INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yan Fang,Jiawen Chen,Qinglin Li,Qinhui Chen
Excessive bleeding and bacterial infection leading to death is a major concern worldwide, particularly in cases of deep and narrow noncompressible hemorrhage. Herein, a novel Janus cryogel with anisotropic surface wettability, antibacterial activity, and rapid shape recovery was designed by constructing a hydrophilic porous cryogel using chitosan (CS), acacia gum (AG), and quaternized mesoporous bioglass (QMBG), with subsequent surface hydrophobic modification using octadecanol. The asymmetric hydrophobic surface modification of octadecanal endowed OCAQ with outstanding antiblood and antibacterial permeability, effectively preventing blood outflow and the invasion of bacteria to the wound. The hydrophilic parts with interconnected macroporous structure give the cryogel with ultra-high water uptake (5167 ± 182 %) and rapid water-trigged shape recover ability (≈2.1 s). The presence of active CS, AG, and QMBG in cryogel contributes to its exceptional blood clotting ability. Janus cryogel presents outstanding hemostatic performance (0.14 ± 0.03 g) in rat's liver injury model. Moreover, Janus cryogel exhibits excellent antibacterial properties due to the combination of its hydrophobic surface and antimicrobial quaternary amine groups. Meanwhile, the Janus cryogel has favorable hemocompatibility and biocompatibility. A Therefore, the Janus cryogel will become a candidate with great potential for clinical application of noncompressible wound as a multifunctional dressing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xiangjian Fan,Ying Ou,Huiyu Yang,Haiyang Yang,Ting Qu,Quanyuan Zhang,Fan Cheng,Fuqiang Hu,Hai Liu,Zushun Xu,Chunli Gong
Currently, achieving a simultaneous improvement in proton conductivity and mechanical properties is a key challenge in using chitosan (CS) as a proton exchange membrane (PEM) substrate in direct methanol fuel cells (DMFCs). Herein, a novel nanofiller–zwitterionic molecule, (3-(3-aminopropyl) dimethylammonio) propane-1-sulfonate, ADPS)-modified polydopamine (PDA) (PDA-ADPS) was synthesized by the Michael addition reaction and was incorporated into a CS matrix to prepare CS/PDA-ADPS composite membranes. PDA-ADPS, which contains an acid–based ion pair can create new proton conduction channels in the composite membrane, improving proton conductivity. The proton conductivity of the CS/PDA-ADPS composite membrane was as high as 38.4 mS cm −1 at 80 °C. Moreover, due to the excellent compatibility and dispersibility of PDA-ADPS in the CS matrix, the obtained CS/PDA-ADPS composite membranes exhibited favorable mechanical properties. Such outstanding proton conductivity and mechanical properties guarantee good performance of the composite membranes in fuel cells. The peak power density of the CS/PDA-ADPS composite membranes was 30.2 mW cm −2 at 70 °C. This work provides a new strategy for fabricating high-performance CS based PEMs for DMFCs.
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JOURNAL OF MOLECULAR LIQUIDS
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2023
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IF 6
Feifei Lu,Guanjun Ding,Xiaoyu Ma,Biao Huang,Lijun You
Magnetic chitosan (CS) cross-linked gelatin (Gel) polymer composites (MCGC) were fabricated by reacting CS with Gel in the present of carboxyl modified Fe 3 O 4 nanoparticles and cetyltrimethylammonium bromide using glutaraldehyde as a crosslinking agent. MCGC possessed high zeta potential, abundant active functional groups including amino and hydroxyl groups and facile magnetic separation properties. The prepared MCGC exhibited excellent adsorption performance for AR 18 and the adsorption capacity reached as high as 344.63 mg/g. The adsorption kinetics was fitted well with the pseudo-second order model, while the adsorption isotherms followed the Redlich-Peterson equation best. The thermodynamic studies indicated the adsorption process was exothermic and spontaneous. The adsorption mechanism was studied including electrostatic interaction, hydrogen-bond interaction and π-π stacking between dyes and MCGC. Desorption and renewable experiments proved MCGC possessed high regeneration properties and reusability as an adsorbent.
