FASEB JOURNAL
·
2026
·Vol. 40
·期 3
·e71499
·
IF 4.2
Liwen Xu,Fei Zheng,Dandan Wang,Qing Yang
N-terminal acetyltransferases are emerging as potential therapeutic targets in cancer. N-alpha-acetyltransferase 30 (NAA30), which serves as the catalytic subunit of the NATC complex. However, the role of NAA30 in ovarian cancer remains unknown. In this study, we found that NAA30 expression was abnormally upregulated in ovarian cancer tissues compared to normal tissues. Functionally, NAA30 promoted cell proliferation, migration, and invasion in ovarian cancer cells. Moreover, in vivo experiments revealed that NAA30 enhanced tumor growth and intraperitoneal metastasis in mouse models. We further explored the regulatory mechanisms underlying NAA30 upregulation. Dual-luciferase assays demonstrated that the transcription factor nuclear receptor subfamily 2 group C member 2 (NR2C2) significantly enhanced the transcriptional activity of the NAA30 promoter. Besides, NR2C2 increased the migratory, invasive, and proliferative capabilities of ovarian cancer cells. Importantly, NAA30 knockdown reversed the pro-tumorigenic effects of NR2C2 overexpression on the malignant phenotype. To identify the downstream targets of NAA30, we employed IP-LC/MS and N-terminal acetylation modification omics. Actin-Related Protein 2/3 Complex Subunit 1B (ARPC1B) was identified as a direct target of NAA30. It was demonstrated that NAA30 protein binds to ARPC1B protein and that NAA30 knockdown enhanced the polyubiquitination of ARPC1B and promotes its degradation. Crucially, the re-expression of ARPC1B in NAA30-silenced cells effectively restored these malignant phenotypes. These findings highlight the critical role of the NR2C2-NAA30-ARPC1B axis in ovarian cancer progression and provide more foundation for the development of more effective treatment strategies for patients with ovarian cancer. Graphical In ovarian cancer, transcription factor NR2C2 is highly expressed and enhances the transcription of NAA30. This subsequently suppresses the ubiquitination of ARPC1B, leading to its protein stabilization, which ultimately promotes malignant tumor behaviors and disease progression.
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DOI
PubMed
高影响因子
Gels
·
2026
·Vol. 12
·期 4
·271
·
IF 6.4
Tianji Li,Delong Dai,Luohui Wang,Minghui Zhao,Lianfeng Shen,Youming Dong,Fei Xiao,Cheng Li,Jianwei Zhang
In order to achieve rapid and qualitative detection of soluble heavy metal ions, nitrogen-doped fluorescent carbon quantum dots (N-CQDs) were synthesized using chitin extracted from shrimp and crab shells as the carbon source. The structural, morphological, and optical properties of the synthesized N-CQDs were systematically characterized using transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FTIR), Raman, X-ray photoelectron spectroscopies (XPS), ultraviolet-visible (UV-Vis) absorption spectroscopy and fluorescence spectroscopy. The resulting N-CQDs exhibited a carbonization yield of 54.46% and a fluorescence quantum yield of 34.33%. Their morphology, structure and optical properties were thoroughly characterized using a range of analytical techniques. The synthesized N-CQDs exhibited excellent fluorescence properties, and remarkable stability. When applied for metal ion detection, the N-CQDs displayed a distinct and selective fluorescence quenching response exclusively toward Fe3+ions. The detection limit for Fe3+at room temperature was 4.04 μmol/L. Furthermore, due to the inherent nitrogen present in the acetyl amino groups of chitin, nitrogen doping was achieved without the need for external dopants during the hydrothermal synthesis process. Owing to their high stability, low cost and low toxicity, the N-CQDs synthesized in this study provide a promising fluorescence sensing platform with excellent selectivity for Fe3+detection, achieved through precise control of surface functional groups.
