VETERINARY RESEARCH COMMUNICATIONS
·
2024
·
IF 1.8
Zhang Wanjun,Tang Yutong,Fan Ruiqi,Zhang Fude,Li Yongchen,Zang Jianjun,Yang Wenjun,Wang Zongyi,Yuan Xiaoyan,Yang Yuan,Chen Yiqiang
Pesticide residues may enter the human body through the food chain when livestock and poultry consume pesticide-contaminated feed. Therefore, monitoring and limiting pesticide residues in animal feed and animal-origin foods is necessary. Carbendazim is one of the most frequently detected pesticides in food and feed and has various toxic effects on non-target animals. This study investigated the effects of varying concentrations of carbendazim contamination in feed on broiler chicken growth performance, serum biochemical indicators, histopathology, and carbendazim residues in broiler muscles and livers. The results demonstrated that contamination of 5–100 mg/kg carbendazim in feed did not affect broiler growth performance or health. Carbendazim contamination in feed at 200–800 mg/kg slightly reduced growth performance. Broiler kidneys showed minor histopathological alterations after 400 mg/kg carbendazim exposure. Furthermore, when the carbendazim content in feed was less than 25 mg/kg, the residual carbendazim in the muscles and livers of broilers did not exceed the maximum residue level set by the European Union and China. Based on the above findings, carbendazim residues in the feed of less than 25 mg/kg can be considered safe for chicken products.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 3
·1-10
·
IF 2.8
Li Yong,Wei Yu,Huang Wenjia,Ru Hongfu,Zhao Shujun,Fu Feiya,Xiang Shuangfei
Durable and robust antibacterial fabrics are attracting growing attention due to increasing demands in the medical, feminine products and personal protection fields. Here, we report a simple yet effective method for embedding zinc oxide (ZnO) nanoparticles on polyester surfaces to produce an antibacterial polyester-cotton fabric with remarkable laundering and abrasion resistance. The fabric is prepared by pad-rolling, followed by hot-pressing to embed the ZnO nanoparticles onto the polyester fibers. The modified fabric achieves 100% bacterial reduction (BR) rates against both S. aureus and E. coli , exhibiting remarkable laundering durability even after 30 cycles and 600 abrasion cycles. Compared to other strategies using metal nanoparticles for antibacterial fabrics, this preparation is simple, cost-effective, low toxicity, and environmentally friendly, and effectively imparts durable antibacterial properties to fibers. This work represents a practical strategy for developing eco-friendly and cost-effective durable antibacterial textiles.
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Biomass Conversion and Biorefinery
·
2024
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IF 3.5
Gong Xiujin,Wang Dengfeng,Zheng Qiannan,Liu Lin,Wu Han,Li Zihan,Hong Haojie,Yao Juming
Lignin extraction and upgrade are the great importance to lignin valorization but are closely related to raw material sources, separation methods, and conditions. The advantage of this work is to firstly exploit an efficient and practical approach to extract highly reactive lignin from waste mulberry branches (MB) using green deep eutectic solvent (DES). To better understand the relationship between the extraction conditions and the properties of lignin, the influences of DES components, extraction temperature and time on the extraction efficiency, average molecular weight, chemical structure, and thermal stability of lignin were systematically investigated and analyzed. The synergistic effects of processing conditions resulted in high extraction efficiency with 62.9% of yield and 94.5% of purity. Under optimal conditions with LA/ChCl ratio of 2:1, extraction temperature of 150 °C, and time of 6 h, the obtained lignin had relatively low molecular weight ( M n = 1900 g/mol and M w = 2841 g/mol) and narrow distribution (PDI = 1.49), simultaneously had high total hydroxyl content of 9.15 mmol/g. Benefiting from high hydroxyl content and low molecular weight, the extracted lignin possessed excellent miscibility and reactivity which could participate in polymerization reaction to synthesize lignin-derived rigid polyurethane foam (LRPUF). The integration of the highly reactive lignin significantly improved the specific compressive strength and modulus of LRPUF to 6.4 and 76.0 MPa/(g/cm 3 ), which increased by 7% and 22.4% than those of petroleum-based RPUF. Therefore, this work not only provided an efficient and practical strategy for lignin extraction and upgrade, but also proposed a potential of high value-added utilization of waste mulberry branches. Graphical Abstract
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 4
·1-14
·
IF 2.8
Xian Changqing,Deng Tao,Sun Bocun,Yang Wenbo,Li Boyan,Li Youbing,Xia Tian,Yang Chaolong,Yang Yi
