Cell Communication and Signaling
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2025
·Vol. 23
·期 1
·1-21
·
IF 8.9
Li Lei,Peng Ruilong,Wang Cong,Chen Xin,Gheyret Dilmurat,Guan Siyu,Chen Bo,Liu Yafan,Liu Xilei,Cao Yiyao,Han Cha,Xiong Jianhua,Li Fanjian,Lu Taoyuan,Jia Haoran,Li Kaiji,Wang Jinchao,Zhang Xu,Xu Jianye,Wang Yajuan,Xu Xin,Li Tuo,Zhang Jianning,Zhang Shu
Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary tissue damage. The precise molecular controls that dictate the inflammatory behavior of neutrophils post-TBI, however, remain largely elusive. Our comprehensive analysis of the molecular landscape surrounding the trauma in TBI mice has revealed a significant alteration in the abundance of β2 integrin (ITGB2), predominantly expressed by neutrophils and closely associated with immune responses. Using the fluid percussion injury (FPI) mouse model, we investigated the therapeutic efficacy of Rovelizumab, an agent that blocks ITGB2. The treatment has demonstrated significant improvements in neurologic function in TBI mice, attenuating blood–brain barrier permeability, mitigating oxidative stress and inflammatory mediator release, and enhancing cerebral perfusion. Moreover, ITGB2 blockade has effectively limited the adherence, migration, and infiltration of neutrophils, and has impeded the formation of neutrophil extracellular traps (NETs) upon their activation. Finally, it was demonstrated that ITGB2 mediates these effects mainly through its interaction with intercellular adhesion molecule-1 (ICAM 1) of endotheliocyte. These findings collectively illuminate ITGB2 as a crucial molecular switch that governs the adverse effects of neutrophils post-TBI and could be targeted to improve clinical outcome in patients.
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JOURNAL OF ELECTRONIC MATERIALS
·
2024
·
IF 2.2
Cao Yang,Zhang Yong,Wei Wei,Wang Chen,Zhao Xiaoyu,Chen Xudan,Lu Zhenhao
Organic–inorganic metal halides have recently garnered significant interest owing to their excellent photoluminescence performance and high stability. Therefore, a synthetic procedure was designed here to obtain (PPZ)ZnBr 4 (PPZ = 1-phenylpiperazine) nanocrystals (NCs) incorporating Pb 2+ and Sn 2+ ions, obtaining blue and orange light emitters, respectively. Photoluminescence quantum yields of blue and orange emissions were up to 43.2% and 29.9%, respectively, under 365-nm excitation. The prepared NCs also demonstrated long-term stability and humidity resistance. This study not only provided a deep comprehension of low-dimensional perovskites, but also established an avenue for the strategic design of high-performance light-emitting perovskites.
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JOURNAL OF ELECTRONIC MATERIALS
·
2024
·
IF 2.2
Kang Juewei,Qin Yanxi,Yan Jingjing,Tong Xili
Developing high-performance electrocatalysts for alkaline hydrogen evolution reaction (HER) remains a significant challenge in reducing noble Pt consumption due to its poor water dissociation activity. In this study, phosphorus (P) atoms were successfully integrated into a PtRu alloy via a facile phosphating reaction of NaH 2 PO 2 ·H 2 O. Through optimization of the electronic structure of Pt and Ru induced by P-doping, the process of water dissociation was markedly accelerated. Thus the P-PtRu/C catalyst exhibited superior activity in terms of low overpotentials of merely 1 mV and 68 mV at 10 mA cm −2 and 100 mA cm −2 , respectively, compared to the counterparts and commercial 20 wt.% Pt/C-JM. Furthermore, the introduction of P atoms substantially reduced the agglomeration of PtRu nanoparticles, thus producing strong electrocatalytic stability toward alkaline HER. This work provides a promising advancement in designing advanced electrocatalysts for sustainable hydrogen production and beyond. Graphical Abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-16
·
IF 12.6
Chu Hongyu,Xu Yajun,Shan Yuezhan,Sun Mengmeng,Zhao Weidong,Fang Xuedong,Shen Na,Tang Zhaohui
