Natural Product Communications
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2024
·
IF 1.5
Hui-Peng Song,Ming-Yue Zhao,Zhi-Li Xu,Jia-Nuo Zhang,Wen-Yu Wang,Zi-Xuan Ding,Ying Wang,Li-Bin Zhan,Xi Chen,Ruo-Nan Li,Yue-Hua Chen
ObjectivesThe aim is to discover α-glucosidase/acetylcholinesterase inhibitors as lead compounds from a traditional herbal prescription of Qi-Li-Qiang-Xin capsule (QLQX).MethodsA novel strategy combining time-based fractionation, LC-QTOF-MS, enzymatic activity assay, molecular docking and component-target association analysis was performed to discover α-glucosidase/acetylcholinesterase inhibitors from QLQX. Time-based fractionation combined with enzymatic activity assay was used to find the distribution period of active compounds in the herbal prescription. LC-QTOF-MS was used to analyze the structure of active compounds. Molecular docking was applied to explore the interaction between active compounds and targets.ResultsAccording to time-based fractionation, the active components of QLQX for acetylcholinesterase were primarily concentrated in the highly polar region, whereas the active components for α-glucosidase were predominantly found in the moderately polar area. A total of 33 compounds were identified by comparing with chemical reference substances. Dihydrotanshinone Ⅰ (16.98 µM), hydroxysafflor yellow A (84.57 µM), salvianolic acid A (76.62 µM) and cryptotanshinone (112.68 µM) were identified as acetylcholinesterase inhibitors from QLQX. Similarly, rosmarinic acid (62.29 µM), isochlorogenic acid A (17.95 µM), 4,5-dicaffeoylquinic acid (117.93 µM), danshensu (207.88 µM), salvianolic acid A (1.31 µM), 3,4-dicaffeoylquinic acid (91.71 µM), formononetin (67.26 µM), ginsenoside Rd (3.43 µM), ginsenoside Rb1 (26.37 µM) and ginsenoside F1 (18.79 µM) were discovered as α-glucosidase inhibitors. Notably, salvianolic acid A inhibited both acetylcholinesterase and α-glucosidase. The results of molecular docking indicated that hydrogen bonds, hydrophobic interactions and Pi-Pi T-shaped interactions were crucial for inhibiting acetylcholinesterase. Meanwhile, hydrogen bonds, hydrophobic interactions and Pi-Pi stacked interactions were significant in suppressing α-glucosidase.ConclusionQLQX contains numerous acetylcholinesterase and α-glucosidase inhibitors, demonstrating its potential therapeutic benefits for Alzheimer's disease and diabetes.
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高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Yang Zhang,Junwei Meng,Keyi Chen,Qingping Wu,Xiaoxue Wu,Chilin Li
The frustrating interfacial issue between Li metal anode and solid electrolyte is the main obstacle that restricts the commercial promotion of solid-state batteries. The garnet-type ceramic electrolyte with high stability against metallic Li has drawn much attention, but it also suffers from huge interfacial resistance and Li dendrite penetration due to the unavoidable formation of the carbonate passivation layer and limited interface contact. Herein, we propose a facile and effective method of flame vapor deposition to spray candle soot (CS) coating on the garnet surface. It enables the reduction of the carbonate layer and the conversion to a highly lithiophilic interlayer especially when in contact with molten Li. The lithiophilicity is rooted in the enrichment of graphitic polycrystalline domains in CS, which can be chemically or electrochemically lithiated to form the ionic/electronic dual-conductive network containing LiC6 moieties. The CS interlayer binds the Li metal with the garnet electrolyte tightly with gradual transition of Li-ion conductivity, leading to a significant reduction of the area-specific resistance to 50 Ω cm2 at 60 °C with high cycling and current endurance. Garnet-based symmetric cells and solid-state full cells conducting this strategy exhibit impressive electrochemical reversibility and durability under the preservation of the compact interface and smooth Li plating/stripping. The modified Li/garnet/FeF3 batteries exhibit a discharge capacity as high as 500 mA h g–1 and long-term cyclability for at least 1500 cycles (with capacity preserved at 281.7 and 201 mA h g–1 at 100 and 200 μA cm–2, respectively). This candle combustion strategy can be extended to more ceramic electrolytes compatible with high-temperature pretreatment.
