JOURNAL OF NANOBIOTECHNOLOGY
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2017
·Vol. 15
·期 1
·1-18
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IF 4.946
Wang Yuan,Zhang Xue-Yin,Luo Yan-Ling,Xu Feng,Chen Ya-Shao,Su Yu-Yu
Background Stimuli-responsive polymer materials are a new kind of intelligent materials based on the concept of bionics, which exhibits more significant changes in physicochemical properties upon triggered by tiny environment stimuli, hence providing a good carrier platform for antitumor drug delivery. Results Dual stimuli-responsive Fe 3 O 4 graft poly(acrylic acid)- block -poly(2-methacryloyloxyethyl ferrocenecarboxylate) block copolymers (Fe 3 O 4 - g -PAA- b -PMAEFC) were engineered and synthesized through a two-step sequential reversible addition-fragmentation chain transfer polymerization route. The characterization was performed by FTIR, 1 H NMR, SEC , XRD and TGA techniques. The self-assembly behavior in aqueous solution upon triggered by pH, magnetic and redox stimuli was investigated via zeta potentials, vibration sample magnetometer, cyclic voltammetry, fluorescent spectrometry, dynamic light scattering, XPS, TEM and SEM measurements. The experimental results indicated that the Fe 3 O 4 - g -PAA- b -PMAEFC copolymer materials could spontaneously assemble into hybrid magnetic copolymer micromicelles with core–shell structure, and exhibited superparamagnetism, redox and pH stimuli-responsive features. The hybrid copolymer micromicelles were stable and nontoxic, and could entrap hydrophobic anticancer drug, which was in turn swiftly and effectively delivered from the drug-loaded micromicelles at special microenvironments such as acidic pH and high reactive oxygen species. Conclusion This class of stimuli-responsive copolymer materials is expected to find wide applications in medical science and biology, etc., especially in drug delivery system.
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 6
·1-11
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IF 3.8
Yu Congrong,Li Mengfan,Guo Xuan,Fan Feifei,Wang Chuanhai
Graphene quantum dots (GQDs), characterized by nanostructures with diameters below 10 nm and strong hydrophilicity, exhibit advantageous migration behavior in groundwater environments. The impacts of ionic strength, cation type and pH on the transport of GQDs in porous media diverge from those observed for other nanosized particles. We investigated the cooperative effects of ionic strength (IS, 1 mM NaCl and 100 mM NaCl, 1 mM CaCl 2 and 10 mM CaCl 2 ), cation types (Na + , Ca 2+ ), and pH (4, 7, 9). Through saturated column experiments and numerical modeling, we observed increased GQDs deposition with rising IS, notably enhanced by the presence of divalent cations due to bridging effects and self-aggregation. In the presence of monovalent cations, acidic environment favored the deposition of GQDs, whereas in the presence of divalent cations, an acidic environment with 1 mM CaCl 2 was the most favorable for the deposition of GQDs, and shifted to an alkaline condition at 10 mM CaCl 2 , which may be due to the deprotonation process and the enhancement of self-aggregation. This research sheds light on critical factors governing the environmental behavior of ultra-small nanoparticles and thereby aids in the assessment of their ecological impact.
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MOLECULAR MEDICINE
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2025
·
IF 6.4
Quanpeng Qiu,Yi Ding,Xiaolong Guo,Jing Han,Jiaqi Zhang,Yaping Liu,Junjun She,Yinnan Chen
Background Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinical practice. Methods We conducted a Circle‐Seq analysis on clinical samples at different stages of colorectal cancer progression to examine the dynamic changes of eccDNA during the progression of colorectal cancer. We used breakpoint-specific PCR to verify candidate eccDNAs identified by Circle‐Seq. The results were further validated using the AOM/DSS-induced colorectal cancer model. Results There was an increase in the abundance of eccDNA with the progression of colorectal cancer. The genes associated with these eccDNA molecules were primarily related to signaling pathways involved in tumor development and metastasis. Our analysis also revealed that eccDNA abundance positively correlates with gene expression, and eccDNA derived from specific genes has potential value for the early diagnosis of tumors. Conclusions This study revealed a connection between eccDNA and colorectal cancer progression and highlights the clinical potential of eccDNA for the early diagnosis of colorectal cancer. Supplementary Information The online version contains supplementary material available at 10.1186/s10020-025-01164-y.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Liu Mingda,Zhang Zhichao,Li Chenyu,Jin Sen,Zhu Kunlei,Fan Shoushan,Li Jia,Liu Kai
The methanol oxidation reaction is the bottleneck for direct methanol fuel cells. Unfortunately, the state-of-the-art Pt-based catalysts suffer heavily from the CO poisoning problem. Isolating Pt atoms in a material can avoid CO poisoning. However, single-atom Pt catalysts alone are inert towards methanol oxidation reaction. Here, we report high-entropy alloyed single-atom Pt catalysts, in which single-atom Pt sites are alloyed with non-noble elements in a high-entropy structure. This catalyst not only possesses active Pt sites but also inherits the ability of single-atom Pt to resist CO poisoning. Consequently, the catalyst shows a notable mass activity of 35.3 A mg −1 at only 2.3 at% Pt and maintains high activity even after operation for 180,000 s. Both experimental and theoretical results reveal that the high-entropy structure induces a synergistic effect, wherein the elements coordinated around single-atom Pt sites effectively remove adsorbed CO from Pt. This mechanism facilitates the key reaction steps of methanol oxidation reaction and avoids CO poisoning. This work presents a high-entropy alloyed single-atom strategy to realize efficient and durable methanol oxidation reaction catalysis with low costs.
