PHYSICS AND CHEMISTRY OF LIQUIDS
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2024
·
IF 1.2
Tianhao Cao,Yizhong Zhang,Qian Gong,Qun Zou,Ruifeng Pan,Zhixia Wang
At T = (278.15–318.15) K and atmospheric pressure, Hepler’s constant values, (∂2VB/∂ T2)P, and apparent molar expansivities (Eφ) were calculated using the temperature dependence of apparent molar volumes (VB). Because of the increase in hydrophobic hydration of tetramethylpiperidine 1-oxyl-based ionic liquids (TILs), the Hepler’s constant values were found to change from positive to negative, indicating that the TILs under consideration changed primarily from structure-promoting to structure-breaking. The critical micelle concentration of conductivity (CMC) was calculated based on experimental conductivity, which reflects the dissociation and the interaction and aggregation behaviour of TILs.
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Acta Biomaterialia
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2024
·
IF 9.4
Cheng Lu,Miao Chen,Yuanyuan Zhao,Yongxin Zhan,Xin Wei,Laijin Lu,Mingxi Yang,Xu Gong
Avoiding ischemic necrosis after flap transplantation remains a significant clinical challenge. Developing an effective pretreatment method to promote flap survival postoperatively is crucial. Cobalt chloride (CoCl 2 ) can increase cell tolerance to ischemia and hypoxia condition by stimulating hypoxia-inducible factor-1 (HIF-1) expression. However, the considerable toxic effects severely limit the clinical application of CoCl 2 . In this study, cobalt-based metal-organic frameworks (Co-MOF) encapsulated in a microneedle patch (Co-MOF@MN) was developed to facilitate the transdermal sustained release of Co 2+ for rapid, minimally invasive rapid pretreatment of flap transplantation. The MN patch was composed of a fully methanol-based two-component cross-linked polymer formula, with a pyramid structure and high mechanical strength, which satisfied the purpose of penetrating the skin stratum corneum of rat back to achieve subcutaneous vascular area administration. Benefiting from the water-triggered disintegration of Co-MOF and the transdermal delivery via the MN patch, preoperative damage and side effects were effectively mitigated. Moreover, in both the oxygen-glucose deprivation/recovery (OGD/R) cell model and the rat dorsal perforator flap model, Co-MOF@MN activated the HIF-1α pathway and its associated downstream proteins, which reduced reperfusion oxidative damage, improved blood supply in choke areas, and increased flap survival rates post-transplantation. This preprotection strategy, combining MOF nanoparticles and the MN patch, meets the clinical demands for trauma minimization and uniform administration in flap transplantation. Statement of significance Cobalt chloride (CoCl 2 ) can stimulate the expression of hypoxia-inducible factor (HIF-1) and improve the tolerance of cells to ischemia and hypoxia conditions. However, the toxicity and narrow therapeutic window of CoCl 2 severely limit its clinical application. Herein, we explored the role of Co-MOF as a biocompatible nanocage for sustained release of Co 2+ , showing the protective effect on vascular endothelial cells in the stress model of oxygen-glucose deprivation. To fit the clinical needs of minimal trauma in flap transplantation, a Co-MOF@MN system was developed to achieve local transdermal delivery at the choke area, significantly improving blood supply opening and flap survival rate. This strategy of two-step delivery of Co 2+ realized the enhancement of biological functions while ensuring the biosafety.
