NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 39
·期 7
·5272-5281
·
IF 3.086
Jian Liu,Libin Liu,Xiwen Wu,Xiaokai Zhang,Tianduo Li
A green approach to the preparation of reduced graphene oxide (RGO) films has been developed using L-ascorbic acid/water vapor as the reducing agent. Except for the use of gaseous hydrazine hydrate or hydroiodic acid, this is the first reported use of an environmentally friendly gaseous phase for the reduction of graphene oxide (GO) films into RGO films. The as-prepared RGO films were flexible and showed a high electrical conductivity of up to 3500 S m−1. The L-ascorbic acid/water vapor was able to penetrate into the GO films and reduce the Ag ions. The as-reduced RGO–Ag composite films could be used as effective surface-enhanced Raman scattering active substrates and the Raman signals could be adjusted by changing the amount of Ag ions. The RGO–Ag composites also showed antibacterial activity against Escherichia coli, Staphylococcus aureus and white rot fungi. This is a straightforward and green approach to fabricating RGO–Ag composites for use in biological applications and materials science.
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高影响因子
ENERGY & FUELS
·
2024
·
IF 5.2
Ying Xu,Dong Wang,Xin Wang,Jian Dong
The rapid growth of natural gas clathrate hydrate has been a significant safety hazard in off-shore natural gas drilling and gas transport. Alleviation of hydrate formation can be achieved by applying low-dosage hydrate inhibitors of polymers during operation. In order to combine the advantages of high adsorption potential and environmental friendliness, we study the kinetics of hydrate inhibition of amphiphilic highly branched poly(l-lysine) (PLL) by NMR relaxometry. The introduction of n-butyl and cyclohexyl groups in PLLs was found to be significantly effective in prolonging the induction times of sII clathrate hydrates. Key physical–chemical factors involved in the mechanism previously proposed by molecular dynamics simulations can be clarified by NMR relaxometry. Induction times for the formation of hydrate are associated with the interfacial water amount but are not related to the hydrogen bonding strength or dynamics of the free water component. The amphiphilic PLLs in the interface interact with the hydrate surfaces through their hydration shell. Analysis of the molecular motion and freezing kinetics of water in the fluid before and during hydrate formation reveals that the polymers can reduce the rates of hydrate growth from the free water by a factor of 5 to 10. A further significant decrease in the growth rates from small hydrate particles by a factor of 10 to 2600 was observed in the presence of the amphiphilic PLLs with n-butyl and cyclohexyl groups. The distinct crystal growth kinetics in the heterogeneous interface are influenced by the terminal alkyl groups of the polymers, with changing growth geometry or crystal shapes and consistent with the interfacial Gibbs–Thomson effect. A high Avrami index value of the isothermal crystal growth and nonfreezable water amount favors a long induction time. The PLL inhibitors adsorb to the hydrate surface and act via an interfacial mechanism.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Yanzi Zhao,Yujing Niu,Xuefei Wang,Peng Wan,Zhanfei Ma,Jian Sun,Shoufang Jiang,Ling Xue,Nan Liu
Indium-tin oxide nanoparticles (Nano-ITO) are widely used in various applications as infrared shielding materials, which increase the risk of occupational exposure. According to reports, Nano-ITO can cause indium lung disease in occupational exposed workers, but the specific mechanism of Nano-ITO-induced pulmonary toxicity remains unclear. In this study, 50 8-week-old male Sprague-Dawley rats were divided into five groups (10 rats in each group) as follows: control group (physiological saline), 1.2 mg/kg Nano-ITO group, 6 mg/kg Nano-ITO group, N-Acetyl-L-Cysteine (NAC) control group (200 mg/kg), and NAC + Nano-ITO group (200 