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高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Haojing Liu,Weiya Li,Hui Chang,Hongkai Hu,Shengrui Cui,Chunchao Hou,Wei Liu,Yongcheng Jin
To satisfy the demand for high safety and energy density in energy storage devices, all-solid-state lithium metal batteries with solid polymer electrolytes (SPE) replacing traditional liquid electrolytes and separators have been proposed and are increasingly regarded as one of the most promising candidates as next-generation energy storage systems. In this study, poly(vinylidene fluoride)-hexafluoropropylene/lignosulfonic acid (PVDF-HFP/LSA) composite polymer electrolyte (CPE) membranes with a micro area interface wetting structure were successfully prepared by incorporating LSA into the PVDF-HFP polymer matrix. The enhanced interaction between the polar functional group in LSA and the C═O in N-methylpyrrolidone (NMP) hinders the evaporation of solvent NMP, thus creating a micro area wetting structure, which offers a flexible region for the chain segment movement and enlarging the area of the amorphous zone in PVDF-HFP. From the results of IR and Raman spectroscopy, it was found that the presence of LSA induced unique ion transport channels created by the massive aggregated ion pair (AGG) and contact ion pair (CIP) of ion cluster structures composed of Li+ and multiple TFSI– and, at the same time, effectively reduced the crystallinity of the polymer electrolyte, hence further contributing to the Li+ diffusion. As a result, at a rate of 2 C, the Li|CPE-15|LiFePO4 solid-state battery delivers an initial discharge-specific capacity of 134.9 mAh g–1 and maintains stability with a retention of 84% during 400 charge–discharge cycles while the Li|CPE-0|LiFePO4 battery fails after only a few cycles at the same rate.
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DOI
高影响因子
GREEN CHEMISTRY
·
2025
·
IF 9.2
Xue Bai,Yanzhi Sun,Jiahong Xie,Huayi Yin,Rui He,Zhenfa Liu,Xifei Li,Junqing Pan
The sluggish leaching kinetics and low separation efficiency of Li/Co/Ni ions with high chemical consumption greatly hindered the recovery efficiency and cost of spent Li-ion batteries. Herein, we propose a self-generated H2 drives gradient reduction of spent cathode via surface enrichment of Li+ from retired Li-ion batteries, achieving a facile, efficient extraction of Li (>99.3%) by water as a leaching agent without chemicals. Characterizations and calculations reveal the adsorption and electron transfer mechanism between H2 and LiCoO2, the new phase transition mechanism of the layered structure and the changes in the electronic bonding and coordination environment of elemental Co during H2 precise reduction. Economic and environmental analyses showed that this work exhibits 22.6% energy consumption with 0% CO2 emissions and chemical consumption than hydrometallurgy, respectively, fully demonstrated its green and energy saving prospects for recycling spent Li-ion batteries.
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高影响因子
Nanoscale
·
2019
·Vol. 11
·期 18
·8967-8977
·
IF 6.97
Li Li,Rui Zhao,Tinghua Xu,Dandan Wang,Du Pan,Kun Zhang,Caiyan Yu,Xia Lu,Guanjie He,Ying Bai
LiNi0.5Mn1.5O4 (LNMO) spinel has drawn increasing attention due to its high voltage, stabilized electrochemical performance and safety features as a cathode for lithium-ion batteries. However, the main challenge lies in its unstable surface structure, especially at elevated temperatures. In this paper, we decorate the LNMO precursor with a solid electrolyte of Li1.4Al0.4Ti1.6(PO4)3 (LATP) via a facile sol–gel method, followed by a co-crystallization process at 820 °C, to successfully generate a LATP modification shell at the surface of LNMO. The LATP modification shell could not only optimize the morphology of LNMO including the limitation of particle growth and control of crystalline orientation, but also realize ion doping during the co-crystallization process. By tuning the LATP contents, the 2 wt% LATP modification is found to be the most effective at balancing the interfacial stability and Li+ diffusion kinetics of LNMO, as well as enhancing its rate capability and capacity retention at high temperatures. As a result, the 2 wt% LATP-modified LNMO cathode exhibits a high reversible capacity of 84.8 mA h g−1 after 500 cycles with a capacity retention of 68.9%, and a superior rate capability (102.0 mA h g−1 at 20 C) at room temperature. Moreover, this electrode also delivers a good capacity retention of 85.7% after 100 cycles at 55 °C, which is ascribed to the stabilized interface with a LATP protective layer.