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ENERGY & FUELS
·
2017
·
IF 3.091
Cheng Sun,Shujing Wen,Jingkai Zhao,Chongjian Zhao,Wei Li,Sujing Li,Dongxiao Zhang
In this work, the blends of 1-hydroxyethyl-3-methylimidazolium glycine ([C2OHmim][Gly]) synthesized by our laboratory and N-methyldiethanolamine (MDEA) in aqueous solution were prepared for CO2 capture, and the maximum absorption performance of the blends was obtained at the mole ratio of 8:2 of MDEA/[C2OHmim][Gly] with a total concentration of 1.0 mol L–1. CO2 loading of the blended absorbent was less adversely influenced by the temperature and O2 concentration than that of MDEA aqueous, and it had a good performance in regeneration ability. The reaction mechanism of the CO2 absorption in MDEA/[C2OHmim][Gly] was investigated by 13C nuclear magnetic resonance. CO2 first reacted with [C2OHmim][Gly] to form carbamate, and then carbamate promoted the reaction between CO2 and MDEA, which could be described as a shuttle mechanism. The kinetics of CO2 absorption was investigated in a double stirred-cell absorber at different temperatures, and some important kinetic parameters were obtained, such as the reaction rate constant (k2) and the overall rate constant (kov). Experimental results indicated that the addition of [C2OHmim][Gly] enhanced CO2 absorption of MDEA under low CO2 partial pressure, which could improve the application of MDEA in industry.
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Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 34
·7153-7163
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IF 4.543
Yan Li,Zuyuan Luo,Xiao Xu,Yongliang Li,Siqi Zhang,Ping Zhou,Yi Sui,Minjie Wu,En Luo,Shicheng Wei
Several bone diseases, including arthritis, fracture and osteoporosis, have a pathophysiologically important inflammatory component. Sustained inflammation can result in delayed bone healing. Therefore, to promote bone repair, it is important to inhibit inflammatory bone erosion and suppress pro-inflammatory mediators. In this study, aspirin significantly enhanced immunomodulation and osteogenic differentiation in human mesenchymal stem cells (hMSCs). Additionally, an osteogenic BFP-1 peptide-decorated substrate (PS-PEP) enhanced osteogenic differentiation of aspirin-treated hMSCs compared to a pristine substrate. Alkaline phosphatase assay, quantitative real-time polymerase chain reaction, immunostaining and Alizarin Red S staining revealed that aspirin-treated hMSCs cultured on PS-PEP exhibited enhanced osteogenesis compared with untreated cells. Thus, we report here that the anti-inflammatory and osteogenic effects of aspirin promote the activity and osteogenesis of hMSCs. The combination of aspirin and an osteogenic BFP-1 peptide-decorated substrate suppresses the production of pro-inflammatory mediators and promotes osteogenic differentiation of hMSCs; therefore, this novel strategy has potential for application in cell therapy and bone tissue engineering.
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Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 24
·12144-12148
·
IF 8.867
Qianqian Yang,Jie Zhou,Genqiang Zhang,Cong Guo,Meng Li,Yongchun Zhu,Yitai Qian
Sb nanoparticles encapsulated in 1-D N-doped porous carbon (denoted as Sb/NPC) have been fabricated by an in situ nanoconfined replacement reaction between SbCl3 and the intermediate Ni/NPC, in which Ni/NPC was obtained by annealing the hydrothermally synthesized nickel–nitrilotriacetic acid (Ni–NTA) precursor in an argon atmosphere. The Sb nanoparticles with a size of 10–20 nm were uniformly encapsulated in the 1-D N-doped porous carbon scaffolds. When the Sb/NPC composite was applied as an anode material in the batteries, it exhibited a high reversible capacity of 556 mA h g−1 at 200 mA g−1 after 100 cycles for Li-ion batteries (LIBs) and a reversible capacity of 400.9 mA h g−1 at 100 mA g−1 after 100 cycles for Na-ion batteries (NIBs). Such enhanced electrochemical performance of the designed Sb/NPC can be attributed to the synergistic effect between uniformly dispersed Sb nanoparticles and the 1-D N-doped porous carbon matrices.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2017
·
IF 2.323
Jing Zhao,Jianzhou Wu,Yitong Dai,Xinxin Cheng,Haiyun Sun,Yongsheng Guo,Wenjun Fang
Measurements on density and viscosity at T = (293.15, 298.15, 303.15, 308.15 313.15, 318.15, 323.15, 328.15, and 333.15) K and the pressure P = 0.1 MPa for binary mixtures of n-dodecane or methylcyclohexane with 1-heptanol or cyclohexylmethanol have been carried out over the whole composition range. Densities were measured with a vibrating-tube densimeter. Viscosities were determined by an automatic microviscometer based on the rolling-ball principle. The excess molar volumes (VmE) and viscosity deviations (Δη) were calculated with experimental data and fitted to the Redlich–Kister equation. The results of these excess or deviation functions are explained by molecular interactions and structural effects. Freezing points were measured with a differential scanning calorimeter. The fundamental data, VmE and Δη can be used to study the nature of mixing behaviors between new hydrocarbon fuels.
