MICROCHIMICA ACTA
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2024
·Vol. 191
·期 11
·1-11
·
IF 5.3
Huang Ziyu,Yang Guangwei,Deng Qiuling,Zhang Xuhui,Wei Xiaoping,Li Jianping
Methidathion (MTDT), a common organophosphorus pesticide with high insecticidal activity, is widely used for pest control. However, the misuse of MTDT leads to widespread residues and endangers human health. Therefore, it is crucial to develop a simple and highly sensitive method for the detection of MTDT residues. Herein, ZIF-90/MnO 2 /g-C 3 N 4 /Fe 3 O 4 composite particles were synthesized: The MnO 2 nanosheets could absorb the energy of the excited g-C 3 N 4 to quench the ECL of g-C 3 N 4 while ZIF-90 acted as a mimetic enzyme to catalyze the formation of thiocholine from MTDT. The thiocholine caused the reduction of MnO 2 to Mn 2+ , restoring the ECL signal of g-C 3 N 4 . Combined with molecular imprinting technique, an electrochemiluminescence sensor was constructed for the determination of MTDT. The determination range was 1.00 × 10 –9 ~ 7.00 × 10 –7 g/L, and the detection limit was 6.58 × 10 –10 g/L. Structurally similar organophosphorus pesticides showed no cross-reactivity. The method has high sensitivity and specificity, and has been successfully applied to the determination of MTDT residue in fruits with recoveries in the range 93.75% ~ 102.37%. Graphical abstract
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 5
·1-14
·
IF 2.4
Wang Xiangke,Meng Xuan,Shi Li,Liu Naiwang,Wang Jiyu
In the tert-butyl removal reaction, solid acid catalysts have emerged as a preferred alternative to liquid acid catalysts due to their environmentally friendly advantages. Various zeolites, such as ZSM-5, MCM-41, USY, and H beta, as well as mesoporous materials, such as γ-Al 2 O 3 and active clay were employed for the first time to prepare m-cresol through the tert-butyl removal reaction of 4,6-di-tert-butyl-m-cresol (4,6-DBMC). γ-Al 2 O 3 and active clay catalysts were found to have excellent catalytic performance in this reaction. The thermodynamic properties of the tert-butyl removal reaction of 4,6-DBMC were studied. Under different temperature and solvent conditions, the product distribution was investigated. A proposed reaction pathway and mechanism were proposed. And through cyclic experiments, the stability of γ-Al 2 O 3 and active clay catalysts was investigated separately. After six cycles, the m-cresol yield for active clay catalyst was still maintained at about 90%. The causes of deactivation of the two catalysts were analyzed. After regeneration, both catalysts exhibited good regeneration performance. This study offers a basis for the selection of solid acid catalysts for the tert-butyl groups removal of 4,6-DBMC. Graphical abstract
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BMC Complementary Medicine and Therapies
·
2024
·Vol. 24
·期 1
·1-13
·
IF 3.3
Li Jiao,Zhang Qi-Yun,Lu Qing-Yu,Liu Qiao-Zhou,Guo Li,Li Min,Sun Qian-Yun
IntroductionAcute lung injury (ALI) as one kind of acute pulmonary inflammatory disorder, manifests primarily as damage to alveolar epithelial cells and microvascular endothelial cells. Activation of the complement system is a common pathological mechanism in ALI induced by diverse factors, with the complement alternative pathway assuming a pivotal role. Baicalin, a flavonoid derived from the root of Scutellaria baicalensis Georgi, exhibits noteworthy biological activities. The present study attempted the interventional effects and underlying mechanisms of baicalin in microangiopathy in ALI induced by complement alternative pathway activation.Methods Activation of the complement alternative pathway by cobra venom factor (CVF). HMEC cells were pretreated with baicalin and then exposed to complement activation products. The expression of inflammatory mediators was detected by ELISA, and the intranuclear transcriptional activity of NF-κB was assessed by a dual fluorescent kinase reporter gene assay kit. Before establishing the ALI mouse model, baicalin or PDTC was gavaged for 7 d. CVF was injected into the tail vein to establish the ALI model. The levels of inflammatory mediators in BALF and serum were determined by ELISA. HE staining and immunohistochemistry evaluated pathological changes, complement activation product deposition, and NF-κB p65 phosphorylation in lung tissue.Results Baicalin reduced complement alternative activation product-induced expression of HMEC cells adhesion molecules (ICAM-1, VCAM-1, E-selectin) and cytokines (IL-6, TNF-α) as well as upregulation of NF-κB intranuclear transcriptional activity. Baicalin intervention reduced the number of inflammatory cells and protein content in the BALF and decreased the levels of IL-6, TNF-α, and ICAM-1 in serum and IL-6, TNF-α, ICAM-1, and P-selectin in BLAF. In addition, baicalin attenuated inflammatory cell infiltration in the lung of ALI mice and reduced the deposition of complement activation products (C5a, C5b-9) and phosphorylation of NF-κB p65 in lung tissue.Conclusion Baicalin relieves complement alternative pathway activation-induced lung inflammation by inhibition of NF-κB pathway, delaying the progression of ALI.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