mg/kg NAC intraperitoneal injection, after 1.5 h, 6 mg/kg Nano-ITO intratracheal instillation), twice a week for 12 weeks. Pathological and ultrastructural changes in the rat lung tissue, immunofluorescence assays, immunohistochemistry, protein and mRNA levels of apoptosis- and autophagy-related genes were measured. The levels of ROS, MDA, H 2 O 2 , and LDH, and the activities of T-AOC and SOD, were determined using oxidative stress assay kits. The results showed that Nano-ITO caused strong pulmonary inflammation, pulmonary alveolar proteinosis, and pulmonary interstitial fibrosis. In addition, Nano-ITO-induced oxidative stress in rat lungs presented as increased levels of ROS and H 2 O 2 in the lungs, increased LDH and MDA levels, SOD and T-AOC activity in BALF, and activation of the Nrf2/NQO1/HO-1 signaling pathway. Intriguingly, Nano-ITO significantly increased the protein expression of microtubule-associated protein light chain 3 (LC3-II), the protein levels of autophagy-related genes 5 (ATG5), and Beclin-1 (BECN1), and reduced the protein levels of phosphatidylinositol 3-kinase (PI3K) in lung tissues. In addition, transmission electron microscopy (TEM) showed a significant increase in autophagic vesicles in the cytoplasm of lungs treated with Nano-ITO, indicating that Nano-ITO induces autophagy in rat lungs. Moreover, apoptosis also participates in Nano-ITO-induced pulmonary injury in a synchronous manner, as evidenced by the enhancement of TUNEL-positive signals and activation of the apoptosis pathway (Bax and Bcl-2 positive proportions). NAC supplementation restored most of the pathological structural features of rat lung tissue to their physiological range and effectively weakened apoptosis, as demonstrated by the notable reductions in TUNEL, Bax, and Bcl-2 protein expression levels in the lungs. Although autophagy was detected in the lungs of rats in the Nano-ITO and NAC + Nano-ITO groups, we discovered that NAC could rescue the expression of ATG5 and BECN1 induced by Nano-ITO, thus indicating that exposure to Nano-ITO promotes pulmonary apoptosis and autophagy by mediating oxidative stress. These results indicate that Nano-ITO can cause pulmonary injury by inducing oxidative stress, which activates apoptosis and autophagy, ultimately leading to alveolar proteinosis and interstitial fibrosis.
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高影响因子
TALANTA
·
2025
·
IF 6.1
Liang Liu,Shiao Ren,Yangyi Hao,Lijuan Yue,Chenli Yue,Longyu Li,Wenlei Zhang,Zengliang Gao,Xin Hai
The aim of this study was to establish a simple, sensitive, and robust ultra-high performance liquid chromatography coupled with fluorescence detection method (UPLC-FLD) for the determination of chiral D/L-serine in cells. D/L-serine in cells were derivatizated by o-phthalaldehyde (OPA) and N-acetyl-L-cysteine (NAC). Carbocisteine was selected as the internal standard. The derivatives were separated on a C18 column by gradient elution. The excitation and emission wavelengths for fluorescence determination are 340 nm and 450 nm, respectively. The retention time of D-serine and L-serine was 23.3 and 23.9 min respectively, which presented a perfect separation. The accuracy of D-serine and L-serine were ranged from 96.46 % to 109.63 % and 95.50 %–102.20 %, respectively. The precision of D-serine and L-serine were ranged from 4.34 % to 14.56 % and 3.56 %–13.73 %. The limit of quantitation of D-serine and L-serine were 0.1 nmol/mL. The concentration of D/L-serine varies in different cell lines. This method can satisfy the determination of D/L-serine in astrocytes and other cells, which can be used for the study of D/L-serine metabolism and related mechanisms. In short, we have established a simple, stable, reliable and robust method for the determination of D/L-serine in cells. In addition, the D/L-serine levels in different cells were quantified in this study, which can provide a reference for the study of D/L-serine metabolism in cells.
