BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Cong Tang,Zhaosheng Qian,Yuanyuan Huang,Jiamin Xu,Hang Ao,Meizhi Zhao,Jin Zhou,Jianrong Chen,Hui Feng
A convenient, reliable and highly sensitive assay for alkaline phosphatase (ALP) activity in the real-time manner is developed based on β-cyclodextrin-modified carbon quantum dots (β-CD-CQDs) nanoprobe through specific host-guest recognition. Carbon quantum dots were first functionalized with 3-aminophenyl boronic acid to produce boronic acid-functionalized CQDs, and then further modified with hydropropyl β-cyclodextrins (β-CD) through B-O bonds to form β-CD-CQDs nanoprobe. p -Nitrophenol phosphate disodium salt is used as the substrate of ALP, and can hydrolyze to p -nitrophenol under the catalysis of ALP. The resulting p -nitrophenol can enter the cavity of β-CD moiety in the nanoprobe due to their specific host-guest recognition, where photoinduced electron transfer process between p -nitrophenol and CQDs takes place to efficiently quench the fluorescence of the probe. The correlation between quenched fluorescence and ALP level can be used to establish quantitative evaluation of ALP activity in a broad range from 3.4 to 100.0 U/L with the detection limit of 0.9 U/L. This assay shows a high sensitivity to ALP even in the presence of a very high concentration of glucose. This study demonstrates a good electron donor/acceptor pair, which can be used to design general detection strategy through PET process, and also broadens the application of host-guest recognition for enzymes detection in clinical practice.
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2015
·
IF 4.504
Xiangli Zheng,Shan Liu,Xiaoxia Hua,Fangquan Xia,Dong Tian,Changli Zhou
ABSTRACT A new electrochemical sensor for determination of 2,4,6-trichlorophenol (2,4,6-TCP) was fabricated. The characterization of the sensor was studied by scanning electron microscopy, electrochemical impedance spectroscopy and cyclic voltammetry techniques. The electrochemical behavior of 2,4,6-TCP was investigated using cyclic voltammetry and differential pulse voltammetry at the HS-β-cyclodextrin (HS-β-CD)/gold nanoparticles (AuNPs) composite modified indium tin oxide (ITO) electrode. The results showed that the current responses of 2,4,6-TCP greatly enhanced due to the high catalytic activity and enrichment capability of composites. The peak current of 2,4,6-TCP increases linearly with the increase of the 2,4,6-TCP concentration from 3.0 × 10 −9 to 2.8 × 10 −8 M, with the limit of detection of 1.0 × 10 −9 . Further more, the modified electrode was successfully applied to detect the level of 2,4,6-TCP in tap water samples with excellent sensitivity.
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2024
·
IF 2.3
Bing Shao,Yang Fu,Bo Li,Siming Huo,Jiayu Du,Xuliang Zhang,Xin Yin,Yanfei Li,Zheng Cao,Miao Song
Faced with infectious bone defects, the development of a thermosensitive hydrogel containing icariin (ICA) represents a promising therapeutic strategy targeting infection control and bone regeneration. In this study, we prepared and evaluated the physicochemical properties, in vitro and in vivo drug release, antimicrobial activity, anti-inflammatory properties, and bone repair effects of ICA/Chitosan/β-Glycerophosphate (ICA/CTS/β-GP) thermosensitive hydrogel. Our findings demonstrate that the ICA/CTS/β-GP thermosensitive hydrogel undergoes a liquid-to-gel transition at body temperature, which is crucial for maintaining local drug release at the defect site. Additionally, the hydrogel exhibited sustained release of ICA over 28 days, showing high antimicrobial activity against Staphylococcus aureus and good biocompatibility in blood compatibility tests. In a canine model of infectious bone defects, the ICA/CTS/β-GP thermosensitive hydrogel showed effective infection control and modulated inflammation, vascular formation, and bone factor expression, while also activating the Wnt/β-catenin signaling pathway. In conclusion, the ICA/CTS/β-GP thermosensitive hydrogel could control infection and repair bone tissue. Its antimicrobial and osteogenic properties provide hope for its clinical application.
