Journal of Chemistry
·
2021
·
IF 2.506
Xiaoxiao Zhu,Yijun Zhang,Pengfei Liu,Xiuzhi Bai,Na Chen,Yuping Zhang
Carbonized aramid fiber was prepared as a new type of adsorbent for in-tube solid-phase microextraction. The surface structure, chemical composition, and graphitization degree of the resulted fiber was determined and characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman spectrometry. The prepared fiber was packed in a stainless-steel tube instead of the sample loop of a six-port and tested for the extraction of five environmental estrogen hormones coupled with high-performance liquid chromatography. Several parameters affecting the estrogens’ extraction including the sampling volume, sampling rate, NaCl content, and desorption time were investigated in detail. The extraction tube with carbonized aramid fiber exhibited remarkable extraction performance towards five estrogen targets. The analysis method was established, and it exhibited a wide linear range (0.5–10.0 μg/L) with good linearity (correlation coefficient ≥0.9906), low limits of detection (0.011–0.13 μg/L), and high enrichment factors (178–1335) for the five analytes. Relative standard deviations (n = 3) for intraday (≤4.8%) and interday (≤4.0%) tests indicated that the extraction material had satisfactory repeatability. Bisphenol A released from a polycarbonate (PC) bottle was quantitatively detected with a concentration of 8.3 μg/L. The relative recoveries spiked at 5 and 10 μg/L were investigated, and the results were in the range of 74.3–121% for real water samples.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2021
·
IF 5.571
Xiao Peng Zhang,Bei Bei Wang,Wen Xuan Li,Wen Min Fei,Yong Cui,Xin Dong Guo
Dissolving microneedles (DMNs) are widely used in drug delivery systems since they are based on one-step application, which is simple and convenient for patients, especially for the patients such as diabetes who need daily or long-term self-administration. In general, the matrix materials of DMNs are water-soluble materials that can release the encapsulated drugs gradually by dissolving in the skin without generating sharp needle waste. However, the matrix materials of DMNs will also leave in the skin after application. Thus, it is vital to evaluate whether the matrix material of DMNs dissolved in the skin will cause health risks such as toxicity to the body or some skin-related complications to patients who frequent or long-term administration. In this work, PVA , as one of the typical matrix materials of DMNs, was selected to prepare the DMNs to research the safety of PVA-based MNs to the body after being dissolved in the skin. Briefly, in a 160 – days trial, the healthy mice were daily administrated by PVA MNs. The results showed that PVA materials mainly accumulated in the skin tissues of mice after dissolving and the concentration of PVA in the insertion sites gradually decreased and was almost undetectable at 6 days after administration. The observation of general conditions, blood hematological analysis and histological examinations of the mice demonstrated that the PVA-based MNs do not cause appreciable toxicity to the healthy mice after daily insertion in a 160 – days trial. Altogether, these results encourage further studies of PVA MNs for biomedical applications and support translation of PVA-based DMNs from pre-clinical development into clinical trials .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SAUDI PHARMACEUTICAL JOURNAL
·
2020
·
IF 2.879
Qing Wang,Di Zhuang,Wenchang Feng,Bitao Ma,Liping Qin,Lilun Jin
Osteoarthritis (OA) is a disease characterized by degeneration of the joint complex due to cartilage destruction. Fraxetin, a widely used and studied coumarin compound extracted from a traditional Chinese herb (Qin Pi), has shown anti-inflammatory and antioxidant properties, but its effects on OA have not been studied. In the present study, western blotting, immunofluorescence, and terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) were used to evaluate the effects of fraxetin on IL-1β-induced apoptotic activity, inflammatory responses, and catabolism in rat chondrocytes. The results showed that fraxetin prevented IL-1β-induced apoptosis of chondrocytes and inhibited inflammatory mediator release by regulating the Toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF)-κB pathway in chondrocytes. Additionally, fraxetin suppressed the upregulation of matrix metalloproteinase 13 (MMP13) and degradation of collagen II in the extracellular matrix (ECM). Moreover, the effects of fraxetin in vivo were assessed in a monosodium iodoacetate (MIA)-induced rat model of OA using hematoxylin and eosin (H&E) and Safranin O-fast green staining and magnetic resonance imaging (MRI). The results showed that fraxetin protected the cartilage against destruction. In conclusion, fraxetin could be a potential therapeutic for OA.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2020