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EUROPEAN JOURNAL OF MEDICAL RESEARCH
·
2025
·Vol. 30
·期 1
·1-13
·
IF 3.4
Luo Liling,Jiang Chao,Xie Songxi
Background Previous studies showed that high mobility group box-1 (HMGB1) facilitates the initiation and progression of esophageal squamous cell carcinoma (ESCC), and the current research investigated the detailed mechanisms implicated.Methods The impact of HMGB1 and IGFBP3 levels on the survival of ESCC was examined by plotting Kaplan–Meier (KM) curves based on the data collected from The Cancer Genome Atlas (TCGA). Quantitative real-time PCR (qRT-PCR) was performed to detect the expressions of HMGB1 in both human esophageal epithelial cells (HEEC) and ESCC cells. After cell transfection, the proliferation of ESCC cells was measured, and the cell metastasis was determined based on the levels of cadherins (CDHs) and Vimentin (VIM). Macrophage polarization was determined by calculating the mean fluorescence intensity (MFI) of CD206 and CD86. In addition, co-immunoprecipitation and immunoblotting were applied to evaluate the interaction between insulin-like growth factor binding protein 3 (IGFBP3)/DNA-dependent protein kinase catalytic subunit (DNA–PKcs) and HMGB1.Results A high level of HMGB1 was predictive of an unfavorable prognosis of ESCC (p < 0.05). HMGB1 showed a higher expression in ESCC cells (p < 0.05), while knockdown of HMGB1 inhibited ESCC cell proliferation, downregulated the levels of CDH2 and VIM and upregulated the level of CDH1 (p < 0.05). In contrast, overexpressed HMGB1 showed the opposite effects (p < 0.05), suggesting the role of HMGB1 in the epithelial–mesenchymal transition (EMT) of ESCC. After the knockout of HMGB1, the MFI of CD86 was increased but that of CD206 was reduced, indicating the polarization towards M1 macrophages (p < 0.05). However, the results were reversed when HMGB1 was overexpressed (p < 0.05). Meanwhile, HMGB1 could interact with the IGFBP3/DNA–PKcs complex (p < 0.05). Low-expressed IGFBP3 was predictive of an unfavorable prognosis of ESCC, and IGFBP3 silencing promoted the proliferation of ESCC cells (p < 0.05). Besides, HMGB1 and IGFBP3 could act antagonistically in influencing the proliferation of ESCC cells and macrophage polarization.Conclusion sThrough in vitro experiments, this study found that HMGB1 was linked to the proliferation and polarization of macrophages in ESCC, providing novel evidence for the role of HMGB1 in ESCC development.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Chao Wen,Huan Chen,Yunbing Tang,Hang Lin,Congcong Xu,Yingfen Ying,Yang Zhu,Xinjun Miao,Ren-shan Ge,Chao Chen,Shangqin Chen
Per- and polyfluoroalkyl (PFAS) substances are enduring industrial materials. 17β-Hydroxysteroid dehydrogenase isoform 1 (17β-HSD1) is an estrogen metabolizing enzyme, which transforms estrone into estradiol in human placenta and rat ovary. Whether PFAS inhibit 17β-HSD1 and what the structure-activity relationship (SAR) remains unexplored. We screened 18 PFAS for inhibiting human and rat 17β-HSD1 in microsomes and studied their SAR and mode of action(MOA). Of the 11 perfluorocarboxylic acids (PFCAs), C8-C14 PFCAs at a concentration of 100 μM substantially inhibited human 17β-HSD1, with order of C11 (half-maximal inhibition concentration, IC 50 , 8.94 μM) > C10 (10.52 μM) > C12 (14.90 μM) > C13 (30.97 μM) > C9 (43.20 μM) > C14 (44.83 μM) > C8 (73.38 μM) > others. Of the 7 per- and poly-fluorosulfonic acids (PFSAs), the potency was C8S (IC 50 , 14.93 μM) > C7S (80.70 μM) > C6S (177.80 μM) > others. Of the PFCAs, C8-C14 PFCAs at 100 μM markedly reduced rat 17β-HSD1 activity, with order of C11 (IC 50 , 9.11 μM) > C12 (14.30 μM) > C10 (18.24 μM) > C13 (25.61 μM) > C9 (67.96 μM) > C8 (204.39 μM) > others. Of the PFSAs, the potency was C8S (IC 50 , 37.19 μM) > C7S (49.38 μM) > others. In contrast to PFOS (C6S), the partially fluorinated compound 6:2 FTS with an equivalent number of carbon atoms demonstrated no inhibition of human and rat 17β-HSD1 activity at a concentration of 100 μM. The inhibition of human and rat enzymes by PFAS followed a V-shaped trend from C4 to C14, with a nadir at C11. Moreover, human 17β-HSD1 was more sensitive than rat enzyme. PFAS inhibited human and rat 17β-HSD1 in a mixed mode. Docking analysis revealed that they bind to the NADPH and steroid binding site of both 17β-HSD1 enzymes. The 3D quantitative SAR (3D-QSAR) showed that hydrophobic region, hydrogen bond acceptor and donor are key factors in binding to 17β-HSD1 active sites. In conclusion, PFAS exhibit inhibitory effects on human and rat 17β-HSD1 depending on factors such as carbon chain length, degree of fluorination, and the presence of carboxylic acid or sulfonic acid groups, with a notable V-shaped shift observed at C11.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 37
·e55934
·
IF 2.7
Feng Zhou,Yu Dai,Wei Qin,Zhenyong Li,Yu Song,Fuli Bian,Quanwei Song,Xianyan Ren
Existing adsorption materials with drawbacks in the weak organic solvents/oil retention ability, slow adsorption speed and low adsorption capacity for alkanes still hardly meet demands of the application field, especially in emergencies. The copolymerization of the long-chain alkenes, 1-octene, with isoprene was designed in this paper to synthesize an adsorption resin (PIOT), instead of acrylate monomers reported in the literature. And trimethylolpropane triacrylate was designed as a crosslinking agent. Results show that the PIOT grows in the form of powders, which are the loose accumulation of nanoflakes with a diameter of about 47.89 ± 11.06 nm. In view of the chain structure and morphology of the PIOT, it can quickly reach the maximum adsorption within 10 s along with a high adsorption capacity for various solvents and kerosene. Even for hexane, the adsorption capacity of the PIOT increases by 345.2% compared with the reported adsorption resin. The oil retention rate of PIOT can be maintained at 86 ± 6% after centrifugation at 1000–3000 rpm for 5–25 min. Compared with commercial activated carbon, the PIOT has outstanding advantages in recycling property and oil retention rate and compared with the reported acrylate adsorption resin, the PIOT has made a great breakthrough in adsorption capacity for alkanes.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Zhenbo Du,Ruoshui Li,Le Yang,Fengli Liu,Jianming Lin,Jihuai Wu,Zhang Lan
CsPbI 2 Br is a potential material for perovskite solar cells (PSCs) due to its better thermal stability and high efficiency. Centrifugal deposition for film formation greatly simplifies the steps of the conventional anti-solvent spin coating method, but there are still problems hindering progress, such as small grain size and poor photoelectric performance. In this work, NH 4 SCN was introduced as an additive during the preparation of heptylamine (C 7 H 17 N) stabilised CsPbI 2 Br nanoparticles (NCs) and the films were prepared by centrifugal deposition. The results show that the low melting temperature compounds which formed by thiourea from NH 4 SCN decomposition during annealing and unreacted PbX 2 would link the small grains together by melting and flowing; after PbX 2 precipitation and reaction with CsX, the grain size was significantly increased by about 95 % compared to that of the untreated film. Due to large grains, less defects and high crystallinity, the final power conversion efficiency and fill factor reached 12.25 % and 0.70, respectively.
