ANALYST
·
2011
·Vol. 136
·期 13
·2825-2830
·
IF 3.913
Fuqiang Zhang,Leyong Zeng,Cui Yang,Junwei Xin,Haiyan Wang,Aiguo Wu
A new approach for the detection of Hg2+ is reported based on color changes from which gold nanoparticles (Au NPs) are surrounded by a layer of HgS quantum dots to form in situ Au@HgS core–shell nanostructures. The surface plasmon resonance (SPR) absorption of the gold core was changed due to a shell layer of HgS formed on the surface of the Au NPs, which brings the colour change of the aqueous solution. Therefore, Hg2+ can be recognized by visualizing the colour change of the Au@HgS core–shell nanostructures, and can be detected quantitatively by measurement of the UV-vis spectra. Some effects on the detection of Hg2+ were investigated in detail. This method was used to detect Hg2+ with excellent selectivity and high sensitivity. In our method, the lowest detected concentrations for mercury ions were 5.0 × 10−6 M observed by the naked eye and 0.486 nM as measured by UV-vis spectra. At the range from 8.0 × 10−5 to 1.0 × 10−8 M of Hg2+, this method was shown to have a good linear relationship.
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ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Yanan Deng,Zihao Zhang,Yuanhao Pang,Xueying Zhou,Yu Wang,Yun Zhang,Yali Yuan
The poly-L-cysteine modified Au nanoparticles (Au@p-L-Cys) were constructed on electrode surface as a highly efficient chiral interface for tryptophan (Trp) enantiomers recognition via one step electropolymerization. With the aid of Cu 2+ , L-Cys residues and D-Trp target formed a sandwich complex D-Trp-Cu 2+ -L-Cys, while L-Trp was unable to form such complex due to the steric hindrance provided by the chiral interface, which was confirmed by the electrochemical and SEM results. With the introduction of ferricyanide probe, D-Trp produced significant current decrease while L-Trp produced a slight current increase, which implied the successful enantioselective recognition of Trp enantiomers (specifically D-Trp) in the true sense. This novel sensor showed a surprisingly wide linear range toward D-Trp of 6 × 10 −7 M to 1 × 10 −2 M, with a detection limit as low as 75 nM (S/N = 3). Moreover, the exclusive enantioselectivity toward D-Trp was discovered since other amino acids showed negligible interference to detection of D-Trp. The recovery of D-Trp in human serum was between 91.30 and 109.3%, which further verified the satisfying specificity and practicality of the proposed strategy. The coordination thermodynamics by UV–Vis spectroscopy and DFT simulation were also used to investigate the enantioselective mechanism. These results highlight the great potential of using Au@p-L-Cys to construct chiral interface for enantiomers recognition and hold the promise of practical application of electrochemical chiral sensors in fields like pharmaceutics and bioanalysis .
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NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 31
·13344-13349
·
IF 3.288
Jingtian Chi,Manli Guo,Chi Zhang,Yuanhong Zhang,Shiyun Ai,Juying Hou,Peng Wu,Xiangyang Li
In this work, glucose oxidase and Au nanoclusters co-encapsulated in zeolitic imidazolate frameworks (GOx & AuNCs@ZIF-8) were obtained by simply mixing Zn2+, dimethylimidazole, glucose oxidase (GOx) and Au nanoclusters (AuNCs) at room temperature. The GOx & AuNCs@ZIF-8 composite can be used as a sensitive colorimetric sensor for glucose based on the following cascade reaction: GOx converts glucose to gluconic acid and generates H2O2, which acts as a substrate for AuNCs oxidizing 3,3′,5,5′-tetramethylbenzidine (TMB) to form oxidized TMB (oxTMB) detectable at 652 nm. Owing to the effective cascade reaction and protective effect of the ZIF-8 shell on enzymes, the catalytic activity of GOx & AuNCs@ZIF-8 was enhanced 19.3-fold compared with the free GOx/AuNC solution, and the glucose sensor showed high selectivity and sensitivity. Furthermore, the GOx & AuNCs@ZIF-8 composite showed high long-term storage stability and stability against digesting enzymes and chelating compounds due to the shielding effect of the ZIF-8 scaffold.