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高影响因子
MOLECULES
·
2026
·Vol. 31
·期 7
·1172
·
IF 5.1
Bing Chen,Yiwen Li,Chaojiang Fan,Qingpei Zhou,Wenhu Li,Hang Su,Cong Li,Shixiong Zhang,Chenhui Yang,Teng Wang
Lithium–sulfur (Li-S) battery technology has attracted significant research interest owing to sulfur’s remarkable theoretical capacity and exceptional energy density potential. Nevertheless, the low conductivity of sulfur and the “shuttle effect” pose challenges to its practical applications. To enhance electrochemical performance, this work developed nitrogen-doped graphene (NG) nanosheets as a separator coating for Li-S battery. As a modification layer for separators, NG acts as a physical barrier that prevents polysulfides from migrating across the separator to reach the anode, thereby mitigating the shuttle effect. Additionally, NG improves the conductivity of the separator and enhances wettability between the separator and electrolyte, facilitating uniform transmission of lithium ions. Notably, NG functionalized separators demonstrate excellent mechanical flexibility, contributing to improved cycle stability for batteries. Furthermore, theoretical calculations indicate a strong interaction between NG and lithium polysulfides (LiPSs), effectively inhibiting polysulfide migration. The Li-S battery utilizing the NG modified separator maintains a capacity retention rate of 51.5% after 100 cycles at 0.1 C with a sulfur loading of 1.47 mg/cm2and exhibits a capacity decay rate of only 0.092% after 500 cycles at a discharge rate of 1 C. This work highlights the potential advantages of employing NG as a separator coating layer in enhancing the electrochemical performance of the Li-S battery.
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DOI
PubMed
高影响因子
ACS Catalysis
·
2026
·
IF 13.6
Guanyi Zhang,Zhihao Zheng,Na Liu,Lei Wang,Yongfang Xu,Dawei Wang,Xun Zhao,Zhitong Qian,Haisong Feng,Xin Zhang,Weiming Zhai,Feng Liu,Zhihai Hu,Yusen Yang
Abstract The aqueous-phase hydrodeoxygenation of biomass-derived fatty acids offers an alternative route for the production of diesel-range hydrocarbons, but remains a major challenge. Herein, we report a hydrophobic CoP catalyst anchored on P–N co-doped carbon spheres (CoP@PNC-900), which exhibits high performance for the aqueous-phase hydrodeoxygenation of palmitic acid at 270 °C and 2 MPa H2, delivering nearly complete conversion together with over 99% yield of C15+C16 alkanes. The enhanced performance arises from the synergy between CoP active sites and the hydrophobic interface, which promotes C–O bond cleavage while enhancing the contact between hydrophobic substrates and catalytic sites. Isotopic-labeling experiments demonstrate that water acts exclusively as the reaction medium rather than a hydrogen source. In situ FT-IR–MS analysis combined with DFT calculations confirms the hydrodeoxygenation- and decarbonylation-related pathways, with C–O bond cleavage of the alcohol intermediate identified as the rate-determining step in the hydrodeoxygenation pathway. Moreover, the catalyst exhibits a broad substrate scope for various fatty acids and esters as well as stable recyclability under hydrothermal conditions. Finally, a preliminary life cycle assessment (LCA) highlights the potential environmental benefits of the aqueous-phase catalytic process. This work establishes an effective strategy that integrates active-site engineering with interfacial hydrophobic microenvironment regulation for the aqueous-phase valorization of biomass-derived fatty acids.
