JOURNAL OF FOOD ENGINEERING
·
2024
·
IF 5.3
Yajuan Sun,Qiubo Wang,Chen Li,Ying Wang,Yi Mao,Cheng Yang,Yunxing Li
A food-grade Pickering emulsifier was fabricated using heat-assisted pH-shifting (HP) method for enhancing the emulsion stability. The emulsification performance of the modified pumpkin seed protein isolate (PSPI) nanoparticles was initially tested. The results showed that the modified PSPI had substantially improved emulsifying capacity, with the internal oil phase volume fraction reaching up to 80%, and the emulsion remaining stable after centrifugation at 10,000 g for 60 min and 30 days of storage. The data from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), UV–visible, intrinsic fluorescence and fourier transform infrared spectroscopy (FTIR) indicated that the primary, secondary and tertiary structures of PSPI were disrupted, resulting in changes in interfacial tension, wettability, particle size, and dispersibility of the protein, which promoted the adsorption of modified PSPI nanoparticles to the surface of oil droplets and improved the emulsion stability. Overall, the HP modified PSPI is a promising Pickering emulsifier for various applications.
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高影响因子
Exploration
·
2025
·
IF 22.5
Qingyuan Deng,Ao Hua,Shiyou Li,Zhijie Zhang,Xiang Chen,Qiang Wang,Xing Wang,Zhiqin Chu,Xiangliang Yang,Zifu Li
An extracellular acidic environment and an intracellular mildly alkaline environment induced by carbonic anhydrase 9 (CA9) play a critical role in self-renewal, invasion, migration, and drug resistance of cancer stem cells (CSCs) within hypoxic solid tumors. Here, we report an antitumor strategy leveraging hyperbaric oxygen therapy (HBO) to regulate tumor pH and boost hydroxyethyl starch-doxorubicin-copper nanoparticles (HHD-Cu NPs) against CSCs. HBO overcomes tumor hypoxia, downregulates pH-regulatory proteins such as CA9, and leads to intracellular accumulation of acidic metabolites. As a result, HBO promotes intracellular acidification of both tumor cells and CSCs, triggering efficient doxorubicin release and the potent copper-mediated chemical dynamic effect of subsequently administered dual-acid-responsive HHD-Cu NPs. The combination of HBO with HHD-Cu NPs not only eliminates tumor cells but also inhibits CSCs, altogether leading to potent tumor inhibition. This study explores a new function of clinical-widely used HBO and establishes a novel combination therapy for treating CSCs abundant hypoxic solid tumors.
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PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
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2025
·
IF 7.4
Yue Cao,Dan Wang,Kai Qi,Yubing Qiu,Xingpeng Guo
The poor stability of polypyrrole (PPy) restricts its application in biomedical pH sensing. This study incorporated Ti 4 O 7 particles with PPy and deposited them onto activated carbon foam (ACF) via a galvanostatic method, preparing a (Ti 4 O 7 + PPy)/ACF composite that significantly enhances the long-term stability of PPy. The prepared Ti 4 O 7 was modified with p-toluenesulfonate (pTS – ), forming negatively charged Ti 4 O 7 -pTS particles via S–O–Ti bonds between pTS – and Ti 3+ /Ti 4+ on Ti 4 O 7 . These particles can tightly bind with N δ+ in PPy chains, effectively inhibiting pTS – loss and PPy degradation. During a 90-day immersion test in Hank's solution (37℃), the pH sensitivity of (Ti 4 O 7 + PPy)/ACF increased from 65 to 74 mV/pH during 0–7 days (activation period), stabilized at 63–64 mV/pH during 30–60 days, then decreased to 58 mV/pH, showing significantly enhanced sensitivity and long-term stability compared to PPy/ACF. In (Ti 4 O 7 + PPy)/ACF, PPy provides primary pH response, while Ti₄O₇ enhances its sensitivity and stability. The decline in its pH sensing performance is primarily caused by the degradation of PPy and the loss of Ti 4 O 7 particles. The involved mechanisms are discussed in detail.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Ran An,Penghui Li,Haizheng Li,Chunai Dai,Yuandu Hu
In the last decade, photonic structures based on responsive poly(ethylene glycol) (PEG)-analogues have drawn considerable attention. Nevertheless, the majority of reports concentrate on building 2D-like film-based photonic structures and lack multifunctionality. In this work, we report the construction of multifunctionalized PEG-analogues hydrogel-based photonic microspheres with an inverse opal structure. Opal-structured photonic microspheres (OSPMs) were firstly created using microfluidics-produced droplets of an aqueous dispersion of SiO 2 colloidal particles (CPs) as templates. The OSPMs were sequentially subjected to monomer infiltration, UV-induced polymerization and crosslinking, and wet etching of the SiO 2 CP building blocks, ultimately producing inverse opal photonic microspheres (IOPMs) with pH- and thermoresponsiveness. The IOPMs have a broad thermal operating window and can detect temperatures as high as 75 °C. The carboxylic acid groups in the skeleton of the IOPMs were further utilized to bind with positively charged compounds, such as ruthenium-functionalized polymers with fluorescence. The photonic microspheres are expected to show promising prospects in advanced sensing, visual temperature detection, anti-counterfeiting, and other related fields.