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JOURNAL OF STORED PRODUCTS RESEARCH
·
2024
·
IF 2.7
Jingyi Su,Zhaoxin Cao,Yueyang Mao,Wen Shen,Xinyu Wang,Siyu Zhang,Yanqi Chen,Xueme Ge
The S/O/W method of solvent evaporation was utilized in this work for manufacturing poly ( ε −caprolactone) (PCL) microspheres loaded with 1−methylcyclopropene (1−MCP−α−CD) and eugenol (EUG) for temperature- and humidity-regulated EUG release. The composite microspheres with higher encapsulation efficiency (71.39 % ± 2.71 %) were attained by optimizing the rotation speed and mass ratio of PCL to composite powder . The microspheres had good spherical shape without large pores. The rate of release could be managed by different temperature and relative humidity conditions with the release of microspheres (96.82 % ± 0.81 % in 12 days) at the temperature of 60 °C (90 % relative humidity) and (86.50 % ± 2.71 % in 12 days) at the 90 % relative humidity (60 °C). Microsphere encapsulation of EUG and 1−MCP−α−CD was demonstrated by Fourier transform infrared spectroscopy and X-ray diffractometer. Thermal gravity analysis demonstrated that the degradation of EUG@β−CD and 1−MCP−α−CD was delayed after encapsulation. The deterioration of loquat (Baiyu, white-fleshed) can be postponed after treatment of EUG/1-MCP composite microspheres. Relative conductivity, total soluble solids, hardness, color, titratable acid , and weight loss of the loquat were also improved. It could significantly inhibit polyphenol oxidase (PPO) and peroxidase (POD) activities and inhibited browning of loquat tissue. EUG/1−MCP composite microspheres we formulated in this work might be employed to increase the shelf life of loquat.
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International Journal of Nanomedicine
·
2024
·
IF 6.6
Tingting Chen,Zimei Wu,Qiaodan Hou,Yixin Mei,Kunkun Yang,Jing Xu,Lin Wang
Purpose Given the escalating prevalence of diabetes, the demand for specific bone graft materials is increasing, owing to the greater tendency towards bone defects and more difficult defect repair resulting from diabetic bone disease (DBD). Melatonin (MT), which is known for its potent antioxidant properties, has been shown to stimulate both osteogenesis and angiogenesis.Methods MT was formulated into MT@PLGA nanoparticles (NPs), mixed with sodium alginate (SA) hydrogel, and contained within a 3D printing polycaprolactone/β-Tricalcium phosphate (PCL/β-TCP) scaffold. The osteogenic capacity of the MT nanocomposite scaffold under diabetic conditions was demonstrated via in vitro and in vivo studies and the underlying mechanisms were investigated.Results Physicochemical characterization experiments confirmed the successful fabrication of the MT nanocomposite scaffold, which can achieve long-lasting sustained release of MT. The in vitro and in vivo studies demonstrated that the MT nanocomposite scaffold exhibited enhanced osteogenic capacity, which was elucidated by the dual angiogenesis effects activated through the NF-E2–related factor 2/Heme oxygenase 1 (Nrf2/HO-1) signaling pathway, including the enhancement of antioxidant enzyme activity to reduce the oxidative stress damage of vascular endothelial cells (VECs) and directly stimulating vascular endothelial growth factor (VEGF) production, which reversed the angiogenesis-osteogenesis uncoupling and promoted osteogenesis under diabetic conditions.Conclusion This study demonstrated the research prospective and clinical implications of the MT nanocomposite scaffold as a novel bone graft for treating bone defect and enhancing bone fusion in diabetic individuals.
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