Advanced Science
·
2026
·
IF 14.1
Zi-Jian Huang,Feng-Ming Li,Yi-Fan Tu,Ke-Ke Feng,Cheng-Lei Li,Shi-Cheng Tian,Yong-Shan Hu,Jing-Wei Shao,Zhen-Hua Liu
Photothermal therapy (PTT), a non-invasive tumor treatment, shows promise but is limited in solid tumors by restricted tissue penetration, thermotolerance, anti-apoptotic and immunosuppressive effects. In this study, tumor microenvironment-responsive nanoplatform VARH was constructed based on MXene. Under NIR-II laser irradiation, VARH achieves a high photothermal conversion efficiency of 44.21%. Loaded 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride decomposes at high temperatures to generate alkyl radicals, synergizing with hydroxyl radicals from V 4+ -catalyzed endogenous H 2 O 2 decomposition, enabling chemodynamic therapy (CDT) and thermal dynamic therapy to enhance tumor cell oxidative damage. Triggered by high glutathione, VARH releases ribonucleoprotein (RNP) complexes to knockout heat shock protein 90 (HSP90), attenuating cellular heat resistance and promoting apoptosis. It also enhances T cell-mediated anti-tumor immunity and, with free radicals, promotes tumor cell immunogenic cell death (ICD), achieving immunotherapeutic multi-effect synergy. Integrating nanotechnology with precise gene editing, this study develops a novel multimodal synergistic therapy system, providing new insights for multi-modal treatment R&D and advancing PTT and free radical-based cancer therapies.
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高影响因子
RENEWABLE ENERGY
·
2026
·
IF 9.1
Bofeng Shang,Zhenyuan Zhang,Bin Zhang,Erjun Liang
Solar-driven interfacial evaporation (SDIE) holds great potential to mitigate global freshwater scarcity. However, its practical application is hindered by the intermittency of solar irradiation, which leads to operational instability and reduced energy utilization efficiency. To solve this issue, we proposed the incorporation of photothermal composite phase change materials (CPCMs) instead of conventional photothermal material into the SDIE system. These materials store residual heat generated during irradiation and release it under low-light or dark conditions, thereby sustaining the evaporation process and improving overall energy efficiency. In this study, a three-dimensional carbon foam (CF) derived from biomass was first synthesized and infused with MXene to enhance its photothermal properties. This modified framework was subsequently impregnated with a liquid PCM under vacuum to form the CPCMs. The resulting composites exhibited a high latent heat of 241.1 J/g and achieved a photothermal conversion efficiency of 92.2%. Finally, the CPCM-based SDIE system achieve a freshwater production rate 2.4 times higher than that of conventional systems in dark conditions, along with a 13.4% increase in total water production. Therefore, the proposed strategy effectively alleviates the operational instability caused by intermittent solar radiation, enabling efficient and stable all-weather interfacial evaporation.
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Small Science
·
2026
·Vol. 6
·期 4
·e202500526
·
IF 7
Bangul Khan,Bilawal Khan,Syed Bilal Ahmed,Wasim Ullah Khan,Junchen Liao,Md. Shohidul Islam,Iyappan Gunasekaran,Rafi U Shan Ahmad,Mohamed Elhousseini Hilal,Bee Luan Khoo
MXene (Ti 3 C 2 T x )-based hydrogels hold great promise for wearable bioelectronics but are limited by unstable interlayer spacing, poor mechanical resilience, and inadequate skin compatibility. An ion-driven interfacial engineering strategy is introduced that stabilizes Ti 3 C 2 T x nanosheets via Ca 2+ intercalation and Cl − electrostatic screening, expanding interlayer spacing and enabling ultrafast gelation (<5 min). The resulting Ti 3 C 2 T x −polyacrylamide hydrogel exhibits ultrastretchability (2920%), high conductivity (0.39 s m −1 ), and ≈99% cell viability, surpassing existing MXene and commercial hydrogels in terms of cytocompatibility, durability, and skin adherence. Molecular dynamics simulations reveal dynamic interlayer adaptability (6.2–8.2 Å) and ion transport mechanisms that underpin strain-adaptive sensing and stability across a temperature range of –20 to 40 °C. Integrated into wearable electrodes, the hydrogel enables high-quality electrocardiography (ECG) acquisition across diverse skin types, achieving signal-to-noise ratios of up to 27.2 dB without the need for auxiliary treatments. Coupled with a convolutional neural network–bidirectional gated recurrent unit model trained on ECG data from 17 subjects, the system delivers real-time, cuffless blood pressure estimation with MAE ± SD of 2.91 ± 3.03 mmHg (systolic blood pressure) and 2.36 ± 2.33 mmHg (diastolic blood pressure), meeting Association for the Advancement of Medical Instrumentation and British Hypertension Society standards. This synergistic material and AI framework establishes a new paradigm for smart, long-term cardiovascular monitoring.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Zhang Wenjuan,Zhang Panpan,Li Yuheng,Wang Youliang,Liu Chunli