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APPLIED SURFACE SCIENCE
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2023
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IF 6.7
Yuhui Zhang,Fei Liu,Li Zhong,Zhaoji Dong,Chuchu Chen,Zhaoyang Xu
Tetracycline antibiotics are currently detected in most water sources. The presence of such pollutants in the environment is becoming increasingly common, and addressing this contamination is a significant challenge due to its potential threat to human health and ecosystem stability. This study successfully prepared cellulose nanofiber/titanium dioxide/chitosan (CNF/TiO 2 /CS) aerogels by directional freeze-drying technique for photocatalytic degradation of tetracycline-contaminated wastewater. The CNF/TiO 2 /CS aerogel photocatalysts have a three-dimensional mesh structure with a large specific surface area, which provides many active sites for the highly efficient photocatalytic degradation of tetracyclines. The CNF/TiO 2 /CS aerogel showed 99.5% tetracycline removal efficiency within 180 min. Free radical scavenging experiments investigated the adsorption and photodegradation mechanism of tetracycline by CNF/TiO 2 /CS aerogel. The critical participation of •O 2 - and h + in the decomposition of tetracycline was verified, which provided experimental support for the photocatalytic reaction mechanism. In addition, the CNF/TiO 2 /CS aerogel has high stability and recyclability for photocatalytic degradation, which can be recycled 7 times, and the recycling process is environmentally friendly. An in-depth analysis of the intermediate degradation products using liquid chromatography-mass spectrometry (LC-MS) revealed two efficient photocatalytic degradation pathways. These findings strongly confirm the extensive potential of photocatalytically active aerogels for wastewater treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Huanyang Yu,Yuan Ge,Huanqi Ding,Yongtai Yan,Liyan Wang
Cross-linking is the most promising method for preparing high-performance chitosan/gelatin bio-polymer film. In this work, vanillin cross-linked chitosan/gelatin bio-polymer (CGGV) film with good mechanics, water resistance, antioxidant and ultraviolet-proof property was prepared. The micro-structure, physical and functional properties of CGGV film were studied. Results showed that vanillin as a cross-linking agent provided a compact inner micro-structure through Schiff base and hydrogen bond interaction. Moderate cross-linking significantly improved mechanical strength, thermal ability, hydrophobicity of the films and reduced the water vapor permeability, swelling ratio and water solubility. Especially, CGGV films showed stronger ultraviolet-proof properties and possessed potent radical scavenging activity. Therefore, CGGV film is suitable to protect per-mature fruits and could be used as novel multifunctional packaging in the agriculture and foods industry.
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ELECTROCHIMICA ACTA
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2023
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IF 6.6
Chunxia Yan,Jie Guan,Zhimao Li,Fangyue Cheng,Ziqiang Shao
Due to the growing demand for clean and renewable energy, the effective utilization of renewable resources in energy storage and has been concerned. And high specific capacitance and stable electrochemistry for energy storage devices are challenging to develop. Learning from unique structure of goniastrea coral, we design to construct three-dimensional layered conductive electrodes material made of MoS 2 @chitosan carbon spheres (MNCCS) composite. The NiCoLDH nanosheets construct on the surface of conductive chitosan carbon spheres to effectively form open permeable channels and rich conductive networks, improves the efficient energy storage and electrochemical stability. MoS 2 is strongly coupled with NiCoLDH nanosheets through heterointerface, which resembles tentacles on the surface of coral, exposing more active sites to efficiently trap ions. Besides, the obtained material possesses favorable heterojunction interface and defects, which provide sufficient available electroactive sites and numerous storage charge area. Hence, The MNCCS presents an outstanding specific capacitance of 2605.9 F g −1 at 1 A g −1 . Notably, a supercapacitor fitted with MNCCS electrode and CCS electrode achieves high specific capacitance (234.4 F g −1 at 1 A g −1 ), the maximum energy density of 77.0W h kg −1 at highest power density of 667.4W kg −1 , along with the excellent cycling stability of 90.8% retention over 10,000 cycles. This work provides a new perspective for fabricating high-performance and stable supercapacitors electrode material for clean energy storage.