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高影响因子
JOURNAL OF FOOD AND DRUG ANALYSIS
·
2024
·
IF 2.6
Xiaowei Chen,Jiajia Chen,Jian Peng,Yuanshan Yu,Jijun Wu,Jing Wen,Zhiying Kang,Yanhui Wang,Yujuan Xu,Lu Li
Pomelo sponge layer (PSL) had been considered as a potential source of soluble dietary fiber (SDF), while they were mostly disposed of as waste. To promote high-value utilization of pomelo wastes, this study extracted SDF from PSL of six varieties of pomelo, and their physicochemical, structural and functional properties were investigated. Results indicated that all PSL-SDFs showed good physicochemical and functional properties. Among them, PSL-SDF from grapefruit (GRSDF) showed better water holding capacity and swelling capacity, whereas Shatian pomelo PSL-SDF and Guanxi pomelo PSL-SDF had the highest thermal stability and oil holding capacity, respectively. Furthermore, compared with other PSL-SDFs, GRSDF displayed the lowest hydrolysis degree coupled with the best antioxidant and probiotic growth-promoting abilities. Finally, the correlation analysis showed that multiple beneficial effects of PSL-SDFs were markedly associated with their molecular weight and the concentrations of total phenolic, total flavonoids, rhamnose, galacturonic acid, glucose and arabinose. Collectively, these findings contributed to a better understanding of the physicochemical and functional properties of SDFs extracted from different PSLs, which provided a scientific basis for the development of PSL-SDFs into functional foods.
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高影响因子
Journal of Macromolecular Science Part B-Physics
·
2022
·
IF 1.366
Jiaming Gu,Zhihua Zhou,Tianlong Huang,Wei Wu,Wenjuan Liu,Yanmin Zhao,Ping Chen,Ziwei Zhou,Dan Wang,Chao Zhang,Meilin Yi,Xiao He,Jianjun Fang
Composite porous microspheres based on blends of poly(D,L-lactide-co-glycolide-co-ε-caprolactone) (PLGCL) and 1,4-butanediamine modified poly(D,L-lactide-co-glycolide) (BMPLGA) were prepared by using a combined solvent evaporation and particle leaching technique. The morphologies and porous structure of the PLGCL/BMPLGA microspheres were observed by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and cytocompatibility were studied. The resultant microspheres showed a porous surface and a three-dimensional network structure with interconnecting pores. The changes of morphologies, pH value and mass loss during in-vitro degradation in phosphate buffered solution (PBS) at 37°C indicated that the degradation rate of the BMPLGA was faster than that of the PLGCL in the PLGCL/BMPLGA blends. We suggest the PLGCL/BMPLGA porous microspheres were non-cytotoxic and showed excellent cytocompatibility. We suggest the PLGCL/BMPLGA porous polymeric microspheres have great potential for application for drugs delivery and tissue regeneration.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Yong Liu,Chao Wu,Zhongming Zhou,Wei Liu,Hongyu Guo,Baoquan Zhang
The development of high-performance mixed matrix membranes (MMMs) with satisfactory structure stability has attracted much attention for the past few years. The rational design and synthesis of fillers to well coordinate themselves in the polymeric matrix is still challenging. The core-shell structured fillers were synthesized via the heteroepitaxial growth of ZIF-8 on ZIF-L(Co) surface (ZIF-L(Co)@ZIF-8), which were then embedded into Pebax to fabricate MMMs for enhanced CO 2 /CH 4 separation. The synthesized fillers and MMMs were characterized via SEM with EDS mapping, TEM, XRD , FIIR and nanoindentation measurements. The effects of ZIF-L(Co)@ZIF-8 loading and filler components on gas separation performance were studied with the evaluation of membrane stability. The experimental results indicated that the filled ZIF-L(Co)@ZIF-8 could be evenly distributed within the bulky Pebax. The synergistic effect of the core-shell structured fillers in adsorption and molecular sieving endowed the synthesized MMMs with superior gas separation performances. The optimal separation performance is achieved for the MMM containing 3 wt% of ZIF-L(Co)@ZIF-8 with a CO 2 permeability of 145.7 Barrer and a CO 2 /CH 4 selectivity of 40.9, corresponding to 79.1% and 110.1% increases over pure Pebax membrane.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Lie Zou,Yangping Wen,Hui Zhang,Jingdang Chai,Xuemin Duan,Liang Shen,Ge Zhang,Jingkun Xu