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DOI
PubMed
高影响因子
Materials Today Sustainability
·
2024
·
IF 7.1
Sining Liu,Xin Yan,Pengyu Li,Xinru Tian,Sinan Li,Fei Teng,Shao-hua Luo
Li-rich Co-free Mn-based cathode materials have attracted considerable attention in the development of lithium-ion batteries (LIBs) due to their impressive theoretical capacity and cost-effectiveness. Nevertheless, the inherent shortcomings in cycling stability and rate capability hinder their widespread application. Herein, Na-doped Li 1.2-x Na x Mn 0.6 Ni 0.2 O 2 (x = 0, 0.01, 0.03, 0.05, 0.08, 0.10) is synthesized using Na 2 CO 3 as the source of Na. Density functional theory (DFT) calculations reveal that the presence of Na + introduction enlarges the between-layer spacing of Li 1.2 Mn 0.6 Ni 0.2 O 2 , reduces the band gap width, reduces the cation mixing phenomenon, and increases the Li + diffusion rate and electronic conductivity. Experimental electrochemical assessments demonstrate that the cathode material with a Na doping level of 0.03 exhibits remarkable performance: it achieves a discharge specific capacity of 204 mAh·g −1 at 0.1C and retains 87.4% of its capacity after 100 cycles. These findings underscore the efficacy of Na doping in enhancing the electrochemical properties of Li-rich Mn-based cathode materials, thereby advancing their potential for practical application in LIBs.
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高影响因子
Materials Today Communications
·
2024
·
IF 3.7
Lingli Xu,Jingbo Chen,Jing Zhu,Tianxiang Li,Chaoyun Shi
Recently, SiO 2 has attracted increasing attention as an anode material for lithium-ion batteries (LIBs) owing to its low cost and high theoretical specific capacity. However, its inherent poor conductivity limits its practical application. To address this issue, nanostructured material design is considered an effective solution. Herein, based on the traditional ammonium tartrate template-directed sol-gel method, we use low-cost and easily available L-tartaric acid in place of D, L-tartaric acid to prepare high-yield silica nanotubes (SNTs) with a thin wall (ca. 50 nm), small diameter (ca. 150 nm), rough surface and open ends, as well as tiny spongy-like silica nanoparticles (SNPs) by adjusting the feeding amount and feeding mode of NH 4 OH solution. The electrochemical characterization results suggest that the SNTs show better cyclability and rate performance than the SNPs, which maintain a reversible capacity of 741.3 mAh g −1 after 500 cycles at a current density of 0.4 A g −1 and deliver a high rate capacity of 819.4 mAh g −1 at a high current rate of 2 A g −1 . The excellent electrochemical performance suggests that hollow one-dimensional hollow nanotubes are more efficient in improving the electrochemical performance of SiO 2 than zero-dimensional nanoparticles , and SNTs with thin tube walls and rough surfaces are demonstrated to be fascinating and promising anode materials for LIBs.
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高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 37
·e02508
·
IF 2
Ziyi He,Zhengquan Zhang,Jing Liu,Yuling Wang,Liangfeng Li,Xingquan Zhang,Yong Ren
Micro–nano structures with hydrophobic properties are promising in self-cleaning, anti-corrosion, and anti-icing performance. Here, we report a solvothermal method to construct micro–nano structures on Al–Li alloy by introduction oleylamine. The results show the concentration of oleylamine has an effect on morphology and hydrophobic property of micro–nano structures formed on Al–Li alloy. The X-ray diffraction results indicates the micro–nano structure is mixture with AlOOH and Al(OH) 3 . When the concentration of oleylamine is about 0.48 mol/L, the length of micro–nano structures is up to microscale, the width of micro–nano structures is about 100–200 nm, and the water contact angle can achieve 152.3°. Graphical A hydrothermal solution was prepared by mixing oleylamine, sodium formate, and DMF. Then, the uniform mixed solution was successfully used to prepare micro–nano structures on the surface of Al–Li alloy by a one-step hydrothermal method. The results show that when the concentration of oleylamine reaches the optimal level (0.48 mol/L), the micro–nano structure is uniform and the voids are filled with air, thus forming a superhydrophobic state.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Chaojie Li,Yan Zhao,Yongguang Zhang,Dan Luo,Jiabing Liu,Tong Wang,Wanjie Gao,Haipeng Li,Xin Wang
Lithium-sulfur (Li-S) batteries have been long deemed as next generation power supply for portable electronic and vehicle application due to their extremely high theoretical energy and power density. However, the shuttle effect of soluble lithium polysulfides (LiPs) and sluggish Li-S chemistry has severely limited their wide implication. Herein, we designed an ultrathin and vacancy-rich ZnCo-layered double hydroxide (ZnCo-LDH) anchored on CNT substrate (noted as CNT-LDH/Ar). Theoretical calculations and analysis at the experimental level are used to comprehensively explain the mechanism by which the oxygen vacancies (Vo) regulate the catalytic activity and adsorption capacity mechanism. The introduction of CNT not only improves a three-dimensional conductive network, but also exposes more active sites for polysulfide adsorption and conversion. More importantly, our design of Vo endows the material with excellent half-metallicity properties, adsorption capacity and low redox barrier. Benefiting from these properties, the S/CNT-LDH/Ar cathode exhibited excellent rate capability with 524.3 mAh g −1 at 5 C, and maintained an excellent cyclability over 500 cycles at 1.0 C with a capacity fading of only 0.042% per cycle. Most importantly, decent cyclability can be acquired with a remarkably raised sulfur loading up to 5.5 mg cm −2 with the lean electrolyte/sulfur (E/S) ratio of 6 mL g −1 .