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Journal of Materials Chemistry B
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2023
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IF 7
Bin Zhu,Yu Liu,Yanlei Zhao,Xinyu Dou,Linbang Wang,Shuyuan Min,Xiaoguang Liu,Dong Qiu
The ideal skull defect repairing material should have good biocompatibility, mechanical properties, and contribute to osteogenesis. In this study, we designed and fabricated biodegradable, bioactive and mechanically robust porous scaffolds composed completely of biological materials. We used gelatin-chitosan blend as the matrix, sodium phytate instead of toxic glutaraldehyde for cross-linking, and the pH-neutral bioactive glass (PSC) to improve biological activity and mechanical properties. The chitosan-gelatin-30%PSC/sodium phytate composite scaffold avoided the problems of high toxicity in conventional cross-linking agents with glutaraldehyde, the poor mechanical support of pure chitosan or gelatin scaffold, and the mismatch of degradation rate with bone repair, being promising as a new candidate for skull defect repair.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Qing Yin,Jiali Liu,Zicheng Zhong,Yueyuan Zhang,Feiran Zhang,Mingming Wang
In this study, chitosan (CS) and phytic acid (PA) were employed as raw materials to synthesize a range of chitosan–phytic acid complexes (CP) with different ratios (CS:PA = 12:1, 9:1, 6:1, 3:1, 1:1). The structures and elemental compositions of the compounds were characterized using Fourier-Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (SEM-EDS). The thermal stability of the synthesized materials was analyzed using a Thermogravimetric Analyzer (TG). Electrochemical testing was conducted to explore the corrosion inhibition effect of the modified inhibitors with varying ratios on Q235 steel in 3.5 wt% NaCl solution. Additionally, Scanning Electron Microscopy (SEM) was utilized to investigate the surface morphology of the immersed samples. When the CS:PA ratio was 3:1, CP exhibited an impressive corrosion inhibition efficiency of 94.9 %. Furthermore, the antimicrobial properties of CP were evaluated using the colony plate counting method. At a CS:PA ratio of 1:1, CP demonstrated the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) at 0.1250 % and 0.5000 %, respectively. This research introduces a novel green corrosion inhibitor capable of simultaneously reducing the electrochemical corrosion of Q235 while inhibiting biocorrosion, avoiding the antagonistic effects arising from the simultaneous use of biocides and corrosion inhibitors in the system.
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CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Tianyi Zhou,Haiyan Zhou,Fei Wang,Peng Zhang,Jian Shang,Leilei Shi
The intricate, hostile, and diverse nature of osteomyelitis (OM) poses a challenge for complete bacterial eradication and osteogenesis promotion via conventional treatment. Recently, functional hydrogels exhibiting antibacterial and osteogenic properties emerge as a promising avenue for OM wound healing in clinical practice. However, the preparation procedures and associated costs on cytokine and cell therapies for certain functional hydrogels can be complex and prohibitively expensive. In our research, a hybrid hydrogel dressing has been formulated utilizing carboxymethyl chitosan (CMCS) as the base material, and designed with inherent antibacterial, adhesion, proliferation, and differentiation characteristics, showing promise as a candidate for eradicating infection and promoting bone regeneration . The hybrid hydrogel is composed of interconnected networks of Fe 3+ -induced self-assembled CMCS and the antibacterial drug ciprofloxacin (CIP), resulting in excellent injectability and moldability. Notably, the CMCS/Fe 3+ /CIP hybrid hydrogel is capable of regulating antibacterial responses and stimulating osteogenesis in infected microenvironments without additional additives. This injectable antibacterial and osteogenic-promoting hydrogel establish a high-potential platform for low-cost, safe and effective treatment of OM by expediting the initial stages of infected bone wound repair.
