Journal of Neuroinflammation
·
2025
·Vol. 22
·期 1
·1-19
·
IF 10.1
Chi Zhexi,Lu Bo,Liu Rongjun,Pan Chen,Meng Bo,Xing Xiuzhong,Yuan Hui,Wu Xuewei,Chen Yushan,Ren Yuxuan,Wu Wenwei,Miao Mengmeng,Chen Junping,Chen Xiaowei
Neuropathic pain, a debilitating nerve injury-induced condition, remains a significant clinical challenge. This study evaluates the effect of histone deacetylase 6 (HDAC6) inhibition in a spared nerve injury (SNI) mouse model. Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in mice of both sexes. ACY-1215 increased acetylated signal transducer and activator of transcription 3 (Ac-STAT3) and reduced phosphorylated STAT3 (p-STAT3) in the lumbar spinal cord of SNI mice. HDAC6 and p-STAT3 were expressed in spinal dorsal horn neurons, and SNI-enhanced HDAC6/STAT3 interaction was reversed by ACY-1215. Neuronal STAT3 overexpression induced pain hypersensitivity and elevated p-STAT3, tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), effects suppressed by ACY-1215. Cytokine profiling identified CC-chemokine ligand 7 (CCL7) as a key downstream effector of the HDAC6/STAT3 axis, with ACY-1215 attenuating SNI-induced CCL7 upregulation. HDAC6 knockdown in neurons reduced p-STAT3, while HDAC6 or STAT3 knockdown diminished CCL7 production. These findings demonstrate that ACY-1215 mitigates neuropathic pain by modulating STAT3 acetylation/phosphorylation and suppressing HDAC6/STAT3-driven CCL7 and cytokine release. This study underscores the role of the HDAC6/STAT3/CCL7 signaling axis in neuropathic pain and highlights the therapeutic potential of HDAC6 inhibitors for pain management.
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 3
·1-14
·
IF 5.3
Zhang Yiwen,Zhao Chenyang,Yan Wen,Tian Tian,Zhao Min,Zhao Longshan
Carbon quantum dots (CQDs) were synthesized from brominated 1-hexadecyl-3-vinylimidazolium and citric acid, and a mixed-mode chromatographic (MMC) stationary phase, which can be used in the RPLC/HILIC/IEC chromatographic modes with a good separation efficiency, was successfully synthesized by click-chemistry bonding to a sulfhydryl-modified silica surface. The successful synthesis of the chromatographic stationary phase was demonstrated by its characterization. The effects of organic phase ratio, column temperature and buffer salts on the column were investigated, established the van’t Hoff equation, and verified the ion-exchange effect of the column by separating benzoic acid and phenolic compounds under different pH conditions. The reversed-phase performance of the column was characterized by Tanaka test. Compounds such as alkylbenzenes, polycyclic aromatic hydrocarbons, and nucleosides can all be separated on the column in a short period of time. The reproducibility and stability of the columns were verified under the corresponding chromatographic conditions, and the results showed good reproducibility and stability of the columns. The chromatographic column was used to separate the base nucleosides in apples, and four base nucleosides were successfully isolated from apples. Graphical
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 5
·1-9
·
IF 5.3
Zhang Guiyun,Lai Zhiwei,Xie Jianhua,Yang Weiqiang
Methylmercury (CH 3 Hg + ), a lipophilic environmental pollutant, accumulates in fish, shellfish, and other organisms, posing significant risks to human health through the food chain. Developing a convenient and sensitive analytical method for CH 3 Hg + detection is crucial for reducing costs and enhancing the efficiency of food safety testing. In this study, we prepared an octyl-modified silica isoporous membrane on the indium tin oxide (ITO) electrode (Octyl-SIM/ITO) via the electrochemical-assisted self-assembly (EASA) method using octyltrimethoxysilane (O-TES) as the functional organosilane. The Octyl-SIM/ITO electrode exhibits vertically-ordered nanochannels and strong hydrophobic affinity, enabling selective penetration and enrichment of weakly polar analytes. Utilizing square wave anodic stripping voltammetry (SWASV), the Octyl-SIM/ITO electrode demonstrates superior electrochemical response signals for CH 3 Hg + detection, achieving a detection limit as low as 4 nM. This method allows for accurate and reproducible detection of CH 3 Hg + in fish and oyster samples with minimal sample preparation, offering promising potential for portable in situ detection. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the Australian Ceramic Society
