MATERIALS & DESIGN
·
2026
·
IF 8.2
Qingmei Zhang,Yuanming Sun,Kaitao Yao,Siyuan Cheng,Yifei Zhou,Haoyu Wang,Fei Lei,Yiran Yin,Yingfu Jiao,Weifeng Yu,Liqun Yang,Yuanhai Li,Po Gao,Xingtao Chen
A Ce 3+ -crosslinked injectable self-healing hydrogel with pH responsiveness is developed for wound analgesia and ROS removal. • Hydrogel enables rapid drug and cerium release in acidic wounds, while achieving sustained release with minimal leakage at physiological pH. • Acid-triggered cerium release achieves ≥78% ROS clearance, with the hydrogel maintaining excellent cytocompatibility (viability ≥95%) at neutral pH. • A single perilesional injection achieves 36-hour analgesia in the mouse plantar incision model, significantly surpassing free ropivacaine. • Analgesia is achieved by inhibiting TRPV1+ neuron activation in DRG and spinal dorsal horn, with reliable biosafety and intact wound healing. Since tissue acidification in wounds is tightly linked to pain and inflammation, pH-responsive hydrogels are promising candidates for local analgesia and ROS scavenging in wound management. Herein, an injectable, self-healing and pH-responsive hydrogel crosslinked by coordination bonds between cerium ions and carboxylate moieties of carboxymethyl cellulose (CMC) is developed to encapsulate ropivacaine (Rop). The hydrogel features rapid matrix dissolution accompanied by fast release of both Rop and cerium ions under acidic conditions (pH 6.2), while providing sustained Rop release and extremely limited cerium ion release at physiological pH of 7.4. These features contribute to prominent antioxidant activity (ROS clearance rate ≥78%) under acidic conditions, and excellent cytocompatibility (cell viability ≥95%) at pH 7.4. Injecting the hydrogels into mouse plantar incisions resulted in prolonged analgesia (36 h) matching their Rop release feature, alongside excellent biosafety without impairing wound repair. Immunofluorescent assays demonstrate that such analgesic effects are realized by inhibiting the activation of TRPV1 + neurons in the DRG and neurons in the spinal dorsal horn. These findings provide an injectable, self-healing and pH-responsive hydrogel crosslinked by cerium ion coordination for local anesthetic loading and antioxidation in wound healing. Download: Download high-res image (104KB) Download: Download full-size image
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PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Peng Xu,Xinwei Wang,Tianguan Wang,Xinyu Zhao,Jingsha Tan,Wenfeng Ge,Bo Zhang,Guozhe Meng
To overcome the limited protective performance of waterborne epoxy (WEP) coatings, a novel scalable cerium-polyphenol-amine ternary system (Ce-TA-PEI, CTP) was synthesized via a simple dynamic supramolecular self-assembly strategy. The material effectively anchored corrosion-inhibiting cerium ions within its network through cerium-phenolic coordination, achieving an exceptionally high cerium loading capacity of 20.3 wt%. The polyphenol–amine crosslinked network of the CTP nanocontainer can form chemical bonds with the epoxy matrix, ensuring good interfacial compatibility and significantly reducing the intrinsic defects of the coating. Consequently, the dry and wet adhesion strengths of the coating increased to 3.13 MPa and 2.99 MPa, respectively. After 60 days of immersion in 3.5 wt% NaCl solution, the | Z | 0.01Hz value of CTP2/WEP remained as high as 1.21 × 10 9 Ω·cm 2 , more than an order of magnitude greater than that of pure WEP (1.05 × 10 8 Ω·cm 2 ). In addition, UV–Vis analysis confirmed that CTP is pH-responsive and can sustain continuous cerium release for up to 144 h. This behavior arises from changes in coordination strength between cerium ions and phenolic hydroxyl groups, together with variations in electrostatic interactions within the CTP framework under different pH conditions, which promote rapid cerium release in acidic environments. When incorporated into WEP coatings, this “smart” nanocontainer responded dynamically to localized acidic corrosion at coating defects. It not only enhanced the physical barrier properties of the coating but also imparted active self-healing functionality. This work therefore provides a new strategy for advancing environmentally friendly WEP coatings toward broad engineering applications.
