JOURNAL OF MATERIALS SCIENCE
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2024
·Vol. 59
·期 18
·7779-7792
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IF 3.5
Zhan Qingyan,Yang Po
Frontal ring-opening metathesis polymerization (FROMP) of dicyclopentadiene (DCPD) shows promise for manufacturing thermosets and composites. To widen the applications, this work develops a novel approach for the upgrading of polydicyclopentadiene (PDCPD) and fiber-reinforced composites via sequential FROMP and radical reactions to achieve high performance. Herein, we mixed DCPD, Grubbs catalyst and radical initiators in one pot, and initiated FROMP, a self-perpetuating reaction, to obtain FROMP-prepared PDCPD. Then, the further radical reactions were carried out at elevated temperature. With our strategy, the performances of PDCPD and its composites were dramatically upgraded. For instance, the T g of PDCPD could be significantly improved from ~171 °C to ~240 °C. The T g , flexural strength and modulus of FROMP fabricated composite were successively increased from 141 °C, 135.3 MPa and 36.9 GPa to 262 °C, 467.1 MPa and 43.2 GPa, respectively. We believe that this novel strategy will greatly improve the performance of PDCPD and composites, and open new avenues to apply FROMP to wider applications. Graphical Abstract
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ONCOGENE
·
2024
·
IF 6.9
Meng Hui,Li Ling,Nan Manman,Ding Yi,Li Yizhen,Zhang Mingzhi
Dendritic cells (DCs) are critical mediators of antigen priming and T-cell activation. Zymogen granule protein 16 (ZG16) is demonstrated as an anti-oncogene in T-cell mediated antitumor immunity, but its effect on DCs is largely unknown. Herein, we wonder whether ZG16 affects the activation of DCs in pancreatic cancer. Firstly, the increased ZG16 expression was observed during the maturation of DCs derived from mouse bone marrow or human peripheral blood. Then, overexpression of ZG16 or exogenous introduction of recombinant ZG16 protein induced the expression of MHC II, CD86, CD84, and CCR7 on the surface of DCs, thereby facilitating the secretion of proinflammatory mediators IL-1β, IL-6, TNF-α, and IL-12/p70, supporting the promoting effect of ZG16 on DC maturation. By establishing the subcutaneous and orthotopic mouse models of pancreatic cancer, we confirmed that intraperitoneal injection of recombinant ZG16 protein (Re-mZG16) could induce tumor regression by stimulating DC maturation and enhancing antitumor responses of CD4 + , CD8 + , PD-1 + , and Ctla4+ cells. Besides, Re-mZG16 in combination with gemcitabine showed a synergistic effect in the treatment of pancreatic cancer. Mechanistically, we demonstrated that ZG16 inhibited the ubiquitination and degradation of CD40, which depended on the lectin domain of ZG16. In conclusion, this study provided a novel insight into the role of ZG16-CD40 axis in DC-based immunotherapy for pancreatic cancer.
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Natural Products and Bioprospecting
·
2024
·Vol. 14
·期 1
·1-17
·
IF 4.8
Yang Suqin,Huang Jingtao,Tan Wenjing,Xia Xiankun,Gan Dali,Ren Yalei,Su Hanwen,Xiang Meixian
Xiaoyankangjun tablet (XYKJP) is a traditional Chinese medicine formulation used to treat intestinal disorders in clinical practice. However, the specific therapeutic mechanism of action of XYKJP in colitis has not yet been elucidated. This study aimed to reveal the multifaceted mechanisms of action of XYKJP in treating colitis. The model established based on DSS-induced colitis in C57BL/6 mice was employed to estimate the effect of XYKJP on colitis, which was then followed by histological assessment, 16S rRNA sequencing, RT-qPCR, ELISA, and Western blot. XYKJP alleviated the symptoms of DSS-induced colitis mainly by reducing oxidative stress, inflammatory responses, and intestinal mucosal repair in colitis tissues. In addition, XYKJP regulated the intestinal flora by increasing the relative abundance of Akkermansia and Bifidobacterium and reducing the relative abundance of Coriobacteriaceae_UCG-002 . Mechanistically, XYKJP increased the content of short-chain fatty acids (SCFAs) in the feces, particularly propanoic acid and butyric acid, activated their specific receptor GPR43/41, furthermore activated the Nrf2/HO-1 pathway, and suppressed the JAK2/STAT3 pathway. XYKJP significantly alleviated the symptoms of experimental colitis and functioned synergistically by regulating the intestinal flora, increasing the production of SCFAs, and activating their specific receptors, thereby repressing oxidative stress and inflammation. Graphical Abstract
