Meng,Xiaoyan Wu,Ziyang Xiong,Chunyan Lin,Zuhong Xiong,Ethan Blount,Ping Chen
Compared to organic–inorganic hybrid metal halide perovskites, all-inorganic cesium lead halides (e.g, CsPbBr3) hold greater promise in being emissive materials for light-emitting diodes owing to their superior optoelectronic properties as well as their higher stabilities. However, there is still considerable potential for breakthroughs in the current efficiency of CsPbBr3 perovskite light-emitting diodes (PeLEDs). Electrode quenching is one of the main problems limiting the current efficiency of PeLEDs when poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) is used as the hole injection layer. In this work, electrode quenching control was realized via incorporating Au NPs into PEDOT:PSS. As a result, the CsPbBr3 PeLEDs realized an improvement in maximum luminescence ranging from ∼2348 to ∼7660 cd m−2 (∼226% enhancement) and current efficiency from 1.65 to 3.08 cd A−1 (∼86% enhancement). Such substantial enhancement of the electroluminescent performance can be attributed to effective electrode quenching control at the PEDOT:PSS/CsPbBr3 perovskite interface via the combined effects of local surface plasma resonance coupling and enhanced hole transportation in the PEDOT:PSS layer by Au nanoparticles.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Xiao Wang,Ying Zheng,Lan Xu
An electrochemical strategy for adenine detection was described. In order to generate a 3D net-work composite film, gold nanoparticles (Au NPs) capped with 3-thiophene acetic acid (3-TAA) were used to couple with molecular imprinting technique (MIT). In the presence of the 3-TAA capping Au NPs (Au NPs-T), the electrode-surface-tethered 3-TAAs were polymerized to form a homogeneous conductive material immobilized into the electrode. Through this sensor fabrication, Au NPs-T associating with the Au electrode resulted in enhanced sensitivity and MIT contributed to the specificity.
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高影响因子
MICROCHIMICA ACTA
·
2010
·Vol. 168
·期 3
·347-354
·
IF 2.648
Qian Ping,Ai Shiyun,Yin Huanshun,Li Jinhuan
Au-Pd bimetallic nanoparticles were prepared in the presence of an amine-terminated dendrimer of a fourth generation poly(amidoamine) type. A biosensor was fabricated by immobilizing dsDNA on a thin layer of a dendrimer-encapsulated bimetallic nanoparticles (Au-Pd) in a chitosan composite on a glassy carbon electrode. The biosensor was evaluated by square wave voltammetry for the determination of the oxidative damage of immobilized DNA and the antioxidant capacity of sericin. The biosensor is shown to be suitable for the rapid detection of DNA damage and the assessment of the antioxidant capacity of sericin.
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高影响因子
ACS Sensors
·
2020
·
IF 7.333
Wei Chen,Lijun Yang,Chao Yan,Bangben Yao,Jianfeng Lu,Jianguo Xu,Guodong Liu
Overuse and abuse of morphine (MOP), one of the main components of pericarpium papaveris, have attracted increasing attention in the medical field owing to its pharmacological and toxicological activity. Herein, we proposed a new electrochemical nano-biosensor for MOP detection based on surface-confined building of Au@Pt-centered and multi-G-quadruplex/hemin wire-surrounded electroactive super-nanostructures. The center Au@Pt was flower-shaped and irregularly protruded, allowing substantial loading of multiple G-quadruplex wire/hemin complexes on its surface to accomplish the assembly of electroactive super-nanostructures. Interestingly, as the super-nanostructures were closely confined on the electrode surface, a significantly amplified electrochemical signal was thus obtained in the absence of MOP. In contrast, the introduction of target MOP can induce an intense competitive effect and strongly destroy the assembly process, resulting in the reduction of the electrochemical response that is correlated with the logarithmic concentration of MOP. Under optimal conditions, the electrochemical nano-biosensor is capable of highly sensitive detection of MOP in a dynamic concentration range from 1 ppt to 500 ppb. The limit of detection is achieved as low as 0.69 ppt, and the practical application was confirmed by examining MOP from chafing dish condiments. We expect the electrochemical platform utilizing this unique nanoarchitecture to provide rational guidelines to design high-performance analytical tools.
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高影响因子
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