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Food Chemistry-X
·
2026
·
IF 9.2
Hui Teng,Minyi Yan,Chong Chen,Chao Ai,Huangjuan Huo,Lei Chen
In this study, chitosan-modified dihydromyricetin liposomes (CHI-DMY-Lips) were developed via electrostatic adsorption to overcome the low bioavailability of dihydromyricetin (DMY). Employing conventional DMY liposomes (DMY-Lips) as controls, a comprehensive assessment was conducted on the physicochemical properties, activity preservation, in vitro release kinetics, as well as the structural stability and bioaccessibility during simulated gastrointestinal (GI) digestion of the delivery system. CHI-DMY-Lips exhibited a positive surface charge with larger size, more uniform distribution, and higher encapsulation efficiency (54.00% compared to 41.01% in DMY-Lips). The encapsulation by liposomes preserved the antioxidant activity of DMY, whereas CHI further augmented its activity through synergistic effects. CHI-DMY-Lips presented enhanced structural and electrostatic stability during storage and superior in vitro sustained-release performance (especially at pH 7.4). Besides, CHI-DMY-Lips retained structural integrity throughout GI digestion and preserved its effective concentration and activity, resulting in a bioaccessibility approximately threefold that of free DMY (25.97% vs. 9.73%).
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高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Jiepei Lin,Min You,Xinbei Lv,Vanessa Vimbiso Mavhunure,Qinying Wang,Ziqing Tang,Hui Yu,Qiang Chen,Feng Lin,Huijuan Hu
Intrauterine adhesion (IUA) leads to abortion and infertility that poses a severe threat to female reproductive and psychological health. The highly oxidative microenvironment and fibrosis of the endometrial wound are critical factors driving IUA pathogenesis. Here, a pH and reactive oxygen species (ROS) dual-responsive hydrogel (DRH) with antifouling property, which could be gelated in situ click chemistry, was developed to effectively treat IUA via anti-oxidative and anti-fibrosis. This DRH was prepared by a dual-crosslinking structure, which was based on the thiol-ene click chemistry reaction of poly(ethylene glycol) diacrylate (PEGDA), 4-arm poly(ethylene glycol) acrylate (4-arm-PEG-AC) and dithiothreitol (DTT), coupled with borate ester bonds between borax and DTT. This DRH presented excellent antifouling and good ROS scavenging, which reduced protein and cell adhesion, as well as alleviated oxidative stress. Additionally, the DRH also exhibited pH and ROS responsiveness, enabling degradation in the intrauterine microenvironment. In the rat endometrial injury model, the DRH successfully exerted an effective therapeutic effect on IUA, and thus eventually restored fertility by attenuating the endometrial oxidative damage, inhibiting the activation of myofibroblasts, and reducing epithelial-mesenchymal transition.
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Foods
·
2026
·Vol. 15
·期 13
·2401
·
IF 6
Huiqiong Wu,Yuxuan Zhu,Huan Liu,Yingying Deng,Zhipeng Wang,Hongning Liu,Zhe Li,Liangshan Ming
This study developed a pH-responsive dual-network polyvinyl alcohol (PVA) active packaging film by integrating cellulose nanocrystal (CNC)-stabilizedMosla chinensisessential oil (EO) emulsions with a tannic acid–Fe3+metal–phenolic network (MPN). The CNC-stabilized emulsion improved EO dispersion and retention in the PVA matrix and contributed to network reinforcement through hydrogen-bonding interactions, while the dynamic MPN further strengthened the film structure and acted as a pH-gated domain for regulating EO release. Composite film achieved high UVA and UVB blocking efficiencies of 90.06% and 99.60%, respectively, together with improved mechanical, barrier, antioxidant, and antibacterial properties. Compared with neutral conditions (pH = 7), EO release increased by 179.9% and 181.3% at pH = 4 and pH = 9, respectively, confirming the pH-gated release behavior of the film. In yam preservation, composite film effectively delayed browning, weight loss, firmness decline, and spoilage. Metabolomic analysis further indicated that the film treatment regulated phenylpropanoid metabolism and flavonoid biosynthesis, which may contribute to maintaining antioxidant-related metabolic homeostasis. This work offers a pH-responsive controlled-release active packaging strategy for browning-prone fresh produce.