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Journal of Physical Chemistry C
·
2012
·
IF 4.805
Yajuan Hao,Yanzhu Chong,Shuru Li,Hengquan Yang
Au nanoparticles with different sizes were introduced into the nanocages of a mesoporous material SBA-16 with the aid of chemical modification, leading to new Au-supported catalysts Au/SBA-16. These catalysts were characterized with Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), transmission electron microspectroscopy (TEM), N2 sorption, and X-ray photoelectron microspectroscopy (XPS). These results revealed that uniform Au nanoparticles with sizes of a few nanometers were successfully positioned inside the nanocages of SBA-16. Such catalysts were catalytically active in the oxidative esterification of various alcohols even including less reactive straight-chain alcohols. It was found that the activity of this catalyst strongly depended on the Au loading, and the Au loading of 5 wt % (corresponding to Au particles of 2–3 nm in sizes) led to the highest activity. Its activity was much higher than those of the analogous catalysts prepared from commercial silica gel as well as SBA-15. Furthermore, Au/SBA-16 could be reused at least eight reaction cycles without significant decrease in activity and selectivity. Its recyclability was much superior to that of the catalyst derived from commercial silica gel. The underlying reason may be that the unique nanostructure of SBA-16 can effectively prevent the growth of Au nanoparticles into less active, larger particles, as evidenced from TEM investigations. This study not only supplies a new, active, recoverable catalyst for the green transformations of alcohols to esters but also demonstrates that the three-dimensional mesoporous cage-like material SBA-16 has a superior ability in reducing the diffusion resistance and stabilizing metal nanoparticles against growth.
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Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 32
·19173-19186
·
IF 10.733
Xiaoming Liu,Xueya Chen,Yizu Li,Bingquan Wu,Xubiao Luo,Sheng Ouyang,Shenglian Luo,Abdulaziz A. Al Kheraif,Jun Lin
Here, we demonstrate a g-C3N4@Au@SrAl2O4:Eu2+,Dy3+ composite as a novel efficient self-luminous visible-light plasmonic photocatalyst for photocatalytic degradation of organic pollutants and hydrogen evolution from water around the clock. The g-C3N4@Au@SrAl2O4:Eu2+,Dy3+ composite was prepared by integrating a g-C3N4@Au plasmonic photocatalyst composite with a SrAl2O4:Eu2+,Dy3+ long-afterglow phosphor through a simple Pechini-type sol–gel method followed by a mechanical mixing and high-temperature calcination process. Owing to the synergistic effect of surface plasmon resonance of the Au nanoparticles in g-C3N4 and long-lasting phosphorescence of the SrAl2O4:Eu2+,Dy3+ phosphor, the prepared g-C3N4@Au@SrAl2O4:Eu2+,Dy3+ composite shows a continuous and efficient photocatalytic activity for photocatalytic degradation of organic pollutants and hydrogen evolution from water in a sunless environment. The current research study could provide a new strategy for designing a highly efficient composite photocatalyst for solar environmental purification and hydrogen energy production around the clock.
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American Journal of Translational Research
·
2018
·
IF 3.061
Zhenlong Liu,Xiaoqing Hu,Peng Yang,Jiying Zhang,Chunyan Zhou,Yingfang Ao
Using a rabbit model of early-stage osteoarthritis (OA) and a sampling patients with OA, we evaluated the diagnostic utility of a fluorogenic peptide-conjugated gold nanoparticle (AuNP) probe in detecting mild cartilage injury, based on the a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) enzyme. Synthesis of this fluorescent turn-on probe (or AU-probe) required conjugation of AuNPs with a fluorescein isothiocyanate (FITC)-modified ADAMTS-4-specific peptide (DVQEFRGVTAVIR). Synovial fluid samples were then collected from 48 adult rabbits and 100 patients for comparative testing (ADAMTS-4 ELISA and AU-probe). Rabbit and patient MRI images were also evaluated and scored. Receiver operating characteristic (ROC) curve analysis was applied to various diagnostic methods (MRI, ELISA, AU-probe, and arthroscopy), performing comparisons via logistic regression. In rabbits, the AU-probe proved nonsuperior to MRI T2 mapping and ELISA (fluorescence cutpoint > 864.965 au). In patient groups, logistic regression analysis indicated that combined AU-probe/MRI testing outperformed MRI alone, thus offsetting low MRI sensitivity and low AU-probe specificity for improved detection of mild cartilage injury (sensitivity, 82.5%; specificity, 80.0%). We have consequently confirmed the efficacy of this AU-probe, using ADAMTS-4 activity in synovial fluid to diagnose mild cartilage injury. Combining the AU-probe with conventional MRI assessment proved optimal in this setting.
