Food & Function
·
2023
·Vol. 14
·期 4
·1971-1988
·
IF 6.1
Ya-Li Wang,Song-Xia Lin,Yuan Wang,Tao Liang,Tao Jiang,Peng Liu,Xiao-Yi Li,Deng-Qin Lang,Qiang Liu,Chun-Yan Shen
Oxidative stress and inflammation play important roles in the development of diabetes mellitus. p-Synephrine, the primary pharmacologically active protoalkaloid in Citrus species, has been popularly consumed as a dietary supplement for weight loss management. However, the effects of p-synephrine on diabetes mellitus and the action mechanisms have not been clearly elucidated. In this study, the in vitro antioxidant effects of p-synephrine were evaluated. The data showed that p-synephrine treatment exhibited significant scavenging effects against DPPH, ABTS and OH radicals and showed high reducing power. Diabetic mice were developed by alloxan injection, followed by p-synephrine administration to investigate its hypoglycemic effects in vivo. The results showed that p-synephrine intervention significantly prevented alloxan-induced alteration in body weight, organ indexes, serum uric acid content and serum creatinine content. Meanwhile, p-synephrine application significantly improved the lipid profiles, superoxide dismutase (SOD) and catalase (CAT) activities and glutathione (GSH) contents in the serum and kidneys of diabetic mice and reduced the malondialdehyde (MDA) content in the serum of diabetic mice. Further assays suggested that p-synephrine treatment improved alloxan-induced decreases of glucose tolerance and insulin sensitivity. Also, p-synephrine supplementation altered histopathological changes in the kidneys and interscapular brown adipose tissues in diabetic mice. In addition, p-synephrine administration inhibited renal inflammation through suppressing tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) gene expression levels, as well as CD45 expression levels. The anti-inflammatory effects were probably involved in the regulation of nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinase (MAPK) phosphorylation. In conclusion, p-synephrine application significantly ameliorated alloxan-induced diabetes mellitus by inhibiting oxidative stress via suppressing the NF-κB and MAPK pathways.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Pengwu Xu,Gaopeng Qi,Dongxuan Lv,Deyu Niu,Weijun Yang,Huiyu Bai,Xiuping Yan,Xu Zhao,Piming Ma
Polyhydroxyalkanoates (PHA) is a biodegradable polyester, and its application range is limited by the poor flame retardancy and low modulus. Bentonite (BNT) as a green inorganic filler can improve the modulus and flame retardancy of PHA to a certain extent. An in situ polymerization method was designed to intercalate P-N-containing hyperbranched macromolecules (HBM) among BNT layers (HBM-B) and to improve the flame retardancy while improving the dispersion of BNT in the PHA matrix. The layer spacing of BNT was increased from 1.2 nm to 4.5 nm. The effect law of the joint action of in situ intercalation of BNT and the HBM on flame retardancy and mechanical properties of PHA was systematically studied. The HBM-B showed stronger flame retardancy when the mass ratio of HBM to BNT was 75/25. The limiting oxygen index (LOI) of the PHA/HBM-B composite was increased to 27.6 % while maintaining good toughness. Compared to the physical blend of HBM and BNT (HBM/B), the elongation at break of PHA/HBM-B 25 composites can be increased by up to 10 times. When the content of HBM-B is up to 15 wt%, the LOI of PHA-Based composites can reach 29.6 % and the UL-94 rating reaches V-0, which meets the standard of flame-retardant material. Therefore, the present work is expected to expand the application of PHA-based composites in the field of flame retardancy.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Yanghe Liu,Quan Li,Shenghuan Wang,Mengzhu Liang,Yanhong Ji,Zhenyu Cui,Mohammad Younas,Jianxin Li,Benqiao He
High-performance nanofiltration (NF) membrane plays a key role in Li + /Mg 2+ separation process. In this work, a new NF membrane with positively and negatively charged groups was prepared by grafting p-aminosalicylic acid (AS) onto the surface of polyamide (PA) membrane followed by chelation with Fe 3+ ions for Li + /Mg 2+ separation. The AS grafting (PA-g-AS) and Fe 3+ chelating (PA-g-AS-Fe) NF membranes had almost same surface and section structure and surface pore size as the PA membrane. But Zeta potential (about −8 mV at pH 7) of the obtained PA-g-AS-Fe membrane was improved in comparison with the PA and PA-g-AS NF (about −20 mV at pH 7) membranes due to Fe 3+ addition, suggesting that there were positively and negatively charged groups on the membrane surface. The PA-g-AS-Fe membrane showed a high Mg 2+ rejection of 97.7% and high Li + permeation (negative rejection of −87.6%); while a high Li + /Mg 2+ separation factor (S Li , Mg ) of about 81.5 was achieved, which is much higher than those for PA and PA-g-AS NF membranes and surpassed those of the results reported in literature. The fluxes of three membranes were about the same. The results demonstrated the NF membrane with positively and negatively charged groups was suitable for efficient separation of Li + /Mg 2+ and would have promising applications in recovery of lithium from brine.
