NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
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2020
·
IF 1.27
Yixiao Li,Jing Li,Jinfeng Du,Changfan Zhang,Xiaoyan Wang,Qingpei Xiang,Chuanfei Zhang
The thermoelectric materials working in radioisotope thermoelectric generators or space reactor power system will be exposed to neutron irradiation in space missions . Herein, the influences of neutron irradiation with doses of 10 13 n/cm 2 and 10 15 n/cm 2 on the transport properties of p- and n-type Half-Heusler thermoelectric alloys were investigated. It was found that, neutron irradiation showed negative effects on thermoelectric properties of p-type Hf 0.5 Zr 0.5 CoSb 0.85 Sn 0.15 and p-type Hf 0.5 Ti 0.5 CoSb 0.85 Sn 0.15 . But neutron irradiation had no effects on thermoelectric properties of n-type Hf 0.5 Zr 0.5 NiSn 0.985 Sb 0.015 and n-type ZrNiSn 0.985 Sb 0.015 . After 10 15 n/cm 2 neutron irradiation, the electrical conductivity , power factor and ZT of p-type Half-Heusler alloys decreased by 7–22%, which was caused by the decreased carrier concentration. However, the radiation-induced changes in the thermoelectric properties proved to be essentially healed by annealing at 773 K ~ 873 K. The anti-annealing effects were also studied.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Yu Jia,Xuehui Gao,Changqing Teng,Xiaoyu Li,Yi Liu,Mingjia Zhi,Zhanglian Hong
Hydrogen evolution reaction (HER) is a crucial half-reaction of water splitting to produce possible future energy carrier: H 2 , which is directly associated with the conversion and storage of clean energy. There is a great demand on efficient earth-abundant electrocatalysts to replace Pt, especially in alkaline medium . Herein, we report Co 2 Ni alloy anchored on nitrogen-doped carbon nanotubes (Co 2 Ni alloy/N-CNTs) as an efficient alkaline HER electrocatalyst. The alloy is prepared from a straightforward hydrothermal reaction and a post-annealing process in NH 3 atmosphere, which in situ reduces the nickel cobalt carbonate hydroxide precursor to alloy and brings N-doping to CNTs without changing original morphology. The as-obtained Co 2 Ni alloy/N-CNTs hybrids exhibit superior alkaline HER performance with a small Tafel slope of 87 mV dec −1 , high exchange current density of 0.8 mA cm −2 and a low overpotential of 100 mV to drive current density of 10 mA cm −2 , which is comparable to commercial Pt/C and surpasses numerous reported earth-abundant electrocatalysts . This electrocatalyst can also endure long-time HER process (>24 h). The excellent catalytic performance can be attributed to accelerated charge transfer, more exposed active sites and structural robustness which all benefit from the structural and component configuration that brought by alloy and N-doped CNTs.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2020
·
IF 4.65
Zhi Yang,Siqi Wang,Yuejun Sun,Yu Xiao,Li-Dong Zhao
The n -type PbTe still maintains relatively low thermoelectric performance compared with its p -type counterpart. Thus, to promote its performance in n -type PbTe, we conduct successive strategies that firstly suppressing the lattice thermal conductivity ( κ lat ) through alloying with ternary compound AgSbSe 2 , and then optimizing carrier density with Sb, Bi or I doping. In AgSbSe 2 -alloyed PbTe samples, the κ lat can be evidently reduced, and the minimum κ lat decreases from ∼1.1 Wm −1 K −1 in undoped PbTe to ∼0.8 Wm −1 K −1 in PbTe–5%AgSbSe 2 . Based on PbTe–5%AgSbSe 2 matrix, several dopants (Sb, Bi or I) are used to optimize its carrier density, and found that I element is verified to be the most effective dopant to enhance its electrical transport properties. In I-doped PbTe–5%AgSbSe 2 samples, the carrier density raises from ∼2.49 × 10 16 cm −3 in PbTe–5%AgSbSe 2 to ∼1.15 × 10 19 cm −3 in PbTe 0.992 I 0.008 -5%AgSbSe 2 , which contributes to the maximum power factor ∼14.8 μWcm −1 K −2 . Combining the reduced lattice thermal conductivity and improved power factor, the maximum ZT max and average ZT ave values in PbTe 0.992 I 0.008 -5%AgSbSe 2 are boosted to ∼1.0 at 723 K and ∼0.77 at 300–823 K, respectively. This work points out a valid avenue to improve thermoelectric transport property in n -type PbTe with separately successive strategies to adjust its thermal and electrical performance.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2020
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IF 4.192
Xiang Zhou,Yu-Mei Feng,Pu-Ying Qi,Wu-Bin Shao,Zhi-Bing Wu,Li-Wei Liu,Yi Wang,Hao-Dong Ma,Pei-Yi Wang,Zhong Li,Song Yang