Polyamide nanofiltration membranes have been widely used in seawater desalination and water treatment. Enhancing water permeability while sustaining high rejection in nanofiltration (NF) membranes has garnered significant research interest. In this study, we combined the MXene intermediate layer and amine monomer enrichment by one-step co-deposition strategy and then fabricated MXene-based composite nanofiltration film (MCF) via interfacial polymerization (IP). Ethylenediamine (EDA) adsorbed onto MXene surfaces via hydrogen bonding or electrostatic interactions, thereby improving MXene dispersion, enhancing interfacial bonding with the polyamide (PA) selective layer, and optimizing the composite membrane structure. MXene doping enhanced surface roughness, hydrophilicity, and electronegativity of the composite membrane, strengthening Donnan exclusion and size sieving. The optimized membrane sample has a water permeability of 103.8 L m -2 h -1 at 6 bar, rejection rate for methylene blue (MB) and Congo red (CR) > 99%, and a high rejection rate of metal ions (Mg 2+ , Cu 2+ , and Ca 2+ > 93%, Na + >83%). This membrane overcomes the traditional trade-off effects between water permeance and salt selectivity, achieving simultaneous improvement in water flux and rejection rate. This work is expected to provide a new way for the preparation of nanofiltration membranes with excellent performance.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Chun Yang,Zunquan Zhao,Qichen Yang,Yanjun Fang,Jingran Sun,Liqin Du,Yonghui Wang,Xiaoli Li,Nan Su,Jin Wu,Mingzhu Liu,Ying Liu,Jialei Bai
MXene-based fluorescent aptasensors detect targets through MXene-mediated adsorption of labeled aptamer probes and subsequent target-induced release of the probe signals, providing a promising programmable detection approach. However, their sensitivity is limited by the low signal output per aptamer or the incomplete quenching of the ultrabright aptamer probes by MXene. This study proposes an advanced MXene-based detection platform that addresses these challenges through material engineering and innovative sensing strategies. Polydopamine-mediated interface engineering endows monolayer MXene nanosheets (p-MXene) with excellent nanocolloidal stability and dynamic reversible internanosheet networks. While concentrated, it exhibits complete self-settling and adhesion behavior with a tendency toward spontaneous solid–liquid separation. This characteristic enhances the adhesion of the p-MXene/aptamer nanocomposites during mild centrifugal precipitation without compromising the target-induced aptasensing capability of these nanocomposites. Free from incomplete quenching concerns, the platform leverages ratio-controlled click chemistry to synthesize red fluorescence quantum dot-aptamer conjugates (RQDs@APT) for maximum signal per aptamer. The p-MXene/RQDs@APT achieves near-zero-background specific detection of aflatoxin B1 with a high signal-to-noise ratio and outstanding reproducibility. It shows a linear range of 0.90–35 μg/kg and a detection limit of 0.27 μg/kg in real food samples, while supporting visual detection. The aptasensor is easy to rapidly assemble, and each module has long-term storage stability. The azide-modified aptamer lyophilized powders can be stored and replaced separately, enabling the platform to be easily expanded to detect other targets. The platform has demonstrated satisfactory performance in detecting deoxynivalenol, ochratoxin A, zearalenone, and fumonisin B1. This sensitive, robust, and universal technology shows great potential for various detection applications.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Ziyang Fan,Jianpeng Wu,Wei Yang,Xinyi Wang,Shuai Liu,Yue Yao,Xinglong Gong,Ken Cham-Fai Leung,Shouhu Xuan
A hierarchical gradient-structured Leather/Aerogel/MXene (LAM) composite is fabricated. • Facile fabrication with tailorable and scalable manufacturing potential. • Impact force absorption of 80% and impact energy dissipation of ~98%. • Features thermal insulation, Joule heating, and real-time impact monitoring. • Intelligent marching blanket shows great potential for extreme environment protection. Mechanical impacts and drastic temperature fluctuations pose escalating threats to human operations in extreme environments, driving an urgent need for advanced personal protective materials that integrate superior impact resistance and efficient thermal regulation capabilities. Herein, a Leather/Aerogel/MXene (LAM) composite with hierarchical gradient porous structure is fabricated via in-situ freeze-casting of aramid nanofiber (ANF) aerogel on a natural leather skeleton combined with spray-coating of conductive MXene nanosheets. Interfacial hydrogen bonding and multiscale fiber bridging between the leather matrix and ANF nanofibers enable stable heterogeneous integration and effective interfacial stress transfer. Benefiting from this rational structural design, the LAM composite achieves excellent mechanical and thermal insulation