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 1
·1-13
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IF 21.8
Tang Yubo,Huang Sheng,Chen Wei-chih,A Garu,Linghu Xitao,Wa Qingde,Huang Shuai,Chen Jian
Zn-Mn alloys are particularly promising biodegradable implant materials, but they are plagued by poor mechanical performance. In this work, a Zn-Mn alloy with ultrahigh strength and excellent ductility was achieved through addition of trace Mg (0.1 wt%) and equal channel angular pressing (ECAP). Specifically, the ECAP processed Zn-0.5Mn-0.1 Mg alloy exhibits an ultimate tensile strength (UTS) of 428 MPa, which is highest ever achieved in Zn-Mn-based alloys, along with a good elongation (EL) of 39%. In addition, the alloy exhibits excellent antibacterial performance against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ). Trace Mg addition results in the formation of Mg 2 Zn 11 and MgZn 2 nano-precipitates in the alloy, which effectively pins grain growth during dynamic recrystallization (DRX) and postpones the inverse Hall–Petch relation. Consequently, the alloy possesses quite fine grains of an average grain size (AGS) of 0.71 μm, much smaller than that of its counterpart without Mg (AGS = 2.54 μm). The ultrahigh strength of the alloy is mainly ascribed to grain boundary strengthening and precipitation strengthening. The remarkable ductility of the alloy is related to deformation twinning suppression, pyramidal < c + a > slip activation, and low dislocation density.
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Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-15
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IF 36.3
Zheng Haiying,Liu Guozhen,Dong Xinhe,Chen Feifan,Wang Chao,Yu Hongbo,Zhang Zhihua,Pan Xu
Interface modification has been demonstrated as an effective means to enhance the performance of perovskite solar cells. However, the effect depends on the anchoring mode and strength of the interfacial molecules, which determines whether long-term robust interface for carrier viaduct can be achieved under operational light illumination. Herein, we select squaric acid (SA) as the interfacial molecule between the perovskite and SnO 2 layer and propose a self-regulated bilateral anchoring strategy. The unique four-membered ring conjugated structure and dicarboxylic acid groups facilitate stable hydrogen bonds and coordination bonds at both SnO 2 /SA and SA/PbI 2 interfaces. The self-transforming property of SA enables the dynamic bilateral anchoring at the buried interface, ultimately releasing residual stress and constructing a stable interfacial molecular bridge. The results show that SA molecular bridge not only can effectively inhibit the generation of diverse charged defects but also serves as an effective electron transport pathway, resulting in improved power conversion efficiency (PCE) from 23.19 to 25.50% and excellent stability at the maximum power point. Additionally, the PCEs of the flexible and large-area (1 cm 2 ) devices were increased to 24.92% and 24.01%, respectively, demonstrating the universal applicability of the bilateral anchoring to PSCs based on different substrates and larger area.
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Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-11
·
IF 36.3
Liu Jianbo,Zhang Meng,Sun Xiaoran,Xiang Linhu,Yang Xiangyu,Hu Xin,Wang Zhicheng,Hou Tian,Qin Jinzhao,Huang Yuelong,Abdi-Jalebi Mojtaba,Hao Xiaojing
RbI is the most effective in mitigate PbI 2 precipitation caused by Pb(SCN) 2 while maintaining large grains.
Rb is kept at the grain boundaries during crystallization and Ostwald ripening, contributes to a slow growth of the grains.