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高影响因子
GREEN CHEMISTRY
·
2025
·
IF 9.2
Liwu Qiang,Meng Bai,Zonghang Liu,Peipei Zhao,Shuai He,Man Zhao,Qinyun Yan,Wei Wen,Qilin Guo,Yanxia Zhang,He Xiao,Jianfeng Jia
The development of efficient pH-universal electrocatalysts for the hydrogen evolution reaction (HER) remains a critical challenge in renewable energy technologies. While Pt-based catalysts exhibit exceptional activity in acidic media, their performance deteriorates significantly in alkaline and neutral conditions due to sluggish water dissociation kinetics. Here, a carbon dots (CDs)-driven strategy is designed to engineer the spatial distribution and electronic structure of Ru species on graphene, achieving remarkable HER activity across the full pH range. By modulating the Ru-CDs interfacial configuration from CDs@Ru-coated to Ru&CDs-dispersed and Ru@CDs-encapsulated structures, it’s found Ru-6CDs/G exhibits excellent performance with the planar Ru&CDs arrangement. This Ru-6CDs/G catalyst exhibits ultralow overpotentials of 77 mV (0.5 M H₂SO₄), 58 mV (1.0 M KOH), and 39 mV (0.5 M PBS) at 10 mA cm-², alongside exceptional mass activities surpassing commercial Pt/C by up to 129 times. Combined experimental and theoretical analyses reveal that the Ru&CD configuration with optimal dispersion and the smallest size (~1.14 nm) of Ru nanoparticle induces a moderate d-band center position, balancing hydrogen adsorption/desorption energetics and accelerating the Volmer-Heyrovsky pathway. Density functional theory (DFT) calculations further demonstrate that charge redistribution at the Ru-CDs interface enhances H* intermediate stabilization, while COHP analysis confirms optimized Ru-H bond strength. This work not only establishes a universal design principle for metal-CDs hybrid catalysts but also provides deep insights into the electronic and spatial regulation of active sites for advanced electrocatalysis.
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高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Bo Chen,Shanshan Huangfu,Jiayi Cai,Wen Nie,Ke Li,Yu Wang,Yanhong Bai
This study investigated the synergistic effects of magnetic field (MF) and pH-shifting (pH 9–11) on the oxidative stability and in vitro digestibility of frozen denatured myofibrillar protein (MP). Results revealed that MF-assisted pH-shifting at pH 9 (MP-9 + MF) exhibited the better synergistic effect, significantly enhancing oxidative stability by promoting a compact, ordered protein conformation that minimized carbonyl formation and preserved sulfhydryl content. However, pH-shifting at pH 10 without MF achieved the highest in vitro digestibility, but this benefit came at the cost of reduced oxidative stability, as evidenced by the significant increase in carbonyl content. These findings demonstrate that this combined approach presents a clear trade-off, allowing for the targeted modulation of MP properties to prioritize either oxidative stability or digestibility, providing a novel strategy to enhance the quality of meat products.
