Food Chemistry-X
·
2023
·
IF 6.1
Yiwei Tang,He Meng,Wenxiu Wang,Yang Song,Shuo Wang,Zhuanying Li,Xianghong Wang,Xuelian Hu
An innovative core–shell magnetic molecularly imprinted polymers, Fe 3 O 4 @SiO 2 @MIPs, was elaborately tailored for specific separation and enrichment of olaquindox (OLA) and its metabolic marker methyl-3-quinoxaline-2carboxylic acid (MQCA). Herein, benefiting from the combination of functionalized magnetic nanoparticles (Fe 3 O 4 @SiO 2 ) and MIPs, Fe 3 O 4 @SiO 2 @MIPs not only possessed favorable magnetic properties and stability, avoiding tedious sample pretreatment process, but also demonstrated exceptional selective recognition ability and adsorption capacity, suppressing influence of coexisting interfering substances. Encouraged by prominent merits, Fe 3 O 4 @SiO 2 @MIPs-based magnetic solid phase extraction with HPLC method was developed, realizing simultaneous measurement of OLA and MQCA. Under optimal conditions, excellent linear ranges of 0–100 μg/L with detection limit of 0.175–0.271 μg/L were obtained. The proposed method was finally utilized for determination of OLA and MQCA in fish muscle and milk samples with satisfactory recoveries (80.56–95.26%) and relative standard deviation below 8.1%, furnishing a reliable and sensitive strategy for enrichment and detection residual veterinary drugs in food samples.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2018
·
IF 2.831
Zhaokun Wang,Pengfei Zhao,Bolin Zhu,Zhen Jiang,Xingjie Guo
In this work, a nanocomposite, Fe 3 O 4 /graphene was prepared and characterized. Five profens (including ibuprofen, flurbiprofen, pranoprofen, indoprofen and loxoprofen sodium) were extracted from three environmental water samples by using the synthetic Fe 3 O 4 /graphene, followed by simultaneous determination of the enantiomers on a Chiralcel OJ-RH column coupled with a triple quadrupole mass spectrometry. Factors affecting the extraction efficiency, such as amount of adsorbents, solution pH, ionic strength, type and volume of desorption solvent, as well as elution time were thoroughly investigated. Method validation showed high sensitivity with method quantification limits in the range of 8.49–26.3 ng/L. Satisfactory recovery (73.6–90.2%), good intra-day precision (RSD 3.2–9.7%) and inter-day precision (RSD 5.2–10%) were also obtained. Furthermore, possible interactions between analyte and graphene, such as electrostatic attraction, charge-π interaction, hydrophobic interaction and π-π stacking were discussed by combining the experiment results and molecular docking study, which provided a new insight into the adsorption mechanism of graphene.
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RSC Advances
·
2016
·Vol. 6
·期 56
·50487-50496
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IF 3.289
Wenhua Ji,Mingming Zhang,Wei Liu,Xingmin Wang,Wenjuan Duan,Hongkai Xie,Xiao Wang
Hydrophilic magnetic molecularly imprinted polymers (HMMIPs) have been synthesized by directly coating onto Fe3O4 alkenyl glycosides glucose as a novel water-miscible functional monomer, which introduces an abundance of hydrophilic groups into polymers. Photographs of the dispersion properties and water contact angles demonstrated that these HMMIPs have excellent hydrophilicity compared with those prepared using the traditional hydrophilic functional monomer, methacrylic acid. HMMIPs were characterized by Fourier transform infrared spectroscopy, vibrating sample magnetometry, transmission electron microscopy, scanning electron microscopy, and X-ray diffraction. Binding experiments indicated that HMMIPs had an excellent imprinting effect and high selectivity. Under optimum magnetic molecular imprinted solid phase extraction (MMISPE) conditions, a wide linear range (0.01–50.0 μg mL−1), with low limits of detection and quantification (0.005–0.01 μg mL−1 and 0.019–0.033 μg mL−1, respectively), was achieved for eight iridoid glycosides (IGs). Typical chromatograms obtained using MMISPE showed that major interferences around the IGs were eliminated efficiently and matrix interference was minimized. The results suggest that our newly developed method, combining MMISPE with HPLC, could be used for the selective enrichment and determination of IGs.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2013
·Vol. 14
·期 5
·10397-10411
·
IF 2.464
Ning Gan,Jing Zhou,Ping Xiong,Tianhua Li,Shan Jiang,Yuting Cao,Qianli Jiang
The CdTe quantum dots (QDs), graphene nanocomposite (CdTe-G) and dextran–Fe3O4magnetic nanoparticles have been synthesized for developing an ultrasensitive electrochemiluminescence (ECL) immunoassay for Carcinoembryonic antigen 19-9 (CA 19-9) in serums. Firstly, the capture probes (CA 19-9 Ab1/Fe3O4) for enriching CA 19-9 were synthesized by immobilizing the CA 19-9’s first antibody (CA 19-9 Ab1) on magnetic nanoparticles (dextran-Fe3O4). Secondly, the signal probes (CA 19-9 Ab2/CdTe-G), which can emit an ECL signal, were formed by attaching the secondary CA 19-9 antibody (CA 19-9 Ab2) to the surface of the CdTe-G. Thirdly, the above two probes were used for conjugating with a serial of CA 19-9 concentrations. Graphene can immobilize dozens of CdTe QDs on their surface, which can emit stronger ECL intensity than CdTe QDs. Based on the amplified signal, ultrasensitive antigen detection can be realized. Under the optimal conditions, the ECL signal depended linearly on the logarithm of CA 19-9 concentration from 0.005 to 100 pg/mL, and the detection limit was 0.002 pg/mL. Finally, five samples of human serum were tested, and the results were compared with a time-resolved fluorescence assay (TRFA). The novel immunoassay provides a stable, specific and highly sensitive immunoassay protocol for tumor marker detection at very low levels, which can be applied in early diagnosis of tumor.Keywords:dextran-Fe3O4magnetic nanoparticles;sandwich immunoassay;graphene CdTe QD nanocomposite;carcinoembryonic antigen 19-9;electrochemiluminescence