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CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Hanyu Ren,Andi Guo,Chunhui Luo
Developing artificial substitutes that mimic the structures and performances of natural cartilage is of great importance. However, it is challenging to integrate the high strength , excellent biocompatibility, low coefficient of friction , long-term wear resistance, outstanding swelling resistance, and osseointegration potential into one material. Herein, a sandwich hydrogel with cartilage-mimetic structures and performances was prepared to achieve this goal. The precursor hydrogel was obtained by freezing-thawing the mixture of poly vinyl alcohol, chitosan and deionized water three cycles, accompanied by soaking in sodium hyaluronate solution. The top of the precursor hydrogel was hydrophobically modified with lauroyl chloride and then loaded with lecithin , while the bottom was mineralized with hydroxyapatite . Due to the multiple linkages (crystalline domains, hydrogen bonds , and ionic interactions), the compressive stress was 71 MPa. Owing to the synergy of the hydrophobic modification and lecithin , the coefficient of friction was 0.01. Additionally, no wear trace was observed after 50,000 wear cycles. Remarkably, hydroxyapatite enabled the hydrogel osseointegration potential. The swelling ratio of the hydrogel was 0.06 g/g after soaking in simulated synovial fluid for 7 days. Since raw materials were non-toxic, the cell viability was 100 %. All of the above merits make it an ideal material for cartilage replacement.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2023
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IF 5.8
Xiyuan Yi,Yong Luo,Qi Zhou,Jun Wang,Zengtao Yang
Insulin therapy is the most effective way to control the blood glucose value of diabetic patients. The most effective administration route for insulin is subcutaneous injection because bioavailability for non-injection administration is low and unstable. However, patients often need a multiple daily insulin injection regimen to control basal and postprandial blood glucose, which causes various complications. Controlled pulsatile drug release technology using ultrasound as an external stimulus source is a very promising method to avoid multiple injections of insulin. However, most of the drug-loaded microbubbles used for ultrasound-mediated treatment have a short half-life, which limits their use in controlled pulsatile drug release. More importantly, how to control insulin release is still a challenge. In this paper, chitosan poly-acrylic acid nanobubbles as drug carriers of insulin were prepared to achieve a visually controlled pulsatile release of insulin triggered by focused ultrasound. The experimental results in vivo demonstrated that nanobubbles were stable enough to achieve long-term visualization for 7 days after intramuscular injection in rats. Under the guidance of ultrasound imaging, it is visible to find the position and observe the gray values change of nanobubbles. Thus, when triggered by focused ultrasound, the amount of insulin could be accurately pulsatile released from nanobubbles. In vivo experiments in rats showed that the visually controlled pulsatile release of insulin could be achieved for a long time, up to 3 consecutive days. The blood glucose level could be repeatedly reduced by focused ultrasound irradiation with just one injection. Our research provided a promising way for visually controlled pulsatile release of insulin, which would significantly reduce the injection frequency of insulin.
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ACS Applied Polymer Materials
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2023
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IF 5
Aowei Lv,Xue Lv,Song Tian,Ting Xie,Xiaoyan Xu,Shulin Sun
Conductive hydrogels, as a flexible electronic material, have found emerging applications in the fields of wearable devices, health monitoring, and electronic skin. However, the current conductive hydrogels lack antimicrobial properties and excellent mechanical properties, which severely limit their applications in wearable and biological interfaces. Herein, a conductive nanocomposite hydrogel consisting of silver nanowires (AgNWs), carboxylated carbon nanotubes (c-MWCNTs), chitosan (CS), and polyacrylamide (pAAm) was prepared by in situ free-radical polymerization without adding any cross-linking agents. Ingeniously, physical interactions (hydrogen bonding) endow the hydrogels with excellent tensile strength (503.64 kPa), ultrahigh tensile (16,000%), high toughness (22.8 MJ·m–3), and self-healing properties. Remarkably, hydrogels based on AgNWs and CS exhibit excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Simultaneously, under the synergistic effect of AgNWs and c-MWCNTs, the fabricated conductive hydrogel sensor exhibits excellent strain sensitivity (gauge factor = 10.42, up to 900%), high conductivity, and fast response time (200 ms). The c-MWCNTs-AgNWs-based hydrogel sensors can sensitively and stably detect human activities, which show that pAAm/c-MWCNTs@CS-AgNWs hydrogels have great potential in the fields of human activity monitoring, e-skin, and soft electronic devices.
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