✓ 已验证
DOI
高影响因子
Advanced Electronic Materials
·
2023
·Vol. 9
·期 5
·2201241
·
IF 6.2
Bingquan Peng,Quan Zhang,Yueyu Zhang,Yimin Zhao,Shengyue Hou,Yizhou Yang,Fangfang Dai,Ruobing Yi,Ruoyang Chen,Jun Wang,Lei Zhang,Liang Chen,Shengli Zhang,Haiping Fang
2D materials are promising nanomaterials for future applications due to their predominant quantum effects and unique properties in optics, electrics, magnetics, and mechanics. However, explorations in unique properties and potential applications of novel 2D materials have been hampered by synthesis and their stability under ambient conditions. Recently, in the graphene, 2D β-CuI is observed experimentally under ambient conditions. Here, it is shown that this 2D β-CuI@graphene possesses unexpected piezoresistive effect and room-temperature ferromagnetism. Moreover, this 2D β-CuI crystal is likely to be stable in a wide range of temperature, that is, below 900 K. Theoretical studies reveal that the unexpected piezoresistive effect is mainly attributable to the convergence of the electrons on Cu and I atoms to the Fermi level with increasing strain. There is a magnetic moment that is ≈0.97 μ B on the edge of β-CuI nanocrystal created by an iodine vacancy, which is considered the origin of such strong room-temperature ferromagnetism. Clearly, the 2D β-CuI@graphene provides a promising nanomaterial in the nano-sensors with low power consumption pressure and magnetic nano-devices with a size down to atomic scale. The discovery in the present work will evoke various new 2D nanomaterials with novel properties in nanotechnology, biotechnology, sensor materials, and technologies.
✓ 已验证
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Jin Zhang,Mengting Gao,Pengqi Zhu,Yunwei Wang,Ruiyi Wang,Zhanfeng Zheng
The design of efficient photocatalyst for selective hydrogenation of α,β -unsaturated aldehydes to unsaturated alcohols is changeling. In this study, oxygen vacancy enriched MgAl-layered double hydroxide (MgAl-LDH) supported Co 3 O 4 nanoparticle photocatalysts are developed taking the advantage of the semi-memory effect of CoMgAl-LDH. Excellent photocatalytic performance was achieved with a 99 % cinnamaldehyde conversion and 98 % cinnamyl alcohol selectivity at 100 °C under visible light irradiation. The electron enriched Co 3 O 4 nanoparticles facilitated the activation of isopropanol to provide active H species under light irradiation. In situ DRIFTS and DFT calculation results suggest the oxygen vacancies of MgAl-LDH were beneficial to the terminal O adsorption of –C O group in cinnamaldehyde and ensure the high selectivity of cinnamyl alcohol. This study demonstrated a novel synthesis strategy of Co 3 O 4 nano-photocatalyst for the efficient selective hydrogenation under visible light irradiation.
✓ 已验证
DOI
高影响因子
PROCEEDINGS OF THE COMBUSTION INSTITUTE
·
2022
·
IF 6.535
Wen-luan Xie,Bin Hu,Ying Liu,Hao Fu,Ji Liu,Bing Zhang,Qiang Lu
Lignin pyrolysis involves complex radical reactions, whereas the radical chain process, especially the influence of aliphatic substituents , has been rarely studied. Herein, the typical β -O-4 lignin dimer, phenethyl phenyl ether (PPE), and three aliphatic substituted derivatives of PPE, namely α -OH substituted, β -CH 2 OH substituted, and α,β -disubstituted PPE ( α PPE, β PPE, and αβ PPE) were employed as model compounds. DFT calculations, electronic analyses, and fast pyrolysis experiments were combined to investigate three core steps of the radical chain mechanism in lignin pyrolysis, i.e., homolysis, hydrogen abstraction , and radical decomposition. The pathway involving successive C β -O homolysis → α -hydrogen abstraction → C β -O breakage of α -dehydrogenated radical is dominated for the pyrolysis of aliphatic substituted β -O-4 linked lignin, with the formation of phenolics . The hydrogen abstraction reactions at the C α site are obviously superior to those at other sites for PPE derivatives, due to the p- π conjugate stability. Notably, α -hydrogen abstraction can be significantly promoted by the π -electron-dispersing α -OH substitution. The decomposition step of dehydrogenated radicals can be facilitated by the electron-donating β -CH 2 OH substitution, where the C β -O breakage of the α -dehydrogenated radical is dominant. Totally, aliphatic substituents can improve the radical growth stage and change the competitiveness of the hydrogen abstraction and radical decomposition reactions. The fast pyrolysis experiments of PPE and α PPE gave direct proof that the generation of characteristic products from the radical chain process, i.e., benzaldehyde and phenylacetaldehyde, was enhanced by the α -OH substitution. The present work offers the potential to give a comprehensive image of the radical chain mechanism in lignin pyrolysis.