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JOURNAL OF POLYMER RESEARCH
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2025
·Vol. 32
·期 10
·1-10
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IF 2.8
Jiang Bihe,Zhang Zhihui,Shi Jianze,Liu Siyuan,Li Dazhen,Cao Zengwen
In this study, a mercaptan-disulfide exchange mechanism was used to modify liquid polysulfide rubber through the reaction between JLY155 and 1,6-hexanedithiol to reduce the viscosity of the liquid polysulfide. The results indicated a decrease in the viscosity and molecular weight of JLY155 and a notable improvement in the peeling strength of the prepared polysulfide sealant, demonstrating an approach to facilitating sealant preparation without sacrificing mechanical performance. Compared to JLY155, the modified liquid polysulfide rubber exhibited a reduction in viscosity, and the reduction extent could be modulated by adjusting the ratio of JLY155 and 1,6-hexanedithiol. The mechanical properties of the prepared polysulfide sealant demonstrated optimal results at a molar ratio of 4:1 between the reactants and Tris(dimethylaminomethyl)phenol (DMP30) catalyst at a loading of 0.05 wt%. The tensile strength of the prepared polysulfide sealant reached 2.38 MPa with an elongation at break of 119.68%, and the sealant exhibited excellent peel performance, undergoing substrate failure rather than adhesion failure. This was associated with a slightly lowered storage modulus (E’) in dynamic mechanical analysis. However, increasing the amount of DMP30 catalyst increased the efficiency of the thiol-disulfide bond exchange reaction and accelerated the sealant’s curing process in later stages, consequently reducing the elongation at break.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Wei Yi,Zhang Yan,Li Yawen,Li Chen,Wang Yuxuan,Luo Zhishan,Liu Yulian,Kang Huimin,Chen Xihan,Quan Zewei
Chiral recognition through fluorescence changes enables the rapid and sensitive determination of enantiomers. However, the rational design and synthesis of fluorescent probes for efficient chiral recognition remain a challenge. Here we present a novel platform for chiral recognition based on zero-dimensional hybrid copper halides with unique symmetry-dependent properties. The use of mesomeric 1,2-diaminocyclohexane (DACH) ligands promotes the formation of centrosymmetric, non-luminescent Cu 2 I 6 4− units. The incorporation of enantiopure S - or R -DACH ligands into these mesomeric compounds breaks their symmetry, spontaneously transforming them into chiral compounds and generating Cu 4 I 6 2− units that exhibit intense circularly polarized luminescence. Additionally, introducing opposite chiral ligands into these chiral compounds leads to the formation of racemic, non-luminescent CuI 3 2− units, whereas the addition of same-chirality ligands preserves the structure and optical properties of the chiral Cu 4 I 6 2− units. This enantioselective response by utilizing symmetry-dependent optical properties offers a pathway toward advanced chiral sensing technologies.