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DOI
PubMed
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Analytical Methods
·
2018
·Vol. 10
·期 37
·4543-4548
·
IF 2.073
Xiaopeng Hu,Yingying Feng,Hao Wang,Faqiong Zhao,Baizhao Zeng
A novel electrochemical sensor was prepared for the detection of bisphenol A (BPA), and it was based on a molecularly imprinted polymer/carbon nanotubes-Au nanoparticles/boron-doped ordered mesoporous carbon composite. The composite showed a porous 3D structure and had a large surface area, good recognition capacity and high electrocatalysis to BPA; thus the sensor presented a sensitive and selective electrochemical response to it. Under optimal conditions, the sensor showed a large linear range of 0.01–10 μM and a low detection limit of 5 nM determined by using differential pulse voltammetry. It was applied to detect BPA in milk samples successfully.
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RSC Advances
·
2017
·Vol. 7
·期 43
·26559-26565
·
IF 3.108
Chenghua Zong,Min Wang,Bo Li,Xiaojun Liu,Wenfeng Zhao,Qingquan Zhang,Aiye Liang,Yang Yu
Fe2+ can act as a catalyst to disproportionate hydrogen peroxide (H2O2) to produce extremely reactive hydroxyl radicals (˙OH) through the so-called Fenton reaction. Combining this reaction with the prominent sensitive nature of gold nanoclusters (Au NCs), we present herein a simple strategy of sensitive and rapid detection of H2O2. Compared with H2O2, the produced hydroxyl radical exhibits a much stronger oxidizing ability, and therefore could lead to a more efficient oxidation of the Au NCs and an improved sensitivity and oxidation rate. The results indicate that the detection limit for the determination of H2O2 was 0.2 μM (signal/noise = 3) and the linear range was 0.4–12 μM. Furthermore, in combination with the specific catalytic effect of glucose oxidase, the present sensing strategy can be successfully expanded to detect glucose in blood. The preliminary results are in good agreement with those provided by the hospital, which suggests the generalizability and great potential of the Au NCs/Fenton hybrid system for research and clinical diagnosis of diabetes.
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Acta Biomaterialia
·
2018
·
IF 6.383
Yun Wang,Feihu Wang,Ying Liu,Shaohui Xu,Yuanyuan Shen,Nianping Feng,Shengrong Guo
Effects of nanosized drug delivery systems on cancer are often compromised due to their low drug loadings, premature drug release and multi-drug resistance (MDR). Herein, we reported a glutathione detonated and pH responsive nano-cluster of Au nanorods (AuNRs) with chemotherapeutic doxorubicin (DOX) and pre-chemosensitizer polycurcumin to treat MCF-7/ADR cells. The nano-cluster was prepared by self-assembling of AuNRs conjugated with DOX and amphiphilic poly(curcumin-co-dithiodipropionic acid)-b-biotinylated poly(ethylene glycol) via an emulsion/solvent evaporation technique, termed AuNR Cluster. The AuNR Cluster had a high drug loading (31.5% DOX), presenting much better aqueous solubility and stability at physiological pH than their individual AuNRs. The AuNR Cluster could be detonated to be their individual AuNRs at an intracellular concentration level of glutathione (GSH) (5 mM) and triggered to release DOX at an acidic pH (pH 6.8 or 5.0), which effectively facilitated cellular uptake of DOX (607 vs 356 a.u. for AuNRs at 12 h) and inhibited DOX efflux (471.33 vs 39.17 a.u. for free DOX at 24 h). The IC 50 value of DOX against MCF-7/ADR cells for AuNR Cluster was 4.15 µg/mL, much lower than that for free DOX (90.97 µg/mL). The AuNR Cluster took much more photothermal effects than their corresponding AuNRs and presented enhanced anti-tumor effect (IC 50 : 2.61 µg/mL) under 808 nm laser irradiation. Statement of Significance Nano-sized drug delivery systems for anti-MDR cancer is still a challenging task. Herein, AuNR Cluster was self-assembled by individual AuNRs via emulsion/solvent evaporation technique, having a structure consisting of hydrophobic DOX/PCDA-AuNR core and hydrophilic biotin-PEG chain shell. AuNR Cluster is detonated to disintegrate and yield its individual AuNRs at an intracellular concentration level of glutathione (5 mM) and triggered to release DOX at an acidic pH (6.8 or 5.0). In comparison with its individual AuNRs, AuNR Cluster has better water solubility and stability, greater photothermal effects under NIR irradiation, bigger cytotoxicity against MCF-7/ADR cells. AuNR Cluster is expected to be a potential nanomedicine for treatment of MDR cancer.