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PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Yuchi Guo,Zongxue Yu,Haidong Chen,Bokai Peng,Junlei Tang
This study aimed to design a composite epoxy coating HZB/EP with pH-responsive behavior by grafting different material functions. In this approach, ZIF-8 particles were self-assembled on the surface of hydroxyapatite (HAp) through in situ growth, followed by encapsulation of the corrosion inhibitor BTA. Scanning electron microscopy (SEM) analysis of the coating section revealed a significant improvement in the dispersion of HZB in the resin compared to hydroxyapatite (HAp), resulting in a notable reduction in coating defects upon the addition of HZB. Electrochemical impedance spectroscopy (EIS) tests demonstrated that HZB/EP maintained a high low-frequency impedance value even after immersion in a 3.5% NaCl solution for 40 days, exhibiting an impedance magnitude 4–5 orders of magnitude higher than Pure EP. Additionally, scratch and salt spray tests validated the release and action process of the corrosion inhibitor BTA. This study presents a novel strategy for the development of multifunctional anticorrosive coatings.
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高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2019
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IF 1.163
Huayao Chen,Junlong Hu,Hongjun Zhou,Xinhua Zhou,Hua Xu
The triblock copolymer F127 (molecular formula (EO)106(PO)70(EO)106) was adopted as template with TMOS as the silica source. They were hydrolyzed by acidic aqueous solution in which chlorpyrifos (CH) and metal ions (Mn+) were introduced to the products to construct "F127-Mn+-CH" coordination structure in one step. Different sustained release systems were prepared through changing the composition of acidic aqueous solution added during the preparation. The characterization results confirmed the coordination interaction existing among metal ions, mesoporous silica and chlorpyrifos. It was also proved that the chlorpyrifos loaded in the sustained release system existed as amorphous state. According to SEM and TEM observation, the pore of the material presented as face-centered cage-type cubic structure with IM-3M symmetry similar to SBA-16 which is in accordance with N2 adsorption isotherms. The as-synthesized system showed significant pH sensitivity in the sustained release process indicating that the sustained release system can be well stored in neutral environment and activated while sprayed into earth in acid or basic environment. Their sustained release curves can be described by Korsmeyer-Peppas equation in neutral while accords with Higuchi under acid or basic environment.
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高影响因子
BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2024
·Vol. 47
·期 3
·355-366
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IF 3.5
Duan Xiaoyan,Pi Qian,Tang Lei
Dyes in wastewater have adverse effects on the environment and human health. Dye-decolorizing peroxidase (DyP) is a promising biocatalyst to dyes degradation, but the decolorization rates varied greatly which influencing factors and mechanisms remain to be fully disclosed. To explore an effective decolorizing approach, we have studied a DyP from Rhodococcus jostii ( Rh DyPB) which was overexpressed in Escherichia coli to decolorize four kinds of dyes, Reactive blue 19, Eosin Y, Indigo carmine, and Malachite green. We found the decolorization rates of the dyes by purified Rh DyPB were all pH-dependent and the highest one was 94.4% of Malachite green at pH 6.0. ESI–MS analysis of intermediates in the decolorization process of Reactive blue 19 proved the degradation was due to peroxidase catalysis. Molecular docking predicated the interaction of Rh DyPB with dyes, and a radical transfer reaction. In addition, we performed decolorization of dyes with whole E. coli cell with and without expressing Rh DyPB. It was found that decolorization of dyes by E. coli cell was due to both cell absorption and degradation, and Rh DyPB expression improved the degradation rates towards Reactive blue 19, Indigo carmine and Malachite green. The effective decolorization of Malachite green and the successful application of whole DyP-overexpressed cells in dye decolorization is conducive to the bioremediation of dye-containing wastewaters by DyPs. Graphical abstract
