FOOD CHEMISTRY
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2025
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IF 9.8
Guangzhi Wang,Yuchen Guo,Yang Yu,Yan Shi,Yuxiang Ying,Hong Men
Pork freshness is crucial for flavour, nutrition and consumer health. The current colorimetric sensor array (CSA) detection systems face challenges related to high sensor development costs, low recognition accuracy and limitations in the platform use. Herein, we developed a CSA and ColorNet framework to detect pork freshness. The 53-point CSA was designed by selecting sensitised pH indicators and aldehyde/ketone indicators. To optimize the sensor, the Euclidean distance method was used to identify 24 array points with dyes that exhibited more sensitive responses. The ColorNet captured the color information of pork freshness, allowing real-time detection with a 99.5 % accuracy. For practical deployment and mobile applications, a refined 12-point CSA was developed using gradient activation mapping, maintaining a 99 % recognition rate, which is comparable with the 24-point CSA. The proposed CSA and model ensure consumer health and safety, providing strong technical support for quality monitoring and control in the pork industry.
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RENEWABLE ENERGY
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2024
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IF 9
Cuicui Wu,Meng Wang,Yunming Fang
The productive motivation of high-energy-density fuels from sustainable feedstocks has been prompted by environmental concerns and resource scarcities. To address this demand, here, the energy-rich C10 cycloalkanes were first afforded with biomass-derived 2-cyclopentenone (2CPE). Initially, bio-based 2CPE can be converted to tricyclo-diketones by (2 + 2) cycloaddition under UV irradiation or zeolite catalysis. The UV-light photocatalysis for dimerization of 2CPE to diketol-cycloadducts disclosed outstanding advantages of cost-effectiveness and feasibility than traditional zeolite-catalyzed manner, with a yield of 53.61 % at ambient temperature for 2 h. Despite the potential for high dimer yield (77.28 %) under thermo-catalysis of H-ZSM-5 zeolite, the reaction conditions (120 °C, 18 h) were found to be suboptimal. Subsequently, diketol-cycloadducts were selectively and efficiently hydrodeoxygenated to provide cyclopentane-based hydrocarbons using a Huang-Minlon methodology with a yield of 97.04 %, where the target components were directly distilled during the reaction. Specifically, the as-synthesized C10 cycloalkane mixture originated from 2CPE possess high density of 0.96 g mL −1 , large volumetric heat net of combustion (NHOC) of 40.02 MJ L −1 , along with low freezing point of −49 °C. These properties suggest that the bio-liquid cycloalkanes can be used as a standalone high-energy fuel or as a blending agent to enhance the performance of conventional jet fuels.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-13
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IF 14.7
Li Yongqiang,Yang Siwei,Bao Wancheng,Tao Quan,Jiang Xiuyun,Li Jipeng,He Peng,Wang Gang,Qi Kai,Dong Hui,Ding Guqiao,Xie Xiaoming
Investigating proton transport at the interface in an excited state facilitates the mechanistic investigation and utilization of nanomaterials. However, there is a lack of suitable tools for in-situ and interfacial analysis. Here we addresses this gap by in-situ observing the proton transport of graphene quantum dots (GQDs) in an excited state through reduction of magnetic resonance relaxation time. Experimental results, utilizing 0.1 mT ultra-low-field nuclear magnetic resonance relaxometry compatible with a light source, reveal the light-induced proton dissociation and acidity of GQDs’ microenvironment in the excited state (Hammett acidity function: –13.40). Theoretical calculations demonstrate significant acidity enhancement in –OH functionalized GQDs with light induction ( \({{\mathrm{p}}}{K}_{{\text{a}}}^{*}\) = –4.62, stronger than that of H 2 SO 4 ). Simulations highlight the contributions of edge and phenolic –OH groups to proton dissociation. The light-induced superacidic microenvironment of GQDs benefits functionalization and improves the catalytic performances of GQDs. Importantly, this work advances the understanding of interfacial properties of light-induced sp 2 – sp 3 carbon nanostructure and provides a valuable tool for exploring catalyst interfaces in photocatalysis.