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高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xiang Liu,Mutian Zhang,Wei Zheng,Junjiang Fan,Miaoxi Guo,Li Yang,ZhengMing Sun,Guobing Ying
Aqueous ammonium-ion batteries are promising for safety, low cost, and fast energy storage. However, the influence of electrode surface chemistry on NH4+ storage remains poorly understood. Two-dimensional Ti3C2Tx MXene, with metallic conductivity, tunable interlayer spacing, and abundant surface terminations, serves as an ideal platform to elucidate NH4+ storage mechanisms. Herein, the role of MXene surface termination in regulating NH4+ storage behavior is systematically investigated using density functional theory calculations and experimental validation. The calculations reveal that the -N terminations offer moderate NH4+ adsorption and high electronic conductivity for rapid charge transfer and ion transport, whereas the -O terminations exhibit stronger ion affinity and enhanced surface stability. Importantly, the mixed -N/-O terminations effectively balance adsorption strength and transition-state stabilization, resulting in the lowest NH4+ migration barrier among the modeled pathways. The calculations employ idealized vacuum-separated surfaces with isolated NH4+ and do not explicitly include solvation or electrolyte effects. Guided by these findings, a mixed -N/-O terminated Ti3C2Tx MXene is constructed via a urea-assisted hydrothermal strategy. The optimized NTC-20 electrode delivers 107 mAh g-1 at 1 A g-1, retains 67% capacity at 10 A g-1, and maintains 91% capacity after 10,000 cycles. Ex situ XRD, XPS, and FTIR analyses are consistent with reversible NH4+-associated changes in the local chemical environment and possible storage involving Ti-N···H-N and Ti-O···H-N interactions. Furthermore, the NTC-20//MnO2/CNTs full cell achieves an energy density of 26.7 Wh kg-1 at 1.3 kW kg-1. The results support a dominant role for mixed -N/-O terminations in regulating NH4+ adsorption and diffusion, providing insights into surface-termination engineering for high-performance AAIBs.
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高影响因子
ACS Applied Nano Materials
·
2026
·
IF 5.8
Zihan Zhang,Yang Kang,Xuan Li,Wushuang Bao,Liuan Li,Longtao Yang,Wei Chen,Xin Liu,Yuanmin Luo,Wengang Gu,Yang Li,Reza Taheri Ghahrizjani,Zongzhi Yin,Junsong Cao,Haiding Sun
Abstract Photoelectrochemical sensing within complex biochemical environments typically necessitates the simultaneous determination of multiple analytes, as single-parameter measurements provide limited information. However, most existing biosensing platforms encode analyte information within a single signal dimension, which restricts their ability to achieve intrinsic multiplexing. Here, we report a polarity-encoded photoelectrochemical biosensing platform based on a wavelength-resolved p-AlGaN/n-GaN heterojunction. In this system, photocurrent polarity functions as an additional signal dimension beyond conventional amplitude-based encoding. The device exhibits illumination-dependent polarity switching, enabling analyte-specific signal transduction. Regulation of carrier transport across the heterojunction generates bipolar photoresponses, in which polarity determines analyte identity while current amplitude remains proportional to concentration. This mechanism enables wavelength-resolved dual-analyte detection on a single electrode, as demonstrated by the selective discrimination of glucose and hydrogen peroxide under different illumination conditions. Moreover, surface modification with RuO2 enhances interfacial charge-transfer kinetics and improves carrier utilization efficiency, leading to amplified bipolar signals and improved detection performance. The system achieves sensitivities of 723 μA mM−1 cm−2 and 0.11 mA mM−1 cm−2 for hydrogen peroxide (H2O2) and glucose, respectively. This work establishes a polarity-resolved signal-encoding strategy for intrinsically multiplexed photoelectrochemical biosensing.
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高影响因子
Sustainable Chemistry and Pharmacy
·
2026
·
IF 6.7
Mengxuan Wang,Wenfeng Zhao,Qingmei Ge,Jiang Zhao,Nan Jiang,Yin-Hui Huang,Hang Cong
The development of efficient, sustainable photocatalytic systems for CO 2 utilization remains critical for green chemical processes. In this work, a biomass-derived conjugated polymer (FDS) was synthesized via Schiff-base condensation of renewable 2,5-diformylfuran and 1,5-naphthalenediamine and employed as a metal-free heterogeneous photocatalyst for the cycloaddition of CO 2 with epoxides. Under visible-light irradiation, FDS enabled the solvent-free conversion of epichlorohydrin and CO 2 at room temperature and atmospheric pressure, affording 4-(chloromethyl)-1,3-dioxolan-2-one in 97% yield within 3 h. The catalyst delivers yields above 90% for a series of epoxide substrates with prolonged reaction time of 6 h, maintains high catalytic performance after 10 consecutive recycling runs, and exhibits considerable activity under natural sunlight irradiation. Mechanistic studies supported by DFT calculations revealed that the imine-linked framework facilitates photoinduced charge separation and epoxide polarization, while CO 2 is cooperatively activated at the imine N and furan O sites. This work presents a sustainable approach for metal-free photocatalytic CO 2 valorization, providing a promising strategy for green chemical manufacturing.