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Qiwen Ran,Hongyuan Zhao,Youzuo Hu,Shuai Hao,Jintao Liu,Hao Li,Xingquan Liu
Achieving a highly stabilized surface structure is the key to successfully enhancing the cycling stability of LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM) cathode material for Li-ion batteries at high cut-off voltage (4.5 V). In this work, we report a highly surface-stabilized NCM material via a high-valent titanium ion (Ti 4+ )-induced nanostructured hybrid surface with a core-shell structure. Consequently, the Ti-modified LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode provides an excellent cycling stability with 92.3% capacity retention (100 cycles, 0.5C, 2.7–4.5 V). This proposed hybrid core-shell nanostructure prominently mitigates the surface structural degradations, continuous microcracking and parasitic reactions, effectively improving the surface structural stability . This efficient strategy provides a step towards further commercial application of the LiNi 0.8 Co 0.1 Mn 0.1 O 2 material and can be extended to other layered cathode materials.
研究领域:
材料科学
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电化学
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储能技术
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纳米材料
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锂离子电池
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2023
·Vol. 27
·期 5
·1165-1175
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IF 2.5
Liu Shuling,Zhang Wei,An Yiming,Li Ying,Wang Jie,Wang Chao
The Si-based flexible electrodes attracted increasing research interests owing to the growing demand for high-performance flexible energy storage devices. Herein, a facile and smart self-assembly strategy is adopted to address huge volume expansion and particle aggregation issues of Si-based anodes, and a high-performance freestanding film anode (NC@Si/CNTs/N-rGO) is synthesized. The 3D-crosslinked porous graphene-CNTs networks offer abundant electric conductive pathways, high active sites, large internal space to accommodate the expansion of Si NPs, and facilitate Li + diffusion and insertion/extraction kinetics. The synergistic effect between the well-dispersed Si/NC nanoparticles and 3D porous networks significantly enhances electrochemical performance of Si NPs. The as-prepared NC@Si/CNTs/N-rGO electrode exhibits a high reversible specific capacity of 1089 mAh·g −1 at a charge–discharge current density of 1 A·g −1 after 500 cycles. Even at 2 A·g −1 , the electrode still exhibits an excellent reversible specific capacity of 606 mAh·g −1 after 300 cycles. These indicate that the NC@Si/CNTs/N-rGO is a promising candidate for high-performance flexible anode material in lithium-ion batteries.
研究领域:
材料科学
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电化学
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纳米科技
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能源存储
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先进电池技术
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高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2023
·Vol. 37
·期 4
·e5589
·
IF 1.8
Chenchen Liu,Huiling Chen,Yida Zhang,Meng Li,Qiyao Jiang,Zhendong Wang,Liangwen Yu,Qi Wang,Huafeng Pan,Yue Zhuo
Li-Zhong-Xiao-Pi granules (LZXP) are effective for treating gastric precancerous lesions (GPL) in traditional Chinese medicine. However, the active compounds of LZXP and their potential therapeutic mechanism in GPL remained unclarified. The purpose of this study is to investigate the chemical composition and potential targets of LZXP. Based on the accurate masses, ion fragments, and literature data, a total of 128 compounds were identified in the LZXP sample using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC–Q-TOF–MS) in both positive and negative ion modes, and 28 of these compounds were exactly determined by comparison with authentic reference standards. Meanwhile, 11 typical components were quantified via UPLC during a 24 min period. The linearity, accuracy, stability and recovery of the method were all proven. Through the network pharmacological analysis, six chemicals (quercetin, 4′-hydroxywogonin, sinensetin, 5, 7, 8, 3′, 4′-pentamethoxyflavanone, 8-gingerdione and quercetin) were identified as the active ingredients, and five LZXP targets (AKT1, CYP1B1, PTGS2, MMP9 and EGFR) were found to be the crucial molecules in the treatment of GPL. This study provides a systematic and applicable method for the rapid screening and identification of the chemical constituents from LZXP, and an effective understanding the mechanism of LZXP in the treatment of GPL.
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PubMed
高影响因子
危险品化学品经营许可证（带存储）