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高影响因子
Scientific Reports
·
2026
·
IF 4.9
Jafari Seyed Mostafa,Masoum Saeed,Hosseini Elahe Seyed
In recent years, carbon dots have attracted considerable attention within the nanocarbon family due to their remarkable advantages and interesting properties such as high solubility, biocompatibility, tunable photoluminescence, and so on. Carbon dots can also be designed and synthesized according to the desired functionalities (such as sensors, biosensors, or drug delivery systems). In the present study, nitrogen- and boron-co-doped carbon dots (abbreviated as “NBCDs”) were successfully used as highly fluorescent and efficient nanocarriers to load two hydrophobic anticancer drugs, namely curcumin (CUR) and paclitaxel (PTX). The NBCDs were characterized before and after conjugation with CUR and PTX using spectroscopic techniques. After calculating the drug loading capacity (LC%) and adsorption efficiency (AE%) of the NBCDs nanocarriers, the drug release behavior was evaluated in two buffer media (pH 5.0 and pH 7.4) using the dialysis bag method for 72 h. Finally, the pH-dependent release behavior of the drugs was analyzed using several kinetic models.
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高影响因子
ChemSusChem
·
2026
·Vol. 19
·期 13
·e70866
·
IF 5.9
Guyu Xiao,Yile Li,Jiayue Lu,Wenli Zhang,Fangbao Fu,Qiyu Liu,Xueqing Qiu,Yuhe Liao
Lignin, the most abundant aromatic biopolymer in nature, holds great promise for carbon-neutral materials development yet is limited by its inherent dark color and poor solvent stability. Transforming it into uniform lignin colloidal spheres (LCSs) with ordered arrays enables specific visible light reflection and thus presents tunable colors. However, industrial lignin-derived LCSs via self-assembly typically exhibit broad size distribution and poor solvent resistance. To address these challenges, we proposed a novel strategy combining solvent fractionation and surface covalent polymerization. Acetone/water fractionation effectively reduced lignin heterogeneity, narrowing LCSs size distribution. Bisphenol A diglycidyl ether (BADGE) was used as cross-linker to covalently polymerize hydroxyl groups, inhibiting LCSs dissolution. Two hybrid LCSs were fabricated: hy-LCSs via co-self-assembly of lignin and BADGE and hy@LCSs through subsequent surface cross-linking. Hy-LCSs20 (20 wt% BADGE) shows stability in pH 12 alkali and acetone/water, while hy@LCSs70 exhibited unprecedented alkaline resistance up to pH 14, far exceeding the highest reported value of pH 12 for lignin colloidal spheres to date. Critically, BADGE incorporation preserved monodispersity of both hy-LCSs20 and hy@LCSs70, enabling precise size control without compromising uniformity. After centrifugation to form ordered structures, both hy-LCSs20 and hy@LCSs70 reflect specific wavelengths with tunable colors, overcoming key barriers in lignin valorization. Graphical This study developed a method to produce lignin-epoxy hybrid colloidal spheres via a co-self-assembly process between fractionated enzymatic hydrolysis lignin and BADGE. The formed hybrid lignin colloidal spheres performed narrow size distribution which can be used as photonic materials, together with an exceptional alkaline resistance (up to pH 14), overcoming key barriers in lignin valorization for sustainable materials.
