JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Decai Wang,Tong Zhou,Yalan Cui,Chen Bao,Shuaiqi Yuan,Chengchen Wu,Qian Liu,Chao Liu,Jiannan Hu,Mingrong Liu,Ziling Li,Xinyue Ma,Yunfei Zhu,Jingjing Sun,Shuyun Xu,Yuzhou Wu
The persistent opening of the mitochondrial permeability transition pore (mPTP) plays a critical role in bronchial asthma pathogenesis. The ATP synthase c subunit (c subunit) constitutes a core component of mPTP. A novel c subunit inhibitor, 1,3,8-triazaspiro [4.5] decane derivatives (PP10), effectively suppresses pathological mPTP opening without impairing ATP synthesis. Although intraperitoneal PP10 administration mitigates airway inflammation in asthmatic mice, its hydrophobicity hinders inhaled delivery to airway epithelial mitochondria, requiring penetration of the mucus layer, cell membrane, and mitochondrial outer membrane. To overcome this, we developed inhalable human serum albumin-triphenylphosphine-polyethylene glycol-PP10 nanoparticles (HSA-TPP-PEG-PP10 NPs). These NPs demonstrated efficient mucus penetration, high drug loading, mitochondria-targeting capability, and biosafety. They suppressed house dust mite/lipopolysaccharide (HDM/LPS)-induced mPTP opening, inhibited the mitochondrial DNA (mtDNA)-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, reduced inflammation in human bronchial epithelial (HBE) cells, and alleviated airway inflammation in asthmatic mice upon inhalation.
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高影响因子
Foods
·
2026
·Vol. 15
·期 16
·2886
·
IF 6
Luyao Wang,Xuelian Wu,Yizi Mahai,Wenjing Ma,Lin Zhou,Jing Zhang,Xinhui Wang,Jing Li
Monitoring dopamine (DA) in pork can provide useful information for assessing meat freshness and quality deterioration. In this work, an Fe@N-S-O-C nanocomposite was fabricated as an electrode modifier for DA determination. The Fe@N-S-O-C nanocomposite was synthesized via precipitation followed by calcination using melamine and ferrous sulfate as precursors. The crystal structure, surface chemical composition, and morphology were characterized by XRD, XPS, SEM, and TEM. The Fe@N-S-O-C-modified glassy carbon electrode (Fe@N-S-O-C/GCE) was then evaluated for its electrocatalytic performance toward DA. Under the optimized conditions (pH 6.0), the sensor showed linear responses to DA over 1–65 and 65–220 μM. The sensitivities for these two ranges were 4.357 and 1.685 μA μM−1cm−2, respectively, with an LOD of 40 nM. In addition, the Fe@N-S-O-C/GCE showed excellent reproducibility, good repeatability, and strong anti-interference capability against common coexisting substances. After 30 days of storage, 82.74% of the initial current response was retained by the same electrode. Practical applicability of the sensor was verified in pork samples, with recoveries of 95.97–106.73%. These results demonstrate that the Fe@N-S-O-C/GCE sensor offers a reliable and effective platform for DA detection in complex food matrices.
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Journal of Energy Storage
·
2026
·
IF 10.7
Jiacai Xiong,Zhimin Zou,Yu Bai,Yutao Xing,Chunhai Jiang
Decorating transition metal oxide in combination of carbon coating has been verified as an effective way to boost the cycling stability of SiO anode. However, the weak bonding between the transition metal oxides and SiO matrix tends to weaken the modification effect. Herein, SiO@C anode is modified with in situ formed Mn 2 SiO 4 interphase through solid-state reaction between SiO and the hydrothermally grown MnO 2 at the presence of resorcinol-formaldehyde (RF) resin coating layer. The Mn 2 SiO 4 interphase buffers the volume change of the composite anode through a reversible conversion reaction, leading to greatly enhanced cycle stability. For the optimized SiO/Mn 2 SiO 4 @C anodes, capacity retention ratios higher than 84% are preserved after 500 cycles at 1.0 A g −1 , significantly outperforming that of the SiO@C anode (65%). This work provides a facile strategy to fully exploit the modification effect of transition metal oxide on SiO-based anode, thus paving the way for high energy density Li-ion batteries with superior cycling stability.