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CATALYSIS LETTERS
·
2022
·Vol. 153
·期 3
·732-739
·
IF 2.936
Li Jianying,Liu Rong,Ye Qian,Cai Mingzhong
[RuCl 2 ( p -cymene)] 2 in a mixture of poly(ethylene glycol) (PEG-400) and water is shown to be a highly efficient catalyst for the annulation of N -methoxybenzamides with alkynes. The reaction proceeded smoothly at 60 ºC with MesCO 2 K as a cocatalytic additive under external oxidant-free conditions, delivering a variety of substituted isoquinolones in mostly good to excellent yields. The isolation of the crude products can be easily performed by extraction with diethyl ether and more importantly, [RuCl 2 ( p -cymene)] 2 /PEG-400/H 2 O system could be facilely recycled and reused more than six times without any apparent loss of catalytic efficiency. Graphical Abstract
Ruthenium-catalyzed annulation of N -methoxybenzamides with alkynes leading to isoquinolones by using [RuCl 2 (p-cymene)] 2 /PEG-400/H 2 O as a highly efficient and recyclable catalytic system is described.
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MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 5
·1-9
·
IF 6.408
Zhu Anni,Wang Tiansheng,Jiang Yuning,Hu Sen,Tang Wanxin,Liu Xinling,Guo Xiaoyu,Ying Ye,Wu Yiping,Wen Ying,Yang Haifeng
A specific surface-enhanced Raman scattering (SERS) assay for dopamine (DA) based on an azo derivatization reaction is proposed for the first time by preparation of p-aminothiophenol (PATP)-modified composite SERS substrate, composed of metal–organic framework (MIL-101) decorated with Au and Ag nanoparticles. As the result, the SERS method for detection of the azo reaction between PATP and DA exhibits superior sensitivity, selectivity, and stability. A reasonable linearity in the range 10 −6 to 10 −10 mol∙L −1 is achieved, and the limit of detection is 1.2 × 10 −12 mol∙L −1 . The reactive SERS assay is free from interference in complex physiological fluid. The feasibility of the proposed SERS method for the detection of DA levels in fetal bovine serum (FBS) samples and human serum samples is validated by HPLC–MS methods, displaying promising application potential in early disease diagnosis. Graphical abstract
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Small
·
2022
·Vol. 18
·期 20
·2108094
·
IF 15.153
Chongchao Yao,Jiaxin Li,Zhihao Zhang,Chunli Gou,Zhongshen Zhang,Gang Pan,Jing Zhang
Projecting a cost-effective and highly efficient electrocatalyst for the oxygen reaction reduction (ORR) counts a great deal for Zn-air batteries. Herein, a hierarchical core–shell ORR catalyst (Co 2 N/CoP@PNCNTs) is developed by embedding cobalt phosphides and/or cobalt nitrides as the core into N, P-doped carbon nanotubes (PNCNTs) as the shell via one-step carbonization, nitridation, and phosphorization of pyrolyzing Co-MOF precursor. The globally N, P-doped structure of Co 2 N/CoP@PNCNTs demonstrates an outstanding electrocatalytic activity in the alkaline solution with the onset and half-wave potentials of 1.07 and 0.85 V respectively. Moreover, a Zn-air battery assembled from Co 2 N/CoP@PNCNTs as the air cathode delivers an open circuit potential of 1.49 V, a maximum power density of 151.1 mW cm −2 and a specific capacity of 823.8 mAh kg −1 . It is reflected that Co 2 N/CoP@PNCNTs provides a long-term durability with a slight decline of 15 h in the chronoamperometry measurement and an excellent charge–discharge stability with negligible voltage decay for 150 h at 10 mA cm −2 in Zn-air batteries. The results reveal that Co 2 N/CoP@PNCNTs has superiority over most Co-N x -C or Co x P@C catalysts reported so far. The excellent catalytic properties and stability of Co 2 N/CoP@PNCNTs derive from synergistic effects between Co 2 N/CoP and mesoporous N, P-doped carbon nanotubes.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Shaopei Jia,Yifan Cheng,Quan Huang,Qisong Li,Qian Zhang,Zhixin Wang,Yan Zhang,Niu Zhang,Yunchao Mu