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高影响因子
Materials Today Chemistry
·
2026
·
IF 7.4
Qiujun Hu,Xiaowei Liang,Xiaomiao Zhao,Panjun Wang,Chunlong Guan,Shun Wang,Zhiwei Zhao
Thermal-driven Ag intercalation enables vdW-gaps doping in 3D-printed n-type Bi 2 Te 2.7 Se 0.3 . • vdW-gaps Ag enhances electrical transport and lowers lattice thermal conductivity. • Peak ZT of 1.26 and module efficiency of 6.0% are achieved. Bi 2 Te 3 -based materials are recognized as the benchmark thermoelectrics for near-room-temperature applications. However, substantially inferior thermoelectric performance in n-type Bi 2 Te 3 compared to highly performance p-type variants creates a critical performance asymmetry, restricting energy conversion efficiency. Herein, we develop thermal-driven Ag intercalation into van der Waals (vdW) gaps of 3D-printed n-type Bi 2 Te 2.7 Se 0.3 (BTS), achieving vdW-gaps doping. The first-principles calculations demonstrate that interstitial Ag atoms are mainly located at the vdW gaps, which reduces their direct perturbation to the conductive layers. As a result, they provide spatially separated conduction electrons, increasing carrier concentration while sustaining high carrier mobility. Furthermore, the Ag-intercalation-induced superlattice structures efficiently scatter mid-to-long wavelength phonons, thereby effectively suppressing lattice thermal conductivity. Ultimately, the BTS + 0.2% Ag intercalated sample achieves a peak ZT of 1.26 at 375 K, with an average ZT ∼1.12 maintained across the operational temperature range of 300-500 K. Leveraging such exceptional thermoelectric performance, a thermoelectric module assembled with 127 pairs legs delivers a conversion efficiency of 6.0% under ΔT = 180 K. This work provides a facile thermal-driven Ag intercalation strategy for vdW-gaps doping of n-type Bi 2 Te 3 -based thermoelectrics, breaking the performance asymmetry bottleneck and enabling high-efficiency near-room-temperature thermoelectric modules.
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高影响因子
Nature Synthesis
·
2026
·
IF 22.6
Zhang Hao,Liu Ziming,Li Di,Wu Chenxin,Hua Lei,Li Haiyang,Yi Yanhui,Huang Rui,Yu Liang,Deng Dehui
Direct co-conversion of earth-abundant N 2 and CH 4 to high-value C–N–O compounds is a promising synthetic method but remains challenging, as the activation of N 2 and CH 4 typically requires high-energy conditions that can cause product decomposition. Here we report a plasma-cascade process for synthesizing cyclohexanone cyanohydrin (Cy(OH)CN) via direct coupling of N 2 and CH 4 plasma with cyclohexanone. This catalyst-free process achieves a Cy(OH)CN formation rate of 0.60 mmol h −1 with a high selectivity of 95.8% towards the cyclohexanone-derived products under mild conditions, concurrently generating ammonia as a valuable coproduct. Comprehensive mechanistic studies reveal that plasma-generated ·CH x and hydrogen radicals enable direct α-carbonyl functionalization of cyclohexanone to α-CH x cyclohexanol intermediates, which then coupled mainly with excited-state N 2 and are further activated by hydrogen radicals to generate Cy(OH)CN. This plasma-cascade strategy decouples the activation of inert molecules from the formation of relatively unstable C–N–O compounds, enabling selective cyanohydrin synthesis that avoids using high-cost NH 3 and toxic HCN. The alternative text for this image may have been generated using AI.