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JOURNAL OF CHROMATOGRAPHIC SCIENCE
·
2024
·
IF 1.5
Yang Shu-Tong,Cao Yi-Wen,Zeng Zi-Ying,Gang Zheng,Chen Min,Du Bing-Yan,Su Miao-Miao,Yang Zhong-Hua,Tang Zhu-Hua,Zeng Yun-Liu
In this work, a magnetic adsorption material based on metal–organic framework (Fe3O4@ZnAl-LDH@MIL-53(Al)) was synthesized and used as an adsorbent in the process of magnetic solid phase extraction. Then, a high-performance liquid chromatograph was used to quantitatively detect triazole fungicides in samples. In order to verify the successful preparation of the material, a series of characterization analyses were carried out. Besides, the key parameters that may affect the extraction efficiency have been optimized, and under optimal conditions the three triazole fungicides showed good linearity in the range of 10–1000 μg/L (R2 ≥ 0.9796); Limit of detections were ranged from 0.013 to 0.030 μg/mL. Finally, the established method was applied to the detection of triazole fungicides in four fresh juice samples. The results showed that the target analyte was not detected in all the test samples. By detecting the recoveries (73.3–104.3%) and coefficient variation (RSD ≤ 6.8%) of triazole fungicides in fortified samples, it proved that this established method meets the requirements of pesticide residue analysis and showed excellent application potential.
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Analytical Methods
·
2025
·
IF 2.6
Wei Li,Xin Hu,Anyi Chen,Rongxin Wu,Chaorui Li
Metal–organic framework (MOF-818) and nanocomposite (Fe3O4@PB-Au) dual nanozymes for enhanced cascade signal amplification were designed. MOF-818 has excellent catechol oxidase mimetic activity and catalyzes the production of color and in situ generation of hydrogen peroxide from the substrate 3,5-di-tert-butylcatechol (3,5-DTBC). Subsequently, Fe3O4@PB-Au with peroxidase-like activity catalyzes the generation of reactive oxygen species from hydrogen peroxide, which oxidizes 3,3′,5,5′-tetramethylbenzidine (TMB) to generate the oxidized state of oxTMB, resulting in a signal-enhancing effect. The prepared dual nanozymes can be combined with aptamers with specific recognition ability, thus developing a colorimetric aptamer sensor with high sensitivity and selectivity for detecting Golgi protein 73, which provides a feasible assay for clinical detection of GP73 protein. Detection of GP73 was accomplished by measuring the UV absorption peak at 415 nm. Under the optimal conditions, the concentration of GP73 was linearly correlated with the absorbance in the range of 10.0–100.0 ng mL−1 with a detection limit of 1.83 ng mL−1. The proposed colorimetric biosensor was successfully applied to the determination of GP73 in spiked human serum samples with recoveries of 96.15–100.95% and RSDs of 1.52–6.85%, which demonstrated the great potential of the highly sensitive GP73 assay in clinical detection.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Tianfei Qi,Ruonan Jia,Linbo Zhang,Guanyu Li,Xuefeng Wei,Jianting Ye,Ruilian Qi,Haiyuan Chen
Self-reporting corrosion protection coatings offer effective means to detect potential failures in advance, allowing for timely maintenance and extending the lifespan of metal materials. However, there currently remains a challenge in developing techniques capable of concurrently monitoring coating damage and metal corrosion throughout a procedure. Herein, N-CDs/Fe 3 O 4 hybrid nanoparticles with high peroxidase-like activity were fabricated through a two-step hydrothermal process which exhibit superior affinity (K m =1.2 mM) towards H 2 O 2 than HRP and effectively turn-on the color of TMB . Combined with the excellent responsiveness towards 8-HQ and the strict linear dependent relationships towards Fe 3+ (ranging from 0.75 to 15.15 μM), a novel colorimetric assay is established to not only turn on the signals to report the appearance of damage, but additionally switch the colors of TMB system to reveal the possible crack propagation and metal corrosion underneath. Moreover, the pre-existing corrosion, characterized by higher Fe 3+ concentration, is successfully indicated according to the color intensity enhancement compared with pristine metal sheet. Notably, such a multifunctional colorimetric assay enables the real-time and visual monitoring coating damage and metal corrosion simply through a Python program integrated into smartphones, serving as a promising strategy for promptly alerting of potential structural failures.