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Chinese Medicine
·
2025
·Vol. 20
·期 1
·1-22
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IF 5.7
Yang Shuxuan,Zou Caiting,Li Dexian,Lin Jingxin,Chen Qinghong,Chen Meilin,Wu Chuanghai,Hung Andrew,Liu Yanyan,Sun Xiaomin,Li Hong,Wang Qi,Zhao Xiaoshan
Background Alcoholic liver disease (ALD) poses a major global health challenge, with limited effective interventions. The Dampness-Heat Regulating Formula (DRF), a traditional Chinese herbal tea composed of nine edible medicinal herbs, has shown promise in mitigating alcohol-induced liver injury. This study aimed to identify its core active components and elucidate underlying mechanisms. Methods Active compounds were retrieved from multiple databases and screened using chemical similarity, target prediction, and ADMET filtering. Disease-related targets were identified through public transcriptomic datasets. Three machine learning algorithms—random forest, support vector machine, and LASSO—were used to prioritize therapeutic targets. High-throughput molecular docking and virtual screening were combined with untargeted metabolomics to identify candidate compounds. The interaction between oleanolic acid (OA) and AKT1 was further verified by cellular thermal shift assay (CESTA). In vitro and in vivo assays were conducted to validate hepatoprotective effects. Additionally, the content of OA in DRF was quantified by HPLC to assess the relevance of experimental dosing. Results A total of 690 candidate compounds and 33 ALD-associated targets were identified. AKT1 emerged as the top-ranked hub target. OA showed strong binding affinity to AKT1, and CESTA confirmed their direct interaction. Functional assays demonstrated that OA alleviated ethanol-induced damage in hepatocytes and zebrafish models. HPLC analysis confirmed that DRF contained physiologically relevant concentrations of OA, supporting the translational relevance of the selected doses. Conclusion This study reveals a potential AKT1-centered mechanism through which DRF protects against ALD and identifies oleanolic acid as a bioactive compound with dual computational and experimental validation. It offers a scientific basis for integrating traditional herbal formulas with modern drug discovery approaches in the prevention of alcohol-related liver injury.
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Tungsten
·
2025
·
IF 11.2
Zhou Li-Hai,Li Bing,Li Wei-Ping,Zhang Si-Dong,Chen Cheng,Wang Xue-Feng,Zhou Wei-Dong
All-solid-state sodium-ion batteries (ASSSIBs) that applied inorganic solid electrolytes offer enhanced safety and stand out as promising contenders for the next-generation energy storage systems. Herein, an oxygen-incorporated Na 2 ZrCl 6 (NZC) composite electrolyte with high ionic conductivity (1.52 × 10 ‒4 S·cm ‒1 ) at an ambient temperature was reported. The composite electrolyte, which was prepared through a mechanochemical reaction and formed a highly ionic conductive interface, consists of oxide between ZrO 2 and NZC. A series of characterization confirmed that oxygen interacted with sodium ions, resulting in enhanced Na + diffusivity at the interface. The ASSSIBs, which comprise a NaNi 1/3 Fe 1/3 Mn 1/3 O 2 cathode, a Na 15 Sn 4 anode, and a Na 3 PS 4 anodic interlayer with ZrO 2 -NZC electrolyte, demonstrate a high discharged capacity of 104.9 mAh·g ‒1 , and significantly outstrip the baseline NZC electrolyte. This work offers an idea of methods for improving ion migration in halide solid electrolytes for practical feasibility in all-solid-state batteries. Graphical abstract
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PHARMACEUTICAL CHEMISTRY JOURNAL
·
2025
·Vol. 59
·期 2
·270-274
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IF 1
Bao Yongfen,Wang Xingfeng,Wang Minjuan,Shan Shigang,Wei Mingjie,Ou Yingbao
A fluorescent probe ( N -(4-methyl-2-oxo-2 H -chromen-7-yl)-2,4-dinitrobenzenesulfonamide) for selective detection of tiopronin was synthesized and characterized. The probe displays weak fluorescence attributed to electron transfer from the fluorophore to the electron-withdrawing 2,4-dinitrobenzenesulfonyl group. However, upon effective cleavage of the electron-withdrawing 2,4-dinitrobenzenesulfonyl moiety by tiopronin from the weakly fluorescent probe, the fluorescence intensity is significantly enhanced. Under optimal conditions, the fluorescence intensity exhibited a linear correlation with tiopronin concentration within the range of 30 nM to 50 μM. The proposed strategy is characterized by its simplicity, specificity, and sensitivity. The proposed probe was employed for the determination of tiopronin in urine samples and commercial tablets, demonstrating potential applications in disease diagnosis.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 7