Wide-bandgap perovskite solar cells with blade-coated perovskite in air achieved a certified power conversion efficiency of 23%, among the highest values reported.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-15
·
IF 14.7
Jiang Peng,Zhang Ludan,Liu Xiaolong,Ye Chenliang,Zhu Peng,Tan Ting,Wang Dingsheng,Wang Yuguang
The reaction system of hydrogen peroxide (H 2 O 2 ) catalyzed by nanozyme has a broad prospect in antibacterial treatment. However, the complex catalytic activities of nanozymes lead to multiple pathways reacting in parallel, causing uncertain antibacterial results. New approach to effectively regulate the multiple catalytic activities of nanozyme is in urgent need. Herein, Cu single site is modified on nanoceria with various catalytic activities, such as peroxidase-like activity (POD) and hydroxyl radical antioxidant capacity (HORAC). Benefiting from the interaction between coordinated Cu and CeO 2 substrate, POD is enhanced while HORAC is inhibited, which is further confirmed by density functional theory (DFT) calculations. Cu-CeO 2 + H 2 O 2 system shows good antibacterial properties both in vitro and in vivo. In this work, the strategy based on the interaction between coordinated metal and carrier provides a general clue for optimizing the complex activities of nanozymes.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-18
·
IF 10.6
Zhou Zhixin,Zhou Cheng,Liu Jia,Yuan Ye,Yao Chundong,Liu Miaodeng,Deng Lixue,Sun Jia,Chen Zuoyu,Wang Lin,Wang Zheng
Background Traditional chemotherapeutic agents suffer from a lack of selectivity, poor targeting ability, and drug resistance. Developing tumor-specific therapies is crucial for precisely eliminating tumors while circumventing toxicity to normal tissues. Disulfiram (DSF), an FDA-approved drug for treating alcohol dependence, exhibits antitumor effect by forming complexes with copper ions (Cu(DDC) 2 ). Here, we developed a Cu-doped polydopamine-based nanosystem (DSF@CuPDA-PEGM) to achieve in situ generation of toxic Cu(DDC) 2 . Results In cancer cells with elevated H 2 O 2 contents, CuPDA responsively degrades to release Cu ions and DSF, allowing on-site synthesis of Cu(DDC) 2 with potent antitumor activity. DSF@CuPDA-PEGM exhibits excellent therapeutic efficacy against both drug-sensitive and drug-resistant cancer cells while minimizing toxicity to noncancerous cells. Moreover, DSF@CuPDA-PEGM promotes the immune response by inducing cancer cell immunogenic death, thereby augmenting anti-PD-1-based immune checkpoint blockade therapy. Conclusion A tumor-specifically degradable Cu-doped polydopamine-based nanosystem is developed to achieve in situ synthesis of antitumor compounds, providing a promising approach to precisely eliminate tumors and heighten chemo-immunotherapy. Graphical Abstract
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Communications Biology
·
2024
·Vol. 7
·期 1
·1-16
·
IF 5.2
Ren Huihong,Zhang Yujuan,Huang Wei,Xu Haiyan,He Weixiong,Hao Nan,Zhang Cong
Photothermal therapy (PTT) is a cancer-targeted treatment approach.The occurrence of tumors may be related to microbial infections (Viruses, bacteria, fungi, etc.), which probably provokes anti-tumor immunity. However, T cells in the context of cancer become exhausted and dysfunctional. Galectin-9 (Gal-9) is highly expressed in normal tissues and associates with body immune tolerance, and was firstly evidenced with much higher expression on the primary solid tumors than CD80/86 (B7) and CD274 (PD-L1) here, which suggests that Gal-9 may be a key factor in inhibiting the anti-tumor immunity, and its receptor T cell immunoglobulin and mucin domain 3 (TIM-3) was discovered on the cytotoxic T lymphocytes (CTL) with high expression as well based on the single cell analysis. The immune checkpoint communications showed that the Gal-9/TIM-3 axis played the most vital role on negatively regulating the anti-tumor immunity of CTL for melanoma. Then, we used a novel transdermal photothermal nanosensitizer (FSGG) loading Gal-9 siRNA (FSGG/siGal-9) for knocking the tumor cells down Gal-9 to block the Gal-9/TIM-3 axis and prohibit CTL exhaustion synergizing PTT against melanoma, which evidenced good effects on inhibiting tumor growth and enhancing anti-tumor immunity, named “photothermal immunotherapy”. This paper provides a new perspective for tumor prevention and treatment.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Yuan Ziliang,Han Bo,Liu Bing,Sun Jie,Zhou Peng,Mu Rentao,Zhang Zehui