Developing inexpensive and efficient electrocatalysts for hydrogen evolution reaction (HER) in both acidic and alkaline mediums is of great significance to the hydrogen energy industry. Hereby, we prepared a mixture of precursors with homogeneous composition by using the chelating ability of soybean protein isolate (C and N source) and phytic acid (dopant and phosphating agent) with cobalt ions , and achieved one-step synthesis and construction of Co 2 P/N–P co-doped porous carbon composite by carbonization at 800 °C. The as-synthesized Co 2 P/NPPC-800 electrocatalyst exhibits low HER overpotentials of 121 and 125 mV at 10 mA cm −2 in 0.5 M H 2 SO 4 and 1.0 M KOH, which are close to those of the commercial Pt/C catalyst. Additionally, the NPPC substrate surrounding the Co 2 P could diminish the corrosion during the HER, and Co 2 P/NPPC-800 displays good stability and durability. Furthermore, this work offers a convenient synthesis strategy for phosphide/doped porous carbon composites in other electrochemical energy technologies.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Tianyu Wang,Chen Zhao,Linghui Meng,Yujia Li,Hongyu Chu,Fei Wang,Yingru Tao,Wen Liu,Chong-Chen Wang
Sulfadiazine (SDZ), as a broad-spectrum pharmaceutical antibiotic, has drawn extensive attention owing to its wide application and persistence. Photocatalytic oxidation has been considered as a high-efficiency and environment-friendly technology for degrading organic contaminants. A novel BiOI/UiO-66 p-n heterojunction (BiU- x ) was fabricated via the in-situ deposition of p-type BiOI nanoplates on n-type UiO-66 octahedrons with the aid of a controlled precipitation method. The optimizing BiU-9 heterojunction exhibited a remarkably enhanced photocatalytic efficiency in removing SDZ, in which the SDZ (5 mg/L) removal efficiency over BiU-9 (0.5 g/L) reached nearly 100 % within 90 min of visible light irradiation. The influence of some important environmental factors (e.g., photocatalyst dosage, pH, co-existing inorganic anions and real sunlight irradiation) were systematically investigated. Such improvement mechanism should be assigned to the following three factors. Firstly, the introduction of narrow gap semiconductor BiOI effectively improved photo adsorption capacity. Secondly, benefiting by the large specific surface area, the involvement of UiO-66 contributed to boost the surface active sites. Most importantly, an internal electric field at the contact interface between UiO-66 and BiOI accelerated the separation of photo-generated electrons and holes. Furthermore, · O 2 − and photo-generated holes were identified as the dominating reactive species accounting for the SDZ removal. The decomposition pathways of SDZ and ecotoxicities of the intermediates were analyzed via combing with LC-MS/MS and T.E.S.T theoretical calculation. This work may provide an alternative way for enhanced photocatalytic performance of MOF-based materials through construction of p-n heterojunction with bismuth-based semiconductors.
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JOURNAL OF LUMINESCENCE
·
2021
·
IF 3.599
Cen Zhang,Xiaonan Zhu,Fei Gao,Liu Yang,Weizhen Liu
The development of wavelength adjustable electrically driven panchromatic display light-emitting devices (LEDs), a future direction for lighting sources, still seems necessary because of great development prospects and practical significance. Herein, perovskite quantum dots (QDs) of CsPbBr 3 and CsPbI 3 with multi-color luminescence feature were employed into n-ZnO/p-GaN nano-heterojunction LEDs. A thin polystyrene cover layer was intentionally inserted between CsPbBr 3 and CsPbI 3 to prevent the undesired halogen anion-exchange reaction. A color-tunable electroluminescence (EL) could be achieved by changing the molar ratio of these two types of perovskite QDs. By further optimizing the molar ratio between CsPbBr 3 and CsPbI 3 , that is, the evolution of the share of red, green and blue-violet luminescence in EL spectra, a stable white light emission was obtained. The current research not only achieves multi-color EL emissions in a three-dimensional nano-architecture, but also proposes an effective and clever strategy for preparing and developing single-chip white LEDs.
