Advanced Agrochem
·
2026
·
IF 9.2
Jingyuan Zhang,Chen Yin,Nasi Ai,Fengzhi Lyu,Lili Shi,Bining Jiao,Jun Lv,Guangyang Liu,Ge Chen,Xiaomin Xu,Lin Qin,Donghui Xu
A ZnAg-ZIF@MPN nanopesticide was constructed via hierarchical MOF loading and metal–phenolic network encapsulation. • Metal node engineering significantly enhanced neonicotinoid pesticide loading capacity within ZIF microporous frameworks. • The MPN shell enabled pH-responsive release behavior and improved environmental stability under light exposure. • The hybrid nanoplatform exhibited enhanced foliar adhesion and rainfall resistance, reducing pesticide loss. • The system achieved improved insecticidal efficacy and lower final residue with favorable crop safety. Zeolitic imidazolate frameworks (ZIFs) emerge as promising pesticide delivery platforms due to their high porosity, structural tunability, and potential for stimuli-responsive release. However, their practical application is still constrained by limited loading capacity, insufficient environmental stability, and poor foliar retention under field conditions. Herein, a hierarchical nanopesticide system (ZnAg-ZIF/NIT@MPN) is constructed through a dual-engineering strategy combining bimetallic framework design and interfacial metal–phenolic network (MPN) coating. The incorporation of Zn 2+ and Ag + enables the formation of a stable ZIF matrix with enhanced pesticide loading capacity, which is further improved through parameter optimization. Subsequently, in situ deposition of a tannic acid (TA)-based MPN shell provides an additional functional interface for environmental regulation and delivery control. The resulting nanopesticide exhibits a confinement–interface synergistic mechanism, where the ZIF core ensures efficient pesticide encapsulation and structural stability, while the MPN shell regulates environmental responsiveness and interfacial interactions. This architecture significantly enhances photostability and enables pH-triggered release behavior, achieving rapid pesticide release under acidic conditions following first-order kinetics. In addition, ZnAg-ZIF/NIT@MPN shows improved wettability, foliar adhesion, and rainfastness, thereby reducing pesticide loss under environmental stress. Bioassays demonstrate markedly improved insecticidal efficacy against whiteflies with 95% mortality within 48 h, while maintaining favorable biosafety toward crop germination and early growth. Furthermore, residue analysis indicates reduced pesticide persistence at the harvest stage, while metal-leakage analysis reveals limited release of framework-derived Ag, Zn, and Fe species under the tested conditions. Overall, this work presents a hierarchical nanopesticide design strategy based on core–shell confinement and interfacial regulation synergy, offering a viable approach for improving pesticide efficiency, environmental stability, and agricultural safety in sustainable crop protection systems. Download: Download high-res image (179KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Food and Bioprocess Technology
·
2026
·Vol. 19
·期 10
·496
·
IF 5.6
Gu Nixuan,Zhang Yingfan,Zhu Liang
Highly perishable fruit suffers postharvest losses from respiration, microbes, and microenvironmental shifts, which conventional packaging cannot dynamically address. This study developed dual-responsive active films via in situ hydrothermal synthesis of HKUST-1 within a chitosan (CS)/polyvinyl alcohol (PVA) matrix co-loaded with cinnamaldehyde (Cin). pH-responsiveness stems from CS amino protonation, while humidity sensitivity involves water-induced disruption of HKUST-1 carboxylate-Cu coordination. Structural properties (morphology, crystallinity, and bonding), mechanical strength, barrier function, and pH/humidity-responsive release kinetics were meticulously characterized. The acidic, high-humidity microenvironment generated during postharvest storage triggered the pH/humidity-dependent release of Cin, conferring potent antibacterial activity against Staphylococcus aureus ( S. aureus ). Preservation tests with Chilean blueberries demonstrated that the films prolonged shelf life by reducing decay, suppressing weight loss, and inhibiting microbial growth. This study establishes a novel strategy for microenvironment-responsive active packaging. The dual-release mechanism synchronizes preservative delivery with fruit spoilage signals, advancing intelligent preservation technologies for perishable foods.
