BMC MICROBIOLOGY
·
2026
·
IF 5.4
Ru Yi,Yu Ying,Liu Chuanxin,Liu Yunge,Liu Dongxia,Chen Ruyan,Chen Xiaowan,Bai Xiaoyang,Jiang Tao,Duan Jiajia
Podophyllotoxin (PPT) is a naturally occurring plant-derived insecticide, yet its potent cytotoxicity raises concerns regarding potential neurobehavioral toxicity in non-target organisms. However, the underlying mechanisms remain largely unclear. This study aims to investigate the neurotoxic effects of PPT in zebrafish. Three-day post-fertilization wild-type AB strain zebrafish were exposed to six concentration gradients of PPT (0.997–31.2 µg/mL). Based on the determined LC10 and MNLC values, four concentrations including 0.140, 0.420, 1.26, and 1.57 µg/mL were selected for intestinal-brain toxicity assessments and color preference tests were conducted. Histopathological damage in brain and intestinal tissues were evaluated through hematoxylin-eosin and acridine orange staining techniques. Subsequently, based on the maximum non-lethal concentration of 1.26 µg/mL, the mechanisms were further investigated using 16S rRNA sequencing, HM700 targeted metabolomics, and bulk RNA-seq, with key genes being validated via quantitative PCR. Correlation analysis was employed to elucidate the relationships among gut microbiota, differential metabolites, and gene expression. Our results showed that zebrafish exposed to various concentrations of PPT for 2 days exhibited significant intestinal and neurotoxic effects, including alterations in color preference behavior and structural damage in both the brain and intestinal tissues. 16S rRNA sequencing revealed reduced gut microbial diversity and increased levels of Acinetobacter and Perlucidibaca . Metabolomic profiling revealed that PPT disrupts purine metabolism, significantly reducing neuroprotective metabolites like adenosine and inosine, while increasing neurotoxic compounds such as quinolinic and oxalic acids. Transcriptomic analysis showed that genes associated with neuronal damage and inflammation were affected. qPCR confirmed that PPT exposure suppresses genes crucial for synaptic function (gad1b, drd2b) and upregulates genes related to the complement pathway (c3a.1, c1qc) and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α). Correlation analysis linked changes in gut bacteria, Acinetobacter and Perlucidibaca , to altered purine metabolism and genes involved in synaptic and inflammatory pathways. These findings suggest that PPT-induced neurotoxicity is associated with alterations in gut microbial composition, dysregulation of purine metabolism, and changes in neuroinflammatory and synaptic-related pathways. This study highlights the potential association between microbiota-gut-brain axis disturbances and PPT-induced neurotoxicity and provides new insights for evaluating its environmental health risks. Graphical The alternative text for this image may have been generated using AI.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Huang Ju,Zhu Jianqiu,Liu Bowen,Dai Chencheng,Chen Zhimin,Wu Hao,Li Gang,Du Shichao,Wang Jian-Qiang,Ren Zhiyu,Xu Zhichuan J.,Fu Honggang
Achieving high selectivity in the electrocatalytic hydrogenation (ECH) of concentrated 5-hydroxymethylfurfural (HMF) to 2,5-dihydroxymethylfuran (DHMF) remains a challenge due to competitive adsorption at high HMF concentrations, which limits active-site availability and suppresses *H generation. Regulating the balance between *H generation and HMF adsorption is therefore essential for maintaining selectivity under practical conditions. Here we show a surface amide-functionalized copper nitride catalyst (Ami-Cu 3 N) featuring dual-nitrogen active sites. The catalyst achieves >99% DHMF selectivity and >98% Faradaic efficiency, with a production rate of 63.4 mmol cm -2 h -1 at 500 mA cm -2 under concentrated HMF conditions. Mechanistic studies indicate that the combined roles of lattice nitrogen (promoting water dissociation) and amide nitrogen (modulating HMF adsorption) lower the energy barriers for both *H formation and HMF hydrogenation, facilitating high activity and selectivity. In addition, a coupled electrolysis system enables simultaneous production of value-added products at both electrodes. These findings provide design principles for electrocatalysts that enable selective biomass conversion at high reaction rates.