Xanthomonas oryzae pv. oryzae (Xoo) is an offensive phytopathogen that can invade a wide range of plant hosts to develop bacterial diseases, including the well-known rice bacterial leaf blight. However, few agrochemicals have been identified to effectively prevent and eliminate Xoo-induced diseases. Thus, designing novel antibacterial compounds on the basis of the potential targets from Xoo may lead to the discovery of highly efficient and innovative anti-Xoo agents. Filamentous temperature-sensitive protein Z (FtsZ), an important functional protein in the progression of cell division, has been widely reported and exploited as a target for creating antibacterial drugs in the field of medicine. Therefore, the fabrication of innovative frameworks targeting XooFtsZ may be an effective method for managing bacterial leaf blight diseases via blocking the binary division and reproduction of Xoo. As such, a series of novel N-(cinnamoyl)-N′-(substituted)acryloyl hydrazide derivatives containing pyridinium moieties were designed, and the anti-Xoo activity was determined. The bioassay results showed that compound A7 had excellent anti-Xoo activity (EC50 = 0.99 mg L–1) in vitro and distinct curative activity (63.2% at 200 mg L–1) in vivo. Further studies revealed that these designed compounds were XooFtsZ inhibitors, validating by the reduced GTPase activity of recombinant XooFtsZ, the nonfilamentous XooFtsZ assembly observed in the TEM images, and the prolonged Xoo cells from the fluorescence patterns. Computational docking studies showed that compound A7 had strong interactions with ASN34, GLN193, and GLN197 residues located in the α helix regions of XooFtsZ. The present study demonstrates the developed FtsZ inhibitors can serve as agents to control Xoo-induced infections.
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AQUATIC TOXICOLOGY
·
2025
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IF 4.3
Liu Yang,Xue Tang,Yongsheng Zhou,Shiniu Dai,Kexin Liu,Lina Shi,Xinli Wen
A common tire additive of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is frequently detected in freshwater. To date, the toxicity of 6PPD to aquatic organisms has mainly been based on partial life-cycle test results. However, it remains unclear whether this approach leads to an underestimation of the true environmental risk of 6PPD. Here, the effects of environmentally relevant or greater concentrations of 6PPD on the reproduction and growth of Daphnia magna were specifically compared between day 21 and the day all the maternal daphnia died, with the underlying toxic mechanisms of 6PPD also explored. 6PPD at environmental or near-natural water concentrations (5.68 and/or 9.20 µg/L) significantly decreased the total number of offspring and net reproductive rate after whole-life-stage exposure. However, such adverse effects were not observed on day 21, indicating that environmental levels of 6PPD exerted reproductive toxicity on D. magna , and short-term exposure may underestimate the environmental risk of 6PPD. Elevated malondialdehyde levels in the 5.68, 9.20 and 44.58 µg/L treatment groups, coupled with reactive oxygen species (ROS) emerging as the dominant contributors to the biomarker response index, indicated that ROS overproduction induced by 6PPD triggered lipid peroxidation despite antioxidant capacity was enhanced. Downregulation of the vitellogenin expression in D. magna exposed to 5.68, 9.2 and 44.58 µg/L 6PPD, likely resulting from competitive binding to ecdysteroid receptor based on molecular docking and molecular dynamics simulation, might compromise nutrient provisioning during embryogenesis. Coupled with oxidative stress, these dual mechanisms appeared to mediate 6PPD-induced reproductive toxicity.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 5
·1-12
·
IF 6.232
Dong Wenjuan,Wang Ruiping,Gong Xiaojuan,Liang Wenting,Fan Li,Song Shengmei,Dong Chuan
A far-red fluorescence “off-on” sensing strategy is described for sequential ratiometric determination of Cu 2+ and L-histidine (L-His) based on fluorescence resonance energy transfer (FRET) system. N,S,P co-doped carbon dots (N,S,P-CDs) and N-acetyl-L-cysteine functionalized gold nanoclusters (NAC-AuNCs) are used in the FRET system, which serve as energy donor and acceptor, respectively. After adding NAC-AuNCs into the solution of N,S,P-CDs, the fluorescence of N,S,P-CDs is effectively quenched, while the far-red fluorescence of NAC-AuNCs appears. Cu 2+ can decrease fluorescence of NAC-AuNCs, and then L-His can effectively recover the fluorescence of NAC-AuNCs. The possible reason is that the stronger affinity between Cu 2+ and L-His can pull Cu 2+ away from the surface of NAC-AuNCs. Through it all, the emission intensity of N,S,P-CDs remains nearly constant, so the ratio of fluorescence intensities at 485 and 625 nm exhibits a linear correlation to the Cu 2+ and L-His concentration, respectively. The sensing platform shows good selectivity towards Cu 2+ and L-His with a linear range of 0.65–26.58 μM and 3.13–56.25 μM and determination limits of 0.50 μM and 0.374 μM, respectively. The proposed method has been successfully used for Cu 2+ and L-His determination in real samples with satisfying results.