✓ 已验证
DOI
高影响因子
FUEL
·
2026
·
IF 7.8
Yujie Tang,Yunqi Song,Yumei Zhang,Xueni Ma,Fei Ye,Rui Zou,Yao Yao
Conventional crystalline Ru-based catalysts often suffer from insufficient stability and limited active sites under acidic and alkaline conditions, hindering their practical application. To address these limitations, we designed an amorphous Ru catalyst supported on COF-derived nitrogen-doped carbon substrate (Ru x /NC). By strategically modulating the kinetic nucleation and thermodynamic aggregation behavior of Ru, we precisely engineered amorphous Ru nanoparticles with a size of approximately 3 nm, stabilizing Ru at the critical point of amorphous-to-crystalline transition. This unique structural configuration offers multiple catalytic advantages, including a high density of low-coordination active sites and an electronic structure that enables optimal hydrogen adsorption. Moreover, the isotropic nature of amorphous Ru enhances its resistance to corrosion and structural degradation. Benefiting from these merits and the synergistic effects with the NC framework, the optimized Ru 3nm /NC catalyst establishes a new benchmark for robust hydrogen evolution, demonstrating exceptionally low overpotentials, ultra-small Tafel slopes, and outstanding durability across the wide pH range, which offers valuable insights for the rational design of next-generation electrocatalysts.
✓ 已验证
DOI
高影响因子
Pharmaceutics
·
2026
·Vol. 18
·期 4
·498
·
IF 6.9
Xingmeng Ma,Zhu Wang,Jingyi Wang,Xingyu Chen,Jinggang Zhang,Dengxue Yang,Shiyi Xu,Xueying Yan
Background/Objective : In lung cancer treatment, increasing the concentration of antitumor drugs at the tumor site, enhancing efficacy, and reducing systemic toxicity are significant challenges. This study aims to develop an intelligent responsive polymer micelle system (GPDD) that achieves efficient accumulation and controlled release of drugs at lung tumor sites through targeted and pH-responsive design. Methods : The GPDD system is formed by the self-assembly of GE11-PEG-hyd-DOX conjugates and co-loads free DOX. This system utilizes the targeting effect of the GE11 peptide with the epidermal growth factor receptor (EGFR) to accumulate at the tumor site, while the hydrazone bond serves as a pH-responsive linker that breaks in the acidic tumor microenvironment, triggering drug release. Experiments employed CCK-8 cytotoxicity assays and tumor-bearing nude mouse models (strain not specified) for in vitro and in vivo evaluations. Results : In vitro experiments showed that GE11-modified GPDD effectively inhibited tumor cell growth. In tumor-bearing nude mouse experiments, GPDD demonstrated more significant tumor suppression effects and lower systemic toxicity compared to free DOX and unmodified PDD. Conclusions : The GPDD nanocarrier integrates targeting and pH responsiveness, improving antitumor efficacy and reducing side effects, with translational potential. The novelty of the study lies in its dual-functional design and co-loading strategy, providing new insights for tumor-targeted delivery systems.
✓ 已验证
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2026
·
IF 3.9
Yating Xu,Tingting Lei,Chen Wang,Shaojing Zhao,Cheng Li,Minhuan Lan
Thiram, a widely used dithiocarbamate pesticide, can threaten ecological systems and human health through residual contamination. Here, manganese and nitrogen co-doped carbon dots (Mn, N-CDs) were harnessed as a photo-driven oxidase-like nanozyme to build a visual colorimetric assay for thiram. Under light irradiation, Mn, N-CDs can generate singlet oxygen ( 1 O 2 ) and superoxide (O 2 − ·) and maintain good photozyme activity over a broad pH range. The Mn, N-CDs/3,3′,5,5′-tetramethylbenzidine (TMB) mixture produces a blue oxidized product under illumination; after introducing thiram, the oxidation of TMB is suppressed because thiram consumes 1 O 2 and O 2 − ·, thereby producing a thiram concentration-dependent color-fading signal. Notably, extending the irradiation time enhances the analytical sensitivity by allowing the chromogenic reaction to approach a more stable readout. The proposed method can be coupled with smartphone-based RGB quantification to enable portable digital readout under natural light. In addition, satisfactory recoveries and repeatability were obtained in diverse real water samples. The proposed approach thus offers a feasible strategy for developing broad-pH-applicable, facile, and on-site colorimetric sensing for pesticide monitoring.