·1-12
·
IF 5.3
Meng Xiao,Liu Lingfei,Wang Haitong,Zhang Mengping,Zou Wei,Wu Hongmin,Chen Wenwen,Li Nianlu
A portable kit was developed for on-site high-throughput detection of methyl parathion (MPT) in vegetables by integrating solid-phase microextraction and SERS technology. This portable kit consists of a 96-well plate coated with a copper foil modified by silver nanocrystals, which was fabricated by a galvanic displacement method. The 96-well plate allows multiple samples to be pretreated simultaneously, with each well featuring small pits that isolate individual samples, effectively preventing cross-contamination. Furthermore, the SERS substrate allows the enrichment of MPT on its surface, enhancing detection sensitivity and specificity. The method detection limits calculated from the characteristic peak of MPT is 0.27 ng/cm 2 ( S / N = 3). MPT on spinach, green pepper, and tomato surfaces were directly determined rapidly and the sensitivities were 1.42 ng/cm 2 , 0.84 ng/cm 2 , and 0.87 ng/cm 2 , respectively. The versatility and reliability of this approach underscore its potential for routine pesticide residue screening. Looking ahead, further optimization of this platform could extend its applicability to a broader spectrum of organophosphorus pesticides, bolstering food safety monitoring and reducing potential health risks.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 7
·1-10
·
IF 5.3
Chen Fei,Wang Xiang,Yan Lei,Lin Zhixiong,Zheng Weijun,Wu Dianming,Qiu Bin,Fang Yifan,Liu Mingkun
By preparing gold nanoparticles-graphdiyne (Au-GDY) as sensing substrate and [Ru(NH 3 ) 6 ] 3+ -UiO-66-NH 2 MOFs (Ru-UiO-66) as signaling probe as well as linking the as-prepared Au-GDY and Ru-UiO-66 with the specific peptide (PT) of MMP-7 to form Ru-UiO-66/PT/Au-GDY, a cost-effective and sensitive electrochemical sensor was designed for the detection of matrix metalloproteinase-7 (MMP-7) which is an important biomarker for tumor and biliary atresia. The superior electrical properties, easy preparation, large surface area, and high stability of Au-GDY make it be a desirable substrate to immobilize PT. The unique structure of UiO-66-NH 2 is beneficial to assemble [Ru(NH 3 ) 6 ] 3+ probe and link PT. In the absence of MMP-7, the Ru-UiO-66/PT/Au-GDY modified electrode exhibited a prominent peak current of [Ru(NH 3 ) 6 ] 3+ , which is decreased after the addition of target MMP-7 since it can specifically recognize and cleave PT to induce the Ru-UiO-66 leave the electrode. The experimental results showed that the decrease of the [Ru(NH 3 ) 6 ] 3+ signal has a linear relation with the concentrations of MMP-7 in the range 0.01 pg mL −1 –10.0 ng mL −1 . By optimizing experimental conditions, the achieved detection limit (LOD) for MMP-7 is 5.0 fg mL −1 . The analysis of real serum samples has excellent accuracy. The simplicity of preparation and sensitivity make the Ru-UiO-66/PT/Au-GDY sensor a considerable promising analysis tool for MMP-7 detection. Graphical abstract
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BULLETIN OF MATERIALS SCIENCE
·
2024
·Vol. 47
·期 2
·1-10
·
IF 1.9
Ru Jingjing,Zhao Bing,Zeng Fan,Guo Feiyun
A set of colour tuning K 2 Ba(MoO 4 ) 2 : Dy 3+ /Eu 3+ (KBM: Dy 3+ /Eu 3+ ) phosphors were fabricated by solid-state method. The phase purity of as-prepared materials was validated by XRD and DRS analyses. The KBM: 0.03Dy 3+ sample exhibits two major luminescence lines at 481 and 572 nm when excited by 351 nm light, corresponding to Dy 3+ ions’ typical transitions of 4 F 9/2 → 6 H J (J = 15/2, 13/2). By introducing Eu 3+ ions into KBM: 0.03Dy 3+ phosphor, the ET from Dy 3+ to Eu 3+ ions arises, leading to colour tuning from green via yellowish green to pink with changing Eu 3+ ions’ concentration, along with the lowest CCT of KBM: 0.03Dy 3+ /0.03Eu 3+ sample. It can be verified by PLE and PL spectra analysis combined with the decay times of KBM: 0.03Dy 3+ /yEu 3+ samples. The energy transfer mechanism is also expounded. Meanwhile, the emission intensities at 423 K still maintain 72.8% for Dy 3+ ions and 91.2% for Eu 3+ ions relative to 303 K of the KBM: 0.03Dy 3+ /0.03Eu 3+ sample, displaying its brilliant thermal stability. All these results connote that KBM: Dy 3+ /Eu 3+ phosphors are prospected to be used for the near-UV excited white light-emitting diodes.
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