ACS Applied Energy Materials
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2021
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IF 6.024
Xin Luo,Weiyan Liu,Zeyu Wang,Chao Liang,Xuming He,Yi Yu
The high chemical reactivity of lithium slows down the structural exploration of lithium metals inside batteries. In this paper, in situ gas cell TEM was utilized to study the formation and growth of lithium metal under the argon atmosphere. By electron irradiation, fresh lithium metals could be formed and grown from lithium salts such as lithium fluorides, which was confirmed by electron diffraction and EELS. Minor oxidation of the as-grown lithium metals occurred even in an inert environment. A template matching-based diffraction big-data analysis method was developed and enabled visualization of the phase evolution during the reactions. These results may provide additional understanding of the passivation layers on lithium, and big data processing would facilitate information mining from in situ experiments.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2021
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IF 5.316
Jiang Zhao,Lijuan Gao,Zhitong Wang,Shumeng Wang,Rongqing Xu
As an essential miniature energy storage device, flexible in-plane micro-supercapacitors (MSCs) have the advantages of rapid charge and discharge, instantaneously high power output, long cycle stability and easy integration. However, the synthesis of electrode materials, the preparation of patterned microelectrodes and the subsequent modular integration are usually carried out independently, and the steps are very complicated. Accordingly, an effective and fast fabrication process involving laser direct writing technique is introduced to prepare shape-controllable MoS 2 nanoparticle-embedded laser-induced graphene (MoS 2 /LIG) patterned electrodes on various substrates for flexible planar MSCs. The embedding of MoS 2 nanoparticles can effectively improve the hydrophobic properties of MoS 2 /LIG hybrid electrodes, which is more conducive to the adsorption and desorption of aqueous electrolyte ions. Benefiting from the engineering of pseudocapacitive MoS 2 nanoparticles uniformly embedded in good conductive LIG with 3D porous structure, our flexible planar MoS 2 /LIG MSC demonstrates a superior areal capacitance of 35.3 mF cm –2 , a high energy density of 4.91 mW h cm –2 at a power density of 0.18 mW cm –2 , good cycle stability, outstanding mechanical flexibility, and prominent modular integration. The universal process route developed in this work can be used for controllable assembly of many similar flexible planar integrated MSCs, and may accelerate their potential application in flexible and wearable electronics.
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BIOSENSORS & BIOELECTRONICS
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2021
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IF 10.618
Qilin Li,Yan Zhang,Huiling Fan,Yuji Gong,Yun Xu,Qiying Lv,Yunruo Xu,Fei Xiao,Shuai Wang,Zheng Wang,Lin Wang
Accelerated glucose uptake and “aerobic glycolysis” of tumor cells generates a high-level lactate in extracellular space and within tumor tissue, which is thought to be a hallmark of tumor and closely correlated with tumor development. Here, we report the development of an enzyme-free electrochemical sensing platform based on a Pt-microneedle electrode functionalized with Au nanoparticles (Au-NPs) decorated polydopamine nanospheres (PDA-NSs), and explore its practical application in in vitro and in vivo detection of lactate in different biological samples. Our results demonstrate that in virtue of the nanostructured merits and high electrocatalytic activity , the resultant nanohybrid-microelectrode exhibits good sensitivity and selectivity to the nonenzymatic electrochemical detection of lactate, with a detection limit of 50 μM, a liner range of 0.375–12 mM, and a sensitivity of 11.25 mA mM −1 cm −2 , as well as a good anti-interference ability to other active small molecules . The platform quantifies lactate in complex bio-fluids, including cancerous and non-cancerous cell culture media, as well as serum samples, with detecting time 7.5-fold faster than does a clinically-used approach. Moreover, owing to miniaturized size and satisfactory electrochemical performance, the sensor achieves in vivo recording of lactate-related characteristic voltammetric signals within a living tumor, which are positively correlated with tumor burden and growth. Therefore, the platform cannot only be employed for cancer metabolic investigation, but also potentially for clinical assessment of tumor progression, and even clinical diagnosis of other lactate metabolism disorders.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2021
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IF 5.302
Longlong Jiang,Xiao-Xiong Wang,Jun Zhang,Hao Hong,Kefan Du,Yifei Zhang,Yanqiang Li,Yongcheng Zhang,Yunze Long,Keqing Ruan
It is a challenge to achieve flexibility in purely inorganic piezoelectric materials without organic support, and various thin film flexible inorganic piezoelectric materials has been developed recently. In this work, lead zirconate titanate (PZT) nanofiber membranes were prepared by electrospinning, and a flexible membranes can be obtained by reducing the calcination temperature, and the flexibility was characterized by the three-point method. The fiber membrane was relatively thicker in relative to thin films and confirmed to adsorb Congo Red quickly under the action of ultrasound. The maximum adsorption capacity is 61.78 mg g −1 and saturation time reaches 20 min under ultrasound treatment. In addition, the color change after saturation adsorption can quickly determine the actual load of the fiber membrane. In the future, this load saturation effect can be used to calibrate the relationship between the piezoelectric signal and the adsorption load, so as to obtain more accurate chemical sensors.