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高影响因子
Nature Nanotechnology
·
2026
·
IF 37.5
Huang Yuan,Wang Zeyu,Chen Xi,Gu Lin,Xiao Hai,Liu Qingda,Wang Xun
Industrial seawater electrolysis remains constrained in achieving both high catalytic activity and long-term durability, with key limitations including structural degradation and mechanical instability within catalyst layers. Here we show a self-adhesive high-entropy oxide sub-nanowire monolithic catalyst that overcomes both obstacles. The catalyst is synthesized under mild conditions and incorporates 14 metal elements into uniform ~1.2 nm sub-nanowires with strong intrinsic adhesion to conductive substrates, eliminating the need for external binders. It also features unconventional active sites that enable efficient and durable lattice oxygen activation while preserving structural integrity during prolonged operation. It exhibits overpotentials of 129 mV in 1 M KOH and 153 mV in 1 M KOH + seawater at 10 mA cm −2 , and maintains continuous operation at 1,000 mA cm −2 for 4,700 h and 4,400 h, respectively. Integrated into an anion exchange membrane seawater electrolyser, it delivers 3,000 mA cm −2 at 1.70 V (80 °C) and operates continuously for over 3,819 h at 2,000 mA cm −2 under ambient conditions.
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Nature Communications
·
2026
·
IF 18.1
Ali Mohamed. A.,Mohamed Moushira. A.,Chen Yujie,Ju Zhijie,Deng Renren,Gu Lin,Li Boyuan,Deng Lu,Yang Lei,Gao Lina,Liu Xiaofeng,Yue Yuanzheng,Qiu Jianrong
Vitrification-devitrification process often results in the formation of translucent/transparent bulk glass-ceramics/ceramics with functionalities comparable to their crystalline counterparts. Here we show a significant enhancement and tunability of luminescence in Mg 2 Al 4 Si 5 O 18+1.5 x : x Eu 2+ (MAS: x Eu) powders after being subjected to a vitrification-devitrification protocol. In MAS: x Eu powders, Eu 2+ occupies multiple-sites in MAS hollow channels, demonstrating tunable blue-to-yellow emissions with red-afterglow. After vitrifying-devitrifying MAS: x Eu powders, the derived ceramics showcase red-emissions with a near-unity luminescence efficiency, higher-thermal stability, and longer-persistent luminescence, enabling the fabrication of red-emitting lighting device with an ultrahigh brightness. The luminescence enhancement is ascribed to the increase of oxygen-related defects in the network during vitrification process that facilitates an efficient trapping-detrapping process. From structural analyses, the luminescence tunability can be attributed to the change in the heterogeneous structure of the channel wall, amending the distribution of Eu 2+ multiple-sites. Thus, our approach has opened a new avenue for advancing the design of high-performance luminescent materials.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Xu Wenzhe,Gao Pengfei,Wu Jianfeng,Du Ran,Li Mengtao,Tang Lingfeng,Li Mingrui,Feng Na,Zhang Baoliang,Lu Zongjing,Zhang Lei
Electrosynthesis of 1,3-butadiene from acetylene offers a promising alternative to energy-intensive industrial processes. Nonetheless, achieving selective hydrodimerization of acetylene remains challenging due to competing side reactions, particularly for dilute coal-derived acetylene. Herein, we synthesize a series of dicopper paddlewheel Cu 2 (LCOO) 4 (L = tert-butyl, isopropyl, ethyl, and methyl), featuring bidentate bridging carboxylate ligands with specific Cu···Cu distances for electrocatalytic hydrodimerization of acetylene to 1,3-butadiene. Through catalyst benchmarking, in situ spectroscopy and computational analysis, we reveal that sequential modulation of carboxylate ligands (methyl → ethyl → isopropyl → tert-butyl) progressively enriches electron density at dicopper sites while strengthening structural robustness across the Cu 2 (LCOO) 4 series. The optimized Cu 2 (tert-butylCOO) 4 exhibits favorable reaction energetics for acetylene dimerization and subsequent hydrogenation, achieving 91% Faradaic efficiency with a 1,3-butadiene formation rate of 0.93 mmol h −1 cm −2 in a flow cell. For simulated production of 1,3-butadiene from coal-derived acetylene (15%) in a membrane electrode assembly system, this catalyst demonstrates 83% Faradaic efficiency at −300 mA. This work highlights an effective coordination modulation strategy for producing 1,3-butadiene via dicopper molecular catalysts.
