Russian Journal of Physical Chemistry A
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2019
·Vol. 93
·期 4
·696-702
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IF 0.581
Huanxin Li,Zhang Haihan,Dou Yonghui,Xu Li,Liu Guoji
Abstract The solubility of (1R,2R)-(+)-1,2-diaminocyclohexane L-tartrate (DHT) in methanol + water, ethanol + water, and 2-propanol + water mixed solvents were measured using a synthetic method with alcohols mass fractions varying from 0.1 to 0.5 over 278.15 to 318.15 K under atmospheric pressure ( P = 0.1 MPa). It was proved that the solubility of DHT in the three binary solvents increased with increasing temperature, while decreased with the mass fraction of alcohols rising. The experimental solubility data were correlated by the modified Apelblat equation and Sun model. The modified Apelblat model showed better agreement with the experimental data than the other model. Furthermore, the thermodynamic parameters including \(\Delta G_{{{\text{sol}}}}^{^\circ }\) , \(\Delta H_{{{\text{sol}}}}^{^\circ }\) , and \(\Delta S_{{{\text{sol}}}}^{^\circ }\) for DHT in the dissolution process were obtained from Van’t Hoff plots.
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ULTRASONICS SONOCHEMISTRY
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2014
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IF 3.816
Wang Liju,Keyume Ablajan,Feng Jun
A rapid and efficient ultrasound-promoted one-pot synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives is described here. The reaction of substituted phenylhydrazine and dialkyl acetylenedicarboxylate with substituted isatin and malononitrile is catalyzed by l -proline to give good-to-excellent yields in water/ethanol (v/v, 1:1) at room temperature.
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Chemosensors
·
2023
·Vol. 11
·期 11
·558
·
IF 4.2
Zhenni Lan,Qing He,Mingxia Zhang,Huahong Liu,Liusen Fang,Jinfang Nie
Cadmium (Cd) pollution is an important environmental problem, as it is easily absorbed by plants and gradually accumulates in the human body through the food chain. This study aimed to elucidate the changes in the metabolic response of the rice cultivar “TanLiangYou215” under Cd stress. Rice was grown in soil culture at 0 (Control), 2 (Low group), and 10 (High group) mg/kg CdCl2for 90 days. The ultrastructural, Cd content, antioxidant activity, and metabolic changes to the rice in different tissues were analyzed. Phenotypic characterization and ultrastructure showed that the rice roots and leaves were significantly damaged and plant growth was inhibited in the High group, while plant growth was promoted in the Low group. Overall, Cd showed a regularity of “low promotion and high inhibition”. Physiological indices revealed that rice was significantly affected by Cd stress. Compared to the Control, Cd stress resulted in higher antioxidant enzyme activities, and the Low group suffered less oxidative damage than the High group. Metabolomic studies revealed that Cd stress significantly altered the metabolic profiles of rice plants. Rice responded to Cd stress by upregulating amino acids and regulating related pathways, including alanine, aspartate and glutamate metabolism, and arginine and proline metabolism. The significant expression of flavonoids with antioxidant properties helped rice resist the oxidative damage caused by Cd accumulation in the root tissue; Cd stress significantly downregulated glycerophospholipid metabolism in the stem and leaf tissues, which affected the cellular activities in rice stem and leaf tissues. We investigated the effects of Cd stress on ultrastructure, antioxidant activity, and metabolic changes in different tissues of the rice variety TLY215. Moreover, the different tissues of TLY215 can regulate these metabolic pathways to resist Cd stress, which provides valuable insights into the response of TLY215 to different concentrations of Cd.Keywords:cadmium (Cd);rice (Oryza sativaL.);phenotypic characterization;physiological activity;metabolomics
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2023
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IF 11.4
Lei Chen,Daijie Chen,Shunyi Zhou,Jieying Lin,Yun Liu,Xiongfei Huang,Qingqi Lin,Jean Louis Morel,Zhuobiao Ni,Shizhong Wang,Rongliang Qiu
Hexafluoropropylene oxide (HFPO) homologues, which are important alternatives to perfluorooctanoic acid, have been frequently identified in crops. Although exposure to HFPO homologues via crops may pose non-negligible threats to humans, their impact on crops is still unknown. In this study, the accumulation, transport, and distribution mechanisms of three HFPO homologues in lettuce were investigated at the plant, tissue, and cell levels. More specifically, HFPO trimer acid and HFPO tetramer acid were primarily fixed in roots and hardly transported to shoots (TF, 0.06–0.63). Conversely, HFPO dimer acid (HFPO-DA) tended to accumulate in lettuce shoots 2–264 times more than the other two homologues, thus resulting in higher estimated daily intake values. Furthermore, the dissolved organic matter derived from root exudate enhanced HFPO-DA uptake by increasing its desorption fractions in the rhizosphere. The transmembrane uptake of HFPO homologues was controlled by means of a transporter-mediated active process involving anion channels, with the uptake of HFPO-DA being additionally facilitated by aquaporins. The higher accumulation of HFPO-DA in shoots was attributed to the larger proportions of HFPO-DA in the soluble fraction (55–74%) and its higher abundance in both vascular tissues and xylem sap. Our findings expand the understanding of the fate of HFPO homologues in soil–crop systems and reveal the underlying mechanisms of the potential exposure risk to HFPO-DA.