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Small
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2021
·Vol. 17
·期 45
·2102078
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IF 13.281
Pengsong Li,Xinxuan Duan,Yun Kuang,Xiaoming Sun
Electrocatalytic water splitting in acidic media is a promising strategy for grid scale production of hydrogen using renewable energy, but challenges still exist in the development of advanced catalysts with both high activity and stability. Herein, it is reported that iridium doped tungsten trioxide (Ir-doped WO 3 ) with arrayed structure and confined Ir sites is an efficient and durable bi-functional catalyst for overall acidic water splitting. A low overpotential (258 mV) is required to achieve an oxygen evolution reaction current density of 10 mA cm −2 in 0.5 m H 2 SO 4 solution. Meanwhile, Ir-doped WO 3 processes a similar intrinsic activity to Pt/C toward hydrogen evolution reaction. Overall water splitting using the bi-functional Ir-doped WO 3 catalyst shows low cell voltages of 1.56 and 1.68 V to drive the current densities of 10 and 100 mA cm −2 , respectively, with only 16 mV decay observed after 60 h continuous electrolysis under the current density of 100 mA cm −2 . Structural analysis and density functional theory calculation indicate that the adjusted coordination environment of Ir within the crystalline matrix of WO 3 contributes to the high activity and durability.
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Journal of Orthopaedic Translation
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2019
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IF 3.063
Yong Dai,Han Guo,Linyang Chu,Zihao He,Minqi Wang,Shuhong Zhang,Xifu Shang
Objective To enhance the bioactivity of polyetheretherketone (PEEK) while maintain its mechanical strengths. Methods Suspension coating and melt bonding. Results Silicon nitride (Si 3 N 4 , SN) coating lead to higher surface roughness, hydrophilicity and protein absorption; SN coating could slowly release Si ion into simulated body fluid (SBF), which caused weak alkaline of micro-environment owing to the slight dissolution of SN; SN coating resulted in the improvements of adhesion, proliferation, differentiation and gene expressions of MC3T3-E1 cells in vitro ; SN coating of PEEK with bioactive SN coating (CSNPK) obviously promoted bone regeneration and osseointegration in vivo . Conclusions CSNPK with SN coating as bone implant might be a promising candidate for orthopedic implants. The Translational Potential of this Article The silicon nitride-coated polyetheretherketone (CSNPK) prepared in this article could induce MC3T3-E1 cells adhesion, proliferation and differentiation in vitro ; it could also induce bone regeneration in bone defect in vivo , which indicate its good cytocompatibility and biocompatibility. If the raw materials are medical grade, and preparation process as well as production process of this article are further improved, it will have great translational potential.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2019
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IF 7.149
Zhou Fang,Kexin Li,Yuan Li,Hao Zhang,Kevin C. Jones,Xinyu Liu,Shengyu Liu,Lena Q. Ma,Jun Luo
Psychiatric pharmaceuticals are widely distributed in the aquatic environment and have attracted recent attention due to their potential for environmental effects. A robust and reliable in situ passive sampling approach, the diffusive gradients in thin-films (DGT) technique, is developed here to measure 14 psychiatric pharmaceuticals. A new binding material, mixed-mode cation exchange resin (Poly-Sery MCX, 40 μm, CNW, Germany), was used for the first time in DGT and compared to XAD and HLB. Reliable elution efficiencies of the pharmaceuticals from the binding gels were obtained in methanol/ammonia, and diffusion coefficients for all the compounds were determined. The influence of diffusive layer thickness (0.515–2.015 mm), deployment time (3–168 h), and important environmental conditions—pH (3.02–9.45), ionic strength (0.0001–0.5 M), and dissolved organic matter (0–20 mg L–1)—were evaluated. The capacity of XAD, HLB, and MCX gels for binding all the test pharmaceuticals was ∼335 μg per disc, meaning that DGT could theoretically be deployed for over 30 months if there are no competitive effects or confounding factors. The uptake kinetics of psychiatric pharmaceuticals onto MCX gel were much faster than those onto XAD and HLB gels in the first hour. DGT measured concentrations of test pharmaceuticals at two sample points in a river (over 6 days) were comparable to those obtained by grab sampling. This study demonstrates the accuracy and reliability of DGT for measuring psychiatric pharmaceuticals across a wide range of freshwater conditions found in the natural environment.
