FOOD CHEMISTRY
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2026
·
IF 10.4
Meiru Zhang,Miao Chen,Li Zhang,Hang Li,Enqi Xiong,Shihan Wang,Yongsheng Wang,Zhihan Wang
This work presented a novel stimuli-responsive sodium alginate (SA)/gelatin (Gel) dual cross-linked composite hydrogel beads using Rana chensinensis ovum protein hydrolysate calcium chelates (RPH-Ca) as a unique internal cross-linker to synergize with external calcium. The optimal mass ratio of SA to RPH-Ca was determined at 1:0.5. FTIR and XRD analysis revealed that the beads were stabilized by hydrogen bonding and ligand coordination, forming an amorphous system. The beads exhibited significant pH-responsiveness, with minimal release in simulated gastric fluid (<20%) and controlled, sustained release in simulated intestinal fluid (>95%). High encapsulation efficiencies for curcumin (94.66% ± 0.05%) and rhodamine B (96.84% ± 0.03%) demonstrated capability for simultaneous delivery of lipophilic and hydrophilic bioactives. Release kinetics analysis showed that curcumin followed super Case-II transport, while rhodamine B exhibited composition-dependent release, near-zero-order release in SRGHB3 and non-Fickian transport in SRGHB4. By integrating dual cross-linking, this work demonstrated a promising strategy for constructing smart delivery vehicles for food bioactives. Download: Download high-res image (319KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Ziyu Wang,Haosen Zeng,Chonghui Yue,Tianyue Jiang,Jiayi Tian,Zhouya Bai,Yuanyuan Chen,Peiyan Li,Jinying Guo,Denglin Luo
The S-G system maintained better structural integrity than other systems at pH 5. • The C-G system exhibited the maximum ordered structure content at pH 8. • The G-G system had higher water-holding capacity than other systems at pH 9. • The viscoelasticity and thermal stability of all systems were the lowest at pH 9. This study systematically investigated the effects of pH (5.0–9.0) on wheat gluten (G) and its composite systems with polysaccharides of different ionic characteristics: chitosan-gluten (C-G, cationic), guar gum-gluten (G-G, non-ionic), and sodium alginate-gluten (S-G, anionic). Results demonstrated that pH critically regulates intermolecular interactions and network formation by modulating the charge state of gluten and the ionization behavior of polysaccharides. Conformational rearrangements induced by pH significantly altered intermolecular forces—including hydrogen bonds, hydrophobic interactions, ionic bonds, and disulfide bonds—thereby influencing protein subunit stability and microstructure. Under neutral to weakly alkaline conditions (pH 7–8), all systems formed stable networks with uniform pore structures, primarily stabilized by ordered disulfide cross-linking, with synergistic contributions from electrostatic and hydrogen bonding interactions. In strongly alkaline environment (pH 9), thermal stability decreased significantly, with the lowest peak temperature (Tp) and enthalpy change (ΔH) observed across all groups, notably in G system (80.87 °C, 21.05 J/g). Under acidic conditions (pH 5), the S-G system exhibited superior structural integrity, showing higher storage modulus (G′ = 2350.53 Pa), disulfide bond content (18.2 μmol/L), and intensity of low-molecular-weight glutenin subunits (39.41 a.u.) than the G system (1753.43 Pa, 10.5 μmol/L, 31.5 a.u.), the C-G system (1943 Pa, 12.3 μmol/L, 33.87 a.u.), and the G-G system (1840 Pa, 11.8 μmol/L, 34.13 a.u.). These findings clarify how pH modulates the physicochemical and structural properties of gluten–polysaccharide composites, offering theoretical support for the rational design of gluten-based foods with tailored functionality and optimized process control.