·
IF 5.339
Huilan Piao,Yanxiao Jiang,Zucheng Qin,Pinyi Ma,Ying Sun,Xinghua Wang,Daqian Song,Qiang Fei
In this work, a rapid, convenient, sensitive, and cost-effective in-situ formed magnetic deep eutectic solvent based on a dispersive liquid-liquid extraction method was developed for the determination of triazine herbicides in rice. A novel tetrabutylammonium chloride (TBAC) based magnetic deep eutectic solvent (MDES), [TBAC/ethylene glycol][FeCl 4 ] was generated by means of an simple in-situ reaction of the deep eutectic solvent (DES) with iron chloride in the sample solution. The solvent which has high affinity for target analytes and magnetic ability was successfully employed as an extraction solvent and simplified both the extraction and separation procedure. A series of parameters influencing the extraction efficiency were investigated. Under optimal conditions, calibration curves for the target triazine herbicides were obtained in the ranges of 5–1000 ng g −1 , with correlation coefficients greater than 0.9910. The limits of detection (LOD) and quantification (LOQ) were in the range of 1.49–3.10 ng g −1 and 4.96–10.34 ng g −1 , respectively. The precision of intra- and inter-day were under 6.2% and 9.6%, respectively, and the precision between laboratories were lower than 7.5%. The accuracy of the method varied from 84.9 to 117.5%. Furthermore, the method showed satisfactory matrix effect and robustness. These results indicate that the technique is suitable for rice sample analysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AICHE JOURNAL
·
2020
·Vol. 66
·期 11
·e17015
·
IF 3.519
Caijin Zhou,Bingqi Xie,Shaowei Li,Jisong Zhang
In this work, an unsteady-state strategy for rapid measurement of gas diffusivity in liquid is proposed, which has a quick perturbation of the liquid flow rate in inner tube for obtaining the change of gas flow rate across the membrane with time. The strategy has taken full advantages of the tube-in-tube reactor that possesses a high permeability Teflon AF-2400 membrane to accelerate the diffusion rate of gas to liquid without direct contact between the two phases. With a developed mathematical model fitting the recorded variation of gas flow rate with time, the gas diffusivity in liquid can be determined within 0.5–3 min compared with the conventional methods of 4–14 hr. In addition, the strategy is demonstrated with several gas–liquid systems (O 2 -DMSO, CO 2 -[Emim] [NTf 2 ] and CO 2 -[Bmim] [BF 4 ]) with varied viscosities and temperatures, showing a good agreement with literature values with less than 10% deviation.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Ruoxi Wang,Xueting Zhao,Youyou Lan,Lifen Liu,Congjie Gao
Superhydrophilic and underwater superoleophobic membranes have recently attracted increased attention in oily wastewater treatment because of their potential to promote membrane permeability and minimize membrane fouling . Despite recent advances, the manipulation of membrane superwettability is usually achieved by coating functional layers on commercial hydrophobic porous substrates. The direct fabrication of superhydrophilic and underwater superoleophobic microporous membranes still remains a challenge. In this work, we provide a new in situ metal-polyphenol interfacial assembly strategy and prepare a new type of superwetting PES/SPES/MPN membranes. In the phase inversion of membrane formation, the coordination assembly of tannic acid (TA) and transition metal ions takes place alone with the solvent/nonsolvent exchange, resulting in the in situ deposition of metal-polyphenol networks (MPNs) on as-prepared polyether sulfone (PES)/sulfonated polyether sulfone (SPES) membranes. The PES/SPES/MPN membranes exhibit hierarchical surfaces and bi-continuous pores, and the in situ deposited MPNs provide hydrophilic bases. Among them, the PES/SPES/TA-Fe 3+ membrane showed the highest superhydrophilicity and underwater superoleophobicity. Thanks to the excellent superhydrophilicity, the water flux of PES/SPES/TA-Fe 3+ membrane can reach 4423 Lm −2 h −1 . Moreover, the PES/SPES/TA-Fe 3+ membrane exhibits high-performance for oil-in-water emulsion separation with high flux (>1500 Lm −2 h −1 ), excellent oil rejection (>99.5%) and reliable enhanced antifouling and recycling performance. This study provides a novel and facile strategy for the direct fabrication of superwetting microporous membranes, and predicts the potential application of PES/SPES/MPN membranes in oily wastewater treatment.