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Translational Cancer Research
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2019
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IF 1.07
Heqi Bu,Dianlei Liu,Junhui Cui,Ke Cai,Feng Shen
Background Oridonin has been demonstrated to have anticancer effect on all kinds of cancer cells and it has shown anti-tumor activity in some tumors partially via the inactivation of Wnt/β-catenin signaling pathway. The study investigated the anticancer effect of oridonin on colon carcinoma cell line COLO205 and explored underlying mechanism. Methods Cell Counting Kit-8 (CCK-8) assay was performed to assess cell viability. Flow cytometry was performed to analyze the apoptosis. The key target genes and proteins involved in Wnt/β-catenin pathway were detected by quantitative polymerase chain reaction (qPCR) and Western blotting. The xenograft tumor model of colon cancer COLO205 cell was introduced to detect anti-tumor effects in vivo . Transferase-mediated dUTP nick end labeling (TUNEL) assay was adopted to test the apoptotic cells in the tumor tissues. Results Oridonin inhibited the proliferation of colon cancer COLO205 cells in a dose-dependent and time-dependent manner. Oridonin induced apoptosis by increasing the cleavage of caspases in vitro . Furthermore, the expression levels of β-catenin and its downstream targets, including c-myc, cyclinD1 and survivin were significantly reduced. Nevertheless the knockdown of β-catenin by specific small interfering RNA (siRNA) could augment the anti-proliferative and pro-apoptotic effects by oridonin in COLO205 cells. Meanwhile, oridonin also increased protein expression level of glycogen synthase kinase 3β (GSK3β) and decreased the phosphorylation level of GSK3β. In vivo , oridonin treatment significantly suppressed tumor growth of COLO205 cell xenografts, and which was accompanied by the restrain of Wnt/β-catenin pathway. Conclusions Our present study demonstrated that the growth inhibition and apoptosis induction in colon cancer COLO205 cells by oridonin could be partially mediated through discontinuing Wnt/β-catenin signaling pathway.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
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IF 3.131
Fan Ye,Xia Jiang,Yuanzhu Mi,Jiazhe Kuang,Zhiming Huang,Fan Yu,Zejun Zhang,Huaikui Yuan
In order to reduce the cost of demulsifiers and improve the demulsification performance of carbon material demulsifier, the nano-SiO 2 was grafted onto the surface of oxidized carbon black (Ox-CB) by sol-gel method in current study. The novel composite demulsifier was analyzed by fourier transform infrared spectroscopy (FT-IR), field-emission scanning electron microscope (FE-SEM), energy dispersive X-ray (EDX) and X-ray diffraction spectra (XRD) which confirmed the partial grafting of SiO 2 on the oxidized carbon black (Ox-CB).The influences of temperature, settling time, and concentration of the composite demulsifier on the efficiency for breaking up water-in-oil emulsions were investigated in detail by bottle test. It was found that the best operating conditions to remove more than 90% of the water from the original emulsion were a temperature of 75 ℃ and a demulsifier concentration of 500 mg/L. The wettability , oil-water interfacial tensions (IFT) and interfacial activity of the demulsifier were further measured to explore the demulsification mechanism. Possible demulsification mechanism showed that the composite demulsifier could lead to the breakup of water-in-oil emulsions by bridging, flocculation and coalescence. The high interfacial activity is the main factor affecting the demulsification.