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Wenjun Qin,Yong Zhang,Kai Xiang,Zhaoxia Li,Ziyang Wen,Zixun Wang,Jingying Sun,Peng-Fang Zhang,Zhiping Dai,Chun Jiang,Haiqing Zhou,Xiaolin Wei,Yuxue Mo
Developing highly efficient and economical electrocatalysts with both high activity and excellent stability for the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and ethanol oxidation reaction (EOR) remains a significant challenge. In our work, a heterostructure CoP 2 -Fe 2 P//CoWO 4 catalyst has been successfully integrated onto Ni foam via a two-step hydrothermal reaction and a phosphorization process. Electrochemical evaluations confirm a synergistic catalytic effect between CoP 2 and Fe 2 P. The CoP 2 -Fe 2 P//CoWO 4 catalyst exhibits enhanced HER catalytic activity across a wide pH range, requiring relatively low overpotentials of only 42, 138 and 32 mV to achieve 10 mA cm −2 under alkaline, neutral and acidic conditions, respectively. Meanwhile, for the EOR, the CoP 2 -Fe 2 P//CoWO 4 catalyst requires a potential of only 1.37 V to achieve 100 mA cm −2 , which is much lower than that required for the OER (1.53 V). Furthermore, density functional theory (DFT) calculations and Raman spectroscopy reveal that high-valence metal species CoOOH and FeOOH are likely the real active species responsible for water dissociation and EOR, respectively. This work may provide a new pathway for heterostructured catalysts based on transition metal phosphides in the field of small-molecule electrolysis.
✓ 已验证
DOI
PubMed
高影响因子
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
·
2026
·
IF 6.6
Wei Ma,Hongyan Yang,Xinyue Ma,Jiao Huang,Li Chen,Atsushi Takahara
The development of polymer prodrugs with well-defined architectures capable of forming stable nanomicelles is important for achieving precise and efficient drug delivery. Compared with conventional linear systems, star-shaped copolymer prodrugs offer enhanced micellar stability owing to their covalently tethered architecture. However, many existing synthetic approaches rely on transition-metal catalyzed polymerization and customized monomers, which limit their sustainability and practical applicability. Herein, we report a pH-responsive doxorubicin (DOX)-conjugated benzaldehyde-functionalized star-shaped copolymer synthesized via an environmentally benign metal-free atom transfer radical polymerization (ATRP) strategy. A hydroxyl-functionalized star-shaped copolymer scaffold was first prepared from readily available monomers and subsequently modified to introduce pendant benzaldehyde groups, enabling DOX conjugation through acid-labile imine linkages. This approach affords well-controlled polymer architectures while avoiding transition-metal residues and the need for pre-functionalized monomers. The resulting DOX-conjugated star-shaped copolymers form unimolecular micelles with high colloidal stability and exhibit pH-triggered drug release under acidic conditions. In vitro studies further demonstrate effective cellular internalization and a moderated cytotoxic profile toward human large-cell lung carcinoma (H460) cells, supporting the functional viability of this micellar system as a polymer prodrug delivery platform.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Yaqi Zhang,Shiyao Liu,Hongman Xu,Jiahui Wu,Ruquan Zhang,Yongzhen Tao