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JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 5
·205
·
IF 3.5
Zhu Yimin,Liu Hanxiao,Wang Ruijie,Ma Ke,Dong Yan,Wang Cuiping
Hydrogel is a kind of three-dimensional network gel with water as its core dispersion medium. It is constructed by complex interactions of covalent bonds and non-covalent bonds. Traditional hydrogels usually exhibit soft and fragile mechanical properties, and are difficult to meet the requirements in a variety of practical application scenarios. In this work, 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS), 2-hydroxyethyl methacrylate, and methacrylamide monomer were synthesized through the “one-pot method”, which simplifies the tedious steps of preparation. Then, the hydrogels’ mechanical modification was carried out by adding different ratios of polyvinyl alcohol (PVA). The tensile strength and load-bearing properties of the prepared hydrogels were significantly enhanced as PVA content increased. Meanwhile, the introduction of crosslinking agent N, N’-methylenebisacrylamide (BIS) resulted in a more compact molecular cross-linking network within the hydrogels. The highest tensile strength of the hydrogels was 0.65 MPa, and the maximum bearing capacity was 8.75 kg. In addition, fluorescent components were observed no effect on the hydrogels’ performances, such as mechanical properties and electrical conductivity. The realization of this multi-color hydrogel has contributed to its application in fields such as biomedical, anti-counterfeiting, flexible devices, and other fields.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·347
·
IF 5.4
Li Xiaoming,Mao Qiu,He Lin,Zhang Zhengwei,Liu Dongmei,Liu Lu,Ju Pan,Ding Shijia,Li Siqiao,Luo Rong
Bimetallic Fe/Mo-doped carbon dots (Fe/Mo-CDs) have been developed as a high-performance nanozyme to construct a self-validating dual-mode (colorimetric/fluorometric) platform for hydroquinone (HQ) detection. The Fe/Mo-CDs exhibited strong peroxidase-like activity, catalyzing H 2 O 2 -mediated TMB oxidation to generate oxTMB, which simultaneously yields a colorimetric signal and quenches the fluorescence of Fe/Mo-CDs through a confirmed FRET process. The introduction of HQ competitively scavenges the essential reactive oxygen species, inhibiting oxTMB formation and triggering synchronous signal inversion in both channels. This endogenous self-validating function enables favorable analytical performance, with wide linear ranges and ultralow detection limits (0.03 µM for colorimetric; 0.016 µM for fluorometric). Successful application in commercial creams with satisfactory recoveries underscores its strong potential for accurate and reliable screening in complex samples. This work not only presents a sensitive sensor for HQ but also offers a novel design strategy for developing intelligent, self-validating biosensing systems.
