CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Keping Zhang,Chengqiang Ding,Xiaolin Liu,Jun Gao,Datong Wu,Yong Qin,Yong Kong
Tubular mesoporous silica (T-mSiO 2 ) was facilely synthesized through a co-template method by using cetyltrimethylammonium bromide and α-Fe 2 O 3 as the dual templates, and then disulfide (–SS–) bonds and carboxyl groups (–COOH) were introduced to the resultant T-mSiO 2 via the reaction with 2-carboxyethyl 2-pyridyl disulphide. The obtained –SS– grafted T-mSiO 2 (SS-T-mSiO 2 ) was then grafted with chitosan (CS) via the amidation reaction between the –COOH groups on SS-T-mSiO 2 and the –NH 2 groups on CS. The CS grafted SS-T-mSiO 2 (CS-SS-T-mSiO 2 ) was fully characterized by various technologies such as transmission electron microscopy , energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy . Finally, the as-synthesized CS-SS-T-mSiO 2 was used as the carrier for redox and pH dual-triggered delivery of 5-fluorouracil (5-FU), an anti-cancer drug, and the results indicate that the developed CS-SS-T-mSiO 2 might be a potential responsive carrier for redox and pH dual-triggered drug delivery.
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高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Lu Zhang,Jun Wang,Yingying Zhang,Linjie Ke,Xiaowen Lin,Ziying Li,Haijun Chen,Yu Gao
The outcome of application of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small-cell lung cancer (NSCLC) always suffers from acquired drug resistance. Its combination with other therapies has been explored with promising synergistic results. Photodynamic therapy (PDT) is an established treatment modality for NSCLC, but the low tumor selectivity of currently available photosensitizers (PSs) hampered the wide clinical application of PDT. Here, we synthesized erlotinib modified chitosan (ECs) by click coupling and developed ECs/indocyanine green (ICG) self-assembled nanoparticles (GECs) for combined targeted chemo-photodynamic therapy. GECs showed oval-shaped particles with a diameter of 267.5 nm, a zeta potential of −15.2 mV, and considerable photostability. In vitro release experiment showed that erlotinib and ICG could be slowly released from GECs in acidic condition with lysozyme. GECs were capable of generating reactive oxygen species (ROS) for PDT under near-infrared laser irradiation . GECs showed synergistic molecular targeted and photodynamic therapeutic effects in inhibition of cellular growth and induction of apoptosis in NSCLC cells. This study demonstrated that the GECs could be a promising platform by combination of targeted chemo-photodynamic therapy for NSCLC treatment.
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Materials Science & Engineering C-Materials for Biological Applications
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2019
·
IF 4.959
Jingqi Zheng,Fan Wu,Hong Li,Mingxian Liu
Halloysite nanotubes (HNTs) are widely used in biomedical field due to their special tubular structure and high reinforcing ability, while hydroxyapatite (HAP) is generally used in tissue engineering owing to its excellent biocompatibility and biological activity. In this work, [email protected] nanotubes( [email protected] ) hybrid was synthesized via a facial hydrothermal reaction process. The morphology, particle size, specific surface area, and chemical composition of the hybrid were thoroughly characterized by different techniques. Rod-like HAP nanoparticles can be anchored on the outer surface of the clay tubes, which lead to a maximum increase of 4.7 m 2 /g in the specific surface area of [email protected] over that of HNTs. HAP nanoparticles have little effect on the pores of HNTs, but diffraction peak strength of HNTs is covered by the HAP crystals. [email protected] exhibit improved cytocompatibility and possess osteogenic differentiation ability towards MC3T3-E1 preosteoblasts. Chitosan/ [email protected] composite films were then prepared by doping of [email protected] into chitosan by solution mixing. [email protected] can serve as a functional phase which enhances mechanical properties of chitosan films and osteogenic differentiation of MC3T3-E1 cells. This work provides a facial synthesis routine of bioactive [email protected] , which combines the osteogenic activity of HAP and the good mechanical properties of HNTs. [email protected] can be used a novel bone regeneration biomaterial as local delivery systems with improved osteoinductive properties.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Xiaoxiao Sun,Chao Liu,A.M. Omer,Li-Ye Yang,Xiao-kun Ouyang