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Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 28
·10635-10645
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IF 5.7
Jie Liang,Huinan Zhang,Qingchao Zhang,Yanli Liu,Bo Li,Junbin Zang,Xiyuan Cao,Zhidong Zhang,Libo Gao,Chenyang Xue
Electronic skin (e-skin) aims to mimic human skin functions, which could profoundly affect medical care and robots. However, it still faces challenges in simultaneously detecting and distinguishing pressure and temperature signals in real-time. Herein, a simple and sustainable strategy is proposed to fabricate a reduced graphene oxide (rGO)-coated wood sponge (rGO@WS) for a multifunctional sensor with high pressure and temperature properties. The prepared porous wood sponge presents high elasticity and superior durability. The added rGO endows the sponge with high conductivity and excellent fatigue resistance. The proposed sensor can realize high sensitivity (1.18 kPa−1), a large pressure range (0.2–100 kPa), a low detection limit and can also detect the temperature with a minimal detection limit of 0.6 K and a response time of 0.8 s. Due to the different response principles of piezoresistive and thermoelectric effects, pressure sensing performance and temperature sensing performance are independent. Meanwhile, a 4 × 4 pixel sensing array based on the rGO@WS sensor is fabricated to serve as e-skin to detect and distinguish pressure and temperature signals. This work sheds new light on the development of wearable devices and e-skin for health care.
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Bo Xu,Guoxiang Pan,Xinyu Fan,Haijie Zhou,Chengcong Qiu,Yuhua Guo,Minhong Xu,Jingwei Sun,Xinhui Xia
Conventional jungle-camouflage materials exhibit four prominent vibration peaks (green peak, red-edge, plateau, and water absorption peaks) on the green-vegetation spectrum. However, they cannot accurately simulate the water peaks of green vegetation, and this limits their application efficiency and considerably hinders their further development. Here, an environment-friendly camouflage coating comprising MgAlFe-LDHs-CA, ZnAl-LDH-AG, and BiVO 4 is proposed to facilitate the precise simulation of NIR spectrum of green-vegetation. Next, the developed material is characterized by XRD, FT-IR, TG-DTA, SEM and XPS techniques. The characterization results reveal that the newly developed jungle-camouflage-coating material achieves a 97.56 % simulation of green vegetation. Additionally, the similarity analysis results of the prepared camouflage coating confirm that it simulated all the spectral characteristics of green vegetation. Thus, we propose a new environment-friendly hydrotalcites camouflage material, thereby offering a new research direction in the development of camouflage materials.
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SENSORS AND ACTUATORS B-CHEMICAL
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2024
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IF 8
Yu Lan,Haixia Zhang,Ruichen Xie,Kecheng Li,Feiran Xie,Peihong Xiao,Li Jiang
Glaucoma is a leading cause of irreversible blindness worldwide and characterized by progressive loss of retinal ganglion cells (RGCs). As glaucoma progresses asymptomatically and the lack of specific biomarkers or noninvasive imaging tools during the early stage, it is often discovered at a relatively late stage without cure. Development of an effective tool for early diagnosis remains a necessity. As well known, endoplasmic reticulum (ER) stress and subsequent accumulation of reactive oxygen species (ROS) play a vital role in the development of glaucoma, with peroxynitrite (ONOO − ) as one of the most abundant cytotoxic ROS. In this work, we constructed a novel near-infrared (NIR) fluorescent nanoprobe named ER-ONOO-NPs. It specifically and sensitively targets ER-associated ONOO − with low biotoxicity in cultured RGCs. Systematically applied to the NMDA-induced mouse model of glaucoma, ER-ONOO-NPs performs well for real-time dynamic monitoring of ONOO − fluctuations at the Ganglion cell layer of mice prior to RGCs apoptosis. Thus, our results suggest that the ER-targeted NIR fluorescent nanoprobe could be a noninvasive imaging tool for early diagnosis of glaucoma in high-risk population.