Hu Haojie,He Chen,Zhu Di,Zhang Weilai,Zhuo Xiaocun,Li Yuguo,Shi Quan
While ultra-high-resolution mass spectrometry has enabled the identification of the molecular composition of dissolved organic matter (DOM), elucidating its molecular structure remains a challenging endeavor. Here, two fulvic acids (FAs), one from river and the other from forest soil, were subjected to reduction using an optimized n -butylsilane ( n -BS) reduction method. The reduction products were purified through a combination of liquid-liquid extraction and silica gel column chromatography, resulting in the separation into saturates, aromatics, and polar products. The polar products were analyzed by high-resolution mass spectrometry (HRMS), and the saturates and aromatics were analyzed using gas chromatography-mass spectrometry (GC-MS). HRMS results showed that the number of oxygen atoms and double-bond equivalent (DBE) values of FA decreased after reduction. GC-MS results revealed that a total of 270 hydrocarbon monomers were identified from the reduction products of a single sample, with the highest carbon number of cycloalkanes reaching C 33 . For the first time, steranes and hopanes were detected in the reduction products, potentially serving as evidence for the existence of carboxyl-rich alicyclic molecule (CRAM) precursors. Additionally, a significant number of polycyclic aromatic hydrocarbons were identified, and the potential sources of various compounds were preliminarily inferred based on their isomers. This study extends the knowledge of the possible backbone structure of the DOM and provides a new potential tool for investigating the origin and transformation mechanisms of DOM. Graphical Abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2019
·Vol. 411
·期 18
·4073-4084
·
IF 3.286
Xia Ling,He Yuanyuan,Xiao Xiaohua,Li Gongke
Herein, a total online device based on field-assisted extraction (FAE), micro-solid-phase extraction (μ-SPE), and high-performance liquid chromatography (HPLC) was designed. Solid samples were pretreated with ultrasound-microwave synergic effects, and then the extract was cleaned up online with a monolithic column, followed by HPLC analysis. The cross-actions between ultrasound and microwave along with other extraction parameters were studied systematically. The efficiency of this online method was verified in the determination of polycyclic aromatic hydrocarbons (PAHs) in foods and tetracycline antibiotics (TCAs) in cosmetic samples. The detection limits of nine PAHs including fluorene, phenanthrene, anthracene, fluoranthene, benzo[k]fluoranthene, benz[a]anthracene, benzo[b]fluoranthene, pyrene, and benzo[a]pyrene were all within 0.075–0.30 μg/kg, as well as four TCAs including oxytetracycline, tetracycline, chlortetracycline, and doxycycline were within 0.02–0.06 μg/kg. Six PAHs were found in roast potatoes and baked fish and the recoveries were in the range of 71.5–119.7% with RSDs of 0.2–10.9% ( n = 3). The recoveries for TCAs in cosmetic samples were in the range of 75.3–118.0% with RSDs lower than 8.2% ( n = 3). Compared with those offline methods, this total online FAE-μ-SPE-HPLC method not only simplifies the operation process, but also increases the precision and accuracy. Beyond trace analytes analysis in solid and semi-solid matrixes, application of this total online analysis method can also be extended to investigate field-assisted extraction mechanisms.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 10
·9873-9886
·
IF 2.8
Liu Rong,Zhang Yonggang
Fe 2 O 3 /graphite (Fe 2 O 3 /C) and nano-TiO 2 -coated glass bead were prepared by impregnation and sol–gel method respectively and employed as the catalyst of a novel three-dimensional electrode photoelectrocatalytic (3-D PEC) system. The photoexcited electrons can transfer from TiO 2 , Fe 2 O 3 to counter electrode. It improves the migration of photoexcited charges, retards the fast recombination of electron–hole, and increases the lifetime of photogenerated holes (h + ). In addition, the cycle reaction of Fe 3+ /Fe 2+ on Fe 2 O 3 /C surface enhanced the Fenton reaction which can produce more hydroxyl radicals (·OH) and promote the capacity of mineralization of the pollutants. This novel 3-D PEC system showed excellent performance for the degradation of berberine chloride form (BCF). At the pH value of 3, 93% BCF was removed within 60 min; besides, 98.64% COD removal rate, 78.96% mineralization, 21.47% mineralization current efficiency, and just 3.16 kW h g −1 TOC energy cost were obtained in 120 min. In this study, we proposed the 3-D PEC mechanism. Electron spin resonance (ESR) and scavenging experiments suggest that the major reactive oxygen species (ROS) are superoxide radicals (O 2 ·− ), ·OH, and h + , while the role of sulfate radical (SO 4 ·− ) is insignificant. This work provides a new dimension for the design of reactors for wastewater treatment and the construction of the 3-D PEC system can potentially be utilized in water purification.