The vascular-disrupting agent DMXAA (5,6-dimethylxanthone-4-acetic acid) exhibits potent anticancer activity by targeting tumor vasculature and activating immune responses via the cGAS-STING pathway. However, its clinical application is hindered by nonspecific targeting and significant cardiovascular toxicity. This study introduces a novel self-amplified tumor-targeting delivery system(P@NPPD)comprising azide-functionalized poly(ethylene glycol)- b -poly-[( N -2-hydroxyethyl)-aspartamide]-DMXAA (N 3 -PEG- b -PHEA-DMXAA, NPPD) conjugated to DBCO modified platelets. Among them, NPPD was synthesized by conjugating DMXAA to N 3 -PEG- b -poly-[( N -2-hydroxyethyl)-aspartamide] through esterification. This system enhances tumor-specific drug delivery while minimizing systemic toxicity. Leveraging the natural tumor-homing properties of platelets and the coagulation cascade, P@NPPD selectively targets exposed collagen at tumor sites, initiating a self-amplifying release of DMXAA. This approach achieved a 2.61-fold improvement in targeting efficiency and an 89.1% tumor suppression rate. In addition to improving drug accumulation at tumor sites, P@NPPD significantly activated local immune responses, enhancing therapeutic efficacy and safety. These findings underscore the potential of P@NPPD as a promising platform for cancer therapy. Graphical abstract
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JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 5
·1-12
·
IF 2.6
Liu Jianhui,Li Zhe,Yang Wenjian,Gong Bichuan,He Linwei,Xu Hui,Su Anxiang,Xie Minhao
Triazine pesticides can easily remain in the environment and food, causing serious harm to organisms. Developing a pretreatment technology with strong purification and enrichment capabilities is of great significance for the detection of triazine. In this paper, magnetic dual-template nanomolecular imprinted polymers (MMIPs) were synthesized using silica-modified Fe 3 O 4 magnetic shell nanoparticles as carriers, methacrylic acid (MAA) as a functional monomer, and cyromazine and melamine as template molecules. This material was characterized by transmission electron microscope (TEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The adsorption experiments were carried out and the results showed that the MMIPs had the chemical properties of surface molecular imprinting. The binding constants of MMIPs were 26.95 mg/L and 657.89 mg/L, and their maximum apparent binding capacity was 2.02 mg/g and 8.59 mg/g, respectively. The prepared MMIPs were used as adsorbents for dispersive solid phase extraction, and high-performance liquid chromatography analysis was coupled to determine triazine pesticides from three samples. The recovery of this method was between 84.8% and 109.5% and the limits of detection were between 0.01–0.03 µg/L. This method greatly shortens the sample pretreatment time and achieves the purpose of rapid pretreatment.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2025
·
IF 2
Li Peining,Wang Shouren,Xiao Zhen,Li Yang,Zhang Luyu,Wang Gaoqi
Underwater vehicles can conduct underwater exploration and military rescue operations and play a significant role in marine economic development and national defense. The fluid resistance control and corrosion resistance of underwater vehicles are essential indexes for evaluating the performance of underwater vehicles in particular marine environments and harsh conditions. The 7075 aluminum alloy, widely used in spacecraft shells, was selected as the material. We prepared a drag-reduction and robust surface based on shark skin by laser-ablation and plasma electrolytic oxidation. Then, the surface free energy was further modified by chemical modification. The ceramic coating exhibited superhydrophobicity with a water contact angle of 155.6° and roll-off angle (RA) of 5.5°. Compared with Bare Al, the corrosion current density of the superhydrophobic ceramic coating was reduced by 4 orders of magnitude since ZnO-NPs could notably enhance the corrosion resistance of Al alloys. Moreover, due to the protective effect of the ceramic coating and microstructure, the superhydrophobic coating exhibited excellent mechanical durability. Based on numerical simulation, the drag reduction effect of biomimetic microstructure under different Reynolds numbers was investigated. The experimental results indicated that biomimetic microstructure demonstrated notable drag reduction capabilities compared to smooth surfaces, stabilizing at approximately 28% during laminar flow states. Thus, applying this coating method to the underwater vehicle shell was expected to reduce the fluid resistance and extend the operational lifespan in the marine corrosive environment.