A fluorescent sensor based on the electrosynthesized conjugated polymer poly(Fmoc- l -serine) ( PFOLS ) for highly sensitive analysis of Cr 2 O 7 2− at ultra-trace levels in water and agro-product samples was reported. PFOLS was obtained by potentiostatical electropolymerization of corresponding monomer Fmoc- l -serine in CH 2 Cl 2 -boron trifluoride diethyl etherate system. The introduction of serine group in PFOLS efficiently avoided the interference of anions and other acid substances in agro-products. Although metal ion Fe 3+ could also quench the fluorescence of PFOLS , EDTA could recover the fluorescence of PFOLS -Fe 3+ system. So in the presence of EDTA, PFOLS had a high-selectivity to Cr 2 O 7 2− and it could detect Cr 2 O 7 2− in linear ranges of 80 pM to 1.95 mM with a low detection limit of 72 pM. Then PFOLS was used to detect Cr 2 O 7 2− in water samples (tap water, lake water, and wastewater) and agro-product samples (white rice, red rice, and black rice) with satisfactory results, revealing that PFOLS could be as a practical sensing platform for ultra-trace analysis of Cr 2 O 7 2− in environment and agro-product samples.
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高影响因子
DRUG METABOLISM AND DISPOSITION
·
2026
·
IF 3.6
Jiayi Yao,Jiaqi Wang,Peipei Bu,Kexin Liu,Mingyang Zhao,Jingkai Gu,Xiangjun Meng
Fluorescent probes are extensively used for tracking the in vivo behavior of nanocarriers. However, the impact of fluorescent probes on the in vivo fate of nanomedicines remains uncertain. Potential interference from the probes may lead to misleading conclusions. This study investigated the influence of a commonly used fluorescent probe, DiI, on the in vivo fate of paclitaxel (PTX)-loaded polymeric micelles (PMs) in rats. The drug release kinetics of PTX-loaded PMs (PTX-PM) with DiI/PTX co-loaded PMs (DiI/PTX-PM) in rat plasma was quantitatively compared. The results indicate that co-encapsulation with DiI significantly exacerbated drug release and altered the protein binding of PTX through competitive binding, resulting in an increased proportion of free PTX. DiI enhanced diffusion-driven drug leakage without affecting the micelle dissociation kinetics. Notably, DiI inhibited elimination and increased the systemic exposure of both the free micelle material and the nanocarrier. This study provides evidence that DiI can potentially interfere with the in vivo fate of both the therapeutic payload and the nanocarrier, highlighting the necessity for rigorous validation when employing it for nanocarrier tracking.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zhiwei Li,Teng Liu,Minglong Li,Yun Lin,Peng Guo,Mingfu Lyu,Zhiyong Wei,Lin Sang
Poly (butylene succinate- co -butylene terephthalate)/poly (L-lactic acid) (PBST/PLLA) composite films based on industrially compostable polyester matrices have attracted increasing attention owing to their favorable mechanical properties and packaging potential. In this work, PBST/PLLA was used as the polymer matrix, and an epoxy chain extender was introduced to improve the compatibility between the two phases. Surface-modified coal gangue was further incorporated as a functional filler to regulate the properties of the composite films. The results demonstrated that the dispersibility and interfacial adhesion of modified CG (CGKH 1.0 ) in the matrix were significantly improved. Compared with the composite film material containing unmodified CG (CG-9), the tensile strength and elongation at break of the CGKH 1.0 -9 film increased by 16.2% and 29.5%, respectively. Meanwhile, CG incorporation improved the CO 2 barrier and light-shielding performance, while KH550 modification partially reduced the additional water vapor permeability caused by unmodified CG: the water vapor transmission coefficient ( Pwv ) and carbon dioxide transmission coefficient ( Pco 2 ) of the CGKH 1.0 -9 film were lower than those of the pure PBST/PLLA film, and it also exhibited improved resistance under UV irradiation, hygrothermal aging (85 °C/85% RH), and aqueous hydrolytic environments. This work demonstrates that coal gangue can be transformed into a functional filler for PBST/PLLA composite films, providing a feasible strategy for the high-value utilization of coal gangue in polymer composites. Download: Download high-res image (214KB) Download: Download full-size image