Self-healing polyurethanes are garnering attention as a smart material, and has significant application potential in aerospace, biomedical, and electronics fields. In this paper, castor oil is selected as a soft segment in place of petroleum-based polyol to enhance the mechanical properties of polyurethane while improving the mobility of molecular chains. Meanwhile, a polyurethane with good self-healing properties was successfully prepared by selecting 2,2`-Diaminodiphenyl disulfide (DTDA) containing disulfide bonds as a chain extender. As the proportion of DTDA increases, the initial thermal decomposition temperature of polyurethane decreases by 21°C. Cutting and tensile tests confirmed the high mechanical properties and self-healing characteristics of the polyurethane network. And the self-healing efficiency of the polyurethane materials was improved by prolonging the healing time and increasing the healing temperature. As the content of disulfide bonds and hard segments increased, the tensile strength of polyurethane increases progressively, the elongation at break decreased, and the R(stress) and R(strain) of each specimen tended to increase and then decrease. The healing efficiency of the specimen with a disulfide bond content of 13.45% was optimal, with both R(stress) and R(strain) reaching more than 99%.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
Zheng Zihan,Liu YiZhen,Chen Danli,Yang Jianjun,Ren Lingxuan,Jin Zhen,Wang Weirong,Liu Xuyang,He Jianyu,Zheng Nanbo,Lin Rong
Background and purpose: Catalpol (CAT) has diverse pharmacological functions, including cellular homeostasis maintenance and anti-inflammatory effects. Sirtuin 5 (SIRT5) plays a considerable role in regulating cellular homeostasis in cardiac diseases. Our research explores the therapeutic potential of CAT against myocardial injury and its underlying mechanism. Methods: The H9c2 cells were pretreated with different CAT concentrations for 24 h, or CAT for 24 h followed by CoCl 2 stimulation. Cell viability was determined with MTT assay. Biochemical assays, western blotting, and quantitative real-time PCR (qRT-PCR), combined with bioinformatic analysis, were used to examine the impact of CAT on CoCl 2 -induced myocardial injury in H9c2 cells and further explore its molecular mechanisms. Results: CAT ameliorated levels of myocardial enzymes, increased nicotinamide adenine dinucleotide (NAD + /NADH) ratio and adenosine triphosphate (ATP), while inhibited lactic acid (LD), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 in CoCl 2 -induced H9c2 cells. Mechanistically, SIRT5 knockdown inhibited Lin28a expression and negated the effects of CAT on ATP level, LD content, and the expression of inflammatory factors in cells. CAT likely exerted its protective effects on myocardial function through the SIRT5-mediated signaling pathway. Conclusions: CAT regulates energy metabolism and inflammation via the SIRT5-mediated signaling pathway, exerting a protective effect in myocardial injury.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2024
·
IF 2.6
Xiao Mi,Hui Xinyu,Yang Songyi,Du Xinyue,Gao Xiaofan,Song Zhuoyuan,Zhang Weixi,Xiao Meng
Supercapacitor (SC) electrodes with excellent capacity and multiplicity performance have been in demand for a long time. In this paper, CeO 2 /Co 3 O 4 nanorod arrays were firstly synthesized by hydrothermal method and thermal treatments, and then NiCo 2 S 4 were successfully wrapped around CeO 2 /Co 3 O 4 nanorod arrays by electrodeposition. On the one hand, the CeO 2 /Co 3 O 4 nanorod arrays acted as a core layer to provide a scaffold for the continuous and stable conductivity of the electrochemical reaction, while on the other hand, the NiCo 2 S 4 played an important role in increasing the capacity due to their high conductivity. The electrochemical properties of NiCo 2 S 4 @ CeO 2 /Co 3 O 4 electrode materials were remarkable improvement due to the synergistic and complementary effect. The area capacitance of the prepared NiCo 2 S 4 @ CeO 2 /Co 3 O 4 nanorod arrays was 1576.67 mF cm −2 with a current density of 1 mA cm −2 . And the intrinsic and transfer resistances of the composites were 0.816 Ω and 0.064 Ω. Meanwhile, the asymmetrical supercapacitors exhibited excellent energy density (0.074 mWh cm −2 ) with the power density of 0.805 mW cm −2 . The capacitive retention rate after 5000 cycles was 93.25%. This study demonstrates that the 3D core–shell structure of NiCo 2 S 4 @ CeO 2 /Co 3 O 4 nanorod arrays has a good practical application potential in supercapacitor devices.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·
IF 0
Li Longyun,Xiao Kunkun,Zhang Jinpu,Du Ruihan,Kang Chunli
This study successfully synthesized a composite photocatalyst g-C 3 N 4 /PbTiO 3 through hydrothermal and calcination methods using PbTiO 3 and g-C 3 N 4 . The catalyst was characterized by XRD, FTIR, Raman, XPS, SEM, TEM, UV–vis DRS, PL, and other techniques. The results indicate that the composite photocatalyst exhibits efficient electron transfer, enhanced light absorption, effective separation and utilization of photogenerated electron–hole pairs, demonstrating superior photocatalytic activity. Under simulated sunlight, the removal efficiency of methyl blue (MB) with an initial concentration of 10 mg/L reaches 93.0% after 120 min. After five cycles, the degradation efficiency of MB is 79.2%, still maintaining 85% of the initial catalytic activity. The pH values in the range of 4.0–7.0, inorganic anions, and water quality have a minimal impact on the photocatalytic degradation of MB. Additionally, the composite photocatalyst exhibits strong removal capabilities for other pollutants, such as tetracycline. Therefore, the prepared catalyst demonstrates good feasibility for practical applications. Free radical quenching experiments indicate that hydroxyl radicals (·OH) are the primary active groups in the photocatalytic degradation of MB. Based on this, a photocatalytic mechanism involving a S-scheme heterojunction has been proposed. This study provides new insights into preparing PbTiO 3 composite semiconductors and constructing novel S-scheme heterojunctions.