Section
Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 22
·15926-15939
·
IF 4.4
Feng Yu,Sun Jun,Xu Ruonan,Zhang Wenchao,Liu Baicen,Yue Dong,Yao Yuanhang
The advancement of dielectric capacitors toward achieving high-energy storage density requires polymer-based dielectric materials with both high breakdown strength ( E b ) and high dielectric constant ( ε r ). However, the inherent trade-off between E b and ε r limits further enhancement of energy storage density. In this study, a design approach involving inorganic fillers with gradient dielectric matching is proposed for a double core–shell structure. Barium calcium zirconate titanate (BZCT) nanofibers are utilized as fillers within a double core–shell structure (BT + SiO 2 ), embedded into a polyetherimide (PEI) matrix through electrostatic spinning with an oriented arrangement. This results in the fabrication of BZCT nanofibers PEI-based composite dielectrics with parallel double core–shell structure, demonstrating exceptional energy storage performance. Specifically, the composite dielectric (0.5%-10% BZCT@BT@S/PEI) achieves a charge/discharge efficiency ( η ) of 93.29% and a discharge energy density ( U e ) of 6.97 J/cm 3 with BT and BZCT contents of 0.5% and 10%, respectively. The results show that BZCT enhances the ε r of the composite dielectric, while the double core–shell structure of BT + SiO₂ leads to a gradient change in ε r . This strategy not only can reduce the electric field( E ) distortion caused by the dielectric mismatch between the PEI matrix and BZCT, but also the double core–shell structure shows a relatively significant synergistic effect, successfully increasing the E b of the composite dielectric, with simulation results supporting the design rationale behind the double core–shell structure. This investigation introduces an insight for designing energy storage composite dielectrics. Graphical abstract The alternative text for this image may have been generated using AI.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.9
Sun Zhiguo,Wang Honglong,Wang Xiaoguang,Li Jiali,Lin Qinghua,Tian Fuliang
EB irradiation is widely used for starch modification. Nevertheless, modification mechanism and level are blurry especially at a higher dose irradiation, restraining deep functional material design. In this work, pure corn starch was irradiated by an EB in air with dose up to 500 kGy. Then, microstructural and physicochemical property variations were explored via FT-IR, XPS, 13 C-NMR, GPC, XRD, SEM, whiteness, TGA and viscosity analysis. Later, its post acceleration effect was explored via AA grafting. Main results reveal that irradiation induced severe starch backbone scission. Cleavage mainly occurred at α -1,4 glycosidic bond and the link of C-1 and C-2 atoms within starch glucose unit. Upon 500 kGy irradiation, number-average molecular mass- Mn -decreased from 2.56 × 10 5 to 1.33 × 10 3 Da, conversing macromolecule to small molecule debris. Certain hydroxyls were oxidized to carbonyls. Molecule chain stacking regularity was destroyed. Amorphization occurred shown a crystallinity reduction close to 34%. Synchronously, color be darken, cracks and micropores were generated, thermal-stability and viscosity decreased. In details, whiteness and viscosity decreased from 91.3 ± 0.1 and 1539 ± 5 to 45.3 ± 1.6 and 0 mPas and the fastest speed thermal-decomposition temperature decreased by 6 °C. It seems a dose of 500 kGy EB irradiation deteriorated starch microstructure and physicochemical property sufficiently. However, it promotes post AA grafting efficiently. Via a dose of 100 kGy EB irradiation and certain level AA grafting a QH 2 O as 687.9 ± 19.5 sample was achieved, showing a 1.16 times elevation compared to sample without pre-irradiation, implying sufficient acceleration effect. These findings promote EB irradiation technology use in starch-based functional material design and starch irradiation damage mechanism, sustaining visible use and academic values. In addition, the prepared grafted product possibly sustains a use application in agriculture field, sustaining potential commercial profit, attractive.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 23
·16347-16362
·
IF 4.4
Yuan Yong,Qi Wenjuan,Xu Junjie,Ge Chuntao,Jin Weiliang,Zhang Jun,Xiao Saijun
To address the high-temperature oxidation of carbon/carbon (C/C) composites, this study employed a novel molten salt electrophoretic deposition (MS-EPD) technique to fabricate a zirconium diboride (ZrB 2 ) anti-oxidation coating. Using ZrB 2 nanoparticles synthesized in situ in molten salt as a precursor, a uniform and dense coating with a thickness of approximately 50 μm and good adhesion to the substrate was obtained at an optimized deposition voltage of 1.0 V. The coating exhibited excellent mechanical properties, with its nano-hardness and elastic modulus reaching as high as 35.8 and 510 GPa, respectively, and a critical adhesion load with the substrate of 10.8 N. This technique demonstrated high efficiency, with an average deposition rate of up to 0.865 μm/min. High-temperature oxidation tests revealed that the coating forms a ZrO 2 –B 2 O 3 composite oxide layer above 973 K, effectively blocking oxygen ingress. The coating continued to provide effective protection for the substrate after isothermal oxidation at 1173 K in an air atmosphere for 5 h. This research confirms that MS-EPD is an efficient, feasible, and promising technique for preparing high-performance anti-oxidation coatings on C/C composites.