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INORGANIC CHEMISTRY
·
2026
·Vol. 65
·期 35
·20421-20436
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IF 4.6
Wu Zhiyao,Deng Yuxiang,Yang Zi,Yang Libo,Pan Duoqiang,Zhang Peng,Wang Tianyou,Pan Zihan,Fu Hao
Photocatalytic uranium recovery from water bodies is
hindered by
the poor pH stability and low photocarrier separation efficiency of
conventional photocatalysts. Herein, we constructed a recyclable rGO/g-C 3 N 4 aerogel with a Schottky junction that simultaneously
addressed both limitations. The optimized rGO/g-C 3 N 4 -2 exhibited pH-insensitive performance (pH 2.0–9.0).
Furthermore, the Schottky barrier directs unidirectional electron
migration toward rGO under illumination, boosting charge separation
efficiency to 78.5%. These Schottky-junction-enabled charge dynamics,
large specific surface area, the layered structure that facilitated
mass and electron transport, and the favorable negative surface charge
for UO 2 2+ enrichment collectively contributed
to the photocatalytic performance. Consequently, rGO/g-C 3 N 4 -2 demonstrated a 92.9% uranium extraction efficiency
within 120 min and maintained high efficiency even after 5 cycles
under visible light. DFT calculations revealed band gap narrowing
to 1.65 eV (vs 2.20 eV for pristine g-C 3 N 4 ),
thereby increasing the light utilization rate. In situ DRIFTS spectroscopy revealed the evolution pathway of active species
from • O 2 – to H 2 O 2 . Combined with XPS and XRD analysis, the transformation
of U(VI) into (UO 2 )O 2 ·2H 2 O after
photocatalytic uranium extraction was confirmed. This study presents
a pH-tolerant and recyclable photocatalyst with a Schottky junction
for uranium extraction from complex aqueous environments, offering
a viable strategy for sustainable nuclear fuel cycles.
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Water
·
2026
·Vol. 18
·期 16
·1941
·
IF 3.5
Chunxiao Wang,Zhirong Chen,Jie Zheng,Tangfu Xiao,Mengyang You,Jianqiao Wang,Nana Wang
Stibnite (Sb2S3), the predominant antimony-bearing sulfide mineral, represents a major natural source of antimony (Sb) in mining-impacted environments. Although humic acid (HA) is ubiquitous in mine wastes and surface waters, its influence on the oxidative transformation and mobilization of Sb from Sb2S3under photochemical conditions remains poorly understood. Here, the coupled effects of HA, controlled ultraviolet irradiation and pH on Sb2S3weathering and Sb mobilization were systematically investigated through batch dissolution experiments combined with hydroxyl radical (·OH) determination, elemental sulfur (S0) analysis and complementary solid-phase characterization. Sb release increased with increasing pH and was further enhanced by HA, particularly under circumneutral and alkaline conditions. Controlled UV irradiation further increased Sb mobilization under the investigated conditions, with a more pronounced effect in HA-containing systems. The enhanced Sb mobilization was accompanied by increased ·OH production and greater S0accumulation, indicating increased oxidative activity during weathering. SEM, EDS and FTIR analyses further revealed progressive surface morphological and compositional changes, whereas XRD showed that the bulk crystalline structure of Sb2S3was largely preserved. XPS revealed the formation of oxidized Sb- and S-containing surface species, providing evidence for progressive surface chemical transformation. These results indicate that HA and controlled photochemical conditions were associated with enhanced Sb mobilization and oxidative transformation at the Sb2S3-solution interface, while the overall weathering remained predominantly surface-confined. The findings highlight the importance of considering natural organic matter, photochemical conditions and pH together when evaluating Sb mobility from sulfide minerals in mining-impacted environments.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Jiahao Wang,Tianao Xie,Heng Jiang,Yukai Shan,Sarun Juengpanich,Shijie Li,Win Topatana,Yeling Liu,Hong Wan,Yeben Qian,Peng Chen,Bo Chen
