MEDICINAL CHEMISTRY RESEARCH
·
2023
·Vol. 32
·期 5
·899-909
·
IF 2.6
Ye Zhen,Zhao Tong-Shi-Yao,Li Shan-Bin,Zhou Xian-Li,Luo Qin,Qin Jiang-Ke,Liang Cheng-Qin,Wang Ping,Ge Guang-Bo
Previous in vivo and in vitro studies revealed that esculetin (Fig. 1 ) has anti-hepatitis B virus (anti-HBV) activity as well as a protective effect on liver damage caused by duck hepatitis B virus. We designed and synthesized a series of esculetin derivatives, introduced side chains containing various amino groups into site 7 of the parent structure, and synthesized C-4 and C-8 substituted derivatives with the goal of investigating their anti-HBV activities. In vitro anti-HBV activity was performed against HepG2.2.15 cells by using Enzyme-Linked Immunosorbent Assay(ELISA) kit and cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay with lamivudine as the positive control. The results demonstrated that several compounds showed moderate anti-HBV activity, while the introduction of morpholine groups could significantly inhibit the expression of hepatitis B e antigen (HBeAg) and the introduction of the 2-methylimidazole group could significantly inhibit the expression of Hepatitis B surface antigen (HBsAg). Among all tested compounds, compound 4a demonstrated the best anti-HBeAg activity (IC 50 = 15.8 ± 4.2 μM), while compound 6d demonstrated the best anti-HBsAg activity (IC 50 = 21.4 ± 2.8 μM). Compounds 6b and 6c showed moderate anti-HBV activity and HBsAg inhibition. Compounds 4b showed moderate anti-HBV activity and an inhibitory effect on HBeAg. In addition, compounds 4a , 4c , 4d , 6b , 6c and 6d showed improved metabolic stability. This study provides useful guidance for the discovery of anti-HBV drugs, which merits further investigation. Graphical Abstract
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高影响因子
POWDER METALLURGY AND METAL CERAMICS
·
2022
·Vol. 61
·期 3
·221-229
·
IF 0.913
Liang Dong,Xiong Sang,Zhang Xiaojuan,Lin Qing
Tungsten oxide is widely used in the photolysis of water for hydrogen production, photocatalysis, photoelectric conversion, and electrochromism. Eu 3+ doped tungsten trioxide nanoparticles were prepared by hydrothermal method with the addition of sodium tungstate (NaWO 4 · 2H 2 O). Two different samples were obtained at the temperature set at 160 and 180°C. The third sample obtained from ammonium paratungstate ((NH 4 ) 10 H 2 (W 2 O 7 ) 6 ) was used at the temperature of 160°C. The samples’ morphology, structure, and optical performance were then observed and analyzed. The results show that a rod-like structure of WO 3 : Eu 3+ nanoparticle with a monoclinic crystal system can be successfully generated using sodium tungstate. A spherical structure of WO 3 : Eu 3+ nanoparticle with a triclinic crystal system was prepared using ammonium paratungstate. The finished sample with ammonium paratungstate at a reaction temperature of 160°C has the smallest grain average size of 45.98 nm and Eu 3+ ions successfully doped. Under the excitation of different wavelengths, the three samples demonstrate pronounced emission peaks at around 615 nm, corresponding to the 5D 0 → 7F 2 electronic transition of Eu 3+ . Using ammonium paratungstate as the tungsten source, the prepared WO 3 : Eu 3+ nanoparticle at 160°C has the highest luminous intensity. The luminescence intensity of the prepared WO 3 : Eu 3+ nanoparticle from ammonium paratungstate as a tungsten source is higher than the other two samples obtained from sodium tungstate as a tungsten source at two temperatures. However, the three samples with excitation wavelength λ = 254 nm were monitored at the wavelength of 615 nm. All three samples exhibited the most substantial excitation peaks at about 508 nm, which belonged to the electron transition in 4f of Eu 3+ .