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高影响因子
JOURNAL OF MASS SPECTROMETRY
·
2026
·Vol. 61
·期 8
·e70087
·
IF 2.1
Hanting Li,Liangyin Shu,Suyu Yang,Qing Li,Huanting Li,Wei Cai,Shunli Xiao
Solanum virginianum L., a traditional Solanaceae medicinal plant, is clinically valued for dispelling wind-dampness and relieving pain. Previous phytochemical investigations have predominantly focused on the fruits, identifying alkaloids and steroids with notable anti-inflammatory and antipsoriasis activities. However, systematic research regarding the chemical constituents of other medicinal parts, such as roots and stems, remains scarce, hindering a comprehensive understanding of the plant's material basis. To address this gap, this study systematically characterizes the chemical components of different parts leaves-stems, roots, and fruits-providing essential data for the holistic utilization and quality control of S. virginianum . The chemical constituents of S. virginianum . were fully investigated using Ultra-High Performance Liquid Chromatography-Quadrupole-Exactive Orbitrap Mass Spectrometry (UHPLC-Q-Exactive Orbitrap MS) combined with the Feature-based molecular networking (FBMN). A total of 110 chemical components were identified by comparison with reference standards, databases, and literature. Among them, 89 compounds were reported for the first time in this species, 18 compounds were accurately confirmed, and 51 compounds were simultaneously identified in all three parts, leaves-stems (L), roots (R), and fruits (F). The established method enables rapid and effective identification of the main chemical constituents in S. virginianum , providing a reference for its quality control, studies on active components, and mechanism of action exploration.
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高影响因子
Applied Food Research
·
2026
·Vol. 6
·期 2
·102406
·
IF 5.4
Huaying Wen,Xiaoqing Yin,Chen Zhang,Zhen Da,Yuhong Zhang
Highland barley and Potentilla anserina L. (juema) were used for the first time as substrates for fermentation with Lactiplantibacillus plantarum LL6-1 over a period of 0-9 days. Changes in physicochemical parameters, antioxidant activities and flavour profiles were systematically evaluated. Lactic acid became the predominant organic acid after fermentation, whereas total phenols, free amino acids and reducing sugars peaked on day 1. Flavonoid content and hydroxyl radical scavenging activity increased throughout the process, while SOD activity and DPPH radical scavenging capacity rose initially and then declined. Correlation analysis revealed that 16 of the 17 detected compounds were positively intercorrelated, with acetic acid as the sole exception. Fermentation markedly improved sensory characteristics: bitterness, bitter aftertaste and astringent aftertaste were significantly reduced. Electronic nose analysis clearly discriminated samples from different fermentation stages. A total of 17 new volatile compounds were identified after fermentation, and the total flavour compound content increased 3.2-to 8.2-fold compared with that before fermentation, peaking on day 2. Esters and alcohols became the dominant volatile constituents. Collectively, these findings demonstrate that LL6-1 fermentation effectively eliminates off-odours and substantially enhances the aroma quality of the beverage, indicating that this strain holds considerable promise for the development of novel plant‑based fermented beverages.
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高影响因子
危险品化学品经营许可证（带存储）