A new pH-sensitive drug carrier based on alginate (Alg), chitosan (Cs), and kappa-carrageenan (kC) marine biopolymers was developed, comprising a dual-layered polyelectrolyte complexes microbead structure. Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) were used to investigate the structures, thermal stability , and morphological changes, respectively, of the microcapsules we developed. In the intestinal environment (pH 7.4), the stability and swelling of Alg microbeads were enhanced after generation of the dual-layered polyelectrolyte complexes. The in vitro release profiles of 5-fluorouracil under simulated GI conditions were also examined. At gastric pH (1.2), the cumulative 5-FU release percentage was decreased by introduction of the additional kC layer from 14% in Alg/Cs microbeads to 7% in the dual-layered Alg/Cs/kC microbeads. Additionally, the release profiles were greatly improved under simulated intestinal and colon conditions. Finally, the microbeads were all biodegradable and showed no cytotoxicity in Chang liver cells. Our results clearly indicate that the dual-layer pH-sensitive Alg/Cs/kC microbeads could be used effectively for the targeted delivery of anticancer drugs to the colon.
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高影响因子
RSC Advances
·
2020
·Vol. 10
·期 3
·1309-1318
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IF 3.119
Rengui Weng,Xin Huang,Dongqi Liao,Sheng Xu,Lei Peng,Xinzhong Liu
Bamboo cellulose (BC) is one of the most abundant renewable, hydrophilic, inexpensive, and biodegradable organic materials. The cellulose membrane is one of the best materials for replacing petroleum-based polymer films used for water purification. In this study, N-methylmorpholine-N-oxide (NMMO) was used as a solvent to dissolve cellulose and chitosan, and a regenerated cellulose/chitosan membrane (BC/CSM) was prepared by phase inversion. A new kind of cellulose/chitosan nanofiltration membrane (IP-BC/CS-NFM) was obtained by the interfacial polymerization of piperazine (PIP) and trimesoyl chloride (TMC). The IP-BC/CS-NFM was characterized by Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM), thermal gravimetric analysis (TGA), the retention rate, and water flux. FT-IR analysis showed that polypiperazine amide was formed. Additionally, FE-SEM and AFM showed that a uniform roughness and dense functional layer was formed on the surface of the IP-BC/CS-NFM. Furthermore, TGA analysis showed that the thermal stability of IP-BC/CS-NFM is better than that of BC/CSM. The inorganic salt retention of IP-BC/CS-NFM was measured using a membrane performance evaluation instrument, following the order R(Na2SO4) > R(MgSO4) > R(MgCl2) > R(NaCl). At a pressure of 0.5 MPa, the retention rates for NaCl, Na2SO4, MgSO4, MgCl2, Methyl Orange, and Methyl Blue were 40.26%, 71.34%, 62.55%, 53.28%, 93.65%, and 98.86%, and the water flux values were 15.64, 13.56, 14.03, 14.88, 13.28, and 12.35 L m−2 h−1, respectively. The IP-BC/CS-NFM showed better water flux and a higher rejection rate in aqueous dye-salt solutions, and had a good separation performance under different operating pressure conditions.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Qi Wenbo,Xu Lijian,Zhao Shuangdan,Zheng Jiahua,Tian Yanpeng,Qi Xuejun,Huang Xianghua,Zhang Jingkun
Herein we report a facile approach for chitosan-heparin hydrogels with controlled release manner and their applications for intrauterine adhesion. The sol precursor was converted to gel at physiological temperature in 15 min. FTIR, SEM and swelling test were performed to characterize their compositions, morphologies and stability. In vitro releasing profiles was investigated in PBS solutions. Intrauterine injured rat model was established and treated with different methods. The results of H&E staining, Masson trichrome staining, western blots assay, immunohistochemical staining and immunofluorescence staining revealed that endogenous c-kit positive stem cells (HSCs) were recruited to the injury site and promoted the wound recovery. After 7 days' treatment, uterus treated with SDF-1α releasing hydrogel showed no difference with control group on endometrial thickness, glands number and fibrosis level. This work provides a possible method for intrauterine adhesion healing.