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Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Jiayu Zheng,Longxiao Zhou,Qiufen Liu,Senwei Wu,Yuting Peng,Xiujian Zhao,Shouqin Tian
Ratiometric optical thermometry has emerged as a vital platform for non-contact temperature monitoring in industrial and scientific applications, demanding sensors with high sensitivity, non-invasiveness, and spatial resolution. Although zeolitic imidazolate framework-8 (ZIF-8) possesses attractive thermal stability and structural tunability, its limited luminescence intensity hinders practical thermometric applications. Meanwhile, ZIF-L, a two-dimensional (2D) polymorph of ZIF-8 with identical ligands, remains unexplored for temperature sensing. Herein, we propose a dual-modulation strategy synergizing lanthanide valence engineering with MOF phase control to develop a multi-emission center Eu3+/Eu2+ co-doped ZIF-L film (Eu/ZIF-L). By introducing Eu3+ into ZIF-8 precursors, the partial reduction of Eu3+ to Eu2+ under thermal treatment triggers a structural evolution from 3D ZIF-8 to 2D ZIF-L. The resultant Eu/ZIF-L exhibits dual emission peaks at 450 nm (Eu2+) and 495 nm (ligand-centered), with their intensity ratio (I495/I450) demonstrating remarkable linear temperature dependence over 296–373 K and achieving a relative sensitivity of 1.95% K−1. This work pioneers the integration of valence-state manipulation and MOF phase transition for thermometric optimization, providing a novel paradigm to design advanced ratiometric MOF thermometers for industrial thermal management.
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JOURNAL OF PHARMACEUTICAL SCIENCES
·
2025
·
IF 3.8
Xiaoxuan Fei,Junyi Pei,Simin Yan,Weihong Ge,Li Li,Jianjun Zou,Huimin Zhang,Lie Sun,Sifei Han,Luojuan Hu
Compared to classic intravenous (IV) administration, subcutaneous (SC) delivery of monoclonal antibodies (mAbs) offers new opportunities to improve patient compliance and healthcare efficiency. However, insufficient understanding of drug absorption process following SC administration, particularly the role of lymphatic transport, may hinder the development of SC formulations for mAbs. The current study aimed to examine the absorption route of widely used anti-PD-(L)1 mAbs following SC injection, and four marketed products (Pembrolizumab, Tislelizumab, Envafolimab, Sugemalimab) were selected as the model drugs. In the thoracic lymph duct cannulated rat model, all mAbs were found to be primarily absorbed via the lymphatics following SC injection, with 63.1–72.0% of the administered dose recovered in the thoracic lymph, contributing to >80% of SC bioavailability. This absorption pattern also resulted in elevated exposure of mAbs in draining lymph nodes (an order of magnitude higher drug concentrations compared to the systemic drug exposure). In addition, markedly different lymphatic absorption profiles were observed following SC administration at different sites, reflecting specific draining routes associated with certain anatomical regions in the rat. Our data suggested that the food pad is likely the optimal SC injection site for quantitative studies of lymphatic transport, whereas injection to the lower hind leg (a common SC injection site in previous studies) appeared to underestimate the absolute extent of lymphatic drug transport in the thoracic lymph-duct cannulated rat model, as these sites are drained by lymphatic networks that cannot be fully captured by the thoracic lymph-duct cannulation model.