properties. In comparison to pure ANF aerogel, the LAM shows significantly enhanced tensile and puncture resistance performance. Notably, the LAM shows high impact force dissipation rate of 80% ± 3% and impact energy dissipation rate of approximately 98% ± 1% under low-velocity impact of 10 cm drop height. Meanwhile, the abundant internal porous structure of the LAM efficiently suppresses gas convection and reduce thermal radiation transmittance, exhibiting excellent temperature isolation effect in both high and low temperature environments. The continuous MXene conductive network further endows the LAM with voltage-tunable Joule heating performance for active thermal management. Finally, detachable intelligent marching blankets and intelligent waist supports are designed, integrating thermo-mechanical protection, active thermotherapy, and impact monitoring functions. This work provides a feasible structural design strategy for multifunctional integrated protective materials, showing promising application potential in personal protection under extreme environments. Download: Download high-res image (176KB) Download: Download full-size image
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Rui Wang,Ziqian Meng,Han Yan,Meiqi Yin,Jinfeng Huang,Hao Zheng,Jingtao Sun,Jiyun Nie,Wei Wu,Qinzhi Wang
Flexible CP-MXene@Au chip fabricated via layer assembly and electrodeposition. • MXene prevented Au NPs aggregation while preconcentrating analytes. • Electrodeposition enabled facile optimization of uniformity and reproducibility. • Thiophanate-methyl in fruits detected with good recovery and practical applicability. For the common fruit contaminant thiophanate-methyl (TPM) residue monitoring, a portable ultra-sensitive flexible surface-enhanced Raman scattering (SERS) chip was developed using carbon paper and electrochemical deposition technology for the rapid and efficient trace detection of TPM in fruits. The flexible chip was constructed using MXene (CP-MXene) through layer-by-layer assembly and plasmonic metal (CP-MXene@Au) by the chronopotentiometry method, which dramatically improved the intrinsic electrical conductivity contributing to forming SERS-active “hot spot” with superior stability and reproducibility. Based on prepared SERS chip, the TPM was rapidly detected as the lowest detection limit as 0.00923 μM and a wide detection linear range of 0.1–100 μM. Furthermore, TPM in fruits can be collected and recognized with excellent reusability and satisfactory recovery of 90.5–109.5%, demonstrating its good practical applicability. This flexible SERS chip is also highly sensitive and low-cost, providing a new idea for efficient food safety monitoring.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yi Chen,Huayu Zhao,Jinze Li,Fujuan Peng,Yuanyuan Zhao,Qian Wang,Ruiping Zhang,Huifang Zhao
Fusiform TiO 2 nanoparticles is in-situ grew on the surface of HCl etching MXene. • MXene/TiO 2 heterojunction is served as the outstanding photoactive material in PEC platform. • This PEC aptasensor adopts the competitive displacement for sensitive and specific quantification of GP73. • The constructed PEC aptasensor is successfully applied to directly monitor GP73 in human serum samples. Golgi protein 73 (GP73) is a promising serological biomarker for the early diagnosis and prognosis of hepatocellular carcinoma (HCC), it is essential to develop a sensitive detection method for GP73. Benefiting from its high sp 2 graphitic degree, efficient photoinduced electron–hole transfer, and robust transport of photogenerated ion migration abilities, the MXene/TiO 2 heterojunction was employed to fabricate a competitive photoelectrochemical (PEC) aptasensor for sensitive GP73 detection. In this study, GP73 possessed higher affinity with GP73 Apt than cDNA, and competitively displaced cDNA from GP73 Apt upon the binding process. This MXene-based PEC aptasensor displayed a logarithmic linear response to GP73 in the concentration range of 7.3–3650 ng/mL with a limit of detection (LOD) of 0.42 ng/mL. Remarkably, this strategy was enabled to directly determinate GP73 in human serum samples of health control, esophageal cancer, gastric cancer, and HCC with analytical performance comparable to ELISA. Therefore, the proposed PEC sensing system may hold promising prospects for clinical detection of gastrointestinal cancers biomarker. The fabricated competitive displacement-triggered PEC aptasensor based on MXene/TiO 2 heterojunction is employed to directly determinate GP73 in human serum samples of hepatocellular carcinoma. Download: Download high-res image (115KB) Download: Download full-size image
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 10
·684
·
IF 5.4
Min Congyu,Sun Haifeng,Zhang Haixia,Zhang Jinzhu,Ding Min,Zhang Xiaoqing