Background: Navitoclax (ABT-263) exhibits strong cytotoxic effects against hepatocellular carcinoma cells in vitro; however, its therapeutic efficacy in vivo is limited by insufficient local drug accumulation and compensatory upregulation of the anti-apoptotic protein myeloid cell leukemia-1 during long-term treatment. In addition, effective immune activation in hepatocellular carcinoma remains challenging due to the immune-privileged hepatic microenvironment. This study aimed to overcome these limitations through a tumor-targeted nanotherapeutic strategy. Results: Dual pH-responsive copolymeric nanoparticles modified with folic acid and co-loaded with navitoclax and indocyanine green (FPN AI ) were developed. FPN AI preferentially accumulated at hepatocellular carcinoma sites through folate receptor-mediated targeting and released navitoclax in response to the acidic tumor microenvironment, thereby inducing mitochondria-mediated apoptosis. Upon near-infrared irradiation, indocyanine green generated excessive reactive oxygen species, leading to downregulation of myeloid cell leukemia-1 and further enhancement of apoptotic signaling. The combined effects of navitoclax and reactive oxygen species synergistically promoted tumor cell apoptosis. Moreover, apoptosis induced by FPN AI triggered immunogenic cell death, characterized by dendritic cell maturation and activation of cytotoxic CD8⁺ T cells. In vivo studies demonstrated that FPN AI with near-infrared irradiation achieved significantly improved antitumor efficacy compared with navitoclax monotherapy, while maintaining favorable tumor-targeting capability and biosafety. Conclusions: This study demonstrates that FPN AI enhances the antitumor activity of navitoclax by integrating targeted drug delivery, reactive oxygen species-mediated mitochondrial apoptosis, and immunogenic cell death induction. The proposed nanotherapeutic platform represents a promising approach for improving hepatocellular carcinoma treatment outcomes.
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MACROMOLECULAR BIOSCIENCE
·
2025
·
IF 4.1
Wei Wang,Jinghang Li,Yaodong Di,Shuai Yang,Youfa Wang,Lesan Yan
Chemodynamic therapy (CDT) is an innovative cancer treatment strategy that leverages Fenton or Fenton-like reactions to convert hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment (TME) into highly cytotoxic hydroxyl radicals (•OH). However, the therapeutic efficacy of CDT against tumor cells is limited by two primary constraints: 1) insufficient H 2 O 2 levels in the TME, which restricts •OH generation; and 2) elevated concentrations of reduced glutathione (GSH) in the TME, which neutralizes excess reactive oxygen species (ROS). To address these challenges, this study developed a nanoplatform based on mixed micelles composed of two distinct polycarbonate materials. One polycarbonate is conjugated with cinnamaldehyde (CA) via side chains to form a polymeric prodrug, enabling pH-responsive release of CA. The other polycarbonate chelates Fe 3+ through side-chain carboxyl groups to initiate Fenton-like reactions. In the acidic TME, the mixed micelles release CA, which elevates intracellular H 2 O 2 levels, thereby overcoming the limitation of inadequate H 2 O 2 supply in tumor cells. Simultaneously, the Fe 3+ complex within the micelles depletes GSH, reducing it to Fe 2+ , which triggers Fenton-like reactions that amplify ROS production, thus enhancing CDT efficacy. Additionally, pH-triggered disassembly of the micelles in the acidic TME releases encapsulated doxorubicin (DOX), which induces tumor cell apoptosis by damaging DNA, further augmenting antitumor therapeutic outcomes. The nanocarrier developed in this study integrates a synergistic strategy of “H 2 O 2 elevation and Fenton-like reaction” with chemotherapy, significantly improving tumor cell eradication and demonstrating substantial potential for cancer treatment.