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2019
·Vol. 35
·期 4
·549-555
·
IF 1.071
Lu Xue,Liu Guocheng,Wang Xiang,Lin Hongyan,Wang Xiuli
We synthesized three new Ni(II) coordination polymers [Ni(L)(HIP)(H 2 O) 2 ]H 2 O(CP 1 ), [Ni(L)(NIP)]·2H 2 O(CP 2 ) and [Ni(L)(NDC)(H 2 O) 2 ](CP 3 )[L= N , N' -bis(pyridine-3-yl)thiophene-2,5-dicarboxamide, H 2 HIP=5-hydroxyisophthalic acid, H 2 NIP=5-nitroisophthalic acid, H 2 NDC=2,6-naphthalenedicarboxylic acid] by hydrothermal method, which were characterized by means of infrared spectra(IR), TG analyses, PXRD and single-crystal X-ray diffraction. The CP 1 is a 1D tubular structure based on [Ni-HIP] 2 loops and pairs of L ligands. CP 2 is a 2D 3,5-connected architecture, which consists of Ni-L linear chains and (Ni-NIP) 2 double chains. CP 3 is a 2D network, which features 4-connected topology. Solid-state luminescent behaviours of CP 1 —CP 3 were investigated. The CP 1 can detect Fe 3+ ions through luminescence quenching. The electrochemical properties of CP 1 buk-modified carbon paste electrode(CP 1 -CPE) has also been investigated, which has bifunctional electrocatalytic activity for oxidation of ascorbic acid and reduction of NO 2 − .
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高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 4
·1-8
·
IF 5.479
Qu Fengdong,Zhang Shendan,Zhang Bingxue,Zhou Xinxin,Du Shiyu,Lin Cheng-Te,Ruan Shengping,Yang Minghui
Hierarchical Co 3 O 4 @NiMoO 4 core-shell nanowires (NWs) were synthesized utilizing a two-step hydrothermal method. The NWs show a high chemiresistive response (at a temperature of 255 °C) to xylene, with an R gas /R air ratio of 24.6 at 100 ppm xylene, while the response towards toluene, benzene, ethanol, and acetone, CO, H 2 S and NO 2 is much weaker. In contrast, pure Co 3 O 4 nanowires exhibit weak responses to all the vapors/gases and poor selectivity. The new NW sensor displays an almost linear response (1–100 ppm) to xylene and a lower detection limit of 424 ppb. The remarkable gas sensing characteristics are attributed to the synergistic catalytic effect and the formation of a heterostructure between Co 3 O 4 and NiMoO 4 .
Schematic presentation of a xylene vapor chemiresistive sensor based on Co3O4@NiMoO4 core-shell nanowires. The Co3O4@NiMoO4 core-shell nanowires-based sensor exhibits a high response (24.6) to 100 ppm xylene at 255 °C and high response/recovery speed (13–15 and 25–29 s).
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高影响因子
BIOTECHNOLOGY LETTERS
·
2021
·Vol. 43
·期 8
·1617-1624
·
IF 2.461
Wang Liuzhu,Jiang Shuiqin,Sun Yangyang,Yang Zeyu,Chen Zhi,Wang Hualei,Wei Dongzhi
Objectives Catalytic promiscuity, or the ability to catalyze a secondary reaction, provides new opportunities for industrial biocatalysis by expanding the range of biocatalytic reactions. Some nitrilases converting nitriles to amides, referred to as the secondary activity, show great potential for amides production. And our goal was exploiting the amide-forming potential of nitrilases. Results In this study, we characterized and altered the secondary activity of nitrilase from Acidovorax facilis 72 W (Nit72W) towards different substrates. We increased the secondary activity of Nit72W towards 2-cyanopyridine by 196-fold and created activity toward benzonitrile and p-nitrophenylacetonitrile by modifying the active pocket. Surprisingly, the best mutant, W188M, completely converted 250 mM 2-cyanopyridine to more than 98% 2-picolinamide in 12 h with a specific activity of 90 U/mg and showed potential for industrial applications. Conclusions Nit72W was modified to increase its secondary activity for the amides production, especially 2-picolinamide.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2020
·Vol. 31
·期 9
·6779-6785
·
IF 2.22
Wu Bao-Shui,Wang Peng,Song Jian
A mixed-solvothermal method was used to synthesize the α-Fe 2 O 3 nanoparticles with nearly spherical, rod-like, disk-like morphologies by varying the precipitant or solvent. When used as the anode material for Li-ion batteries, the nearly spherical α-Fe 2 O 3 nanoparticles with a high monodispersity and an average diameter of about 50.5 nm exhibited much better cycle stability and rate performance than their disk-like and rod-like equivalents. Their reversible capacity reached up to 1500 mAh/g that far exceeded their theoretical value (1007 mAh/g) at a current density of 0.1 A/g. Even after 100 cycles, there was still a capability retention of about 1200 mAh/g. Moreover, the analysis of the Nyquist plots revealed that the nearly spherical α-Fe 2 O 3 nanoparticles presented the lowest charge-transfer resistance among the three samples. The present study provides an effective way to control the morphologies of nanoparticles, and these nanostructures would present great potentials for the applications in LIBs or some other fields.
