AQUATIC TOXICOLOGY
·
2025
·
IF 4.3
Liu Yang,Xue Tang,Yongsheng Zhou,Shiniu Dai,Kexin Liu,Lina Shi,Xinli Wen
A common tire additive of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is frequently detected in freshwater. To date, the toxicity of 6PPD to aquatic organisms has mainly been based on partial life-cycle test results. However, it remains unclear whether this approach leads to an underestimation of the true environmental risk of 6PPD. Here, the effects of environmentally relevant or greater concentrations of 6PPD on the reproduction and growth of Daphnia magna were specifically compared between day 21 and the day all the maternal daphnia died, with the underlying toxic mechanisms of 6PPD also explored. 6PPD at environmental or near-natural water concentrations (5.68 and/or 9.20 µg/L) significantly decreased the total number of offspring and net reproductive rate after whole-life-stage exposure. However, such adverse effects were not observed on day 21, indicating that environmental levels of 6PPD exerted reproductive toxicity on D. magna , and short-term exposure may underestimate the environmental risk of 6PPD. Elevated malondialdehyde levels in the 5.68, 9.20 and 44.58 µg/L treatment groups, coupled with reactive oxygen species (ROS) emerging as the dominant contributors to the biomarker response index, indicated that ROS overproduction induced by 6PPD triggered lipid peroxidation despite antioxidant capacity was enhanced. Downregulation of the vitellogenin expression in D. magna exposed to 5.68, 9.2 and 44.58 µg/L 6PPD, likely resulting from competitive binding to ecdysteroid receptor based on molecular docking and molecular dynamics simulation, might compromise nutrient provisioning during embryogenesis. Coupled with oxidative stress, these dual mechanisms appeared to mediate 6PPD-induced reproductive toxicity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2011
·Vol. 29
·期 9
·1906-1910
·
IF 0.773
Lin Yan,Wenguo Yang,Lixin Li,Yang Shen,Zhiyong Jiang
A mild and facile Wittig reaction between N -substituted maleimides and aldehydes has been developed. Various synthetically valuable alkylidenesuccinimides were obtained from this one-pot reaction in high yields (up to 99%). The product was obtained by simple filtration and no extra purification was necessary. Ethanol, an environment-benign solvent, was found to be a suitable reaction medium.
研究领域:
有机化学
·
药物化学
·
绿色化学
·
合成方法学
·
medicinal chemistry
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 5
·1-12
·
IF 6.232
Dong Wenjuan,Wang Ruiping,Gong Xiaojuan,Liang Wenting,Fan Li,Song Shengmei,Dong Chuan
A far-red fluorescence “off-on” sensing strategy is described for sequential ratiometric determination of Cu 2+ and L-histidine (L-His) based on fluorescence resonance energy transfer (FRET) system. N,S,P co-doped carbon dots (N,S,P-CDs) and N-acetyl-L-cysteine functionalized gold nanoclusters (NAC-AuNCs) are used in the FRET system, which serve as energy donor and acceptor, respectively. After adding NAC-AuNCs into the solution of N,S,P-CDs, the fluorescence of N,S,P-CDs is effectively quenched, while the far-red fluorescence of NAC-AuNCs appears. Cu 2+ can decrease fluorescence of NAC-AuNCs, and then L-His can effectively recover the fluorescence of NAC-AuNCs. The possible reason is that the stronger affinity between Cu 2+ and L-His can pull Cu 2+ away from the surface of NAC-AuNCs. Through it all, the emission intensity of N,S,P-CDs remains nearly constant, so the ratio of fluorescence intensities at 485 and 625 nm exhibits a linear correlation to the Cu 2+ and L-His concentration, respectively. The sensing platform shows good selectivity towards Cu 2+ and L-His with a linear range of 0.65–26.58 μM and 3.13–56.25 μM and determination limits of 0.50 μM and 0.374 μM, respectively. The proposed method has been successfully used for Cu 2+ and L-His determination in real samples with satisfying results.
Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Chiyuan Chen,Ziqi Zhao,Feng Liu,Hongyu Yang,Xiaming Feng,Chaojun Wan
This study addresses the flammability issue of the biodegradable polyester polylactic acid (PLA) by proposing a supramolecular flame-retardant strategy. Leveraging the critical regulatory role of aromatic topology on molecular assembly and flame-retardant performance, two supramolecular flame retardants, HEMPD and HEDAN, were synthesized through hydrogen-bonding networks utilizing hydroxyethylidene diphosphonic acid (HEDP) with m-phenylenediamine (MPD) and 1,5-diaminonaphthalene (DAN), respectively. Comparative studies within PLA composites were conducted to systematically investigate the quantitative influence of aromatic structure on gas-phase/condensed-phase flame-retardant mechanisms and thermal stability. HEMPD and HEDAN achieved a UL-94 V-0 rating at additive loadings of 4 and 2 wt %, respectively. At a 4 wt % loading, both significantly enhanced the limiting oxygen index (LOI) of PLA from 19% to 24% (HEMPD) and 24.5% (HEDAN), while reducing the peak heat release rate (PHRR) by 14.94% and 11.98%, respectively. Consequently, the flame retardancy and thermal stability of PLA were markedly improved. This work provides the first mechanistic insight into the structure–property relationship between aromatic topology and the efficacy of supramolecular flame retardants, paving the way for achieving high-efficiency flame retardancy in biobased materials.
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Energy Research
·
2025
·
IF 2.4
Tianjiao Huang,Wu Xia,Fnu Joshua,Vaishnavii Subbiah Ponnusamy,Qipeng Zhang,Sachin Kumar,Ao Yu
Rational interfacial engineering is crucial to designing non-precious electrocatalysts for the hydrogen evolution reaction (HER). Here we report a Cu3N/1T-MoS2 heterojunction in which ultrathin 1T-MoS2 nanosheets are conformally grown on conductive p-type Cu3N nanocubes. Spectroscopy and microscopy reveal intimate lattice contact and interfacial strain, while XPS indicates charge redistribution across the junction. In 0.5 M H2SO4, the optimized 1:1 composite delivers an overpotential of 387 mV at 50 mA cm−2 and a Tafel slope of 57 mV dec−1, outperforming both constituents (MoS2 ≈ 456 mV; Cu3N inactive at this current density). Continuous operation for 150 h demonstrates excellent acid stability. Electrochemical impedance and double-layer capacitance analyses show the lowest charge-transfer resistance and the highest electrochemically active surface area among all samples (Cdl = 103.6 mF cm−2), corroborating rapid electron transport and abundant accessible sites. The activity enhancement arises from a p–n heterojunction with a built-in field that promotes directional electron flow to MoS2 active edges, together with strain-induced defect exposure. This work identifies Cu3N as an effective platform to stabilize conductive MoS2 and provides design rules for interface-engineered HER catalysts.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Hengyi Lu,Huanxiao Li,Chuyang Liu,Jiayi Shao,Fangqi Guo,Xiang Tian,Xiaopeng Li,Pan Ying,Yujing Zhang,Guangbin Ji
To tackle the complex electromagnetic pollution from advances in radar and network technologies, a simple, low-cost, and efficient absorbing agent has been developed. By optimizing the high-temperature sintering of the melamine/reduced iron powder composite system, we successfully created a Fe-C-N multiphase composite material with multi-level structure and dielectric-magnetic loss properties. The gas produced by the decomposition of melamine at high temperatures fosters the formation of a pore structure. Additionally, controlling the heating temperature and holding time effectively manages the phase transition path, allowing for synergistic evolution of the microstructure and regulation of the microwave-absorbing properties. The analysis of SEM images and XRD results identifies the synergistic enhancement mechanism between the multi-level structure and multi-phase. This endows a reflection loss of -75.91 dB at 5.16 GHz for samples held at 700°C for 3 hours (thickness 4.4 mm), with a maximum bandwidth of 4.92 GHz (1.6 mm). It avoids the traditional multi-step process of carbon/nitrogen doping, effectively regulating the phase transition path and microstructure evolution. This provides a new approach to develop lightweight, broadband microwave absorbing materials.