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Current Research in Food Science
·
2025
·
IF 7
Jiankang Lu,Ruihua Zhang,Mingyan Ai,Chunlan Zhang,Shuting Li,Ruili Zhang,Weihua Wang,Zhiqiang Zhou,Yiming Jia,Zuoli Zhang,Shugang Li
The efficient loading of proteins on bioactive substances had been a research hotspot in the fields of food science and industry in recent years. The complex of ultrasound-assisted phosphorylated cantaloupe seed protein isolate (UP-CSPI) and curcumin (CUR) was prepared by pH shift method to investigate the effects of different concentrations of CUR on the structure and functional properties of UP-CSPI. The results showed that with the increase of CUR concentration, the zeta potential, the antioxidant activity and emulsifying performance of the complex improved. The interaction between CUR and UP-CSPI was a spontaneous reaction driven by Gibbs free energy (ΔG<0). The enthalpy change (ΔH) and entropy change (ΔS)>0, indicating mainly hydrophobic interaction. Furthermore, CUR caused changes in the secondary structure of the UP-CSPI, β-turns increased from 38.33 % to 45 %–47 %, random coils decreased from 25.85 % to 13 %–14 %. In conclusion, the binding of CUR to proteins through pH shift had solved the problem of CUR instability and also provided new insights for the development and application of plant protein-based delivery systems.
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CARBON
·
2025
·
IF 11.6
Ziyue Han,Wei Deng,Yujie Song,Hailiang Cao,Yongqing Shen,Zhijian Dang,Zhi Zheng,Junjie Guo
Carbon-supported platinum (Pt/C) is the most extensively used electrocatalyst for the oxygen reduction reaction (ORR). However, the electrochemical degradation occurring during operation severely restricts the catalyst's cycling stability, posing a critical obstacle for practical commercialization. Here, we developed a high-performance alternative electrocatalyst consisting of ultrafine Pt nanoparticles embedded in hierarchical porous carbon nanofibers (Pt/PCNF). Importantly, we elucidate a novel micropore confinement effect, demonstrating through DFT calculations that micropores serve as high-surface-area anchoring sites for Pt species, effectively stabilizing them. This unique architecture facilitates ultrahigh Pt dispersion, endowing the catalytic with exceptional stability for pH-universal ORR. Remarkably, the Pt/PCNF catalyst achieves 70 % higher electrochemically active surface area than commercial Pt/C while maintaining 99.4 % of its initial activity after 10,000 durability cycles. Furthermore, when integrated into Zn-air batteries, the catalyst delivers a high open-circuit voltage (1.42 V) and remarkable peak power density (216.73 mW cm −2 ). This work provides fundamental insights into the stabilization mechanisms of Pt-based ORR catalysts through micropore confinement, while demonstrating exceptional performance metrics that meet industrial requirements for fuel cell applications.
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PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
·
2025
·
IF 2.8
Wanjun Han,Han Liu,Ting Liang,Lanjing Li,Ru Huan,Chunshan Gui
Organic anion transporting polypeptide 1B3 (OATP1B3) is a liver-specific transporter that mediates uptake of various substances from blood into hepatocytes. The transport function of OATP1B3 was shown to be pH-sensitive. As the protonation state of extracellular histidine residues can be affected by the environmental pH, in the present study, the role of 7 extracellular histidine residues in the function and pH sensitivity of OATP1B3 has been examined. Our results showed that H115 had the most significant effect on the function of OATP1B3. The Cryo-EM structure of OATP1B3 indicated that H115 is involved in the binding and release of bicarbonate during a transport cycle. Functional studies on H115 mutants suggested that a hydrogen-bond forming group was preferred over a positively charged group at site 115, indicating that a hydrogen bond is optimum for bicarbonate's binding/release cycle. This may also explain why OATP1B3 showed lower transport function at pH 4.5 than at pH 7.4, as H115 is positively charged at pH 4.5 but neutral at pH 7.4. In addition, the H115A mutation largely compromised the pH sensitivity of OATP1B3, probably due to the loss of its protonation state switching capability. Taken together, H115 plays an important role in the function and pH sensitivity of OATP1B3.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Zixing Yan,Qingling Nie,Jiajia Liu,Jingxin Chen,Youmei Liu,Yudong Lu,Mengjun Xu,Zhenwen Lin
Stomach disorders are a common category of digestive system diseases. With the increasing emphasis on traditional medicine, the use of herbal medicines in treating gastric diseases has attracted much attention. However, direct administration of herbal medicines with short half-life leads to low drug utilization. To address this problem, pH-responsive composite hydrogel beads consisting of sodium alginate/carboxymethyl chitosan/gelatin-naringenin (SA/CMCh/Gel-Nar) were designed in this study to encapsulate decocted herbal saddle decoctions (AZD) for use as sustained-release medications for gastrointestinal disorders. The SA/CMCh/Gel-Nar hydrogel beads have high drug loading capacity, strong adhesion (98.33 % retention), and excellent pH-responsive sustained-release properties. In SGF, 39 % of the drug was released within 2 h, ensuring rapid therapeutic efficacy, while in SIF, the remaining 61 % was gradually released within 23 h. With excellent antimicrobial efficacy (>93.4 %) and high biosafety (cell viability >97.21 %), these hydrogel beads provide a promising and safe platform for sustained drug delivery in the gastrointestinal tract.