✓ 已验证
DOI
高影响因子
ACS Applied Optical Materials
·
2023
·
IF 0
Jie Zhu,Yang Sun,Meng-Xin Duan,Zheng-Wu Wang,Xin Tan,Zhen Yu,He-Fang Wang
The fast and accurate detection of β-lactamase is a prerequisite of customized treatments and food safety. We present a pretreatment-free dual-excitation three-mode detection of β-lactamase by using ZnAl2O4:Cr3+ etched by ethylenediaminetetraacetic acid disodium (ZAO-EDTA) as a phosphorescent probe and nitrocefin as the signal mediator. The changes in the wavelength overlaps of UV–vis absorbance of nitrocefin upon interactions with β-lactamase and the dual excitation of ZAO-EDTA enable the design of three detection modes: i.e., the enhanced emission when excited at 393 nm, the quenched emission when excited at 533 nm, and the ratio of enhanced excitation of 393 nm and decreased excitation of 533 nm to determine β-lactamase. All three modes have a wide linear range, high sensitivity and selectivity, and fine anti-interference capability. The lowest limit of detection is observed in the ratiometric excitation mode (0.2 U·L–1), and the proposed method can directly detect β-lactamase in bacteria and milk samples without any pretreatments, with the spiked recoveries of 95.3–113% and relative standard deviation < 3.1%. Therefore, the proposed method would be attractive for the detection of β-lactamase in a complex sample, and the ZAO-EDTA probe can be widely used to establish other excitation ratiometric optosensings by changing other signal mediators.
✓ 已验证
DOI
SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Muhammad Usman,Adeel Ahmed,Zhijian Ji,Bing Yu,Youqing Shen,Hailin Cong
Heavy metals and endocrine disrupters often co-exist in wastewater, while their possible competition behaviours make uptake removal more challenging. Therefore, β-Cyclodextrin based nanocomposite adsorbent was successfully fabricated (β-Cyclodextrin/ZrO 2 ) for the simultaneous uptake of Pb(II) and Bisphenol A from wastewater. FTIR, XRD , and XPS confirmed the successful fabrication of the β-Cyclodextrin/ZrO 2 nanocomposite. In this setting, oxygen-containing groups are primarily responsible for the Pb(II) binding, while the β-Cyclodextrin cavities adsorb Bisphenol A through host-guest interaction, enabling the simultaneous removal of Pb(II) and Bisphenol A. In the mono contaminant system, the nanocomposite displayed prominent removal ability toward Pb(II) and Bisphenol A with adsorption characteristics of pseudo-second-order, Langmuir, and Freundlich isotherm model. The maximum adsorption capacities were identified for Pb(II) and Bisphenol A to be 274.4 mg/g and 174.9 mg/g at 298 K, respectively. Most importantly, the β-Cyclodextrin/ZrO 2 could efficiently attain simultaneous removal of Pb(II) and Bisphenol A by avoiding their competitive behaviours was due to the different adsorption mechanisms (electrostatic interaction and host-guest interaction). Moreover, the adsorbed Pb(II) and Bisphenol A could be successfully recovered with a slight decline in nanocomposite removal performance even after 4 cycles in the binary-component system. All these findings provide insights into the fabrication of highly effective adsorbent with separated adsorption sites to treat wastewater bearing heavy metal and endocrine disrupters.