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Nature Communications
·
2020
·Vol. 11
·期 1
·1-11
·
IF 12.121
Zhang Ning,Feng Xiaobin,Rao Dewei,Deng Xi,Cai Lejuan,Qiu Bocheng,Long Ran,Xiong Yujie,Lu Yang,Chai Yang
Anodic oxygen evolution reaction (OER) is recognized as kinetic bottleneck in water electrolysis. Transition metal sites with high valence states can accelerate the reaction kinetics to offer highly intrinsic activity, but suffer from thermodynamic formation barrier. Here, we show subtle engineering of highly oxidized Ni 4+ species in surface reconstructed (oxy)hydroxides on multicomponent FeCoCrNi alloy film through interatomically electronic interplay. Our spectroscopic investigations with theoretical studies uncover that Fe component enables the formation of Ni 4+ species, which is energetically favored by the multistep evolution of Ni 2+ →Ni 3+ →Ni 4+ . The dynamically constructed Ni 4+ species drives holes into oxygen ligands to facilitate intramolecular oxygen coupling, triggering lattice oxygen activation to form Fe-Ni dual-sites as ultimate catalytic center with highly intrinsic activity. As a result, the surface reconstructed FeCoCrNi OER catalyst delivers outstanding mass activity and turnover frequency of 3601 A g metal −1 and 0.483 s −1 at an overpotential of 300 mV in alkaline electrolyte, respectively.
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BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
·
2015
·Vol. 20
·期 5
·901-907
·
IF 1.113
Yang Jianbing,Ni Kefeng,Wei Dongzhi,Ren Yuhong
Ni 2+ -functionalized Fe 3 O 4 @polydopamine magnetic nanoparticles (Ni 2+ -PD-MNPs) were designed and synthesized by in situ coating of magnetic nanoparticles with polydopamine, followed by conjugation of Ni 2+ to the polydopamine film. The Ni 2+ -PD-MNPs were used to purify His-tagged red fluorescent protein (His-RFP) via affinity interaction between Ni 2+ and the His-tag. The results showed that the Ni 2+ -PD-MNPs had extraordinary selectivity for His-RFP purification. In addition, a Histagged transaminase (ω-transaminase BJ110) was selectively immobilized onto the Ni 2+ -PD-MNPs without purification, and the immobilized enzyme showed improved specific activity, as well as enhanced stability and reusability.
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CHROMATOGRAPHIA
·
2013
·Vol. 76
·期 13
·735-745
·
IF 1.437
Peng Xi-Tian,Li Ze,Zhang Yi,Liu Tao,Yu Qiong-Wei,Feng Yu-Qi
A novel mixed-mode stationary phase (OAS) has been prepared by bonding n -octyl and aminopropyl groups with the surface of silica gel. The obtained OAS stationary phase was characterized by Fourier transform infrared spectroscopy, elemental analysis, zeta potential and ion-exchange capacity. The mixed-mode one-site and two-site retention models were used to quantitatively describe the retention mechanism of the OAS stationary phase using three strong acidic analytes. The results indicated that the two-site model is more suitable for the description of mechanism of OAS phase. Then the OAS stationary phase was applied to separate ten water- and fat-soluble vitamins in a single run; the separation is based on the hydrophobic and ionic interaction mechanisms. A method for the simultaneous determination of ten water- and fat-soluble vitamins in commercial multivitamin tablets by high performance liquid chromatography with ultraviolet detection was established and validated according to the stability, linearity, accuracy and precision. Finally, the validated method was used to analyze the content of ten vitamins in two commercial multivitamin tablets and the recoveries were in the range of 89.2–111.0 %, with RSDs <6.1 %, indicating the good reliability of the proposed method.