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 32
·17113-17120
·
IF 6.895
Ziren Xie,Xingjun Li,Renfu Li,Shan Lu,Wei Zheng,Datao Tu,Yanhui Feng,Xueyuan Chen
The metal halide perovskite quantum dots (APbX3 PeQDs; A = Cs or CH3NH3; X = Cl, Br or I) have emerged as a new type of promising optoelectronic material for light-emitting and photovoltaic applications because of their excellent optical properties. However, the precise control over the size and photoluminescence (PL) emission of APbX3 PeQDs remains a great challenge, which has been one of the main obstacles to the applications of PeQDs. Herein, we report a unique strategy for in situ confined growth of MAPbBr3 (MA = CH3NH3) PeQDs by using porous metal–organic framework (MOF) UiO-66 as a matrix. By introducing Pb(Ac)2 and MABr precursors into the pores of UiO-66 via a stepwise approach, ultrasmall MAPbBr3 PeQDs were in situ grown in the matrix with the size tuned from 6.4 to 3.3 nm by changing the concentration of the Pb(Ac)2 precursor. Accordingly, the PL emission wavelength of the resulting MAPbBr3 PeQDs was blue-shifted from 521 to 486 nm with the size reduction, owing to the strong quantum confinement effect of the PeQDs. Due to the surface passivation effect endowed by the UiO-66 matrix, the ultrasmall MAPbBr3 PeQDs also displayed a high PL quantum yield (PLQY) of 43.3% and a long PL lifetime of 100.3 ns. This study proposes a new strategy to prepare ultrasmall PeQDs and effectively control their sizes and PL emissions, which may open up new avenues for the development of high-performance luminescent PeQDs for diverse applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2020
·
IF 2.734
Chao Luo,Weibin Wu,Shuaijie Lou,Saiqi Zhao,Kai Yang
Tanshinone IIA (TA) is a major active ingredient of traditional Chinese medicine Salvia miltiorrhiza Bunge (Danshen) with poor solubility. The strong crystallinity of TA is the main reason for its poor solubility. Since sodium alginate (SA) can suppress the drug crystal growth and has excellent biocompatibility , we hypothesize that SA may be an ideal matrix for preparing solid dispersion (SD) to improve the dissolution rate and bioavailability of TA. In this study, a novel TA-SA-SD was developed via a rapid one-pot approach for improving the dissolution rate, in vivo bioavailability, and pharmacological activity of TA. The results of scanning electron microscopy (SEM), X-ray diffraction (XRD) confirmed the SD process will reduce the crystallinity of TA. The crystallinity reduction of TA in TA-SA-SD can obviously improve the dissolution rate, oral absorption rate and in vivo bioavailability, the relative bioavailability of TA-SA-SD (1:6) and TA-SA-SD (1:8) were 2.08 and 2.75 folds of TA, respectively. In vitro anti-inflammatory assays were performed in RAW264.7 cells by ELISA , fluorescence microscope and Western blot analysis . The results revealed that the TA-SA-SD can significantly improve the pharmacological activity of TA. This study provides a successful method of incorporating hydrophobic drugs into hydrophilic bio-macromolecules matrices for improving the dissolution rate and bioavailability.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2020
·Vol. 101
·期 7
·2779-2787
·
IF 2.614
Wenbi Guan,Yingxin You,Jialing Li,Jiaying Hong,Haiying Wu,Yanna Rao
BACKGROUND Penicillic acid (PA) is produced by Aspergillus spp. and Penicillium spp., which are common postharvest and storage fungi of fruits. PA can be of concern for human health because of its toxicity and high fruit consumption by the population. However, no data on PA occurrence in various fruits have yet been reported. A quick, easy, cheap, effective, rugged and safe (QuEChERS) approach for PA determination in various fruits was developed and applied to explore PA incidence in fruits. RESULTS The modified QuEChERS procedure with extraction by ethyl acetate and purification by multi-walled carbon nanotubes (MWCNTs), primary secondary amine (PSA) and octadecyl silane (C18) was established to determine PA in various fruits by high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS). The average recoveries were 72.9–102.2% and relative standard deviations (RSDs) were 1.3–7.9%. A total of 161 fruits samples, including kiwi, apple, peach, grape and mandarin/orange, were collected in southern China. The incidence of PA in fruits was 14.9% and the levels of PA contamination were 0.200–0.596 μg kg −1 . Our results suggested that orange/mandarin, grape and kiwi were favorable matrices for Aspergillus spp. and Penicillium spp. to produce PA, rather than peach and apple. CONCLUSION To the best of our knowledge, this is the first report about PA contamination in various fruits in China. Our study emphasizes the necessity of the current established method, which could be used for continuous monitoring of PA and reducing the health risk to Chinese consumers. © 2020 Society of Chemical Industry
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Dan Qiao,Zhen Zhang,Lingshuang Wang,Wei Sheng,Qiliang Deng,Shuo Wang