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JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Mansoor Khan,Ozgur Ozalp,Muslim Khan,Mustafa Soylak
In this work, we report the preparation of Fe 3 O 4 -Ti 3 AlC 2 max phase impregnated with 2-(5-Bromo-2-pyridylazo-5-(diethylamino) phenol) and its implementation for the extraction of cadmium, lead and cobalt from water and food samples. Blended Fe 3 O 4 -Ti 3 AlC 2 max phase impregnated with 2-(5-Bromo-2-pyridylazo-5-(diethylamino) phenol) was characterized using different instrumental techniques like scanning electron microscopy (SEM), surface area analyser (SAA), energy dispersive X-rays (EDX), Fourier transform infrared spectroscopy (FT-IR) and X-rays diffraction (XRD) for surface morphology, surface region, elemental composition, functional group and crystallinity, respectively. Factors that impact the % recoveries of analyte i.e pH, sample volume, vortex time, desorption condition and matrix impact were optimized. Analytical parameters like limit of detection (LOD) (Cd: 0.093 µg/L, Pb: 0.297 µg/L, Co: 0.223 µg/L), limit of quantifications (LOQ) (Cd: 0.310 µg/L, Pb: 0.992 µg/L, Co: 0.744 µg/L) preconcentration factors (PF) (Cd = Pb = Co: 40), enrichment factors (EF) (Cd: 39.8, Pb: 39, Co: 40) and relative standard deviation (RSD) (Cd: 3.8, Pb: 5.98, Co: 4.0) were determined under optimized trial conditions. The proposed strategy was tested using certified reference materials like TMDA-64.3 natural water and tobacco leaves (INCT-OBTL-5) for trace metal analysis. The developed strategy was also applied effectively to natural water samples and food samples using the standard addition method with good recovery results.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yun Wu,Yanqun Yang,Ming Wen,Jing Xie,Linchun Bao,Shuting Yang,Xiangming Luo,Xingyi Wang,Qianchun Zhang
Monoamine neurotransmitters play vital roles in cognitive and various physiological and pathophysiological processes, but their trace levels, small sample volumes, and complex biological matrices in biological samples pose significant analytical challenges. This study developed a novel method for the simultaneous quantification of six monoamine neurotransmitters—tyrosine, vanillylmandelic acid, tryptophan, 3,4-dihydroxyphenylacetic acid, 5-hydroxyindole-3-acetic acid, and homovanillic acid—in human serum and urine. The method utilizes magnetic solid-phase extraction coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). A multifunctional magnetic composite, polyethylenimine@polymer dopamine hydrochloride@NH 2 -MIL-53(Al)-SiO 2 @Fe 3 O 4 , was synthesized, exhibiting high extraction selectivity and capacity and achieving an extraction range of 9.61–25.4 nmol/mg for the target neurotransmitters. The analytical method, optimized for the aforementioned composite, exhibited robust linearity for all six monoamine neurotransmitters, with correlation coefficients ( R 2 ) exceeding 0.998. The limits of detection (S/N = 3) ranged from 1.1 to 22 ng/L, indicating high sensitivity. Recovery rates for the targeted analytes varied between 94.5 % and 112 %, and relative standard deviations remained within the range of 1.5–9.4 %. These findings confirm that the developed methodology is sensitive, accurate, selective, and reliable for the quantitative determination of trace monoamine neurotransmitters in complex biological samples.
