Environmental Science-Nano
·
2023
·
IF 7.3
Chuanhao Yan,Xuefeng Yu,Jinlong Zhang,Jinglei He,Wenyi Jia,Jianlong Wang,Fuqiang Liu,Junfeng Liu,Xilong Wang
To significantly enhance the unsatisfactory Au(III) sorption performance (2280 mg g−1) by a material designed in our previous work, we ingeniously fabricated a nano-sized and uniform molybdenum composite (MoCOM) using a household microwave oven; it was embedded in a nanofiber mat by electrospinning technique to synthesize a novel material (CS-MoCOM-Th) for effective Au(III) sorption. After embedding MoCOM, an ultrahigh maximum sorption capacity (4090 mg g−1) of Au(III) at high concentrations and a sorption efficiency at low concentrations by CS-MoCOM-Th (99.59%) were achieved at pH 4.0. Mechanistically, the excellent Au(III) sorption performance was mainly driven by electrostatic attraction by protonated C–N+ groups and coordination interaction with N- or S-containing moieties: C–N, CN, C–N+, CS, S(−II), and Sn(−II). During sorption, 69.42% of Au(III) was directly reduced to elemental gold on CS-MoCOM-Th, and gold foils precipitated on the nanofiber mat. Notably, excellent sorption selectivity of Au(III) on CS-MoCOM-Th was achieved when heavy metals, including Cu(II), Ni(II), Pb(II), and Zn(II), and noble metal Pt(IV) were co-present at 2 × 10−3 mg mL−1. CS-MoCOM-Th could still sorb 82.15% of Au(III) at 0.01 mg mL−1 after four cycles. Overall, this study highlights that CS-MoCOM-Th is one of the most competitive candidates for Au(III) recovery from the aqueous phase.
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高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Jiangsheng Li,Zhu You,Benchao Zheng,Shiyi Zhai,Kuangda Lu
Despite that radiotherapy (RT) is a prevalent treatment of cancer, enhancing tumor dose deposit and reversing resistance are two major challenges in its clinical application. Here, we report Au–ZnO (AZ) nano matches that drastically increase reactive oxygen species (ROS) generation and alleviate hypoxia in RT on triple-negative breast cancer. Upon X-ray irradiation, Au increases X-ray attenuation and excites the adjacent ZnO by electron scattering, electron transfer, and energy transfer. Meanwhile, Au plays the role of a reservoir of electrons that promotes the charge separation in ZnO, thereby significantly improving the ROS production efficiency and causing the ROS burst. The ROS generation efficiency of AZ is determined to be 2.03 times that of Au. In contrast, a physical mixture of Au and ZnO only slightly increased the ROS generation compared to Au (1.18 times). Moreover, AZ catalyzes H2O2 decomposition to produce oxygen at excited states, thus modulating tumor hypoxia. Clonogenic assay showed that AZ had efficient radiosensitization with radiation enhancement factors of 4.01 and 3.50 in 4T1 breast cancer cells under normoxia and hypoxia, respectively. AZ-enhanced RT can successfully eliminate or shrink tumors (two of the six were completely removed) upon 4 Gy of X-ray irradiation on 4T1 tumor-bearing mice. At the end point, the average tumor size in AZ with the RT-treated group was only 1.8% of that of PBS with RT, significantly outperforming the other control groups including a physical mixture of Au and ZnO nanoparticles at the same concentrations..
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ELECTROCHIMICA ACTA
·
2023
·
IF 6.6
Junhong Li,Danhua Zhu,Hui Huang,Shuqian Xie,Jingkun Xu,Ruirui Yue,Xuemin Duan
Herein, the electrochemical sensing platform has been proposed based on metal-organic framework doped Au/poly(3,4-ethylenedioxythiophene) (PEDOT) composites to simultaneously detect the catechin and sunset yellow in tea beverage. The characterization reveals that the Au nanoparticles distribute well on/in conducting PEDOT, and the relatively few UIO-66 particles as the dopant intersperse the Au/PEDOT composites. The electrochemical test has been used to study the sensing properties toward catechin and sunset yellow simultaneous detection. The results show that the Au/PEDOT/MWCNT-CONH-UIO-66 performs a wide range of 0.03∼60 µM and 0.3∼40 µM, low detection limit as 0.01 μM / 0.15 μM towards catechin and sunset yellow simultaneous detection, respectively. Furthermore, the Au/PEDOT/MWCNT-CONH-UIO-66 possesses a wide linear detection range and high sensitivity for catechin and sunset yellow detection. Moreover, the Au/PEDOT/MWCNT-CONH-UIO-66 composite also has great stability and anti-interference ability. Finally, the sensing platform was applied to detect catechin and sunset yellow in the tea beverage compared with the high-performance liquid chromatography method. To the best of our knowledge, our work first reported the electrochemical sensing materials for catechin and sunset yellow simultaneous detection in food, which will provide a certain theoretical analysis and experimental experience for the preparation of materials used for catechin and sunset yellow simultaneous detection in food.