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高影响因子
APPLIED CLAY SCIENCE
·
2019
·
IF 3.89
Zhiming Sun,Jie Xu,Gaofeng Wang,Ankang Song,Chunquan Li,Shuilin Zheng
Mycotoxins contamination has been a worldwide long-standing issue, which poses tremendous threats to human health and food security. However, the detoxification of various mycotoxins, especially apolar species, is still a big challenge at present. In this study, carbon nanoparticles derived from biopolymer chitosan (Cts) and rectorite supported Cts carbon nanocomposite ( [email protected] ) were fabricated via hydrothermal treatment as efficient mycotoxin adsorbents for apolar zearalenone (ZER). Microstructural analysis revealed that Cts nanoparticles with smaller sizes uniformly distributed on the surface of rectorite, forming the [email protected] biocomposite . The obtained two adsorbents contained high organic carbon contents and large specific surface areas, which exhibited superior adsorption efficiency towards ZER. Kinetic study indicated that the adsorption of ZER on Cts and [email protected] reached equilibrium within 120 min, and the adsorption process fitted pseudo-second-order kinetic model better. The adsorption isotherms of ZER on both adsorbents matched obviously with linear model, which implied the existence of adsorption/partition model mechanism. The adsorption capacities were found to be positively correlated to the organic carbon contents and specific surface areas, suggesting that organic matter functioned as partition medium for ZER and the enhanced specific surface areas provided sorption sites for ZER. Furthermore, no desorption happened when changed the simulated pH based on the values from gastric fluid to intestinal fluid, confirming the feasibility of resultant Cts and [email protected] biocomposite as mycotoxins adsorbents in vivo.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yonghai Song,Jiajia Han,Lijuan Xu,Longfei Miao,Canwei Peng,Li Wang
Dopamine (DA) is a nerve-transducing chemical that helps cells transmit pulses. Too high or too low concentration of DA is detrimental to human health. Therefore, finding a fast, efficient and sensitive method for detecting DA is of great significance. Here, a DA-imprinted chitosan (CS) film/ZnO nanoparticles (NPs)@carbon (C)/three-dimensional kenaf stem-derived macroporous carbon (3D-KSC) was prepared for electrochemical detection of DA. The DA-imprinted CS film/ZnO NPs @C/3D-KSC was prepared by growing zeolite imidazole framework-8 (ZIF-8) on 3D-KSC, carbonizing under N 2 atmosphere, electrodepositing AA-CS on ZnO NPs@C/3D-KSC and eluting template AA molecules. The results showed that ZIF-8 derived porous ZnO NPs@C nanospheres were arranged evenly on 3D-KSC surface to form a monolayer. The diameter of nanospheres was approximately 500–600 nm, and the nanospheres were composed of ZnO NPs embedded in porous carbon. A layer of CS with DA-imprinted pores was covered on the ZnO NPs@C nanospheres, so the DA-imprinted CS film/ZnO NPs@C/3D-KSC integrated electrode exhibited better selectivity for DA detection. The linear range was 0.12 nM-152 μM, the detection limit was 0.039 nM, and the sensitivity was 757 μA mM −1 cm -2 . The DA-imprinted CS film/ZnO NPs@C/3D-KSC integrated electrode also showed higher stability.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Shuangyu Xiong,Luminita Marin,Lian Duan,Xinjian Cheng
Nitroaromatic compounds, especially 2, 4, 6-trinitrophenol, have strong biological toxicity and explosive risks, so the detection of 2, 4, 6-trinitrophenol exhibit importantly practical and scientific significance. In this work, three fluorescence functionalized chitosan CNS 3 , CNS 4 and CNS 5 were prepared using chitosan as matrix. When 2, 4, 6-trinitrophenol (TNP) and/or p-nitrophenol (4-NP) was present in spot, these fluorescent chitosan sensors produced notable fluorescence quenching. It renders the chitosan sensing ability to detect TNP and 4-NP selectively and sensitively. The sensing mechanism is investigated as well. When introduced electron-rich moieties to the fluorescent chitosan, the sensitive detecting ability could be obtained. Excellent recognition ability could reach as low as 0.28 μM. The fluorescence fictionalization cause slight influence to the gel performance of chitosan.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2018