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Sustainable Chemistry and Pharmacy
·
2026
·
IF 5.8
Jin-Yue Dong,Rong-Jie Wang,Qing Ran,Xiao-Bei Yang,Wen-Chao Han,Feng-Qi Dong,Di Chen
A novel microextraction method based on switchable natural deep eutectic solvents (SNADES) was developed for the determination of illicitly added non-steroidal anti-inflammatory drugs (NSAIDs) in herbal extracts, enabling one-step phase separation and magnetic retrieval of the extractant. The addition of ammonia solution induces the reversible transition of the hydrophobic SNADES (menthol:decanoic acid = 1:1) to a hydrophilic state, thereby significantly enhancing the extraction efficiency of the target analytes. Citric acid-modified Fe 3 O 4 composites (Fe 3 O 4 @CA) were employed to achieve rapid phase separation and efficient magnetic retrieval of the SNADES phase. After systematic optimization, the optimal conditions were established as 30 μL of SNADES, 70 mg of citric acid, 4 mg of Fe 3 O 4 , an extraction time of 4 min, and 100 μL of acetonitrile for desorption. Under the optimal conditions, four NSAIDs (flurbiprofen, diclofenac sodium, ibuprofen, and ketoprofen) exhibited good linearity over the concentration range of 0.1–20 μg/mL, with correlation coefficients (R 2 ) ≥ 0.993. The method provided relative recoveries of 93.7–109.2 % for the target analytes, with relative standard deviations (RSDs) ≤ 9.7 %. The limits of detection were in the range of 0.016–0.036 μg/mL. Spiked recovery experiments in real herbal extracts confirmed the method's accuracy (96.0–112.3 %), demonstrating that the proposed approach provides a rapid, efficient, and green sample preparation strategy for the screening of illicit synthetic drugs in herbal products.
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JOURNAL OF SUPERCRITICAL FLUIDS
·
2022
·
IF 4.514
Qianrui Xu,Pengcheng Gao,Yang Wang,Wenjie Jiang,Zhifei Wang,Yong Jiang,Zhen Jiao
Porous nanospheres have potential applications in reactions, catalysis and water treatment because of their high surface area, low density and high loading capacity. In this work, a reproducible and well-controlled way to fabricate hollow Polystyrene/Poly(divinylbenzene-co-methacrylic acid)@Fe 3 O 4 /Tannic acid@Ag (PS/P(DVB-co-MAA)@Fe 3 O 4 /TA@Ag) nanocomposites with high catalytic efficiency is developed. Firstly, hollow Polystyrene/Poly(divinylbenzene-co-methacrylic acid) (PS/P(DVB-co-MAA)) nanospheres with an open hole on the surface are produced by supercritical carbon dioxide (scCO 2 ) rapid depressurization methodology. The consequence shows that structure of polymer nanospheres is controllable by altering the reactive conditions, like temperature, pressure, solvent ratio, degree of cross-linking and time. Secondly, the magnetic Fe 3 O 4 and Ag nanoparticles are deposited onto the surface of hollow PS/P(DVB-co-MAA) nanospheres. The result indicates that hollow PS/P(DVB-co-MAA)@Fe 3 O 4 /TA@Ag nanocomposites are highly efficient in degrading dyes, displaying that the apparent rate coefficients of methylene blue (MB), rhodamine B (RhB) and 4-nitrophenol (4-NP) reduction are .0090 s −1 , 0.0239 s −1 , and 0.0073 s −1 , respectively. Besides, hollow PS/P(DVB-co-MAA)@Fe 3 O 4 /TA@Ag nanocomposites can be recycled at least seven times and show no significant loss in catalytic performance.
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JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Lin Wang,Qiya Sun,Yicheng Dou,Zhipeng Zhang,Tingting Yan,Yongmei Li
A novel ternary recyclable Fe 3 O 4 /graphene/sulfur-doped g-C 3 N 4 (Fe 3 O 4 /GE/SCN) composite catalyst was synthesized and adopted in a visible-light driven catalytic system for the degradation of ranitidine, which is an important precursor of the emerging disinfection by-product of N-nitrosodimethylamine (NDMA). The addition of GE and Fe 3 O 4 significantly improved the interface charge transfer of SCN, increased the light collection efficiency and decreased the photogenerated charge recombination efficiency. Considering both the ranitidine removal efficiency and catalyst recovery, the Fe 3 O 4 mass fraction of 20% (20%-Fe 3 O 4 /GE/SCN) was recommended. Ranitidine (≤ 2 mg/L) was completely removed in 60 min under the conditions of an initial pH of 7.0 and a 20%-Fe 3 O 4 /GE/SCN dose of 1.0 g/L, and its degradation fitted well with the pseudo first-order kinetics model. Electron paramagnetic resonance analysis and trapping experiments confirmed that ·O 2 − , ·OH and h + participated in the degradation of ranitidine. Ranitidine was removed through the pathways of demethylation and hydroxylation based on the analysis of the detected degradation intermediates, and 57.3% of the NDMA formation potential (FP) was reduced after the reaction. The visible-light driven 20%-Fe 3 O 4 /GE/SCN catalytic technology is a promising method not only for the control of NDMA FP but also the catalyst could be recovered and reused.
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