·
2024
·
IF 1.8
Wang Xingguo,Li Xin,Chen Bin,Tang Jian,Chang Shilun,Xu Chen
The reaction mechanism of TiB 2 synthesized by carbothermal reduction is unclear due to a lack of thermodynamic research. In this work, the phase diagrams of TiO 2 -B 2 O 3 -C system were analyzed at a large temperature range (900–1800 °C), illustrating that Ti 4 O 7 , Ti 3 O 5 , and TiC were the main intermediate products. According to the Gibbs free energy minimum principle, the synthesis pathways of the main intermediate products and the target product TiB 2 were discussed, respectively. Based on the thermodynamic research, the reaction mechanism of TiO 2 -B 2 O 3 -C system was proposed and verified by experimental research at 900–1500 °C. X-ray-pure TiB 2 powder was synthesized at 1500 °C for 30 min and the possible reaction mechanism could be divided into three stages: TiO 2 (anatase)→TiO 2 (rutile)→Ti 3 O 5 , TiC →TiB 2 .
✓ 已验证
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Lin Yan,Li Hui,Miao Xiaodong,Sun Yunayuan,Ren Hao,Yu Xifeng,Cui Wangyang,Wu Mingbo,Li Zhongtao
Direct electro-epoxidation of propylene (D-EOPO) with a membrane electrode assembly (MEA) system represents a sustainable approach for producing propylene oxide, which can reduce ohmic losses and simplify product separation. To address the challenges of selectivity and activity, we develop an Ag/V catalyst and integrate it into the “liquid-free” MEA reactor for continues D-EOPO. The V in the catalyst facilitates the formation of Ag-O active centers, thereby reducing the generation energy of *O radicals. Meanwhile, V doping also results in a downshift of the d -band center of the Ag sites. Consequently, the formation of the crucial intermediate (*OC 3 H 6 ) is significantly accelerated through the coupling *O with adsorbed propylene, thereby markedly improving propylene oxide (PO) production. The MEA reactor, integrated with the developed Ag/V catalyst, can maintain a stable production rate of PO at 227 μmol/h over a period of 78 hours. Thus, the “liquid-free” electro-epoxidation protocol developed here exhibits greater industrial applicability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-19
·
IF 12.6
Song Zhengwei,Sun Quanwei,Yang Wenshuo,Li Yunlong,Hu Chaoyu,Chen Chen,Liu Kang,Shen Wei,Yang Ye,Yin Dengke
Background Prolonging the duration of photodynamic therapy (PDT) enhances the level of reactive oxygen species (ROS), thereby facilitating tumor ablation. However, our findings indicated that excessive ROS not only induces epithelial-mesenchymal transition (EMT) but also creates an immunosuppressive microenvironment in tumor, thereby triggering tumor metastasis. Methods We initially developed neutrophil membrane hybrid liposomes (NLs) that can specifically target inflamed tumor tissues following PDT. Then, we utilized NLs to encapsulate the antioxidant nanozyme FeGA and the antiplatelet drug Lysine Acetylsalicylate (LAS), resulting in the formulation NLASF. Results Experimental results demonstrated that FeGA effectively scavenges ROS, thereby reversing the immunosuppressive microenvironment induced by prolonged PDT. Furthermore, the incorporation of LAS effectively disrupts the interaction between tumor cells and platelets, mitigating tumor EMT and inhibiting hematogenous tumor metastasis. In a breast cancer mouse model, we observed that treatment with NLASF led to a near-complete suppression of tumor lung metastasis following the prolonged PDT. Additionally, the in vivo application of NLASF did not result in any blood toxicity or organ toxicity, highlighting its significant advantages over the free drugs group. Conclusions This study provides a novel approach to enhance the efficacy of PDT and successfully suppress PDT-mediated tumor metastasis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Cai Jinghan,Lan Shun,Wei Bin,Qi Junlei,Nan Ce-Wen,Lin Yuan-Hua