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高影响因子
LANGMUIR
·
2026
·Vol. 42
·期 31
·22950-22957
·
IF 4.4
Chen Nannan,Yuan Qingle,Liu Qin,Zhang Chao,Wu Zhengcui,Bi Wentuan
Single-atom catalysts (SACs) hold great promise for the
electrochemical
reduction of CO 2 to CO; however, the high selectivity is
typically restricted within a narrow potential window, limiting their
practical implementation. In this study, Ni–N–C catalysts
were supported on ordered and disordered carbon nanofiber membranes
(denoted as o-NiNC and d-NiNC, respectively) via electrospinning to
elucidate the effect of nanofiber alignment on CO 2 reduction
activity. The results demonstrate that o-NiNC catalysts allow for
spatially uniform H + /CO 2 delivery and consumption,
thereby mitigating the selectivity variations arising from uneven
spatial distribution of reactants. As a result, the o-NiNC catalysts
achieve a CO Faradaic efficiency (FE) of 98.5% at −1.0 V and
maintain an FE above 90% across a broad potential range (−0.6
to −1.6 V). This work provides new insights into the rational
design of high-performance CO 2 reduction electrocatalysts
through geometric engineering.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Dali Wei,Zhejie Chen,Xuezhu Wang,Zhou Fang,Qianru Li,Junqin Yu,Xiaoyu Sun,Xuan Wang,Linxin Tian,Bo Tian,Jia Ge,Yu Yang,Weihong Tan
An oxidase-mimicking Cu-N/C single-atom nanozyme is developed for colorimetric detection of isoniazid (INH). • A H 2 O 2 -free “signal-off” sensing platform is established, enabling simplified operation and enhanced robustness. • A low detection limit of 0.16 μM is achieved, with successful validation in real-world samples and excellent agreement with HPLC. • Integration with a paper-based chip and a smartphone enables on-site INH detection. A colorimetric sensing platform based on Cu-N/C single-atom nanozymes (Cu-N/C SAzyme) was developed for the sensitive and selective detection of isoniazid (INH), a first-line anti-tuberculosis drug. The Cu-N/C SAzyme exhibits intrinsic oxidase-mimicking activity, generating hydroxyl radicals (⋅OH) and superoxide anion radicals (O 2 · − ) to synergistically oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into its blue oxidized form (oxTMB) without the addition of H₂O₂. Upon introduction of INH, its strong reducing property rapidly reduces oxTMB and scavenges ·OH and O 2 · − radicals, leading to a concentration-dependent decrease in absorbance at 652 nm. The change in absorbance shows a good linear relationship with INH concentration over the range of 1–50 μM, with a detection limit of 0.16 μM. The method exhibits high reproducibility (RSD < 5%) and excellent selectivity, and has been applied to determine INH in pharmaceutical tablets and human serum samples, achieving recoveries of 95.1–104.7%. The proposed method shows good agreement with the standard HPLC method. Furthermore, a portable point-of-care testing (POCT) platform was established by integrating the Cu-N/C SAzyme with a paper-based chip and smartphone. This platform achieved a detection limit of 0.65 μM over the same linear range (1–50 μM), demonstrating its potential for on-site INH screening. Download: Download high-res image (146KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
He Lu,Qiuhui Shi,Ling Wang,Haoyong Yin,Hui Wang,Xiuwei Ma,Shengji Wu
A reconstructed Mo₂C/NCNTs interface was developed for simultaneous AA, DA, and UA sensing. • Ni removal enlarged mesoporous channels and exposed more accessible Mo₂C active sites. • Mo valence modulation promoted interfacial charge transfer and electrocatalytic oxidation. • Mo₂C/NCNTs/GCE delivered resolved oxidation peaks with low detection limits. • The sensor showed good selectivity, stability, and applicability in urine and serum samples. The simultaneous electrochemical determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA) is important for biological analysis, but it remains challenging because of their close oxidation potentials and coexistence in complex samples. Herein, a reconstructed Mo₂C/NCNTs interface was developed as an efficient sensing platform through a pyrolysis–acid etching strategy. During pyrolysis, Ni nanoparticles promoted the in situ growth of nitrogen-doped carbon nanotubes (NCNTs), while Mo species were converted into Mo₂C, producing a closely integrated Ni/Mo₂C/NCNTs precursor. Subsequent selective removal of Ni generated Mo₂C/NCNTs with preserved tubular architecture, enlarged mesoporous channels, increased pore volume, exposed Mo₂C active sites, and redistributed Mo valence states. These structural and electronic features improved analyte diffusion, interfacial charge transfer, and electrocatalytic oxidation. The Mo₂C/NCNTs-modified glassy carbon electrode exhibited well-resolved oxidation peaks and enhanced current responses for AA, DA, and UA. The detection limits were 3.2 μM for AA, 0.11 μM for DA, and 0.15 μM for UA. The sensor also showed good selectivity, repeatability, reproducibility, and long-term stability. Satisfactory recoveries obtained in urine and serum samples further confirmed its applicability for practical analysis. This work provides an effective interface-regulation strategy for constructing Mo₂C-based electrochemical sensors for multi-analyte detection in biological matrices Download: Download high-res image (200KB) Download: Download full-size image
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JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Ruite Gu,Tingyu Yan,Zeyu Hao,Huanlu Tu,Shansheng Yu,Xiaoying Hu,Hongwei Tian
The preparation of highly efficient, stable, and cost-effective catalysts to address the complex oxygen reduction reaction (ORR) in zinc-air batteries remains a significant challenge. Herein, a surface modification strategy is employed to uniformly encapsulate an Fe-N-C matrix with cobalt-coordinated conjugated organic polymers containing Schiff base structures, successfully yielding a highly active CB(cobalt-coordinated Schiff-base polymer)@Fe-N-C composite catalyst with coexisting cobalt coordination polymers and iron-nitrogen-carbon structures. In alkaline electrolytes, the CB@Fe-N-C catalyst exhibits outstanding catalytic activity (E 1/2 = 0.93 V) and stability, which are attributed to its highly conductive, structurally stable composite architecture with abundant active sites. In a zinc-air battery (ZAB), CB@Fe-N-C exhibits remarkable power density, surpassing the Pt/C benchmark. This work offers an effective synthetic strategy for preparing electrocatalysts with excellent ORR performance in zinc-air batteries.