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Changlei Xia,Hongjie Chen,DongDong Wang,Shilei Ding
The development of highly efficient and stable bifunctional catalysts is of crucial importance for advancing the large-scale application of zinc-air batteries (ZABs). This present study introduces a composite catalyst composed of cobalt-based sulfides supported on nitrogen-doped graphene (Co@NG-S2), synthesized through a two-step sulfurization strategy. The first sulfurization stage was successful in achieving co-doping of sulfur (S) and nitrogen (N) while enhancing the conductivity and activity of the graphene support. The second sulfurization step promoted the uniform distribution of cobalt-based sulfides and strengthened their interfacial coupling with graphene, thereby significantly improving their bifunctional catalytic performance. Electrochemical characterization revealed that Co@NG-S2 exhibited an oxygen reduction reaction (ORR) onset potential of 0.868 V and a half-wave potential (E 1/2 ) of 0.798 V (vs. RHE). For the oxygen evolution reaction (OER), Co@NG-S2 demonstrated a low overpotential of merely 430 mV at a current density of 10 mA cm -2 , thereby demonstrating exceptional ORR/OER bifunctional activity. In addition, a liquid ZAB assembled with this catalyst achieved a peak power density of 110 mW cm -2 and exhibited cycling stability exceeding 200 hours. This study proposes a novel strategy for the synthesis of high-performance transition metal sulfide-carbon-based catalysts, demonstrating considerable promise for future applications.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 5.9
Lidong Gong,Zichao Liang,Xianling Ning,Jianan He,Junjie Huang,Runtao Li,Yuxin Yin,Ridong Li,Zhiqiang Lin
A series of novel 2,4-diarylaminopyrimidine derivatives incorporating a 3-sulfamoylbenzamide moiety were designed and synthesized as potent focal adhesion kinase (FAK) inhibitors. Three compounds ( 5f, 10b , and 10c ) demonstrated FAK inhibitory activities comparable to the reference inhibitor TAE226 . In cellular assays, most analogues exhibited significant antiproliferative effects against four FAK-overexpressing tumor cell lines (HCT116, HeLa, MDA-MB-231, and A375), with IC 50 values below 1 μM. Notably, compound 10c displayed superior potency, showing IC 50 values ranging from 0.08 to 0.31 μM across the tested cell lines, and exhibited approximately 2-fold enhanced activity over TAE226 in inhibiting HCT116, MDA-MB-231, and A375 cell proliferation. Further mechanistic studies revealed that 10c effectively suppressed colony formation, migration, and adhesion of HCT116 cells, while inducing apoptosis via ROS elevation. Molecular docking analysis suggested that the enhanced activity of 10c may arise from an additional hydrogen bond interaction with the Arg426 residue of FAK, leading to stronger binding affinity compared to TAE226 . In vivo , 10c showed good oral bioavailability and significantly inhibited HCT116 xenograft tumor growth (TGI = 62.22 % at 50 mg/kg), outperforming TAE226 (50.98 %) without inducing weight loss or hepatorenal toxicity. These results highlight 10c as a promising FAK-targeted candidate worthy of further preclinical investigation.
✓ 已验证
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 237
·期 1
·8
·
IF 3
Li Xiaoya,Zheng Ru,Duan Guangyu,Cao Zhanfang,Han Kai,Zhong Hong,Ma Xin,Wang Shuai
A poly( N -vinylpyrrolidone)-graphene oxide (NVP-GO) composite with high adsorption capacity for methylene blue (MB) was synthesized and comprehensively characterized using SEM, XRD, FT-IR, TG, elemental analysis, nitrogen physical adsorption, and XPS. The adsorption of MB onto NVP-GO was examined in relation to several variables, including contact time, adsorption temperature, initial concentration of MB, and pH. Adsorption kinetics, isotherms, and thermodynamics were thoroughly investigated. The adsorption kinetics followed the pseudo-second-order model, and the Langmuir isotherm model indicated a monolayer adsorption pattern of MB onto NVP-GO, with the maximum adsorption capacities ranging from 116.6 to 161.3 mg·g −1 at temperatures between 25 and 45 °C. Thermodynamic assessments and activation energy calculations demonstrated that the adsorption process was spontaneous, endothermic, and controlled by chemical activation. XPS analysis highlighted the significance of electrostatic interactions, n–π interactions, π–π stacking, and hydrogen bonding in mediating the adsorption mechanisms between NVP-GO and MB. Notably, NVP-GO maintained stable adsorption efficiency over three consecutive adsorption–desorption cycles, highlighting its potential as a promising adsorbent for wastewater treatment. Graphical
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Hongquan Fu,Chuan Zhang,Yujing Zhang,Zhiyan He
Tetracycline antibiotics are widely used, hard to degrade, and pose significant threats to ecosystems. While biochar adsorption presents both efficiency and cost benefits for tetracycline removal, the specific adsorption sites and underlying mechanism remain inadequately understood. This study investigates the synthesis of nitrogen/oxygen co-doped porous biochar (NSEC) by employing fifth-instar silkworm excrement (fed with formulated feed), melamine, and sodium bicarbonate as activator, through a high-temperature carbonization process. The experimental results revealed that NSEC exhibited a significantly increased specific surface area, higher nitrogen doping levels, and more surface defects, thereby boosting its tetracycline adsorption capacity. Notably, The NSEC900 sample managed to eliminate 87.6% of tetracycline from a 30 mg·L⁻¹ solution in just 2 min and retained about 98.5% after undergoing five adsorption/desorption cycles, showing outstanding stability. The thermodynamic analysis of adsorption aligns with the Freundlich model with multimolecular layer adsorption, the kinetics analysis conforms to the second-order model with an exothermic process. Pyridine nitrogen, pyrrole nitrogen, C O, and O C-OH groups as the primary adsorption sites are from the biochar surface. Furthermore, the adsorption mechanism is characterized by multimolecular layer chemisorption, mainly maintained by van der Waals interactions, hydrogen bonding, and pore filling, which collectively contribute to its high adsorption performance in actual aqueous environments. This study provides novel insights into the development of high-efficiency adsorbent materials and holds significant implications for the control of tetracycline pollution.