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JOURNAL OF POLYMER RESEARCH
·
2021
·Vol. 28
·期 11
·1-13
·
IF 3.097
Liu Yuhang,Wen Youyi,Xu Weiwei,Li Bo,Song Zhimei,Li Yuyao,Xia Fang
The research on film capacitors with high energy density ( \({U}_{e}\) ) has attracted great attention in these years, due to their applications in modern electric system. However, the low \({U}_{e}\) is the major limitation for decreasing the size and weight of ferroelectric film capacitors. In this research, in order to improve the breakdown strength ( \({E}_{b}\) ) and dielectric constant at the same time, P(VDF-HFP) based ternary nanocomposites were prepared by using edge-hydroxyl boron nitride nanosheets (EOH-BNNSs) with high \({E}_{b}\) and the third phase filler with high dielectric constant. Three fillers with dielectric constant from large to small, namely, barium titanate (BT), titanium dioxide (TO), alumina (AO) were added into P(VDF-HFP)/EOH-BNNSs nanocomposites, respectively. The \({E}_{b}\) , dielectric constsnt, dielectric loss, \({U}_{e}\) , thermal conductivities and mechanical properties of the ternary nanocomposites were thoroughly investigated. The results indicate the local electric field concentration has great influence on the \({E}_{b}\) of ternary nanocomposites. However, with low filler loading, the synergy effect and weak local electric field concentration can not only improve the dielectric constant but also the \({E}_{b}\) , finally achieving the best \({U}_{e}\) . The easy preparation process and high \({U}_{e}\) have endow the ternary nanocomposites with great potential application in film capacitors.
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Small
·
2021
·Vol. 18
·期 6
·2103528
·
IF 13.281
Bijiang Geng,Shuang Xu,Ping Li,Xiaokai Li,Fuling Fang,Dengyu Pan,Longxiang Shen
Sonodynamic therapy as a promising noninvasive modality is being developed for tumor therapy, but there is a lack of next-generation sonosensitizers that can generate full ROS at high yields and simultaneously deplete elevated levels of glutathione (GSH) in tumor cells. Semiconductor p-n junctions are engineered as high-efficacy sonosensitizers for sonodynamic tumor eradication using pyridine N-doped carbon dots (N-CDs) as a p -type semiconductor and oxygen-deficient TiO 2− x nanosheets as a n -type semiconductor. The rate constants of 1 O 2 and •OH generation by ultrasound-excited N-CD@TiO 2− x p-n junctions are 4.3 and 4.5 times higher than those of TiO 2 , respectively. A Z-scheme carrier migration mechanism in the p-n junction achieving the rapid spatial separation of the ultrasound-generated electron–hole pairs for enhanced full ROS production is proposed. GSH-cleavable, Pt-crosslinked, N-doped CD fluorescent probes to detect the presence of intracellular GSH are also constructed. A GSH-responsive, p-n junction platform (Pt/N-CD@TiO 2− x ) with integrated GSH detection, GSH depletion, and enhanced sonodynamic performance is then assembled. Malignant tumors are completely eradicated without relapse via intravenous administration of low-dose Pt/N-CD@TiO 2− x under ultrasound irradiation. This work substantiates the great potential of biocompatible, GSH-responsive p-n junctions as next-generation sonosensitizers via p-n junction-enhanced ROS generation and metal ion oxidation of intracellular GSH.
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APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Zhaode Mu,Jiangman Tian,Jie Wang,Jing Zhou,Lijuan Bai
Sensitive detection of endotoxin is especially critical in the fields of food security, therapeutics and medical science. In this work, a new sandwich-type electrochemical aptasensor was designed for ultrasensitive detection of endotoxin. For the first time, nitrogen-doped carbon nanotubes (N-CNTs) was functionalized with polydiallyldimethylammonium chloride (PDDA), forming P-N-CNTs nanocomposite. Then, Fe-based metal–organic framework (Fe-MOF) and silver nanoparticles (AgNPs) was decorated with P-N-CNTs to form the MOF/Ag-P-N-CNTs nanohybrid, which was employed as an enhanced signal indicator, not only exhibited outstanding electrochemical activity, but also could directly label with thiol-modified signal probes (TSPs) to form tracer label. Additionally, the avidin–biotin recognition system was introduced to increase the amount of biotin-modified capture probes (BCPs). Differential pulse voltammetry (DPV) was utilized to investigate the detection performances of the proposed aptasensor, which suggested a wide linear range from 1 fg/mL to 100 ng/mL with a low detection limit of 0.55 fg/mL toward endotoxin.
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危险品化学品经营许可证（带存储）