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FISH & SHELLFISH IMMUNOLOGY
·
2026
·
IF 4.2
Ying-rong Jin,Chuan-yue Chen,Ze-kai Wang,Pan Qin,Zhi Liao,Xiao-lin Zhang,Xiao-jun Yan
C-type lectins (CTLs) play crucial roles in immune defense and feeding regulation, serving as key mediators of pathogen recognition and nutrient uptake in invertebrates. Although previous studies have demonstrated the involvement of CTLs in the immune response of Mytilus coruscus , their role in feeding regulation remains unclear. In this study, we identified a C-type lectin, designated MytiCTL17A , from M. coruscus and investigated its dual function in immune defense and feeding behavior. The purified recombinant MytiCTL17A binds to LPS and PGN. Additionally, it binds to both Gram-positive and Gram-negative bacteria, promoting bacterial agglutination. Notably, this agglutination can be inhibited by PAMPs. These findings confirm that rMytiCTL17A functions as a pattern recognition receptor (PRR), recognizing PAMPs, binding to bacteria, and promoting their agglutination, thereby playing a role in immune defense. Additionally, rMytiCTL17A also exhibits direct antibacterial activity. In feeding experiments, rMytiCTL17A can bind to microalgae and reduce the feeding rate of M. coruscus , indicating its involvement in the feeding process. Moreover, rMytiCTL17A can recognize carbohydrates (D-Man, D-Gal, Glu, Mal, and Suc) on the surface of microalgae and induce microalgal agglutination. Notably, this agglutination can be inhibited by D-Man, demonstrating its dependence on carbohydrate recognition. Thus, rMytiCTL17A also participates in feeding by recognizing microalgae through specific carbohydrates. This study highlights the multifunctionality of rMytiCTL17A and provides new insights into the roles of C-type lectins in bivalves, with potential implications for aquaculture in terms of enhancing disease resistance and feeding efficiency.
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高影响因子
JOURNAL OF THE ENERGY INSTITUTE
·
2026
·
IF 6.5
Shanshan Dai,Hao Wang,Kechao Zhou,Chong Du,Xiuqun Ji,Chunyan Bie,Guozhang Chang,Cuiping Wang,Jian Zhang
This study investigated the thermal decomposition characteristics and long-chain aliphatic hydrocarbons (C ≥ 7) (LCAH) preparation during catalytic co-pyrolysis of reed stems (RS) and polypropylene (PP) wastes. A TG-FTIR system and a Py-GC/MS system were employed to elucidate the characteristics of LCAH generation. Both the shift of the DTG peak from 483 to 468 °C and the reduction in activated energy ( E a ) confirm that the co-pyrolysis technique exerted a positive effect on the decomposition of RS and PP. A higher heating rate enhanced this positive synergy. Semiquantitative analysis of FTIR absorption peaks at ∼2960 and ∼721 cm −1 , combined with GC/MS compositional distributions, demonstrate that the co-pyrolysis of RS and PP exhibited a synergistic effect on the LCAH generation. A reforming effect was observed between RS-derived bio-oils and PP-derived bio-oils, resulting in the production of LCAH molecules with an expanded carbon number distribution. Three possible routes were proposed to clarify the LCAH generation during co-pyrolysis of RS and PP. Temperatures of 600 to 650 °C and prolonged secondary reaction time were favorable for improving the yield of LCAH. In the presence of Ni-SiO 2 /ZrO 2 catalyst, the relative content of LCAH in the bio-oils reached 62.70 area%, and the catalyst maintained excellent performance in consecutive 5 runs.