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Applied Materials Today
·
2024
·
IF 7.2
Xi Wang,Yu Wang,Qihang Zhao,Zhenchu Feng,Qingyi Liu,Gang Wang,Jiakui Zheng,Lin Tao,Jianguo Zhang,Xi Chen
Photothermal immunotherapy, especially combined with immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1), marks a breakthrough in cancer treatment. However, therapy often triggers compensatory upregulation of other immune checkpoints. This study introduces an advanced strategy to enhance the efficacy of photothermal immunotherapy by utilizing a novel nanocarrier that targets both PD-1 and T-cell immunoreceptor with Ig and ITIM domains (TIGIT) immune checkpoints. The dual blockade could counteract the compensatory upregulation of immune checkpoints triggered by PD-1 targeted therapies alone. The nanocarrier of this work is composed of a ZrB 2 photothermal core and a mesoporous silica layer, and finally coated with biocompatible polydopamine. This design could effectively deliver both TIGIT and PD-1 inhibitors directly to tumor sites, minimizing systemic side effects such as cytokine release syndrome. We demonstrate that this approach not only enhances cytotoxic responses of T and NK cells, but also promotes macrophage polarization towards a tumor-suppressing M1 phenotype dendritic cell maturation and immunogenic cell death. Our findings provide a promising avenue for cancer immunotherapy.
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JOURNAL OF MATERIALS SCIENCE
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2024
·
IF 3.5
Li Congcong,Xu Lulu,Pan Xueer,Chen Xinru,Li Xiaobing,Wu Mian
Intelligent materials demonstrate promising applications in switchable oil/water separations. A stearic acid (SA) hydrophobically modified SiO 2 coating (SA/SiO 2 ) with switchable wettability was developed by simply spraying. The SA/SiO 2 coating with micro-nanostructure showed excellent superhydrophobicity with water contact angle (WCA) and oil contact angle (OCA) of 158.7° and 0°, respectively. When the SA/SiO 2 coating was contacted with ammonia, it showed excellent superhydrophilicity, with WCA and underwater oil contact angle of 0° and 155.4°, respectively. After heating treatment, the SA/SiO 2 coating returned to superhydrophobicity. Through wettability switching, the prepared SA/SiO 2 coating could be applied for on-demand separation of oil/water/oil ternary mixtures as well as various water-in-oil emulsions and oil-in-water emulsions, and the separation efficiency of oil-in-water emulsion could reach up to 99.97%, accompanied by a high flux at the same time. More importantly, the SA/SiO 2 coating exhibited significant robustness and excellent reusability, which maintained a superior separation efficiency of over 99.80% after 10 cycles emulsion separation, suggesting its promising potential for oily wastewater treatment. The simple and environmentally friendly coating preparation method as well as easy implementation of response conditions and short switching time provide a reference for the preparation of intelligent response oil/water separation materials. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Hewei Wei,Ting Zhao,Xinglong Liu,Qiteng Ding,Shuai Zhang,Jiali Yang,Ning Wang,Lifeng Zhang,Guodong Chai,Guofeng Xia,Anning Li,Chuanbo Ding,Wencong Liu
To solve the difficulty of natural healing in patients with severe bone defects, and the challenges of insufficient autologous bone graft material and large incisions in conventional surgery, we were designed an intelligent co-regulated hydrogel system with NIR response. The goal is to be able to prevent inflammation and bacterial adhesion, thereby promoting repair and development of the bone defect area. The hydrogel system consisted of hyaluronic acid, carboxymethyl chitosan and Pht-loaded PDA-encapsulated ZIF-8 NPs (Pht@ZIF-8@PDA) by Schiff base reaction. Compared to high-temperature photothermal therapy (PTT), which destroyed surrounding healthy cells, the present study was based on a new strategy of mild photothermal therapy (42.5 ± 1.2 °C) and leaded to a better promotion of osteogenesis. NIR activated the photothermal properties of PDA in scaffolds, intelligently released Pht and Zn 2+ , inhibited Escherichia coli and Staphylococcus aureus (inhibition rate ≥ 96 %), and promoted bone regeneration in the rat model. Meanwhile, it could promote bone regeneration by upregulating osteogenic factors and stimulating the expression of proteins related to BMP/SMAD signaling pathway. The research highlights the potential applications of synergistically modulated hydrogels, which opens up a new application path for this material in bone tissue engineering, regenerative medicine, and other related fields.