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高影响因子
Journal of Energy Storage
·
2026
·
IF 10.7
Xinyu Cui,Peiqin Hong,Yang Jiao,Peng Hu,Haibo Fan,Feng Teng
Heterogeneous atomic doping is the mainstream way to enhance the electrochemical performance of porous carbon electrode materials. Herein, a three-dimensional honeycomb-like porous carbon material was synthesized by directly one-step carbonization-activation polyvinyl alcohol hydrogel method. In this study, a N, S co-doped porous carbon material was prepared by introducing thiourea during the hydrogel formation process. The as-synthesized product possesses a large specific surface area and a well-developed porous structure. Notably, the obtained N, S co-doped porous carbon delivers an excellent specific capacitance of 260.5 F g −1 at a current density of 1 A g −1 in a 6 M KOH electrolyte, along with outstanding cycling stability. These values are much higher than those of undoped porous carbon, single N-doped porous carbon, and single S-doped porous carbon. After 10,000 cycles, the material's specific capacitance retention remains stable, with a Coulombic efficiency approaching 100%. This work presents a facile and effective pathway for the electrode rational design of next-generation energy storage devices.
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高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2026
·
IF 2.4
Zishan Zhou,Hongquan Tao,Haocheng Yang,Ao Duan,Jiahui Yu,Yixin Chen,Yongyan Zhu,Quanhong Zhu
Favorable biocompatibility is essential to biomaterials, and natural amino acids are recognized as the promising building block of polymers due to their non-toxicity and tunable side chains. We prepared polymeric nanoparticles (NPs) using N-acryloyl-L-tryptophan monomer by precipitation polymerization, and modified with polyethylene glycol and folate (PEG-FA) to improve the solubility and target folate-receptors (FR) overexpressed tumor tissues. Serving as drug carriers for vinblastine (VBL), NPs-PEG-FA with about 212.4 nm had the drug loading of VBL of 6.65 ± 0.41% after co-incubating for 1 h and showed sustained-release in pH 7.4 PBS, in which 99.87 ± 1.00% of VBL was released from NPs-PEG-FA during 72 h. Furthermore, NPs-PEG-FA was more efficiently taken up by FR positive Hela cells compared with NPs-PEG, which signified folate could enhance the internalization of NPs-PEG-FA into FR over-expressed cells. And NPs-PEG-FA began to enter Hela cells in large quantities from 3 h onwards, meanwhile the released drug increased more quickly in the first 3 h, which indicated most of the drugs would be released after entering tumor cells. More importantly, NPs-PEG-FA had good biocompatibility to L929 mouse fibroblast cells and exhibited hemocompatibility via the assays of hemolysis, antithrombogenicity, coagulation activation and platelet activation. NPs-PEG-FA could serve as drug carriers for delivering drugs into FR positive tumor cells.
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高影响因子
JOURNAL OF CATALYSIS
·
2026
·
IF 6
Zerui Su,Yang Li,Jianbin Huang,Jian Zhang
Hydrogen energy is regarded as an ideal energy carrier due to its advantages such as high energy density, environmental friendliness, and wide availability. The storage and release of hydrogen using liquid organic hydrogen carriers (LOHCs) such as N-ethylcarbazole (NECZ) offer distinct advantages for safe hydrogen transport and storage. Developing efficient catalysts for this reversible process remains a critical challenge. At present, the high cost of noble metal catalysts hinders their widespread application, and most of the non-noble metal catalysts are not efficient in reversible hydrogenation storage of NECZ. In this study, a silica supported non-noble Ni was prepared by the wet-kneading method, which successfully achieved the reversible hydrogen storage of NECZ. The catalyst exhibited high activity and moderate stability, achieving hydrogen storage of 5.77 wt% within 6 h under 6 MPa of H 2 at 150 °C, and hydrogen release of 5.77 wt% within 1.5 h at 200 °C during 5 cycles. XPS studies identified Ni 0 as the main active site for hydrogenation-dehydrogenation cycles. IR and kinetic studies further revealed that same Ni 0 sites are poisoned by the intermediate 4H-NECZ. This work might pave the way for designing high-performance non-noble catalysts for reversible chemical hydrogen storage.
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高影响因子
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