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Advanced Fiber Materials
·
2024
·
IF 17.2
Zhi Yifan,Zhang Honghua,Zhang Lugang,Li Qianqian,Kuang Xiangtian,Wu Wen,Zhou Qingqing,Li Ping,Li Wei,Zhang Huanxia
Piezoresistive pressure sensors have received considerable attention because of their simple structure, high sensitivity and low cost. Graphene, which is known for its outstanding mechanical and electrical properties, has shown great application potential as a sensor material. However, its durability and performance consistency in practical applications still require enhancement. In this study, magnetic graphene fibers (MGFs) are prepared via wet spinning, using graphene oxide (GO), doped with Fe 3 O 4 nanoparticles. The resulting MGFs exhibit a high tensile strength of 58.6 MPa, a strain of 5.3% and an electrical conductivity of 1.7 × 10 4 S/m. These MGFs are utilised to construct a multilayer fabric for fabrication of flexible pressure sensors. The confinement within the spinning channel facilitates an ordered arrangement of GO sheets, resulting in MGFs with superior electrical and mechanical properties. The issuing MGFs pressure sensors demonstrate a wide detection range (0–120 kPa), high sensitivity (0.233 kPa −1 , 0–40 kPa) and rapid response/recovery times (121 ms/158 ms). In addition, it exhibits a remarkable durability, maintaining performance over 1300 cycles, during continuous operation, with negligible degradation. This sensor shows excellent capability in monitoring human physiological activities, indicating its substantial application potential in wearable devices. Graphical
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Chinese Medicine
·
2025
·Vol. 20
·期 1
·1-20
·
IF 5.7
Liu Changtong,Guo Rui,Zhou Yue,Zhu Miao,Shao Li,Wang Yingchao,Zhao Lu
Background Cardiac hypertrophy, characterized by the thickening of the heart muscle, arises from factors such as hypertension and genetic mutations, often leading to adverse outcomes like heart failure and arrhythmias. Guanxinning tablets (GXNT), a botanical drug composed of the blood-activating herbs Salvia miltiorrhiza Bunge. and Ligusticum striatum DC., are widely used in the treatment of cardiovascular diseases. However, the active ingredients and their molecular mechanisms are yet to be fully understood. Methods We evaluated the anti-hypertrophic effects of GXNT and screened its active substances via cardiac function live-imaging on an aristolochic acid A-stimulated zebrafish cardiac hypertrophy model, and through F-actin immunostaining on a phenylephrine-induced hypertrophic NRCMs model. Additionally, the protective effects of GXNT’s active substances were analyzed in a mouse model of cardiac hypertrophy using echocardiography, histopathology analysis, and western blotting. Results The anti-hypertrophic effects of GXNT were assessed using an aristolochic acid A-stimulated zebrafish model and phenylephrine-induced hypertrophic NRCMs. GXNT demonstrated significant anti-hypertrophic effects in both models. Phenotypic screening identified Senkyunolide I (Sen I) from Ligusticum striatum as the active component in the zebrafish model, while Salvianolic acid B (Sal B) and Rosmarinic acid from Salvia miltiorrhiza emerged as the key anti-hypertrophic compound in NRCMs. In a mouse model of isoproterenol-induced cardiac hypertrophy, Sal B and Sen I showed synergistic effects, improving cardiac function, reducing oxidative stress, and suppressing inflammation. Mechanistically, transcriptomic sequencing highlighted cooperative modulation of MAP3K1 signaling by the two compounds. Notably, siRNA-mediated knockdown of MAP3K1 in cardiomyocytes attenuated the hypertrophic phenotype, supporting its essential role in the pathological process. Molecular docking and dynamic simulations further supported their binding potential to MAP3K1. Conclusion These findings underscore GXNT’s potent anti-hypertrophic effects, possibly driven by the synergistic actions of Sal B and Sen I, and offer insights into its therapeutic potential through MAP3K1 signaling regulation.
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Cellular & Molecular Immunology
·
2025
·
IF 19.8
Bai Ying,Ren Hui,Leng Shuo,Yuan Mengqin,Jiang YiXin,Zhang Shenyang,Wang Yu,Ju Minzi,Wang Zhi,Xi Wen,Xu Lian,Zheng Bingjing,Li Daxing,Huo Xinchen,Zhu Tianhao,Zhang Beicheng,Shen Ling,Zhang Yuan,Jiang Wei,Zhang John H.,Han Bing,Yao Honghong
Splenic sympathetic activity critically modulates peripheral immunity after ischemic stroke, thus intervention in spleen sympathetic activity represents a promising therapeutic strategy for stroke. However, the mechanisms underlying spleen-brain-immune axis communication remain poorly understood. Here, we utilized a surgical denervation protocol to perform splenic sympathetic denervation (SDN), which significantly attenuated brain injury following stroke. Through single-cell RNA sequencing, we identified a novel GZMK + CD8 + CD27 + CCR7 + T-cell subset in patients with acute ischemic stroke (AIS), which we designated stroke-associated T (Tsa) cells. The expansion of Tsa cells was positively correlated with the severity of clinical symptoms and was driven by the splenic sympathetic nervous system. Stroke-induced sympathetic activation triggers the release of splenic norepinephrine (NE), which preferentially signals through ADRB2 on Tsa cells to promote their mobilization. Additionally, ischemic injury induces endothelial cell-specific expression of CCL19, which chemoattracts Tsa cells into the brain parenchyma via their cognate CCR7 receptor, exacerbating neuroinflammatory injury and neurological deficits in a transient middle cerebral artery occlusion (tMCAO) mouse model. We developed a CCR7-targeting peptide to disrupt this chemotactic axis and reduce T-cell infiltration, thereby mitigating brain injury. Our findings highlight SDN as a promising therapeutic strategy to attenuate ischemia‒reperfusion injury and suggest its potential as an adjunctive therapy for reperfusion treatment in AIS patients.