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Materials Today Energy
·
2024
·
IF 9
Yaqi Hong,Song Zhang,Hu Shen,Xingyuan Tian,Bin Zhang,Xin Zhou,Rong Liu,Ying Liu,Yicong Gao,Ruirui Cao,Huilin Li,Fumin Li,Zhitao Shen,Chong Chen
Perovskite solar cells (PSCs) have demonstrated extensive prospects for future applications. However, defects remain as the crucial factor that impedes their further advancement in performance, and passivation of the interfaces (such as the buried and/or top interfaces) is regarded as one of the most effective approaches. Herein, we aim to address another important interface, namely, the indium tin oxide/electron transport layer (ITO/ETL) interface in n-i-p structured devices. Since electron transport layers are typically fabricated using commercial nano tin dioxide, which often display insufficient density. To combat this, we employ the most commonly used bathocuproine (BCP) material to treat the ITO/ETL interface. The incorporation of BCP diminishes the direct contact between the perovskite and ITO layers, while also passivating buried interface and adjusting the crystal orientation of perovskites. Furthermore, the substrate layer exhibits improved transparency, consequently elevating the utilization rate of light by perovskite. As a result, the BCP-based PSC exhibits an impressive efficiency greater than 22%, surpassing the control one of 19.91%, and which simultaneously demonstrates excellent stability. Notably, the optimization of this interface has universal applicability in the improvement of PSCs performance.
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Food Science and Human Wellness
·
2024
·
IF 5.6
Ruijie Xu,Zhijie Yao,Hao Zhang,Haitao Li,Wei Chen
Loss of susceptibility to anoikis signals is a crucial step in metastasis. Anoikis resistance therefore represents a promising adjuvant therapeutic target for cancer management. In this study, we have conducted a rationalized screening to search for novel leading anoikis sensitizer from daily foods. Among 19 tested dietary phytochemicals, the best results were obtained with apigenin, a natural component of celery. Phenotypically, apigenin sensitized breast cancer cells to anoikis, lowered the number of circulating tumor cells, and protected against breast cancer metastasis to lung in mice. Mechanistically, we demonstrated that the thromboxane A 2 (TXA 2 )-TXA 2 receptor (TP) axis has a critical role in acquired anoikis resistance by activating PI3K-Akt signaling pathway. Blockage of TXA 2 signaling up-regulated p53 as well as its target gene p21, caused a G1 phase arrest, and finally led to apoptosis in breast cancer cells. TXA 2 level was positively correlated with breast cancer cell anoikis rate, and apigenin significantly inhibited TXA 2 biosynthesis in vitro and in vivo. Collectively, we identified apigenin as a potent anoikis sensitizer with anti-metastatic properties in a mouse model of breast cancer, and these findings might provide a rationale for introducing apigenin supplementation to breast cancer patients.
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BIOMACROMOLECULES
·
2024
·
IF 5.5
Yuheng Liu,Chuan Guo,Yu Wang,Qing-Quan Kong
Intervertebral disc degeneration is characterized by a localized, chronic inflammatory response leading to a synthesis/catabolism imbalance within the nucleus pulposus (NP) and progressive functional impairment within the NP. Polyphenol molecules have been widely used in anti-inflammatory therapies in recent years; therefore, we designed an injectable, temperature-sensitive hydrogel PLGA-PEG-PLGA-based drug delivery system for local and sustained delivery of two drugs tannic acid (TA) and resveratrol (Res), with the hydrogel carrying TA directly and Res indirectly (carried directly by inflammation-responsive nanoparticles). The delivery system presents good injectability at room temperature and forms a gel in situ upon entering the intervertebral disc. The delivery system can rapidly release TA and sustain Res release. In vitro and in vivo experiments have shown that this hydrogel drug delivery system is effective in anti-inflammation of degenerated intervertebral discs and promotes the regeneration of extracellular matrix in the NP.
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