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Electronic Materials Letters
·
2024
·
IF 2.1
Yao Yubo,Dai Hongfei,Ji Mengnan,Han Ying,Jiang Bo,Cheng Chi,Song Xiaolei,Song Ying,Wu Guangfeng
Flexible strain sensors that combine high sensitivity and wide range are important for developing wearable electronics. In this paper, AgNWs/MXene/SEBS flexible strain sensor with high sensitivity and wide strain range was prepared using a thermoplastic elastomer (styrene-ethylene-butene-styrene) SEBS as the polymer matrix and AgNWs and MXene as the composite conductive fillers. The sensitivity of the AgNWs/MXene/SEBS sensor is significantly higher than that of the AgNWs/SEBS and MXene/SEBS sensors based on a single conductive filler. At 100% strain, the AgNWs/MXene/SEBS sensor has a sensitivity of 176.25. The sensor detects small strains of 0.5-5% as well as large strains of 5–50% with high linearity. The sensors remained stable after 200 cycles. The AgNWs/MXene/SEBS tensile sensors were subjected to array testing and finger bending recognition, and the sensors have promising applications in human motion monitoring. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Zhang Xun,Feng Ximin,Guo Wenqi,Zhang Chengjian,Zhang Xinghong
Polyvinyl chloride (PVC) is the world’s third-most widely manufactured thermoplastic, but has the lowest recycling rate. The development of PVC-like plastics that can be depolymerized back to monomer contributes to a circular plastic economy, but has not been accessed. Here, we develop a series of chemically recyclable plastics from the reversible copolymerization of cyclic anhydride with chloral. The copolymerization is highly efficient through the anionic or cationic mechanism under mild conditions, yielding polyesters with tunable structure and properties from multiple commercial monomers. Notably, these polyesters manifest mechanical properties comparable to PVC and polystyrene. Meanwhile, such polyesters are flame-retardant like PVC due to high chloride content. Of significance, these polyesters can be depolymerized back to starting monomers at high temperatures owing to the reversibility of the copolymerization, leading to a circular economy. Overall, the readily available monomers, simple synthesis, advantageous performance, and practical recyclability make the polymers promising for applications.