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ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Mengyang Li,Baoshan He,Haoyang Yan,Lingling Xie,Xiaoyu Cao,Huali Jin,Min Wei,Wenjie Ren,Zhiguang Suo,Yiwei Xu
A novel ultrasensitive electrochemical aptasensor was proposed for quantitative detection of Cd 2+ . To this end, flower-like polyethyleneimine-functionalized molybdenum disulfide-supported gold nanoparticles (PEI-MoS 2 [email protected] NPs) were used as substrates for the modification of bare gold electrodes (AuE). PEI-MoS 2 [email protected] NPs not only possessed excellent biocompatibility and large specific surface area to enhance the cDNA loading capacity, but also possessed good conductivity to accelerate the electron transfer rate. Furthermore, the preparation of dendritic platinum-palladium nanoparticles (PtPd NPs) can effectively load Cd 2+ -aptamer. Thionine and aptamers were loaded onto PtPd NPs to construct Thi-PtPd NPs-aptamer signal probes. The signal probes were captured by the cDNA immobilized on the electrode via base-pairing rule, and the signal of Thi was detected by differential pulse voltammetry (DPV). In the presence of Cd 2+ , aptamer-cDNA unwinded, and the combination of aptamer and Cd 2+ caused the signal probes to fall off the electrode and the electrical signal decreases. Under optimal conditions, the proposed aptasensor exhibited a linear relationship between the logarithm of Cd 2+ concentration and the current response over a wide range of 1 × 10 −3 nM to 1 × 10 2 nM, with a detection limit of 2.34 × 10 −4 nM. At the same time, the aptasensor was used to detect Cd 2+ in tap water with satisfactory results. In addition, it has good reproducibility, selectivity and stability, and has broad application prospects in heavy metal analysis.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Tingting Ge,Hui Guo,Cuncun Zuo,Yanxia Zheng,Shuyue Li,Haofei Huang,Ming Wang,Guangjun Cui,Xinpeng Guo,Yuchao Li
Series of magnetic metal-doped cerium oxide (MCeO x , M = Fe, Co and Ni) were synthesized and applied to support nano-gold (Au) as catalyst for synthesis of methyl methacrylate (MMA) through gas-liquid-solid three-phase oxidation esterification of methacrolein (MAL) and methanol (MeOH). Hydrothermal synthesis method was applied for MCeO x preparation and deposition-precipitation method was for nano-Au supported catalyst. The catalysts were characterized through XRD, H 2 -TPR, NH 3 -TPD, FT-IR, TG, BET, TEM-EDS and VSM. Results showed that Au/FeCeO x had strong magnetic properties and could be easily separated by external magnetism. Moreover, the doping of Fe could improve the redox properties and acidic sites of the catalyst. Catalyst performances were evaluated in a micro batch reactor. 5% - Au/FeCeO x allowed the highest reaction activity to be observed with MAL conversion of 80.2% and MMA selectivity of 96.1%. Surface catalytic reaction mechanism on Au/CeO 2 was established and transition states of oxidative esterification were obtained using density functional theory (DFT). Magnetically recoverable nano-Au/FeCeO x catalysts maintain stable activity after 5 cycles, which makes it a promising catalyst for industrial application.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Jingxuan Pei,Yibo Sun,Xiang Yu,Zhenfei Tian,Shuting Zhang,Songbo Wei,Yanfang Zhao,Rabah Boukherroub
Development of reliable sensing strategy combining surface-enhanced Raman scattering (SERS) and surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS) is of significant interest to distinguish cysteine enantiomers in body fluid for understanding their physiological roles and toxicity hazards. In this work, a SERS/SALDI-MS dual-mode sensing platform of gold nanoparticles (Au NPs) decorated holey carbon nitride (hg-C 3 N 4 ) was fabricated for sensitive detecting cysteine. The designed Au@hg-C 3 N 4 matrix featured a uniform distribution of Au NPs with the help of anchoring effect of hg-C 3 N 4 holey structure, which was conducive to produce highly repeatable signals. Moreover, the combination of Au NPs and holey g-C 3 N 4 endowed this matrix with superior enrichment capacity, enhanced charge transfer and strong UV absorption. These merits allowed the matrix to acquire high sensitivity and enhanced reproducibility for l -cysteine by means of SERS/SALDI-MS. Likewise, reliable detection of l -cysteine and efficient recognition of d -cysteine in human serum jointly revealed its prospect for detecting cysteine enantiomers in body fluids. This work offers a reliable SERS/SALDI-MS strategy for determining L/D-cysteine enantiomers, and the designed Au@hg-C 3 N 4 matrix becomes a potential application candidate for selective detection of bio-enantiomers.