Test strips as one of micro-devices are widely concerned in the fields of point-of-care detection and in-field diagnosing. For the purpose of on-site detection of tyramine, a carbon dots-molecularly imprinted fluorescent sensing test strip with high selectivity has been successfully obtained via a rapid in-situ preparation procedure (about 2.5 h). Here, the layer composed of carbon dots-molecularly imprinted polymer (CDs-MIP) with the function of the recognition and signal transduce has been formed on the surface of the filter paper strips via the sol-gel method. The developed test strip displayed a high specificity (Imprinting factor, IF = 4.96); and its fluorescence emission was quenched linearly with the increase of tyramine concentration from 0.5 to 10.0 mg L −1 . The limit of detection (LOD) is 0.059 mg L −1 (3 σ/s ). The application potential was verified by sensing of tyramine in rice vinegar and white rice vinegar with the recoveries of 90.9-104.4% (RSD < 5.8%). Many advantages including a rapid preparation and high selectivity make the fluorescence strip suitable for on-site detection of tyramine. In addition, the preparation procedure can also be easily transferred to the preparation of the fluorescence strip toward other targets.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2020
·
IF 3.503
Hengqian Lu,Haiqin Chen,Xin Tang,Qin Yang,Hao Zhang,Yong Q. Chen,Wei Chen
Lipid hyperaccumulation in oleaginous microorganisms is generally induced by nitrogen limitation, while oxygen supply can influence biomass growth and cell metabolism. Although strategies based on nitrogen limitation or oxygen control have been extensively explored and applied in various oleaginous microorganisms, the role of oxygen supply in nitrogen limitation induced lipid hyperaccumulation still remains unclear. Here, we systematically surveyed the effects of oxygen supply on the oleaginous fungus M. alpina cultured in nitrogen limited conditions through integration of physiochemical parameters and metabolomics analysis. Our results indicated that a high oxygen supply promoted carbon/nitrogen consumption and was used for rapid biomass synthesis, while either high or low oxygen supply conditions were adverse to lipid and ARA accumulation. Different oxygen supply level significantly affected the balance between fermentation for lipid synthesis and respiration for energy generation. Under nitrogen limitation, a suitable oxygen supply promoted the recycling of preformed nitrogen and increased the redirection of carbon towards fatty acid synthesis through the hub centred around glutamic acid coupled to the intermediate metabolism of carbon in the TCA cycle, while a high oxygen supply favored the respiration process and enhanced the degradation of LC-PUFAs, rather than fermentation for fatty acid synthesis. This system-level insight reveals the underlying metabolic mechanism of oxygen control in nitrogen limitation induced lipid accumulation, and provides theoretical support for the integration of oxygen control with nutrient supply for efficient microbial oil production.
✓ 已验证
DOI
PubMed
高影响因子
CELLULOSE
·
2020
·Vol. 27
·期 17
·9825-9838
·
IF 4.21
Cao Qi,Ye Tian,Li Wenhui,Chen Jiao,Lu Yanyu,Gan Haifeng,Wu Hongli,Cao Fei,Wei Ping,Ouyang Pingkai
The dehydration of cellulose in polar aprotic solvents produces high-value anhydro-sugars, opening up a new avenue for the utilization of cellulose. However, there are still some problems that need to be solved. Herein, we selected some carbohydrates (e.g. cellulose, starch, cellobiose, maltose, methyl-β-D-glucopyranoside and methyl-α-D-glucopyranoside) to examine the influence of different glycosidic bonds and substituents on the preparation of levoglucosan (LGA). The results of LGA yields, reaction rate constants and activation energies from different saccharides show that β-glycosidic bond is more vulnerable to break, forming LGA more easily. The activation energies of the latter 4 carbohydrates are 89.9, 104.2, 93.3, 113.6 kJ/mol, respectively. The strength of acid affects the dehydration process of cellulose greatly. These acids whose p K a values are between − 3 and − 2, including p -toluenesulfonic acid, methanesulfonic acid, and sulfuric acid, can achieve the best yields of LGA and levoglucosenone (LGO). Accordingly, those acids with higher p K a value have no catalytic activity, whereas the rate of cellulose degradation using lower p K a valued acids as catalyst is too fast to be efficiently monitored and carbonization is severe. The side reaction of cellulose hydrolysis and the formation of byproducts including 5-hydroxymethylfurfural (HMF) and furfural (FF) could be suppressed effectively through the addition of phosphorus pentoxide as water absorbent into the reaction system. The molar concentration ratio of LGO and (HMF + FF + Glucose) reached 12.04, which is 105% higher than those without water absorbent. This ratio can reach 21.38 in LGA dehydration into LGO process when phosphorus pentoxide was added.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）