Graphical abstract
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 237
·期 1
·8
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IF 3
Li Xiaoya,Zheng Ru,Duan Guangyu,Cao Zhanfang,Han Kai,Zhong Hong,Ma Xin,Wang Shuai
A poly( N -vinylpyrrolidone)-graphene oxide (NVP-GO) composite with high adsorption capacity for methylene blue (MB) was synthesized and comprehensively characterized using SEM, XRD, FT-IR, TG, elemental analysis, nitrogen physical adsorption, and XPS. The adsorption of MB onto NVP-GO was examined in relation to several variables, including contact time, adsorption temperature, initial concentration of MB, and pH. Adsorption kinetics, isotherms, and thermodynamics were thoroughly investigated. The adsorption kinetics followed the pseudo-second-order model, and the Langmuir isotherm model indicated a monolayer adsorption pattern of MB onto NVP-GO, with the maximum adsorption capacities ranging from 116.6 to 161.3 mg·g −1 at temperatures between 25 and 45 °C. Thermodynamic assessments and activation energy calculations demonstrated that the adsorption process was spontaneous, endothermic, and controlled by chemical activation. XPS analysis highlighted the significance of electrostatic interactions, n–π interactions, π–π stacking, and hydrogen bonding in mediating the adsorption mechanisms between NVP-GO and MB. Notably, NVP-GO maintained stable adsorption efficiency over three consecutive adsorption–desorption cycles, highlighting its potential as a promising adsorbent for wastewater treatment. Graphical
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2025
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IF 5.9
Lidong Gong,Zichao Liang,Xianling Ning,Jianan He,Junjie Huang,Runtao Li,Yuxin Yin,Ridong Li,Zhiqiang Lin
A series of novel 2,4-diarylaminopyrimidine derivatives incorporating a 3-sulfamoylbenzamide moiety were designed and synthesized as potent focal adhesion kinase (FAK) inhibitors. Three compounds ( 5f, 10b , and 10c ) demonstrated FAK inhibitory activities comparable to the reference inhibitor TAE226 . In cellular assays, most analogues exhibited significant antiproliferative effects against four FAK-overexpressing tumor cell lines (HCT116, HeLa, MDA-MB-231, and A375), with IC 50 values below 1 μM. Notably, compound 10c displayed superior potency, showing IC 50 values ranging from 0.08 to 0.31 μM across the tested cell lines, and exhibited approximately 2-fold enhanced activity over TAE226 in inhibiting HCT116, MDA-MB-231, and A375 cell proliferation. Further mechanistic studies revealed that 10c effectively suppressed colony formation, migration, and adhesion of HCT116 cells, while inducing apoptosis via ROS elevation. Molecular docking analysis suggested that the enhanced activity of 10c may arise from an additional hydrogen bond interaction with the Arg426 residue of FAK, leading to stronger binding affinity compared to TAE226 . In vivo , 10c showed good oral bioavailability and significantly inhibited HCT116 xenograft tumor growth (TGI = 62.22 % at 50 mg/kg), outperforming TAE226 (50.98 %) without inducing weight loss or hepatorenal toxicity. These results highlight 10c as a promising FAK-targeted candidate worthy of further preclinical investigation.
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RSC Advances
·
2024
·Vol. 14
·期 22
·15240-15248
·
IF 3.9
Yuanhui Liu,Guocheng Jin,Han Miao,Shiai Xu
Cardiovascular diseases pose a significant global health threat, and stents play a crucial role in managing these diseases. However, challenges exist with respect to the poor adhesion of stent coatings. Cardiac stents are often composed of titanium–nickel (TiNi) alloys as the metallic component and poly(n-butyl methacrylate) (PBMA) as the coating. The poor adhesion of PBMA to TiNi alloy surface may cause detachment and subsequent thrombosis post-implantation. This study utilizes Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization to synthesize a novel block copolymer, PBMA-b-PVP, composed of PBMA and poly(N-vinylpyrrolidone) (PVP). TiNi alloy surfaces are functionalized with polydopamine (PDA) to enhance polymer coating adhesion. PBMA-b-PVP exhibits a remarkable improvement in adhesion from class 5 to class 0 and high coating stability after a 15 days immersion in a phosphate buffer solution. The corrosion current density is reduced by 44% with the incorporation of PDA into PBMA-b-PVP coatings, suggesting high corrosion resistance. PDA-functionalized coatings promote cell viability without cytotoxicity, suggesting high biocompatibility. This study provides a robust strategy for preparing stent coatings with high adhesion, corrosion resistance, and biocompatibility.