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MARINE POLLUTION BULLETIN
·
2025
·
IF 4.9
Tianshuo Lan,Yiping Du,Meichun Liu,Xinna Yu,Danyang Wang,Haotian Huang,Tianyuan Liu,Meizhen Huang
As a global environmental concern, real-time detection of marine nanoplastics (NPs) has gained increasing attention. However, current detection methods are still confronted with the challenge of detecting low concentration NPs in marine solution conditions, and it is imperative to establish a rapid detection method for directly detecting NPs in marine solution. In this study, a silver coated gold nanoparticle (Au@Ag) based real-time SERS detection strategies is proposed, with a particular focus of the enhancement mechanism of the particle diameter for SERS performance. Compared with common SERS enhancing particles, Au@Ag demonstrates remarkable SERS enhancement capability. For mechanism investigation, particle diameter is a critical factor significantly influenced the signal intensity of testing specimen. Among all diameter combinations, SERS performance reaches the maximum level when the particle diameter of Au@Ag is slightly smaller than polystyrene nanoparticles (PS NPs). Under these conditions, the lowest detection concentration of PS NPs in purified water without any extra pretreatments was determined to be approximately 0.1 μg/mL. By employing the same PS NPs and Au@Ag in artificial seawater solution, the lowest detection concentration of PS NPs reaches to 0.01 μg/mL. These results indicate that the efficacy of Au@Ag for real-time SERS detection of PS NPs in marine solution, and provide a valuable reference for future study of material selection and particle size optimization for NPs in-situ SERS detection for real marine condition.
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JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2014
·
IF 2.302
Xuezhu Wang,Yongyong Wang,Jing Zhang,Xiaoli Zhao,Ye Liu
A series of ionic Au(I)-complexes ligated by the phosphine-functionalized ionic liquids were synthesized and characterized, which are composed of the Au(I)-complex cation and the counteranion of OTf − , AuCl 4 − , or PF 6 − , respectively. The single crystal X-ray diffraction analyses show that the Au(I)-centered vector in 1A , 1B , 2A , 3A , and 4A all possess the slightly twisted linear geometry, and in each individual the Au(I)-center is coordinated by one chlorine and one imidazolium-based phosphine. The aggregation of 1B in acetone can lead to the formation of the trinuclear Au(I)-complex of 1C due to the aurophilic Au(I)–Au(I) interaction, the electrostatic attraction, and the steric preference. When these ionic Au-complexes were employed as precatalysts for hydration of phenylacetylene in aqueous-methanol media, the reaction proceeded selectively according to Markovnikov's rule with moderate to high yields of acetophenone . The highest activities were achieved over 2A with hydrophobic PF 6 − as the counteranion and the trinuclear 1C under mild conditions (75 °C, 2 h), in conjunction with the additive of proton acid H 2 SO 4 . The ion-pair effect on the catalytic performance of the corresponding Au(I)-complexes, coming from the phosphine-ligated cations and the counteranions, were investigated.
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APPLIED CATALYSIS A-GENERAL
·
2021
·
IF 5.706
Lei Chen,Wenxia Zhuang,Jingmin Lan,Xiaoling Liu,Shi Jiang,Lei Wang,Yu Zhou,Jun Wang
Mg-bearing MTW silicalite zeolite, MgSi-ZSM-12, was straightforwardly synthesized by involving an unusual acidic pre-gelation system and engaged as the task-specific support for loading the Au nanoparticles (NPs). The resulting Au/MgSi-ZSM-12 catalyst showed stably excellent activity for the oxidation of HMF into FDCA in the presence of atmospheric dioxygen (O 2 ) without externally adding any liquid base, affording a yield of 87 % and turnover number (TON) of 331 based on the surface Au sites. Superior basicity was evidenced by embedding Mg species into the all-silica zeolitic skeleton, which enables strong, weak, and near-zero affinity towards aldehyde, alcohol, and carboxyl groups, respectively, thus, allows rapid and high-uptake adsorption of HMF, but negligible adsorption of FDCA. This unique feature of the Mg-bearing all-silica zeolite support together with its synergy with the active sites of Au NPs is revealed to accelerate the production of FDCA under the base-free mild condition.
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