·
IF 3.235
Zhen Lin,Xiaotong Xiang,Shuijiao Peng,Xiancai Jiang,Linxi Hou
Nitrogen and boron co-doped activated carbon (BKACS) was synthesized through the carbonization , KOH activation and subsequently hydrothermal doping reaction process with chitosan as the renewable carbon source. The prepared samples were characterized by XRD, SEM, Raman, XPS and BET for their structure, morphology, specific surface area and elemental composition , respectively. The obtained BKACS has a specific surface area of 1129.6 m 2 g −1 , with high conductivity and capacitive character. The BKACS was applied as the electrode material to fabricate the electrochemical double-layer supercapacitor . The supercapacitor performed a high specific capacitance of 316 F g −1 at 0.2 A g −1 in a three-electrode system in the 6 M KOH electrolyte and excellent cycling stability with a capacitance retention of 94.08% after 10,000 cycles at 10 A g −1 . The attractive supercapacitor performance of the BKACS material has the high power density, excellent cycling life, and environmental friendliness , making it potentially a promising replaceable function for future energy storing device.
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高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Yan Zhang,Xinyi Tan,Tianyang Ren,Chao Jia,Zaixing Yang,Hong Sun
A ternary core/shell based nanoparticulate complex was designed for the sequential and site-specific drug delivery. First, bovine serum albumin nanoparticles (BSA NPs) were served as the core for loading gambogic acid (GA). Subsequently, the BSA NPs were adsorbed by polyethylenimine and then shielded with carboxymethyl chitosan-folate (CMCS-FA) as the outer shell for encapsulating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), forming the GA/TRAIL co-delivery BSA (GTB) NPs. In normal tissues, the GTB NPs were negatively charged; in acidic tumor tissues, the shielding CMCS-FA was detached, allowing the release of TRAIL, which binds to the cell death receptor on the plasma membrane. The resulting positively charged complex promoted cellular internalization and escaped from lysosomes, producing a rapid release of GA, which exerted the combined tumor therapy by regulating both intrinsic and extrinsic apoptotic pathways. In vitro and in vivo studies confirmed that GTB NPs could enhance antitumor efficacy and reduce adverse effects.
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ELECTROANALYSIS
·
2018
·Vol. 30
·期 9
·2085-2093
·
IF 2.851
Yanjun Mao,Liping Guo,Xiaohui Ning,Jian Li,Jianbin Zheng
In this work, a novel redox capacitor was designed for signal amplification in electrochemical detection. It was fabricated by co-electrodeposition of a conducting polymer, sulfonated polyaniline (SPAN) and chitosan on a glass carbon electrode, and its function was evaluated for being a localized source to transfer electron between FcCOOH (Fc) and Ru(NH 3 ) 6 Cl 3 in solution via redox cycling. Furthermore, the electrochemical detection of chloramphenicol, a broad-spectrum antibiotic was performed using the redox capacitor in the presence of Fc. A significant amplification in cathodic current response of chloramphenicol was obtained through a continuous redox-cycling reaction. The performance of the amplifying signal responded linearly to chloramphenicol in a concentration range of 0.05 to 50.0 μmol L −1 with a low detection limit of 0.01 μmol L −1 . The proposed approach exhibited good reproducibility and stability, and could be used for detection of chloramphenicol in eye drops by standard addition method with the recoveries from 96.5 % to 103.0 %.
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危险品化学品经营许可证（带存储）