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高影响因子
ACS Biomaterials Science & Engineering
·
2018
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IF 4.432
Yan Ma,Xianwen Wang,Huajian Chen,Zhaohua Miao,Gang He,Junhong Zhou,Zhengbao Zha
To surmount the challenges of limited drug penetration and therapeutic resistance in solid tumors, stimuli-responsive nanocarrier-based drug delivery systems (DDSs) with relatively small sizes are inherently favorable for combined treatment of cancerous cells. In this work, poly(acrylic acid) (PAA) functionalized Co0.85Se nanoparticles (PAA-Co0.85Se NPs) were synthesized through an ambient aqueous precipitating approach for synergistic photothermal-chemo treatment of cancer. The obtained PAA-Co0.85Se NPs possess ultrasmall size (8.2 ± 2.6 nm), considerable near-infrared (NIR) light absorption, high photothermal transforming efficiency (45.2%) and low cytotoxicity, all of which are beneficial for localized photothermal ablation of cancer cells. Doxorubicin hydrochloride (DOX·HCl) was then successfully loaded on PAA-Co0.85Se NPs with a loading capacity up to 8.3% to form PAA-Co0.85Se-DOX composites, which exhibited an exciting acidic pH-responsive drug release property due to the protonation of amino groups in DOX and carboxyl groups in PAA molecules. As expected, when HeLa cells were treated with PAA-Co0.85Se-DOX NPs as well as NIR laser irradiation, a significant synergistic cell-killing effect was observed, greatly improving the treatment efficiency. Thus, this work presents novel insight into the design of ultrasmall stimuli-responsive nanocarrier-based DDSs for synergistic photothermal-chemo treatment of cancer cells.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Dai Ali,Zheng Zhiguo,Wu Ronghao,Ma Dengke,Xu Junyan,Mo You,Duan Liusheng,Tan Weiming
Strigolactone (SL) signaling is an important agricultural target for controlling plant branching and parasitic weeds. Here, based on the SL inhibitor KK094, we describe the design of 32 indole derivatives, of which DK6 exhibits optimal activity. To enhance solubility and bioavailability, we describe a pH-responsive manganese-coordinated carboxymethyl chitosan hydrogel (CMCS-DK6), showing sustained release under alkaline conditions. We demonstrate CMCS-DK6 strongly inhibits germination of parasitic weeds, especially Striga asiatica (IC 50 = 1.80 μM), while promoting rice tillering, reducing height, and increasing dry weight. Molecular simulations, along with microscale thermophoresis results, suggest that DK6 binds stably to SL receptors. Transcriptomics reveal DK6 suppresses SL signaling, modulates metabolic pathways, and interacts with hormone pathways to regulate tillering. This work offers a hydrogel delivery strategy and some potential mechanistic implications for improving crop architecture and weed control.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2026
·
IF 1.7
Liu Jiahong,Shi Shuying,Zhong Haoxuan,Liu Dan,Liang Yueyue,Yang Ailin,Yang Heng,Wen Junjie,Yu Ting,Deng Hao
Efficient separation of Sr 2+ and Y 3+ is crucial for 90 Sr/ 90 Y radionuclide generators. Here, three-dimensional tetragonal zirconium phosphate (τ-ZrP) was synthesized as an inorganic ion exchanger. The material exhibits exceptional Y 3+ selectivity under acidic conditions. Kinetic studies showed rapid Y 3+ uptake, reaching equilibrium within 1 h. The adsorption process followed the pseudo-second-order model. At pH 1, the maximum Y 3+ removal reached 99.4%, with a K d of 1.76 × 10 5 mL g −1 . In contrast, Sr 2+ adsorption was completely suppressed. High Y 3+ uptake persisted even at an extreme Sr 2+ /Y 3+ molar ratio of 5000:1. Furthermore, τ-ZrP retained over 90% removal and recovery after five cycles in strong acid. Spectroscopic analyses confirmed that Y 3+ coordinates with phosphate groups via proton exchange. DFT calculations revealed that the Y 3+ adsorption energy is 1.82 eV lower than that of Sr 2+ . This energy difference markedly exceeds those of α-ZrP (0.68 eV) and γ-ZrP (1.31 eV). Overall, τ-ZrP represents a promising candidate for high-purity 90 Y production.
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高影响因子
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