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JOURNAL OF MATERIALS SCIENCE
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2024
·Vol. 59
·期 38
·18090-18104
·
IF 3.5
Gong Xin,Luo Pan,Wang Kaiming,Yang Yang,Zhu Huacheng,Yan Liping,Zhou Yanping
Vanadium nitride (VN) has gained much attention for microwave absorption due to its high electrical conductivity and easily tunable microscopic morphologies. However, its microwave dissipation ability is yet to be enhanced. In this work, vanadium nitride with 3D/2D hierarchical microflower structure is successfully fabricated via a rapid microwave hydrothermal method followed by a nitridation process enabled by the in-situ upstream thermal decomposition of melamine. By incorporating with N-doped graphene (N-rGO) in different ratios, the proportion of conduction loss and relaxation polarization loss in VN/N-rGO could be tuned, yielding a minimum reflection loss of − 45.9 dB at 10.4 GHz with 5 wt% filler loading. Further, to achieve optimal ultra-broadband microwave absorption, a rational double-layer absorber is constructed by attaching the N-rGO layer with lower normalized impedance but high dissipation capability under the VN/N-rGO layer with excessively high normalized impedance, delivering a maximum effective absorption bandwidth of 10.3 GHz at a total thickness of 4.9 mm. Impedance matching and power loss density distribution analysis are done to illustrate the working mechanism of the double-layer structure. Graphical abstract
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MOLECULAR MEDICINE
·
2025
·Vol. 31
·期 1
·1-15
·
IF 6.4
Pei Lipeng,Zhu Yan,Li Wenpeng,Xu Bin,Sun Jingli
Background Uterine corpus endometrial carcinoma (UCEC) is one of the most frequent female genital malignant tumors. Targeting DNA damage and cell apoptosis are regarded as effective ways for UCEC therapy. Celastrol is a natural anti-cancer product from the Celastraceae plant family, while its role in UCEC has not been investigated. Methods UCEC cell lines Ishikawa and HEC-1-A were applied and treated with different concentrations of Celastrol. The appropriate and nontoxic concentrations were used for the subsequent experiments. Functional experiments analyzed the cell viability, cell cycle distribution, DNA damage, apoptosis and the expression of related proteins. We determined tumor growth in xenograft nude mice. Bioinformatic analysis, protein coimmunoprecipitation (Co-IP), luciferase assay, cell experiments were performed to reveal the relationship of Celastrol/KAT2B/RBPJ/MCM4 in UCEC. Results Treatment of Celastrol inhibited cell viability in a dose-dependent manner, and caused cell cycle arrest, accompanied by the downregulation of CDK2 and cyclin E expression and the upregulation of p21. Celastrol treatment resulted DNA damage and apoptosis in cultured cells, as demonstrated by increased number of TUNEL-positive cells, activity of caspase-3 and expression of cleaved-caspase-9, cleaved PARP1 and γ-H2AX. In xenograft nude mice, Celastrol also repressed tumor growth. Furthermore, lysine acetyltransferase KAT2B was a putative target of Celastrol, and its expression was upregulated by Celastrol in vitro and in vivo. Overexpression of KAT2B in UCEC inhibited cell proliferation and increased DNA damage and apoptosis. KAT2B knockdown overcame the anti-proliferative and pro-apoptotic roles of Celastrol. Moreover, Co-IP demonstrated that KAT2B bound to RBPJ, a transcriptional repressor, and increased the acetylation of RBPJ. RBPJ could bind to the MCM4 promoter to suppress the luciferase activity. Further functional analysis revealed that the functions of KAT2B in UCEC cell proliferation, DNA damage and apoptosis were mediated by MCM4, and Celastrol enhanced RBPJ acetylation and reduced MCM4 expression. Conclusions These results underscore that Celastrol is a promising anti-cancer agent in UCEC with preferential anti-proliferative, pro-apoptotic and DNA damage effects through the KAT2B/RBPJ/MCM4 axis, and KAT2B is a promising therapeutic target for UCEC. Graphical abstract
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高影响因子
International Journal of Minerals Metallurgy and Materials
·
2025
·Vol. 32
·期 4
·892-901
·
IF 7.2
Zhang Yongcheng,Yin Taiqi,Zhang Lei,Zhang Xiaochen,Bo Tao,Tan Xiaoli,Li Mei,Han Wei