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CATALYSIS LETTERS
·
2026
·Vol. 156
·期 6
·150
·
IF 2.5
An Bote,Song Xinran,Wang Shu,Yang Lu,Qu Peifan,Zhang Yubin,Liu Yan,Nan Yanli
Non-noble metal single-atom catalysts (SACs) have emerged as promising alternatives to Pt-based catalysts for the oxygen reduction reaction (ORR) due to their high atomic utilization and low cost. Nevertheless, the facile aggregation of metal atoms during synthesis severely reduces the density of active sites, thereby restricting their practical application in metal-air batteries. Herein, we fabricated a highly dispersed Fe single-atom catalyst (Fe-N-C) anchored on honeycomb-structured carbon (HCC). The synergistic effect of low iron content, physical confinement of honeycomb carbon, and chemical anchoring of nitrogen sites effectively inhibits metal atom aggregation and maximizes the atomic dispersion of Fe active sites. Benefiting from the ordered honeycomb porous structure and high atomic utilization, the as-synthesized Fe-N-C exhibits an outstanding half-wave potential of 0.875 V even at a low Fe loading. Notably, when applied as the air cathode in a flexible solid-state zinc-air battery, this catalyst delivers a peak power density of 160.7 mW cm − 2 , outperforming most reported non-noble metal ORR catalysts to date. This work provides a feasible strategy for the fabrication of highly dispersed single-atom catalysts for high-performance flexible energy conversion devices. Graphical The alternative text for this image may have been generated using AI.
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BMC Chemistry
·
2026
·
IF 5.1
Yang Xiaoyu,Zhao Chaoyue,Ding Yiwen,Li Yining,Zhao Yushang,Lin Wanling,Li Jing,Wang Dong,Yue Zhihong,Pei Lin,Jia Mei,Cao Lin-Lin,Wang Hui
With the global spread of antimicrobial resistance (AMR), infections caused by multidrug-resistant bacteria have become a major challenge in clinical treatment. ‘Imipenem, Cilastatin Sodium and Relebactam for Injection’ is a critical therapeutic agent for treating infections caused by multidrug-resistant Gram-negative bacteria. However, it is associated with gastrointestinal adverse reactions, necessitating therapeutic drug monitoring (TDM) for precise dosing. Currently, there is no method for simultaneously detecting the concentrations of all three components in ‘Imipenem, Cilastatin Sodium and Relebactam for Injection’. Therefore, this study established an analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous quantification of imipenem, relebactam, and cilastatin in serum, urine, and peritoneal drainage fluid (PD). After protein precipitation, samples were separated using a CORTECS ® HILIC column with 5 mM ammonium acetate aqueous solution-acetonitrile as the mobile phase for gradient elution, detected in positive electrospray ionization (ESI+) mode. This LC-MS/MS method showed excellent linearity (R² > 0.99) for all three drugs, and the linearity ranges had well met the clinical requirements. The limits of quantification (LOQ) were 40 ng/mL (serum/ PD) and 80 ng/mL (urine), and the carryover contamination rate was < 0.1%. All intra-day and inter-day coefficients of variation (CVs) were < 15%, the recovery rates ranged from 89.7% to 103.2%, and the matrix effects were acceptable (87.7%–110.8%). In conclusion, this LC-MS/MS method is simple to operate, exhibits high sensitivity and accuracy, and meets the requirements for the TDM of ‘Imipenem, Cilastatin Sodium and Relebactam for Injection’, providing support for individualized treatment and reducing the risk of adverse reactions.
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高影响因子
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