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JOURNAL OF SOILS AND SEDIMENTS
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2025
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IF 3
Yang Wei,Dai Huiping,Wei Shuhe,Robinson Brett H.,Skuza Lidia,Sun Jie
Purpose Cadmium contamination in agricultural soils poses significant risks to food safety and ecosystem health. This study investigated the synergistic effects of humic substances (fulvic acid [FA] or humic acid [HA]) and nitrogen (N) fertilisers on enhancing cadmium (Cd) phytoextraction by Solanum nigrum L. ( S. nigrum ) in moderately contaminated soils. Methods A pot experiment tested ten treatments combining FA/HA with ammonium sulphate ((NH 4 ) 2 SO 4 ), urea (CH 4 N 2 O), ammonium chloride (NH 4 Cl), or ammonium bicarbonate (NH 4 HCO 3 ), measuring plant biomass, Cd uptake, physiological responses, the expression levels of three antioxidant enzyme genes and soil parameters. Results Co-application of FA with (NH 4 ) 2 SO 4 yielded the highest shoot biomass and Cd extraction relative to the control. Biomass augmentation drove these improvements, as Cd concentrations in shoots remained statistically unchanged across treatments. Physiological analysis revealed reduced oxidative stress (H 2 O 2 and MDA levels), elevated antioxidant enzyme activities (SOD and POD) in shoots under combined treatments, meanwhile, the relative expression levels of SnCAT , SnPOD and SnSOD were clearly changed. Soil pH and bioavailable Cd concentrations remained stable, minimising risks of Cd leaching or mobilisation. The results demonstrate that FA or HA combined with ammonium-based fertilisers significantly accelerates Cd phytoextraction by circumventing the “dilution through growth” effect observed in other species, maintaining high Cd uptake efficiency. Conclusions The FA + (NH 4 ) 2 SO 4 treatment emerged as the optimal strategy, offering a practical solution for remediating moderately Cd-contaminated soils within a decade. These findings provide a scalable framework for integrating S. nigrum -based phytoremediation into agricultural systems, particularly where soil buffering capacity limits amendment-induced pH fluctuations.
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Biomedical Materials
·
2025
·Vol. 20
·期 5
·055005
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IF 3.7
Lei Nie,Xinran Li,Taiping Zhang,Yuanyuan Lu,Peng Ding
Hydrogel-based functional dressings for wound healing have garnered increasing attention due to their excellent hydrophilicity, adjustable mechanical properties, and superior biocompatibility. In this study, a composite hydrogel was facilely fabricated through the Schiff base reaction between -poly-L-lysine modified chitosan (CS-PL) and oxidized dextran (Odex). The formed hydrogel displayed the interconnected microstructure (100–200 μm), injectability, and adjustable mechanical properties. Macroscopic observation and alternating strain rheological analysis confirmed the good self-healing ability of the hydrogel. Furthermore, with the incorporation of epigallocatechin-3-gallate, the composite hydrogel exhibited an improved reactive oxygen species (ROS) scavenging capability and good antibacterial activity against E. coli and S. aureus. The designed composite hydrogel dressings exhibited hemolysis rates of 0.75 ± 0.60% to 0.81 ± 0.31%, indicating their excellent hemocompatibility. Moreover, CCK-8 analysis and fluorescent images confirmed the excellent cytocompatibility of the hydrogels after co-culturing with NIH 3T3 cells for various periods. The above results offer a promising strategy for preparing functional hydrogel dressings via -PL modification on CS for wound healing applications.
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2025
·Vol. 47
·期 12
·568
·
IF 3.8
Xie Hongguan,Gong Lian,Lei Shiwei,Li Shida,Feng Yuxin,Liao Lin,Wang Yue,Wang Kongxi
Polycyclic aromatic hydrocarbons (PAHs) pose a significant threat to the ecological environment, and plant–microbe remediation represents a promising strategy for the treatment of contaminated soils. This study aimed to evaluate the effects of foliar application of selenite or selenium nanoparticles (SeNPs) on the remediation efficiency of pyrene by Alfalfa ( Medicago sativa L.) and Bacillus subtilis PSL-1. A pot experiment was conducted with foliar selenium treatments at different concentrations (5–15 mg kg −1 ), and the effects were comparatively analyzed in terms of plant physiological parameters (chlorophyll content, biomass, and antioxidant enzyme activity), soil enzyme activities (dehydrogenase and catalase), soil pyrene speciation, and microbial community structure. The results showed that low-concentration foliar selenium application (5 mg L −1 ) enhanced antioxidant defense, alleviated oxidative stress, and promoted chlorophyll synthesis and growth of Alfalfa, thereby stimulating soil enzyme activity and enriching pyrene-degrading microorganisms. Consequently, the pyrene degradation rate increased from 62.07% to 67.83–71.91%. In contrast, high selenite concentration (15 mg L −1 ) induced phytotoxicity and weakened the stimulation of soil enzyme and microbial activities. Compared with selenite, SeNPs consistently enhanced the remediation efficiency across all tested concentrations, demonstrating a broader safe concentration range. Overall, foliar selenium application effectively promoted plant–microbe remediation of pyrene-contaminated soil, and SeNPs exhibiting a superior promoting effect and higher application potential than selenite.