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TALANTA
·
2025
·
IF 6.1
Liyu Qiu,Xixiang Yang,Nan Zhao,Anqi Luo,Li Wang,Xiaogang Hu
Hybrids of molecular imprinting-aptamers have been used for environmental analysis; however, the weak selectivity and stability inhibited their applications in complex matrices. In this paper, the nano-scale pH-responsive aptamer-molecularly imprinted interpenetrating hydrogels (Fe 3 O 4 @Apt-MIH) were prepared in one step by the modified sol-gel method based on the preparation principle of interpenetrating network hydrogels, with Fe 3 O 4 as the carrier, aminopropyltriethoxysilane and methyltrimethoxysilane as functional monomers, polyethyleneimine (PEI) as the pH-responsive components, and tetraethoxysilane (TEOS) and glutaraldehyde (GA) as dual cross-linking agents. After optimizing the polymerization and extraction conditions, the pH response performance, extraction capacity and reusability of the material with highly magnetism were investigated, which could achieve magnetic separation within 5 s. The SiO 2 coating hydrolyzed by TEOS provided a rigid backbone for interpenetrating hydrogels, which could improve the acid resistance of PEI by adjusting the isoelectric point of Fe 3 O 4 @Apt-MIH and assist in target identification. Selectivity research showed that aptamers and functional monomers have a highly effective synergistic recognition effect on ampicillin, with the imprinting factor of 6.90 and the synergistic recognition factor of 1.48. This solid-phase microextraction material coupled to high-performance liquid chromatography with the linear range of 10–1000 μg/L and the detection limit of 7.67 μg/L enabled the selective separation and detection of ampicillin in milk and honey, with minimal sample matrix interference and recovery between 95.2 and 102 %.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xubo Fang,Yuhan Du,Haq Nawaz,Xin Li,Ning Yan,Wenqiu Zheng,Deqiang Li,Feng Xu
Considering the substantial annual global discharge of oily wastewater, there exists a crucial requirement to develop smart membranes that possess environmentally sustainable attributes, tunable wettability, and potent antibacterial properties, enabling efficient and controlled separation of oil/water mixtures. Here, a photothermal/pH-responsive electrospun cellulose nanofibers (ECF-P-Fe 3 O 4 -N) membrane endowed with wettability modulation and bacterial elimination capabilities was successfully prepared. The advancement in the fabrication method stemmed from the ingenious integration of three key strategies: the interpenetrating network formation between cellulose and the thermosensitive polymer, the co-precipitation embedding of photothermal medium (Fe 3 O 4 NPs), and the chemical grafting of aminosilane. The resultant ECF-P-Fe 3 O 4 -N membrane exhibited fast and reversible wettability transitions between high hydrophilicity (under acid or high-temperature stimulation) and hydrophobicity (under alkali or low-temperature stimulation), achieving on-demand separation of diverse immiscible oil-water mixtures and surfactant-stabilized emulsions. The maximum separation flux for oil-water emulsions attained a value of 225.6 L m −2 h −1 , accompanied by a separation efficiency surpassing 98.53 %. It also possessed strong elimination of bacteria, satisfying for the long-lasting contact usage. This work holds significant implications in designing smart membranes for remotely controlling the oil-water separation.
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危险品化学品经营许可证（带存储）