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JOURNAL OF CHROMATOGRAPHY A
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2019
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IF 3.858
Yike Huang,Gaoyi Yi,Baian Ji,Die Gao,Yuntian Bai,Yao Liu,Lujun Wang,Zhining Xia,Qifeng Fu
Mussel-inspired polydopamine (PDA) based materials are attractive as stationary phase for open-tubular capillary electrochromatography (OT-CEC) due to their many fascinating properties. However, all of the existing strategies for fabricating PDA based OT-CEC columns are limited in aqueous solutions. Consequently, it is a challenge work to directly immobilize the hydrophobic functional materials onto the inner wall of PDA modified capillary. Herein, by using the organic amine-inducing co-deposition strategy, a novel preparative method was developed for in situ one-pot synthesis of PDA/octadecylamine (ODA) co-deposited coating inside capillary as OT-CEC stationary phase. The formation and morphology of the PDA/ODA co-deposited coating were characterized by field emission scanning electron microscopy , atomic force microscope, attenuated total reflectance Fourier transform infrared spectroscopy and contact angle measurements. The separation performance of the fabricated PDA/ODA modified columns was validated by the separation of alkylbenzenes and steroids, which could achieve baseline separation with high separation efficiency. Their separation was found to follow the reversed phase chromatographic retention mechanism. The co-deposited column showed good stability and long lifetime. The repeatability of the PDA/ODA co-deposited column was also evaluated, with the relative standard deviations for intra-day and inter-day runs less than 5% and column-to-column runs less than 6%.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
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IF 3.131
Yiye Wang,Xueyan Luo,Ye Han,Baijun Liu,Yiwei Hu,Xiangchi Liu
Styrene emulsion polymerizations using sodium dodecyl sulfate as an anionic surfactant and in the presence of cationic initiators 2, 2′- Azobis (2-methylpropionamidine) dihydrochloride (AIBA) and 2,2′-azobis(N,N′-dimethyleneisobutyramidine) dihydrochloride (ADIBA) were studied. In this work, an explanation for in situ charge neutralization is proposed, and the effect of in situ charge neutralization on the particle size distribution of the ultimate polymer particles is discussed. Charges of cationic radicals from initiator decomposition shield the anionic charges of surfactant molecules adsorbed on the particle surface and induce particle coagulation during the early particle formation period. As the occurrence of in situ charge neutralization, the particle number decreases and the rate of micelle capture for the initiator radical is enhanced. Thus, the particle nucleation period is shortened, and monodisperse polymer particles with a diameter of ～200−300 nm are prepared using this simple emulsion polymerization process. In addition, hydrolysis of the initiator AIBA at different pH conditions is used to control particle size and stability. Compared to conventional emulsion polymerization theories, the emulsion polymerization in the presence of in situ charge neutralization presents unique kinetics.
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POWDER TECHNOLOGY
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2019
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IF 3.413
Xuechen Tang,Wanli Kang,Bobo Zhou,Yongbo Gao,Changxiao Cao,Shujun Guo,Muhammad Wassem Iqbal,Hongbin Yang
Polymer/nano-SiO 2 composite microspheres (PNSCMs) were synthesized via inverse suspension polymerization with 3-methacryloxypropyltrimethoxysilane (MPS) modified SiO 2 as the reinforcing filler. The influences of these polymerizable nanoparticles on the swelling behavior, mechanical property, thermal stability, viscoelasticity and dispersion stability were examined in detail. Moreover, the plugging behaviors were investigated by sand pack tests. The results indicate that the introduction of these modified nanoparticles revealed a significant enhancement on the comprehensive properties of PNSCMs. By varying the content of MPS-modified SiO 2 , the environmental sensitivity of the microspheres’ swelling behavior was reduced. Besides, the mechanical property, thermal stability and viscoelasticity were greatly improved by increasing the SiO 2 loading. Compared with SiO 2 -free ones, PNSCMs exhibited better dispersion stability and plugging performance, and the maximum plugging rate reached 93.64%, which was increased by 14.69%. These PNSCMs studied can realize in-depth profile control in reservoirs and have great application prospects in the further enhanced oil recovery research.
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