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Science China-Chemistry
·
2021
·Vol. 64
·期 5
·770-777
·
IF 9.445
Qiao Xiaofeng,Lin Yuhan,Li Jiazhen,Ma Wanhong,Zhao Jincai
Both β- and γ- hydroxyketone structures are important units in biologically active molecules, synthetic drugs and fine chemicals. Although there are some routes available for their manufacture from pre-functionalized groups on one or two matrix molecule(s), the approaches to simply and simultaneously deposit two oxygen atoms from dioxygen into two specific C(sp 3 ) positions of pure saturated hydrocarbons have rarely succeeded because they are involved in the targeted activation of three inert C-H σ bonds all at once. Here, we show that a TiO 2 -CH 3 CN photocatalytic suspension system enables the insertion of dioxygen into one C(sp 3 )-C(sp 3 ) bond of strained cycloparaffin derivatives, by which difunctionalized hydroxyketone products are obtained in a one-pot reaction. With the cleavage event to release strain as the directional driving force, as-designed photocatalytic reaction systems show 21 examples of β-hydroxyketone products with 31%–76% isolated yields for three-membered ring derivatives and 5 examples of γ-hydroxyketone products with 30%–63% isolated yields for four-membered ring substrates. 18 O isotopic labeling experiments using 18 O 2 , Ti 18 O 2 and intentionally added H 2 18 O, respectively, indicated that both oxygen atoms of hydroxyketone products were exclusively from dioxygen, suggesting a previously unknown H + /TiO 2 -e − catalyzed arrangement pathway of the hydroperoxide intermediate to convert dioxygen into hydroxyketone units.
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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2019
·Vol. 56
·期 5
·2355-2364
·
IF 1.85
Manzoor Muhammad Faisal,Zeng Xin-An,Rahaman Abdul,Siddeeg Azhari,Aadil Rana Muhammad,Ahmed Zahoor,Li Jian,Niu Debao
The aim of this paper is to investigate the combined impact of pulsed electric field (PEF) and ultrasound (US) to evaluate the physicochemical, bioactive compounds and chemical structure of almond extract. Almond extract was first treated with PEF and then with US. Combined treatment (PEF–US) has attained the highest value of total phenolics, total flavonoids, condense tannins, anthocyanin contents and antioxidant activity in DPPH, reducing power and metal chelating activity than all other treatments. Among all those treatments, there was slightly visible difference in the color. Moreover, FT-IR spectra indicate that the effect of PEF-US on almond extract did not produce new carbonyl compounds, but led to the higher concentration of these compounds. This study demonstrated that the PEF-US could be useful for the extraction of bioactive compounds as well as improving the stability of volatile compounds.
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SN Applied Sciences
·
2020
·Vol. 2
·期 4
·1-11
·
IF 0
Yu Wenjie,Li Hengye,Zhang Lin,Liu Jing,Kong Fenying,Wang Wei
Abstract Adsorption is a promising technique for water treatment. Porous aromatic frameworks (PAFs) have been witnessed as advanced adsorbents for various applications and PAFs with task-specific functionality and porosity are desirable adsorbents. Herein, a charged PAF, PAF-CH 2 N(CH 3 ) 3 I, was prepared through precursor-designed method. The charged PAF is densely and homogeneously functionalized with cationic groups and featured with hierarchical pore structure. The content of the charged groups in the framework reaches up to 52.27 wt% and the hierarchical structure facilitates fast adsorption/desorption of dye molecular. It demonstrates strong affinity, fast adsorption rate, high adsorption efficiency and high adsorption capacity towards not only small model anionic dye but also large-sized one, which can not be adsorbed efficiently by other microporous adsorbents. In addition, benefiting from the hierarchical structure, the charged PAF can be easily regenerated and reused with almost no loss of its efficiency even after 10 adsorption–desorption cycles. These excellent features demonstrate that the charged PAF is a promising adsorbent for wastewater treatment and this study provides a new perspective to explore functionalized PAFs as a versatile type of advanced adsorbents. Graphic abstract
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危险品化学品经营许可证（带存储）