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Chi Lei,Qixiu Weng,Ping Song,Yingchun Zhu,Liangzhi Li,Lingzhao Kong,Lishi Yan
β-Glucosidase (BGL) is limited by the catalytic efficiency and environmental tolerance in the biomass biorefinery process. In this study, maleimide and its derivatives were used to modify BGL. FT-IR, circular dichroism, ζ-potential, ultraviolet, and fluorescence were used to characterize the conformational alteration of the thiol-modified enzyme and induced the enhancement of rigidity and substrate affinity. Molecular docking revealed that the modified BGL, especially Moc-Mal-BGL, had lower binding energy (−6.8 kcal mol–1) and shorter average hydrogen bond length (2.018 Å) with the substrate. The activity of Moc-Mal-BGL increased by 110.6% compared with native BGL and realized a 2.6-fold increase in catalytic efficiency kcat/Km (13.92 s–1/mM). The corresponding cellobiose conversion rate increased by 19.0%. Thermal stability, storage stability, solvent (GVL and DMSO) tolerance, and glucose tolerance of Moc-Mal-BGL were significantly improved. This work provides a rapid strategy to improve the catalytic efficiency and environmental tolerance of BGL and investigates the mechanism in depth.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Hui Cheng,Tong Yu,Yanhong Wang,Yang Zhao,Qinfu Zhao,Huifen Feng
The limited penetration and efficacy of chemotherapeutic agents, constrained by the distinctive pathophysiological conditions of the tumor microenvironment (TME), remain a major therapeutic obstacle. In recent years, there has been growing interest in modulating the TME to overcome these barriers, which provides a promising way for enhancing cancer treatment. To address this challenge, a multifunctional nanoparticle system (DOX/FeNHC-PEG) was developed for oxidative stress-augmented triple-modal therapy. The system was constructed by doping Fe 3+ ions and N atoms into hollow carbon nanostructures, followed by surface functionalization with NH₂-PEG and subsequent loading of doxorubicin (DOX) into its mesoporous cavities. FeNHC-PEG nanozyme exhibited remarkable multi-enzyme mimetic activities, consuming endogenous glutathione while generating substantial OH through the peroxidase (POD)-like and oxidase (OXD)-like activities, thereby intensifying tumor oxidative stress. Furthermore, the nanozyme demonstrated excellent photothermal conversion efficiency under NIR irradiation. Crucially, real-time shear wave elastography (SWE) revealed that the combined effects of photothermal therapy (PTT) and reactive oxygen species (ROS) significantly reduced tumor viscoelasticity by degrading extracellular matrix components. The change not only enhanced intertumoral drug penetration but also cooperated with persistent oxidative stress to remodel the tumor microenvironment, ultimately leading to a significant increase in chemosensitivity to DOX. Meanwhile, the localized hyperthermia further potentiated the enzyme-like activities, enabling amplified ROS generation. In vivo studies indicated that DOX/FeNHC-PEG exhibited outstanding biocompatibility and potent tumor growth suppression (95.8% ± 1.8% inhibition) with negligible systemic toxicity. The triple-synergistic therapy system represented an innovative approach for tumor microenvironment remodeling, showing considerable translational potential.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）