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ACS Agricultural Science & Technology
·
2022
·
IF 0
Can Zhang,Jinnuo Hu,Xiaoxiao Wu,Jiyong Shi,Bruce D Hammock
As a major metabolite of pyrethroid pesticides, 3-phenoxybenzoic acid (3-PBA) can be an indicator of health risk and human exposure assessment. A gold–platinum (Au@Pt) nanozyme is a kind of mimic enzyme with unique properties of nanomaterials and catalytic activity. The anti-3-PBA nanobodies were labeled with Au@Pt (Au@Pt-Nbs) by electrostatic adsorption. The Au@Pt-Nbs lateral-flow nanozyme immunoassay was established for the visual and rapid detection of 3-PBA. The visualization results were quantitatively analyzed by Adobe Photoshop CC and got a cutoff value of 0.005 ng/mL. The samples of milk- and lake water-spiked 3-PBA were also analyzed, and the recoveries ranged from 102 to 108% and 95 to 112%, respectively. The results were also validated by liquid chromatography–mass spectrometry and got good correlation (R2 = 0.945). The Au@Pt-Nbs lateral-flow nanozyme immunoassay was developed by the combination of nanobodies and nanozymes, which will be a promising application in the field of safety inspection.
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DOI
BIOELECTROCHEMISTRY
·
2022
·
IF 5.76
Cuiying Lin,Qingqing Huang,Xiang Hong,Shichai Hong,Xiaolong Shu,Enci Wang,Lixin Wang,Weiguo Fu,Zhenyu Lin
Vascular endothelial growth factor (VEGF 165 ) is a signal protein that plays a central role in the regulation of angiogenesis and can stimulate angiogenesis. The development of highly sensitive and selective detection method for VEGF 165 is very important for disease diagnosis and follow-up treatment monitoring. In this study, an electrochemiluminescence (ECL) aptasensor for VEGF 165 has been developed based on quench of H 2 O 2 toward Ru(bpy) 3 2+ /TPrA ECL system and RecJ f exonuclease induced target recovery and hybridization chain reaction (HCR) as amplification strategy. The presence of VEGF 165 makes a large number of glucose oxidase (GOD) fixed on the electrode surface through the double signal amplification strategies. The present of GOD cause the production of a large amount of H 2 O 2 near the electrode surface under excess amount of glucose, resulting in the inhibition of the ECL signal of Ru(bpy) 3 2+ /Au nanoparticles (Ru(bpy) 3 2+ /AuNPs) film fixed on the electrode surface. The ECL response of the designed biosensor has a good linear relationship with the logarithm of the concentration of VEGF 165 in the range of 0.5 pg/mL to 500 ng/mL with a detection limit of 0.2 fg/mL. The VEGF 165 in serum samples has been detected by the proposed aptasensor with satisfactory results.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Dan Wang,Guanchen Xu,Xingshuang Zhang,Hongyu Gong,Li Jiang,Guanliang Sun,Yu Li,Guoran Liu,Yong Li,Shikuan Yang,Xiu Liang
A novel approach is developed to fabricate an ultra-thin layered flexible wearable Surface-Enhanced Raman Scattering (SERS) substrate named silk fibroin-anodic aluminum oxide-Au nanoparticles (SF-AAO-Au), which consists of biocompatible SF film as flexible support, ultrathin cavity AAO as template, and plasmonic Au NPs. The SF-AAO-Au sensor exhibits excellent SERS mechanical flexibility, homogeneity and sensitivity for its effective enhancement ability and highly ordered 3D periodic porous particle-in-cavity (PIC) arrays structure. The humidity-driven interface structure of biocompatible SF film provides good skin adhesion under various fitness tests and excellent mechanical flexibility as a wearable SERS sensor on natural skin (deformation within 5%). The flexible SF-AAO-Au can be developed as quantitative sweat glucose sensor in the concentration range of 10 − 7 to 10 − 3 M with a limit of detection (LOD) of 1.68 × 10 − 7 M and qualitative human sweat glucose detection ability. This SF-AAO-Au substrate can be further designed as lab-on-glove SERS sensing platform for ultrasensitive (LOD ~5.7 ppt) quantitative on-site detection of agricultural residues in a wide range. The effective dual-functional SERS wearable sensor realized for the first time paves a new way to develop smart wearable and non-destructive devices in environmental safety, forensic identification and point-of-care testing (POCT) diagnosis of physiological disease.