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Materials Today Communications
·
2019
·
IF 1.859
Henan Wang,Zeyu Li,Shuting Lu,Chunyu Li,Wancheng Zhao,Yuliang Zhao,Shuling Yu,Ting Wang,Tiedong Sun
Biocompatibility and targeted therapy are the demand by modern chemotherapy drugs. Meanwhile, the utilizations of biopolymer or environmentally friendly polymer are also the key issues for sustainable development. We have constructed a new drug delivery system with targeted and controlled release capabilities. It has been confirmed that an environmentally friendly polymer (CMC- g -PLA) obtained by grafting polylactic acid on a carboxymethyl cellulose biopolymer has an amphiphilic property and is easy to form micelles , thereby being useful as a hydrophobic drug carrier. In order to have the function of targeted therapy, anti-EpCAM antibody was anchored on the polymer chain of carboxymethyl cellulose by amidation reaction. Doxorubicin and HepG2 cells were used as the model anticancer drug and tumor targeting cells, respectively. The nano scale core-shell structure, critical micelle concentration , drug loading and encapsulation efficiency were studied by TEM, pyrene fluorescent probe method and ultraviolet standard curve method, respectively. Furthermore, the pH induced release function experiments, cytotoxicity experiments and in vivo tumor treatments experiments on mice. The results show that the drug carrier with antibody prepared by us can effectively deliver hydrophobic drugs to specific tumor sites and increase the effect of tumor treatment. This versatile design provides a new solution for future cancer treatments.
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BIOMATERIALS
·
2013
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IF 7.604
Jingbin Huang,He Zhang,Yuan Yu,Yan Chen,Dong Wang,Guoqing Zhang,Guichen Zhou,Junjie Liu,Zhiguo Sun,Duxin Sun,Ying Lu,Yanqiang Zhong
To develop biodegradable docetaxel-loaded self-assembled nanoparticles of poly ( d , l -lactide-co-glycolide)/hyaluronic acid block copolymers were successfully synthesized. These copolymers could form nanoparticles with small size (<200 nm), an acceptable CMC (∼7.9 mg/L), typical core/shell structure and superior stability in one week. DTX-loaded PLGA 502H -b-HA 5.6k nanoparticles (DTX/SANPs) showed a biphasic release pattern within 120 h, and exhibited enhanced cytotoxicity toward CD44-overexpressing MDA-MB-231 cells. Cellular uptake study indicated that PLGA 502H -b-HA 5.6k nanoparticles (SANPs) were taken up in MDA-MB-231 cells by CD44-mediated endocytosis . Pharmacokinetics study revealed DTX/SANPs could prolong the circulation of DTX in the blood. In vivo studies demonstrated that SANPs exhibited enhanced tumor targeting and antitumor activity with lower systemic toxicity. In conclusion, DTX/SANPs have great potential for targeted chemotherapy for CD44-overexpressing breast cancer.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Xingzi Lan,Yurong Liu,Yaqi Wang,Feng Tian,Xiaomin Miao,Han Wang,Yadong Tang
Preparing wound dressing with dual-delivery of antioxidant and antibacterial agents is highly desirable in clinical wound treatment. Herein, a series of coaxial nanofiber membranes loaded with antioxidant tea polyphenols (TP) in the core and antibacterial ε-poly (L-lysine) (ε-PL) in the shell layer were successfully fabricated by coaxial electrospinning. The physicochemical characterizations by transmission electron microscopy , inverted fluorescence microscopy and fourier transform infrared spectroscopy confirmed the formation of core-shell structure. The results of in vitro drug release indicated that ε-PL exhibited a fast release profile while TP released in a sustained manner, which is favorable to the achievement of quick bacteria inhibition in the initial phase as well as long-term antioxidant activity during wound healing. The antioxidant activity of coaxial nanofibers was found to be increased with the increment of TP content and incubation time . The antibacterial assays against Escherichia coli and Staphylococcus aureus demonstrated that the incorporation of ε-PL in the coaxial nanofibers led to strong antibacterial activity . Additionally, all the coaxial nanofibers possessed good cytocompatibility. Therefore, the prepared coaxial nanofibers simultaneously incorporated with ε-PL and TP are promising as potential wound dressing materials.
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