Reductive-coupling of nitro compounds and alcohols is a sustainable route for constructing C = N bonds in organonitrogen chemicals, yet challenging due to the inertness of α-C sp3 -H bond in alcohols and the vulnerability of C = N bonds towards hydrogenation. Here, we report the surprising catalytic activity of ultrafine alkaline-earth metal oxide MgO nanoclusters (0.9 ± 0.3 nm) that efficiently activate α-C sp3 -H bonds, facilitating the transfer hydrogenation and synthesis of value-added chemicals bearing C = N bonds with high to excellent yields (86–99%). Controlled experiments and characterizations showed the crucial role of oxygen vacancies (O v ) and local Mg environment (Mg-O bond) in MgO for substrate adsorption and activation via electronic interactions between substrate’s negatively charged oxygen atoms and O v sites in MgO nanoclusters. Theoretical calculation further confirmed that O v significantly lowered the energy barrier of the hydrogen atom transfer from α-C sp3 -H in ethanol to the nitro group in nitrobenzene (29.3 vs . 52.9 kcal/mol), which is the rate-determining step with the highest energy barrier in reductive-coupling reactions. Our method not only provides an efficient and sustainable pathway for synthesizing organonitrogen chemicals with C = N bonds but also inspires the exploration of main group element catalysts as alternatives to transition metal and noble metal catalysts for organic transformations.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Wang Zhitong,Liu Dongyu,Xia Chenfeng,Shi Xiaodong,Zhou Yansong,Liu Qiuwen,Huang Jiangtao,Wu Haiyan,Zhu Deyu,Zhang Shuyu,Li Jing,Deng Peilin,Vasenko Andrey S.,Xia Bao Yu,Tian Xinlong
Acidic electrochemical CO 2 conversion is a promising alternative to overcome the low CO 2 utilization. However, over-reliance on highly concentrated K + to inhibit the hydrogen evolution reaction also causes (bi)carbonate precipitation to interfere with catalytic performance. In this work, under the screening and guidance of computational simulations, we present a carbon coated tip-like In 2 O 3 electrocatalyst for stable and efficient acidic CO 2 conversion to synthesize formic acid (HCOOH) with low K + concentration. The carbon layer protects the oxidized In species with higher intrinsic activity from reductive corrosion, and also peripherally formulates a tip-induced electric field to regulate the adverse H + attraction and desirable K + enrichment. In an acidic electrolyte at pH 0.94, only 0.1 M low K + is required to achieve a Faradaic efficiency (FE) of 98.9% at 300 mA cm −2 for HCOOH and a long-time stability of over100 h. By up-scaling the electrode into a 25 cm 2 electrolyzer setup, a total current of 7 A is recorded to sustain a durable HCOOH production of 291.6 mmol L −1 h −1 .
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 4.1
Wu Shan-Song,Lu Hui-Juan,Li Yi-Dong,Zhang Shui-Dong,Zeng Jian-Bing
Poly(butylene succinate) (PBS) exhibits many advantages, such as renewability, biodegradability, and impressive thermal and mechanical properties, but is limited by the low melt viscosity and strength resulted from the linear structure. To address this, vitrimeric network was introduced to synthesize PBS vitrimers (PBSVs) based on dynamic imine bonds through melt polymerization of hydroxyl-terminated PBS with vanillin derived imine containing compound and hexamethylene diisocyanate using trimethylolpropane as a crosslinking monomer. PBSVs with different crosslinking degrees were synthesized through changing the content of the crosslinking monomer. The effect of crosslinking degree on the thermal, theological, mechanical properties, and stress relaxation behavior of the PBSVs was studied in detail. The results demonstrated that the melt viscosity, melt strength, and heat resistance were enhanced substantially without obvious depression in crystallizability, thermal stability, and mechanical properties through increasing crosslinking degree. In addition, the PBSVs exhibit thermal reprocessability with mechanical properties recovered by more than 90% even after processing for three times. Furthermore, PBSV with improved melt properties shows significantly improved foamability compared to commercial PBS. This research contributes to the advancement of polymer technology by successfully developing PBS vitrimers with improved properties, showcasing their potential applications in sustainable and biodegradable materials.
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