Polyanionic polysaccharide-based hydrogels were developed as multistimuli-responsive drug carriers. Methacrylated pullulan (MP) acted as a thinner and rigidity regulator. Carboxymethylated-methacrylated xanthan gum (CMMXG) provided negative charges, ionic conductivity, and viscoelasticity. The cumulative ciprofloxacin hydrochloride (CPFXH) release mass dropped dramatically, whether the hydrogel was set at the anode or cathode with a potential of 3 V, due to irreversible electrochemical oxidation. Hydrogels with lower drug-loading amounts exhibited higher release efficiency when an electric stimulus was applied in the initial 5 h. A high CPFXH-loading amount led to rapid diffusion and quick electrochemical oxidation. For CMMXG3-MP7.5-CPFXH1680-LAP, the CPFXH release efficiency ratio of 3 to 0 V decreased from 1.33 ± 0.43 to 1.01 ± 0.06 over a duration of 0.5 ∼ 2 h, further indicating that the encouraged release and electrochemical degradation occurred simultaneously. The CPFXH release efficiency in phosphate buffer saline (pH = 7.4) was 1.5 times higher than that in simulated gastric fluid (pH = 1.2), and the CPFXH diffusion coefficient with loading weight was 6 times higher than that without loading, indicating that it was sensitive to pH and compressive force. The hydrogels exhibited electric, pH, and mechanical stimuli-responsiveness due to the presence of charged groups along the chains and viscoelasticity with robustness enough to respond and withstand compressive loading.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL EDUCATION
·
2026
·
IF 3
Shuaitong Wang,Yang Liu,Yuchen Dong,Meilin Wang,Yanqing Zhang,Shuyan Gao
This laboratory experiment provides undergraduate students with an introduction to functional film materials (FFMs) through the design and fabrication of pH-responsive indicator films. In this experiment, blueberry anthocyanins (BA) are incorporated into a carboxymethyl cellulose (CMC) and xanthan gum (XG) matrix stabilized by citric acid, resulting in films that display distinct and pH-responsive color change from pink (pH 2) to purple (pH 7) and to brown (pH 12). The 3 h module provides a hands-on investigation of structure–property relationships, allowing students to correlate molecular transformations with macroscopic color changes. The experiment incorporates green chemistry principles by employing natural pigments and reducing reagent consumption, while simultaneously fostering core competencies in material synthesis, mechanical testing, and analytical applications. The films exhibit robust mechanical properties, ensuring durability during student handling, and their extension to ammonia gas sensing further illustrates cross-disciplinary adaptability. Implemented in the Functional Materials curriculum (semesters 3–4), this low-cost, simple-equipment approach connects theoretical concepts from Materials Science and Smart Materials courses, fostering system-level thinking and industry-relevant problem-solving skills.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Shanle Zhang,Yunjie Sun,Zhipeng Xu,Yani He,Xiaodi He,Yue Zhang
The integration of inhibitor-encapsulated nanocontainers within organic coatings offers a viable approach for achieving sustained corrosion mitigation and extended protective functionality. In this study, a ZIF-8@LDH-P (ZLP) nanocontainer was developed, consisting of Ni-Co layered double hydroxide (LDH) derived from zeolitic imidazolate framework-8 (ZIF-8) precursors and incorporating trisodium phosphate (TSP) as a corrosion inhibitor. The release of phosphate ions from ZLP exhibited pH-responsive behavior, enabling triggered inhibitor release under corrosive conditions. When uniformly dispersed in the polyvinyl butyral (PVB) resin matrix and coated on Q235 carbon steel, the PVB/ZLP composite coating demonstrated an enhancement of two orders of magnitude in low-frequency impedance modulus (|Z| 0.01 Hz ) relative to pure PVB. Furthermore, the PVB/ZLP coating exhibited long-term protective capabilities, ascribed to the cooperative effect of regulated phosphate ions release for active corrosion inhibition, chloride ion entrapment by LDH interlayers, and the prolonged diffusion pathways for corrosive agents enabled by the lamellar structure of LDH. This study offers novel design strategies for ZIF-derived LDH nanocontainer-based anti-corrosion coatings with inhibitor loading.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Wang Xuewei,Zhang Yue,Wu Hao,Yang Zelei,Ma Sufang,Li Lihong,Guo Lixia,Yan Lili,Zhang Boye,Liu Jianfei,Diao Haipeng,Ren Guodong,Zhang Chengwu,Liu Wen