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高影响因子
ANALYST
·
2022
·Vol. 147
·期 5
·880-888
·
IF 5.227
Qingfang Niu,Pengyue Jin,Yu Huang,Lifang Fan,Caihong Zhang,Cheng Yang,Chuan Dong,Wenting Liang,Shaomin Shuang
Palladium@gold nanoparticle modified three-dimensional-reduced graphene oxide (3D-rGO/Pd@Au) was coupled with carboxymethyl-β-cyclodextrin to form a novel nanocomposite (3D-rGO/Pd@Au/CM-β-CD). The 3D-rGO/Pd@Au/CM-β-CD served as a chiral sensing interface for the electrochemical enantiorecognition of tyrosine (Tyr) via a differential pulse voltammetry (DPV) approach. The 3D-rGO/Pd@Au demonstrates good electrical conductivity and efficient catalytic activity as an electrochemical indicator. Simultaneously, the CM-β-CD displays a supramolecular chiral selectivity to reveal a higher binding affinity to the target L-tyrosine (L-Tyr) than to D-tyrosine (D-Tyr). Under the optimized determining conditions, the oxidation peak current ratio of L-Tyr to D-Tyr (IL/ID) was 2.12, meanwhile, the peak currents of the two isomers were linearly proportional to the concentration over the range of 0.8–130 μM with LODs of 52 nM and 96 nM for L- and D-Tyr (S/N = 3), respectively. This approach exhibits distinguished sensitivity, excellent selectivity and good reproducibility, as well as great stability, which can accurately determine the relative content of L- or D-Tyr enantiomers in a racemic solution.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Zhiyang Zhang,Mi Hu,Qingfeng Gui,Jing Gu,Wenlong Xu,Qingbo Xiao,Wei Huang
Adipic acid is a valuable chemical used to product Nylon-66, and one of the greenest ways to synthesize it is catalyzing the oxidation of cyclohexane by molecular oxygen in the absence of any other chemicals. However, it is challenging to convert cyclohexane effectively with high selectivity to adipic acid using the available catalysts. In response to the dilemma of achieving satisfactory conversion and selectivity at the same time, a remarkable Au@NaX catalyst is proposed using an improved in-situ crystallization method that exhibits Au clusters surrounded by X-zeolite channels. A 29.5% conversion of cyclohexane and an 85.6% selectivity to adipic acid can be obtained in a one-pot oxidation of cyclohexane at 140 °C, 20 bar O 2 , far exceeding most published results. Since determined by detailed characterizations and DFT calculations, the effective dynamic collaboration between Au clusters and zeolite inner micro-environment is the decisive role for superior catalytic performance. Specifically, the surrounding zeolite channel encourages the adsorption and activation of cyclohexane over the confined Au clusters, resulting in an unprecedented activity. The continuous oxidation of cyclohexanol and cyclohexanone to adipic acid is also vulnerable on the enclosed Au clusters, and the subsequent adipic acid can be further stabilized as a result of the strong interaction of –COOH with Na ± in zeolite channels surrounding enclosed Au clusters. It prevents AA from poisoning active sites and generates a higher selectivity for the desired adipic acid. Our study highlighted the critical significance of the dynamic interaction between metal clusters and the zeolite channel microenvironment. It would shed light on the further high-performance catalysts designs for selective oxidation.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Xiu Wang,Wei Li,Shijie Dai,Menghua Dou,Saisai Jiao,Jing Yang,Weiwei Li,Ya Su,Qianjin Li,Jianlin Li
The aim of this research was to develop a simple, rapid, sensitive, high-throughput detection method for foodborne Escherichia coli (E. coli) O157:H7 based on the aptamer-modified gold nanoparticles@macroporous magnetic silica photonic microsphere (Au@MMSPM). Such Au@MMSPM array system for E. coli O157:H7 not only integrated sample pretreatment with rapid detection, but also showed highly enhanced effect to develop a highly sensitive SERS assay. The established SERS assay platform gave a wide linear detection range (10–10 6 CFU/mL) and low limit of detection (2.20 CFU/mL) for E. coli O157:H7. The whole analysis time including sample pretreatment and detection was 110 min. This SERS-based assay platform provided a new high-throughput, highly sensitive and fast detection technology for monitoring E. coli O157:H7 in real samples from the fields of food industry, medicine and environment.
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