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Small
·
2026
·
IF 12.1
Xilin Wang,Ming Yue,Rongjie Xia,Hongxiao He,Yanhe Xiao,Baochang Cheng,Shuijin Lei
2D layered transition metal thiophosphites (MPS 3 ) are promising high-capacity anodes for sodium-ion batteries (SIBs) but are plagued by poor conductivity and severe volume changes. To address these challenges, we report a corn-like multi-MPS 3 heterostructure engineered via a sophisticated MOF-on-MOF templating strategy. This unique architecture, comprising a FePS 3 /ZnPS 3 heterojunction and a conformal N-doped carbon (NC) coating, establishes an interfacial field and spatial confinement synergy that facilitates rapid ion/electron transport and ensures exceptional structural integrity. The designed FePS 3 -ZnPS 3 -C@NC anode delivers remarkable sodium storage performance: a high initial discharge capacity of 1294.5 mAh g −1 at 0.1 A g −1 and long cycling stability with 87.6% capacity retention after 1200 cycles at 2 A g −1 . Such superior performance is attributed to: (i) the elastic carbon coating, which effectively buffers mechanical strain and preserves structural stability; and (ii) the heterointerfacial synergy, which enhances charge carrier mobility and reaction kinetics. Ex situ characterizations unravel a multi-mechanistic sodium storage process, accounting for the high capacity. Density functional theory (DFT) calculations confirm that the built-in electric field at the FePS 3 /ZnPS 3 interface optimizes Na + adsorption energy and interfacial charge transfer. This study provides a generalizable design paradigm for high-performance anodes through the rational integration of architectural control and interfacial engineering.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·294
·
IF 5.4
Xu Xiaowen,Liu Tiandi,Ma Tenghe,Li Tengfei,Wang Jing
A smartphone-assisted colorimetric sensing platform was developed for the sensitive detection of sulfites based on a cobalt single-atom nanozyme (Co-N-C). The nanozyme was synthesized via high-temperature pyrolysis of bimetallic Zn/Co-ZIF precursors, resulting in atomically dispersed Co active sites anchored on a nitrogen-doped carbon framework. Benefiting from the well-defined catalytic centers, Co-N-C exhibits exceptional oxidase-like activity, efficiently catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) into a blue product (oxTMB). The presence of sulfites triggers rapid discoloration through a dual mechanism involving reactive oxygen species (ROS) scavenging and the direct reduction of oxTMB. Under optimized conditions, the proposed assay demonstrates a wide linear range of 0.5–80 µM with a low detection limit of 0.066 µM. To eliminate potential interference from biothiols such as glutathione, a selective masking strategy using N-(2-hydroxyethyl)maleimide (HEMI) was introduced. Furthermore, integration with smartphone-based RGB analysis enables portable and instrument-free quantification. The platform was successfully applied to real food samples (white sugar, liquor, and bean vermicelli), yielding satisfactory recoveries of 92.6%-104.0%. This work highlights the potential of single-atom nanozymes in developing low-cost, portable sensing platforms for practical food safety monitoring.
Section
Graphical abstract
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高影响因子
Catalysts
·
2026
·Vol. 16
·期 4
·319
·
IF 4.5
Jie Yang,Xinyu Jiao,Shihao Lv,Anjiang Gao,Shu Zhang,Yong Huang
Lignin, a complex and heterogeneous polymer, poses significant challenges for effective thermal valorization due to its broad molecular weight distribution and structural diversity. This study systematically compares the effect of lignin’s molecular weight on product distribution under pyrolysis and Ru/C-catalyzed depolymerization conditions. Fractionated lignin samples with distinct molecular weights were subjected to identical thermal and catalytic conversion pathways. Pyrolysis results indicate that, compared with low-molecular-weight (low-MW) lignin, high-molecular-weight (high-MW) lignin more readily generates phenolic compounds, with the relative content of guaiacol increasing by nearly twofold. In contrast, products derived from low-MW lignin contain a higher abundance of unsaturated structures, such as 4-allyl-2,6-dimethoxyphenol, suggesting that side chain cleavage and rearrangement reactions are more pronounced. In contrast, Ru/C-catalyzed depolymerization exhibits a stronger molecular-weight-dependent selectivity, where low-MW lignin is more readily converted into carboxylic acids due to enhanced accessibility of terminal functional groups and reduced structural condensation. This comparative analysis demonstrates that lignin’s molecular weight plays a process-dependent role in governing product distribution, providing guidance for tailored lignin valorization strategies.
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危险品化学品经营许可证（带存储）