Esophageal cancer (EC) is a highly malignant tumor that poses a significant threat to patient survival. Chemotherapy, a mainstay treatment for EC, often yields unsatisfactory outcomes due to chemotherapy resistance, the low efficacy of monotherapy and off-target toxicity. Therefore, it is imperative to develop one novel therapeutic strategy capable of overcoming drug resistance, enabling tumor microenvironment-responsive drug release, and achieving multimodal synergistic therapy. Currently, treatment of chemotherapy-resistant EC (CREC) faces great challenges. To address this, a pH-responsive nanoplatform, CDs-DOX-GOX@PEG (CDG@PEG), composed of iron-doped carbon dots (Fe-CDs), doxorubicin (DOX), glucose oxidase (GOX), and polyethylene glycol (PEG), was fabricated to improve CREC treatment through synergistic and targeted therapy. The physicochemical properties of CDG@PEG were characterized using TEM, XPS, XRD, FTIR and other techniques. Its anti-tumor efficacy was assessed with DOX-resistant KYSE-30 cells and corresponding xenograft mouse models. Moreover, the underlying therapeutic mechanism was further investigated via transcriptomic, immunofluorescence and immunohistochemical analyses. Physicochemical characterization results showed that the designed nanoplatform was successfully fabricated, which was endowed with outstanding pH-responsive behavior and O₂/ROS-generation capabilities. In vitro, CDG@PEG demonstrated excellent cellular uptake and potent tumor cell-killing capacities. In vivo, it displayed superior anti-tumor efficacy with good biocompatibility. Mechanistically, CDG@PEG realized the CREC therapy by down-regulating drug-resistant genes (such as HIF-1α related genes), inducing mitochondrial dysfunction, and triggering cell apoptosis. This work opened new avenues for developing novel therapeutic strategies against chemotherapy-resistant cancers. Graphical The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL PHYSICS
·
2026
·
IF 2.8
Haoming Huang,Xi Wang,Xiaohui Zhang,Chenghang Li,Jing Zhang,Shan Qing,Zhumei Luo
TiO 2 /H 2 O NFs exhibit the highest stability at pH = 2 and pH = 12. • Near the IEP, electrostatic repulsion weakens, leading to particle aggregation. • Combined experimental and DLVO theory to analyze TiO 2 /H 2 O NFs stability. • Temperatures above 318 K and proximity to the IEP degrade TiO 2 /H 2 O NFs thermal performance. Nanofluids (NFs) attract attention in heat transfer due to high thermal conductivity, but nanoparticle aggregation limits their performance. Herein, 0.1 wt% TiO 2 /H 2 O NFs were prepared by a two-step method to investigate the effects of pH (2−12) and temperature (293–353 K) on their stability and thermal performance. Stability was highest at pH = 2 and 12, and the isoelectric point (IEP) was located at pH = 6.5. Near the IEP, weakened electrostatic repulsion promoted aggregation, as confirmed by particle size, Brownian-to-settling velocity ratio, and SEM observations. Derjaguin-Landau-Verwey-Overbeek (DLVO) theory showed that the reduced interaction energy barrier near the IEP increased aggregation, which raised relative viscosity, lowered thermal conductivity, and deteriorated the performance enhancement ratio (PER). The best PER values were obtained at pH = 2 and 12, consistent with the enhanced stability away from the IEP. This study provides a basis for optimizing NF stability and thermal performance via pH control for reliable thermal management. Stability and thermal properties of TiO 2 /H 2 O nanofluids at different pH values. Download: Download high-res image (294KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）