Herein, the electrochemical behaviors of Sr on inert W electrode and reactive Zn/Al electrodes were systematically investigated in LiCl-KCl-SrCl 2 molten salts at 773 K using various electrochemical methods. The chemical reaction potentials of Li and Sr on reactive Zn/Al electrodes were determined. We observed that Sr could be extracted by decreasing the activity of the deposited metal Sr on the reactive electrode, although the standard reduction potential of Sr(II)/Sr was more negative than that of Li(I)/Li. The electrochemical extraction products of Sr on reactive Zn and Al electrodes were Zn 13 Sr and Al 4 Sr, respectively, with no codeposition of Li observed. Based on the density functional theory calculations, both Zn 13 Sr and Al 4 Sr were identified as stable intermetallic compounds with Zn-/Al-rich phases. In LiCl-KCl molten salt containing 3wt% SrCl 2 , the coulombic efficiency of Sr in the Zn electrode was ∼54%. The depolarization values for Sr on Zn and Al electrodes were 0.864 and 0.485 V, respectively, exhibiting a stronger chemical interaction between Zn and Sr than between Al and Sr. This study suggests that using reactive electrodes can facilitate extraction of Sr accumulated while electrorefining molten salts, thereby enabling the purification and reuse of the salt and decreasing the volume of the nuclear waste.
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JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2024
·
IF 2.4
Li Mei,Du Rui,Wei Hedi,Chen Jiayi,Liu Rugeng,Zhang Meng,Han Wei
In order to investigate the influences of the additive (KF) on electrochemistry and deposit morphology of Pr, various electrochemical techniques were used to comparative investigate the electroreduction potential and diffusion coefficient of Pr 3+ and kinetic properties of Pr 3+ /Pr in LiCl–KCl-PrCl 3 before and after the addition of KF at different molar concentration ratios of F − to Pr 3+ ( k ). Cyclic voltammetry, square wave voltammetry, and reverse chronopotentiometry results showed that the value of k ( k = 0, 1, 2, 3, and 4) had no effect on reduction mechanism of Pr 3+ . With the increase of k , the reduction peak potential moved in the negative direction, the diffusion coefficient decreased, and diffusion activate energy increased. Meanwhile, the exchanged current densities ( j 0 ), charge transfer resistances ( R ct ), and activate energies ( E a ) were measured at different k by linear polarization technique, which illustrated that with the increase of k , j 0 gradually decreased, and E a and R ct increased. Furthermore, the electrochemical preparation of Pr aided by KF was explored by potentiostatic electrolysis at different k , and the products were characterized by XRD, SEM, and EDS, which indicated that with the increase of k , the morphology of metallic Pr changed from slender needles to granular. Graphical abstract
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Bioresources and Bioprocessing
·
2025
·Vol. 12
·期 1
·1-14
·
IF 5.1
Ai Yulin,Huang Yusong,Zhao Hongru,Su Bingmei,Lin Juan
5-Hydroxytryptophan (5-HTP) is widely used as a natural remedy for sleep disorders. In terms of biosafety, bio-derived 5-HTP is preferred over chemically synthesized 5-HTP. However, the low titer of 5-HTP in the reported microbiological methods (< 10 g/L) limits the industrialization of 5-HTP biosynthesis. In the present study, a Trp-accumulating E. coli strain TRP1 was constructed by blocking the degradation path (Δ tnaA ), branching paths (Δ pheA , Δ tyrA ) and repression system (Δ trpR , Δ trpL ). Next, the hydroxylation module employing a phenylalanine hydroxylase mutant XcPAH W179F (XC2) coupled with an MH4 regenerating system (CvPCD-EcFolM system) was screened to convert L-Trp into 5-HTP. Protein engineering was performed on hydroxylase XC2 based on the molecular dynamics simulation of the enzyme-substrate complex, and the strain TRP1-XC4 harboring the triple-mutant XcPAH L98I/A129K/W179F (XC4) was able to produce 319.4 mg/L 5-HTP. Genome editing was carried out focused on accelerating product efflux (strengthening YddG) and increasing MH4 supply (strengthening FolM, FolE and FolX), resulting in a strain TRP5-XC4 to produce 13.9 g/L 5-HTP in 5 L fed-batch fermentation with a space-time yield of 0.29 g/L/h, which is the highest production and productivity record for 5-HTP biosynthesis. This study successfully provided an engineered strain and an efficient green method for the industrial synthesis of 5-HTP. Graphical
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