An electrochemical aptamer-based (E-AB) sensor for myeloperoxidase (MPO) was developed that combined a gold nanoparticle /MXene scaffold with freeze-thaw-directed aptamer immobilization and probe-density optimization. Unlike using nanocomposite amplification alone, this strategy regulates probe density and accessibility at the bioreceptor layer to improve target-coupled signal transduction. Using the same aptamer solution, the freeze-thaw method yielded 60.77% greater MPO-induced signal suppression and a 2.4-fold lower regression-derived limit of detection (LOD) than conventional incubation. After target incubation for 50 min at 4 °C, the sensor showed a linear response from 5.00 to 250.0 ng/mL in 1% plasma matrix (equivalent to 500 ~ 25,000 ng/mL in undiluted plasma), with an LOD of 4.15 ng/mL (equivalent to 415 ng/mL in undiluted plasma). These results illustrated that coupling conductive nanointerface design with aptamer-layer organization might provide a practical route for antibody-free and H 2 O 2 -independent MPO determination. Graphical abstract
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 13
·1001
·
IF 3.2
Chen Huyue,Wang Jingrong,Lu Tengfei,Xu Deming,Xu Haiping,Yang Dandan,Chen Lifei
TiO 2 was deposited on the surface of Ti 3 C 2 T x MXene by the sol–gel method to construct core–shell structured MXene@TiO 2 fillers, which were then introduced into the PVDF matrix to prepare dielectric composite films. The effects of TiO 2 deposition ratio and filler loading on the dielectric properties of the composites were systematically investigated, and the thermal and mechanical properties of the optimized system were further evaluated. The results showed that the TiO 2 coating layer could construct an effective interfacial insulating structure, which enhanced interfacial polarization while suppressing carrier migration and the formation of leakage pathways, thereby enabling the synergistic regulation of dielectric constant and dielectric loss. When the TiO 2 deposition mass ratio reached 50%, the composites showed a more effective overall interfacial modulation effect. Under these conditions, the 15 wt% composite delivered the optimal overall dielectric performance, with a dielectric constant of 29.1 and a dielectric loss as low as 0.051, representing a significant reduction compared with that of the unmodified MXene/PVDF composite (0.59), and it also exhibited superior dielectric stability. At the same time, the thermal stability and mechanical performance of the composites were also enhanced. The study confirms that building a TiO 2 interfacial insulating layer is an effective approach to enhancing the dielectric performance of PVDF-based composites while realizing the coordinated optimization of multiple properties.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Qian Zhong,Jin Liu,Gaoke Zhang
Visible-light photocatalytic activation of peroxymonosulfate (PMS) is a promising strategy for treating refractory organic pollutants. In this study, a novel nitrogen-doped TiO 2 /Ti 3 C 2 MXene composite (N-TiO 2 /Ti 3 C 2 ) was synthesized via an impregnation-calcination method using cetyltrimethylammonium bromide (CTAB) as the nitrogen source. N-doping effectively narrowed the bandgap of TiO 2 , while the highly conductive Ti 3 C 2 MXene served as an electron-transfer platform, thereby synergistically enhancing light absorption and charge carrier separation. The N-TiO 2 /Ti 3 C 2 exhibited a Brunauer-Emmett-Teller surface area of 35.86 m 2 /g, approximately 1.94 times higher than that of the undoped TiO 2 /Ti 3 C 2 , due to CTAB intercalation-induced structural regulation. Under LED visible light, the N-TiO 2 /Ti 3 C 2 /PMS system achieved 98.5% of rhodamine B degradation within 100 min and 81.3% of tetracycline degradation within 40 min, with good stability over a wide pH range (3.1-10.0). Mechanistic studies identified that sulfate radicals (SO 4 • − ), singlet oxygen ( 1 O 2 ), and holes (h⁺) were the dominant reactive species. LC-MS analysis elucidated the degradation pathways of rhodamine B and tetracycline. This study presents an efficient MXene-based photocatalyst for PMS activation, offering a promising strategy for wastewater treatment.
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TRIBOLOGY INTERNATIONAL
·
2026
·
IF 7.6
Shuwen Liu,Jing Tang,Peiyuan Zhang,Guangpeng Xi,Zhangpeng Li,Jinqing Wang
Covalent solvent-free nanofluids show excellent tribological properties, yet the effect of organic shell chain length on performance remains unclear. This work innovatively synthesized three MXene-based nanofluids (M1000 NFs, M2070 NFs, M3085 NFs) with tuned canopy chain lengths, revealing chain-dependent performance. Short-chain M1000 NFs achieved superior oxidative stability in water through dense surface grafting, maintaining performance over 180 days. As a water-based additive, M3085 NFs with extended chains reduced friction by 74% at 0.25 wt% via an optimized adsorption layer. Wear resistance depended mainly on MXene core concentration rather than chain length. These insights provide key design guidelines for high-performance aqueous MXene nanofluids, particularly addressing the coupled challenges of oxidative degradation and friction control.
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