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BMC Pulmonary Medicine
·
2025
·Vol. 25
·期 1
·1-13
·
IF 2.8
Huang Zhiheng,Li Liangxian,Zhang Bingxi,Yao Dong,Xiao Bo,Mo Biwen
Background Bronchial asthma, a chronic inflammatory airway disease, is characterized by airway remodeling, including thickening of the airway smooth muscle layer, primarily due to abnormal proliferation of airway smooth muscle cells (ASMCs). CBL0137 (Curaxin-137 hydrochloride), a histone chaperone facilitate chromatin transcription (FACT) inhibitor, has demonstrated anti-tumor properties, including inhibition of proliferation, promotion of apoptosis, and increased autophagy. However, its effects on ASMCs and airway remodeling remain unexplored. Methods Asthma models were established using ovalbumin (OVA) in female C57BL/6 J mice, with therapeutic interventions using CBL0137 and budesonide. Lung tissues were analyzed using Hematoxylin and eosin (H&E), PAS, Masson’s trichrome, and α-SMA immunofluorescence staining. ASMCs extracted from Sprague–Dawley rats were cultured in vitro experiments, with phenotypic changes assessed via flow cytometry. Gene and protein expressions were analyzed using RT-PCR and Western blotting. Results CBL0137 significantly reduced airway resistance, goblet cell proliferation, alveolar collagen deposition, and airway smooth muscle layer thickening in asthmatic mice. In vitro, CBL0137 inhibited ASMC proliferation and induced apoptosis, downregulating cyclin-B1, Cdc2, and Bcl-2 while upregulating caspase-3. Conclusions CBL0137 mitigates airway remodeling of asthmatic mice by modulating ASMC proliferation and apoptosis, presenting a potential therapeutic strategy for asthma treatment.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Qian Hui,Wang Yuxuan,Zhou Xibin,Gu Tao,Wang Hui,Lyu Hao,Li Zhikai,Li Xiuxu,Zhou Huan,Guo Chengchen,Yuan Fajie,Wang Yajie
The UniProt database is a valuable resource for biocatalyst discovery, yet predicting enzymatic functions remains challenging, especially for low-similarity sequences. Identifying superior enzymes with enhanced catalytic properties is even harder. To overcome these challenges, we develop ESM-Ezy, an enzyme mining strategy leveraging the ESM-1b protein language model and similarity calculations in semantic space. Using ESM-Ezy, we identify novel multicopper oxidases (MCOs) with superior catalytic properties, achieving a 44% success rate in outperforming query enzymes (QEs) in at least one property, including catalytic efficiency, heat and organic solvent tolerance, and pH stability. Notably, 51% of the MCOs excel in environmental remediation applications, and some exhibited unique structural motifs and unique active centers enhancing their functions. Beyond MCOs, 40% of L-asparaginases identified show higher specific activity and catalytic efficiency than QEs. ESM-Ezy thus provides a promising approach for discovering high-performance biocatalysts with low sequence similarity, accelerating enzyme discovery for industrial applications.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 5
·1-13
·
IF 2.4
Lu Xingyu,Sun Jiahao,Yang Pengfei,Yang Xianjun,Hu Qin,Chen Liuyun,Qin Zuzeng,Su Tongming
CdS photocatalysts have attracted extensive attention in the area of photocatalytic hydrogen generation, yet their limited light absorption and charge transfer efficiencies still restrict their photocatalytic performance. In this study, NiS was grown on CdS to synthesize xNiS/CdS composites via a hydrothermal method and was used for photocatalytic hydrogen evolution. The introduction of NiS increased the light absorption intensity and broadened the light absorption range in the visible light region. In addition, a close contact interface formed between NiS and CdS, which accelerated the transfer and separation of photogenerated electrons and holes. Furthermore, NiS acts as the electron aggregation center and active site for photocatalytic hydrogen evolution. Therefore, the photocatalytic performance of the xNiS/CdS composites was greatly enhanced. Among the xNiS/CdS composites, the 0.5NiS/CdS composite exhibited the optimal photocatalytic hydrogen evolution rate of 36.75 mmol·h − 1 ·g − 1 , which was 7.84 times greater than that of CdS. A possible mechanism of photocatalytic H 2 production over xNiS/CdS is also proposed. This work provides new inspiration for the rational design of high-efficiency cocatalyst/CdS composites. Graphical
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2025
·Vol. 40
·期 2
·382-388
·
IF 1.1
Cao Tian,Li Wei,Ren Lin,Song Tao,Song Jie,Lin Jiacheng,Yang Li,Liu Wenxiu,Wang Ping,Feng Shaojie
The adsorption of phosphate was conducted by the complex of chitosan/polyacrylamide/ferric(CS/PAM/Fe(III)) prepared. The SEM images and XPS spectra confirmed the successful adsorption of phosphate. The adsorption process was studied by varying the influencing aspects like pH, co-existing ions, contact time, and initial phosphate concentration. The experimental results indicate that the adsorptive capacity decreases with the increase of pH. However, it is commendable that there is still a adsorption capacity of more than 5 mg/g when the pH is 8–11. The adsorption kinetics can be accurately described by the pseudo-second-order model and is controlled by both chemisorption and surface diffusion. The adsorption process is a single layer adsorption. This paper proposed that the adsorption mechanism of CS/PAM/Fe(III) complex is the joint action of electrostatic attraction and ligand exchange.
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