✓ 已验证
DOI
高影响因子
CELLULAR SIGNALLING
·
2026
·
IF 4.7
Yunhe Xu,Yao Wang,Miao Yu,Yang Li,Fuxin Wan,Xiaoning Wang
Periodontitis (PD), a common inflammatory disorder causing irreversible periodontal degradation, is linked to systemic issues. Orthodontic tooth movement (OTM) in the context of PD worsens bone loss, which severely compromises orthodontic treatment stability and increases the risk of treatment failure. This study aims to thoroughly investigate the protective effects of Columbianadin (CBN) against PD/OTM-induced alveolar bone injury and dissect its underlying molecular mechanisms. To induce osteogenic differentiation, MC3T3-E1 cells were maintained in a specialized osteogenic induction medium supplemented with ascorbic acid and β-glycerophosphate. In vitro experiments using MC3T3-E1 cells revealed that CBN treatment substantially fostered osteoblastic differentiation, as reflected by elevated alkaline phosphatase (ALP) activity and robust matrix mineralization. Mechanistically, CBN enhanced SIRT1-mediated β-catenin deacetylation, whereas EX527-driven SIRT1 inhibition reduced β-catenin activity in differentiated cells. A rat OTM model within the framework of PD was established to document alveolar bone loss. We found that CBN exerted a protective effect on alveolar bone mass in PD/OTM rats, as it not only promoted alveolar bone formation but also inhibited bone resorption. CBN treatment also suppressed pro-inflammatory cytokine secretion in the alveolar bone of PD/OTM rats. Network pharmacology analysis identified potential target genes involved in CBN-mediated osteogenic differentiation. In summary, CBN protects against PD/OTM-induced alveolar bone damage in a SIRT1/β-catenin-dependent manner, suggesting CBN as a promising candidate for treating periodontal and OTM-related bone disorders.
✓ 已验证
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Yanyan Zhao,Shuhao Wang,Zhuan Yi,Yong Zhou,Congjie Gao
A novel β-cyclodextrin (β-CD)/polyamide film reverse osmosis (RO) membrane was prepared by in situ interfacial polymerization via mixing β-CD with m-phenylenediamine in the aqueous phase prior to reaction with trimesoyl chloride. The effects of the β-CD concentration on the morphology and separation performance of the RO membrane were studied. β-CD was employed to improve the pure water flux of the membrane. When the concentration of β-CD in aqueous solution was 1.5% (w/v), both the rejection of NaCl and the pure water flux were maintained at a high level. In this case, water flux of the β-CD-modified RO membrane was nearly1.52 times that of the β-CD-free polyamide membrane. This increase might have been caused by the high concentration of β-CD hydrophilic hydroxyl groups, which appeared to directly improve the performance of the composite film. In addition, the unique properties of the resulting membrane, including the loosely cross-linked structure formed by β-CD and the polyamide film, the intramolecular cavity existed in β-CD and the affinity of β-CD to water molecules, was ascribed as the reasons for the improved performance of higher permeability.
✓ 已验证
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2017
·Vol. 314
·期 3
·1607-1618
·
IF 1.282
Liu Huijun,Qi Caixia,Feng Zhiyuan,Lei Lanlin,Deng Shanxia
The adsorption of thorium(IV) was studied using a novel supramolecular polyrotaxane based on β-cyclodextrin derivatives. The effects of pH, contact time, Th(IV) initial concentration and adsorbents dosage on the adsorption of thorium(IV) by polyrotaxane were optimized using Box–Behnken design of response surface methodology. Analysis of variance and correlation coefficients showed that the predicted model was consistent with the experimental data well. The adsorption best fitted to the Langmuir model indicated that the adsorption process happened on homogeneous surface. The thermodynamic parameters (∆ G
0 < 0, ∆ H
0 > 0, ∆ S
0 > 0) demonstrated that the adsorption of Th(IV) ions onto polyrotaxane was spontaneous and endothermic.
✓ 已验证
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2016
·
IF 2.933
Rong Tu,Dingheng Zheng,Hong Cheng,Mingwei Hu,Song Zhang,Mingxu Han,Takashi Goto,Lianmeng Zhang
Halide chemical vapor deposition process was carried out for fast fabricating oriented stoichiometric β-SiC through controlling flow rate of precursors (SiCl 4 and CH 4 ). The effects of molar ratio of C and Si precursors ( R C/Si ) on composition, preferred orientation, microstructure and deposition rate ( R dep ) were investigated. The deposits transformed from silicon-rich to stoichiometric β-SiC to carbon-rich with increasing R C/Si . 〈110〉-oriented stoichiometric β-SiC with lower density of defects were obtained at R C/Si in the range of 0.86–1.00, where the maximum R dep was 883 μm/h at R C/Si = 1.00, leading to a thickness of 1.7 mm in 2 h deposition. Formation of ridge-like morphology has been discussed based on a twin plane propagation model .
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）