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Nature Catalysis
·
2020
·Vol. 3
·期 11
·932-940
·
IF 30.471
Xiao Yequan,Feng Chao,Fu Jie,Wang Faze,Li Changli,Kunzelmann Viktoria F.,Jiang Chang-Ming,Nakabayashi Mamiko,Shibata Naoya,Sharp Ian D.,Domen Kazunari,Li Yanbo
Ta 3 N 5 is a promising photoanode material with a theoretical maximum solar conversion efficiency of 15.9% for photoelectrochemical water splitting. However, the highest applied bias photon-to-current efficiency achieved so far is only 2.72%. To bridge the efficiency gap, effective carrier management strategies for Ta 3 N 5 photoanodes should be developed. Here, we propose to use gradient Mg doping for band structure engineering and defect control of Ta 3 N 5 . The gradient Mg doping profile in Ta 3 N 5 induces a gradient of the band edge energetics, which greatly enhances the charge separation efficiency. Furthermore, defect-related recombination is significantly suppressed due to the passivation effect of Mg dopants on deep-level defects and, more importantly, the matching of the gradient Mg doping profile with the distribution of defects within Ta 3 N 5 . As a result, a photoanode based on the gradient Mg-doped Ta 3 N 5 delivers a low onset potential of 0.4 V versus that of a reversible hydrogen electrode and a high applied bias photon-to-current efficiency of 3.25 ± 0.05%.
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Nature Sustainability
·
2025
·
IF 27.1
Lv Ziwen,Yan Xueqing,Jia Siyu,Pan Jing,Hao Xiang,Chen Gegu,Lü Baozhong,Rao Jun,Peng Feng
Adhesives are ubiquitous in industries and daily life. However, conventional fossil-derived adhesives pose substantial health and environmental risks during manufacturing and utilization. The development of nontoxic high-performance adhesives from renewable feedstocks is therefore highly desired but remains technically challenging. Here we report a high-performing hot-melt adhesive—glue that is applied in a hot molten state—derived from a byproduct of the pulp industry, xylan, a type of hemicellulose. Under optimal conditions, the lap-shear strength between wood chips can reach approximately 30 MPa, surpassing that of classic epoxy resins and far exceeding that of a commercial hot-melt adhesive (ethylene vinyl acetate). Furthermore, the xylan hot-melt adhesive exhibits excellent reusability for multiple applications, retaining more than 100% of its original adhesion strength even after ten reuse cycles. Toxicity tests show good biocompatibility for xylan hot-melt adhesive. Overall, this work provides useful insights into the design of high-performance, reusable, bio-based adhesives for enhanced sustainability.
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Light-Science & Applications
·
2025
·Vol. 14
·期 1
·1-10
·
IF 23.4
Li Haotao,Wang Jiming,Chen Shuming
The realization of solution-processed tandem quantum-dot LEDs (QLEDs) remains a technical challenge due to the limitations of inefficient interconnect layer and the damage caused by multiple solution processes. Here, we develop a high performance tandem QLED by face-to-face integrating a top-emitting QLED with a transparent QLED. The top and bottom units can be addressed independently, thereby enabling the tandem QLED to operate in series, parallel, and color-tunable modes for multifunctionality. In series mode, QLEDs demonstrate an ultra-low turn-on voltage of 3.3 V and a record-breaking external quantum efficiency of 60.7%. In parallel mode, QLEDs achieve an impressive brightness of over 4.8 × 10 6 cd m -2 . In color-tunable mode, the color, brightness, and color temperature can all be adjusted with a color tuning range of 114% NSTC. Moreover, both series and parallel connections contribute to an improved stability, resulting in a T 95 lifetime of nearly 30,000 h at 1000 cd m -2 , which is an improvement of approximately 2.8 times over control devices. Our work offers a feasible solution for achieving multifunctional tandem QLEDs with the advantages of solution processed, high efficiency, high brightness, long lifetime and full color tunability for various light source applications.
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