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IONICS
·
2026
·
IF 3.4
Shang Dong,Ju Xiaocheng,Jia Feiyang,Pan Yuede,Muhammad Naik,Zhang Guoli,Yang Zhewei,Li Gang,Wang Congwei
This work reports the preparation of N/S co-doped titanium dioxide (N/S-TiO 2 ) via in-situ sulfur doping assisted by alkaline hydrolysis followed by subsequent nitrogen doping and the lithium storage application. TiCl 4 is used as the titanium source, and sodium sulfide (Na 2 S) solution provides the alkaline hydrolysis environment and sulfur source, thus enabling the synthesis of S doped anatase TiO 2 (S-TiO 2 ). Urea is applied as the nitrogen source under high-temperature annealing, resulting in N/S co-doped anatase TiO 2 (N/S-TiO 2 ) materials. In addition, oxygen vacancies, which might enhance the electronic/ionic conductivity, is created. Consequently, N/S-TiO 2 (10:1) exhibits excellent rate performance (85.6 mAh g − 1 at 20 C) and long-term cycling stability (116.22 mAh g − 1 after 1500 cycles at 3 C). Further analysis using cyclic voltammetry (CV), galvanostatic intermittent titration technique (GITT), and electrochemical impedance spectroscopy (EIS) shows an enhanced pseudocapacitive contribution, increased lithium-ion diffusion coefficient, and reduced charge transfer resistance. These findings provide new insights for developing high-performance, structurally tunable metal oxide anode materials.
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Membranes
·
2026
·Vol. 16
·期 7
·243
·
IF 4.2
Xinyue Ma,Yuan Li,Kuo Meng,Chengbo Kou,Binling Li,Zhonglei Zhu,Haojie Li,Zhihan Deng,Runze Yang,Hupeng Zhou,Xin Wang,Lang Luo,Fuming Chen,Chengding Gu,Yuxiao Zhang,Lu Guo
Capacitive deionization (CDI) is an environmentally advantageous desalination technology that is particularly suitable for the treatment of low- to medium-concentration saline water. Among different electrode materials, carbon materials are widely used due to their good electrical conductivity and high specific surface area, while they suffer from limited ion adsorption capacity. In this study, a cobalt/nitrogen-doped porous carbon fiber composite with Zn-induced porosity (CoNG@V@CNF), where “V” stands for “volatile pore-forming agent”, has been successfully prepared via electrospinning combined with a high-temperature carbonization process. The introduction of trace Co nanoparticles enhances the stability of porous graphene. In addition, N doping contributes to improved wettability and electronic conductivity, and the carbon fiber structure constructs a three-dimensional conductive network, providing fast channels for ion transport. Electrochemical tests show that the specific capacitance of CoNG@V@CNF reaches 252.76 F g−1, demonstrating its superior charge storage capability. Furthermore, this study achieved a high salt adsorption capacity of 58.28 mg g−1and a competitive desalination rate performance of 1.94 mg g−1min−1. After 40 cycles of testing, the salt adsorption capacity (SAC) remains at 56.72 mg g−1, demonstrating its high stability during multiple charging and discharging processes. This work provides a new design strategy for developing high-performance CDI electrode materials.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Yufeng Liu,Xiaofan Yang,Jinghua Hu,Junhao Liu,Peiwen Wu,Huifang Cheng,Huaming Li,Jixing Liu,Wenshuai Zhu
The hydroisomerization of isobutane is of considerable practical significance for the development of low-carbon and high-efficiency ethylene production technologies. However, conventional noble metal-solid superacid catalysts used for this reaction suffer from drawbacks including high cost and catalyst deactivation caused by the loss of halogen species and other active components. Herein, a series of highly dispersed W-Cu/Beta catalysts were designed and prepared via a facile ion-exchange method, and their catalytic performances toward isobutane hydroisomerization were systematically investigated. The results show that the introduction of WO x species effectively suppresses strong Brønsted acid sites of the Beta zeolite and modifies the Brønsted/Lewis acid balance of W-Cu/Beta catalysts. Although both Brønsted and Lewis acid site concentrations decrease with increasing W loading, Brønsted acidity is reduced to a greater extent, resulting in a lower Brønsted/Lewis acid site ratio. This acidity regulation is associated with suppression of undesired cracking reactions and improved selectivity toward n-butane. Under reaction conditions of 2 MPa, 380°C, and a weight hourly space velocity of 2.0 h ‒1 , the 5%W-Cu/Beta catalyst exhibits the best catalytic performance with isobutane conversion of 62.3% and n-butane yield of 32.4%. This enhanced catalytic behavior is attributed to optimized acidity and an appropriate distribution of catalytic active sites. Kinetic analyses indicate that WO x introduction alters the apparent kinetic behavior of the catalysts and is accompanied by an increase in apparent activation energy. The improved catalytic selectivity is correlated with changes in acidity distribution and suppression of cracking pathways rather than direct evidence of carbocation stabilization.
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