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Gels
·
2026
·Vol. 12
·期 8
·718
·
IF 6.4
Qingqing Xue,Yingli Li,Qing Ao,Guowang Chang,Yang Ji,Shizhang Chen,Ze Wang,Zifan Wang,Zhiqiang Li,Lei Zhao
Conventional microsphere drug carriers for ulcerative colitis (UC) face challenges such as limited residence time, variable drug release, and an increased risk of systemic exposure and side effects. In this study, pH-sensitive, core–shell hydrogel microcapsules were designed and fabricated using a BUCHI B-390 microsphere preparation device via electrostatic interactions and hydrogen bonds. Olsalazine sodium was encapsulated in the microcapsules, allowing for pH-responsive drug release in colon tissue for UC treatment in mice. XRD studies demonstrated the amorphous state of the drug in the formulation. The preparation of SCO microcapsules was optimized based on the drug encapsulation efficiency and the drug loading capacity, with the S2C1O microcapsule having the highest drug encapsulation efficiency (59.2%) and drug loading capacity (21.3%), and the production yield was approximately 62.5%. The degradation experiment results indicated that the alginate/CMCS hydrogel shell has anti-resistant and colon-targeted properties, with minimal drug leakage under acidic conditions (0.1% release at 2 h, pH 1.2) and rapid, controlled release at colonic pH (7.4) (cumulative release of 68.7% at 12 h), protecting the drug from gastric degradation. An in vivo experiment suggested that treatment with these microcapsules in UC mice significantly reduced inflammatory markers (NF-κB p65 was reduced by 18.8% relative to the free drug group) and histological damage in UC models relative to free drug administration. The improved therapeutic efficacy is linked to precise localization in inflamed tissue, reducing systemic exposure and off-target effects. Overall, in vitro and in vivo studies demonstrated that this microcapsule system provides a promising alternative to existing UC drug delivery systems.
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BIOMACROMOLECULES
·
2026
·Vol. 27
·期 8
·5581-5602
·
IF 5.9
Shahid Muhammad,Niaz Mujahid,Ghazal Huma,Naz Tehmina,Munawar Noshaba,Zhong Zhihao,Chen Shihai,Zhang Ping,Guo Lianhong,Zhu Jie
Hydrogel dressings have emerged as versatile platforms
for wound
management. However, effective treatment remains challenging due to
complex wound environments involving hemorrhage, bacterial infection,
and inflammation. Herei, a multifunctional pH-responsive hydrogel
(PCOB 1) was developed via multinetwork cross-linking and freeze–thaw
cycles using oxidized pullulan (OP), collagen, poly(vinyl alcohol)
(PVA), and borax, and was impregnated with in situ stabilized silver nanoparticles (AgNPs). The incorporation of AgNPs
endowed the hydrogel with pH-triggered antibacterial activity, achieving
>99% killing of E. coli and S. aureus , efficient biofilm disruption, >90%
ROS/RNS
scavenging, and catalase-mimetic activity. The hydrogel demonstrated
rapid gelation, self-healing, and hemostasis within 33.3 s. The hydrogel
promoted macrophage polarization from M1 to M2, enhanced collagen
deposition, re-epithelialization, and granulation tissue formation,
achieving 98.5 ± 0.6% wound closure by day 14 in vivo . This study presents a multifunctional hydrogel with antibacterial,
antioxidant, and anti-inflammatory properties for accelerated wound
healing.
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ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 14
·11654-11668
·
IF 5.2
Huang Junjie,Long Haibo,Gu Jin,Zhou Yonghui,Lin Xiuyi,Xu Jiangtao,Hu Chuanshuang
Lignocellulosic
residues, particularly those with a high hemicellulose
content, represent a hitherto underutilized resource for the production
of functional materials. Camellia oleifera shells (COS) have been identified as a potentially valuable feedstock
for the production of value-added materials. In this study, carbon
quantum dots (CQDs) were synthesized efficiently from COS holocellulose
(COSH) by a microwave-assisted method using urea and malic acid as
auxiliary reagents. The obtained carbon quantum dots (CQDs) exhibited
uniform particle sizes (3–5 nm), clear lattice fringes, and
abundant surface functional groups, together contributing to pronounced
pH-dependent fluorescence behavior. Meanwhile, the preparation of
biodegradable regenerated COSH films (rCF) involved the dissolution
and regeneration of COSH in 1-butyl-3-methylimidazolium chloride ([Bmim]Cl).
The incorporation of 2 wt % ascorbic acid during the dissolution process
has been shown to effectively mitigate thermo-oxidative degradation,
thereby facilitating the regeneration of films that exhibit enhanced
crystallinity, a more compact structure, and augmented mechanical
strength (up to 92.19 MPa). The anchoring of CQDs onto rCF resulted
in the fabrication of a flexible and fully biodegradable pH-responsive
composite film. The resulting CQD-loaded regenerated COSH film (C-rCF)
exhibited rapid, reversible, and visually distinguishable fluorescence
changes over a pH range of 3–11. This study provides an efficient
and environmentally friendly route for converting agricultural waste
into functional holocellulose-based materials, offering a basis for
the development of a biodegradable fluorescent composite film.
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CONSTRUCTION AND BUILDING MATERIALS
·
2026
·
IF 8.9
Jun-Feng Su,Qin-Yu Xing,Xiao-Nan Su,Peng Yang,Xin-Yu Wang,Zhi-Yong Tan
This study introduces a paradigm shift in asphalt technology by developing a sustainable bitumen material with autonomous self-nourishing and self-healing capabilities. The innovation centers on pH-responsive microcapsules, engineered with a chitosan/sodium alginate (CS/SA) shell to encapsulate waste soybean cooking oil (WSCO). Unlike conventional passive shells, this intelligent design leverages the local acidification from bitumen oxidative aging as an intrinsic trigger. The microcapsules, fabricated via coaxial electrospray (20–50 μm, 91.5 % encapsulation efficiency), demonstrated excellent thermal stability (up to 250 °C) and mechanical robustness. They exhibited a remarkable pH-triggered release: cumulative WSCO release reached 78.3 % at pH 4.0 over 96 h, compared to only 12.5 % at pH 7.0. In bitumen, this dual functionality was conclusively validated. The self-nourishing action significantly mitigated aging, with 5.0 wt% microcapsules reducing the complex modulus increase after aging to just 43 % versus 1142 % for neat bitumen. Simultaneously, the self-healing efficiency reached 68.4 % with 4.0 wt% microcapsules, maintaining 58.9 % after five healing cycles. This synergistic proactive and reactive system, which effectively upcycles waste oil, offers a transformative solution for drastically prolonging pavement service life and enhancing the sustainability of infrastructure materials.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Xiao-Qing Ling,Xin-Yan Zhao,Qi-Yan Lv,Jun-Yang Chen,Hai-Yang Dai,Hui-Fang Cui,XiaoJie Song
Cuproptosis has gained significant attention in cancer therapy. Use of copper-overloaded combination therapy that employs a variety of cell death mechanisms has emerged as a promising avenue in the treatment of cancer. However, integrating different modes in a system with optimal synergy and minimal side effects remains a challenge. In this study, a multifunctional copper ion-overloaded nanoparticle was fabricated via one-pot self-assembly for enhanced cuproptosis, chemo- and phototherapy. Molecular dynamics simulation was performed to study the self-assembly mechanism, demonstrating they assembled into stable nanoparticles (NPs) in 50 ns. The NPs possess dual-targeting capabilities towards tumor cells and mitochondria, and exhibit excellent stability in neutral PBS, while showing responsive payload release under acidic conditions or NIR laser irradiation. Upon reaching the mitochondria, the NPs release their payloads, where accumulated copper ions trigger aggregation of lipoylated proteins, etc. Released disulfiram chelates excessive copper ion to form toxic Cu(DTC) 2 , which induces apoptosis combining with hydroxycamptothecin. Meanwhile, indocyanine green-generated ROS and photothermal effects further enhance cuproptosis for synergistic therapy. In vitro results revealed potent cytotoxicity of the NPs against CT26 cells while negligible effects on normal cells. Furthermore, significant reactive oxygen species generation, mitochondrial membrane potential alteration, increased apoptosis, and modulated protein mRNA expression levels, confirmed the synergistic combination of chemotherapy, cuproptosis, and photothermal/photodynamic therapies. Notably, in vivo experiments demonstrated selective tumor accumulation and outstanding antitumor efficacy (89.5% inhibition rate) with excellent biosafety profile. The NPs provide a novel strategy for cuproptosis-based combination cancer therapy and shows significant clinical translation potential.
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