Dielectrics with high permittivity, low dielectric loss, and good temperature stability are crucial for electronic components to meet the ever-increasing application demands. However, challenges remain in further optimizing dielectric properties due to the correlation between these parameters. Here, we propose a chemical bonding engineering strategy in high-entropy CaTiO 3 ceramics and realize colossal permittivity with low loss and excellent stability. Our results reveal that the high-concentration oxygen vacancy ( \({{{\rm{V}}}}_{{{\rm{O}}}}^{\cdot \cdot }\) )-related defects and the decreased activation energy of grain/grain boundary led to a colossal permittivity dielectric behavior, which should be ascribed to the weakened chemical bonding and the reduced formation energy of defects confirmed by our first-principles calculation. Consequently, in the high-entropy CaTiO 3 ceramic, a permittivity of 2.37 × 10 5 , low loss of 0.005, and good temperature stability (<± 15%) in -50–250 °C are simultaneously achieved. This finding implies that chemical bonding engineering may be a promising strategy for designing colossal permittivity materials and provides a broad opportunity for the development of other defect-dependent functional materials.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2025
·Vol. 32
·期 5
·1056-1067
·
IF 7.2
Guan Zhenhao,Zhang Ying,Wen Shuming,Zuo Qi,Wu Yu,Li Xiaokang
This study investigated the effect of konjac glucomannan (KGM) on the flotation separation of calcite and scheelite. Microflotation tests showed that under the action of 50 mg/L KGM, the floatability of calcite notably decreased, while the impact on scheelite was negligible, resulting in a recovery difference of 82.53%. Fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM) analyses indicated the selective adsorption of KGM on the calcite surface. Test results of the zeta potential and UV-visible absorption spectroscopy revealed that KGM prevented the adsorption of sodium oleate on the calcite surface. X-ray photoelectron spectroscopy (XPS) analysis further confirmed the chemical adsorption of KGM on the calcite surface and the formation of Ca(OH) 2 . The density functional theory (DFT) simulation results were consistent with the flotation tests, demonstrating the strong adsorption performance of KGM on the calcite surface. This study offers a pathway for highly sustainable and cost-effective mineral processing by utilizing the unique properties of biopolymers such as KGM to separate valuable minerals from gangue minerals.
✓ 已验证
产品关联
DOI
高影响因子
EXPERIMENTAL AND MOLECULAR MEDICINE
·
2025
·
IF 12.9
Wu Jin,Guo Zixiang,Wang Long,Shen Yue,Li Xiang,Zhang Zhewei,Han Xiao,Zhang Jianlan,Cai Kunzhan,Tang Chunbo
Periodontitis is an oral immunoinflammatory disease, and macrophages play a crucial role in its pathophysiology. However, macrophage death during antibacterial activities will exacerbate inflammation and tissue damage. Porphyromonas gingivalis is a major constituent of subgingival biofilm plaques in periodontitis, but the effects and precise molecular mechanisms by which it triggers macrophage death remain unknown. Here we found that P. gingivalis infection notably activated multiple death pathways in bone-marrow-derived macrophages, including pyroptosis, apoptosis and necrosis. Furthermore, using RNA sequencing, we identified that P. gingivalis infection markedly increased the expression of Z-DNA binding protein 1 (Zbp1) in bone-marrow-derived macrophages. Initially identified as an interferon-induced tumor-associated protein, Zbp1 serves as an upstream sensor that regulates cell death by activating PANoptosis. Mechanistically, P. gingivalis induced a mitochondrial stress response, prompting the release of mitochondrial DNA. This mitochondrial DNA then interacted with Zbp1, consequently augmenting its downstream PANoptosis signals. In addition, P. gingivalis stimulated macrophage Zbp1 expression through the Tlr2/4–JNK–Stat3/5 pathway, exacerbating macrophage death. Importantly, blocking the biosynthesis of endogenous Zbp1 by pharmacological delivery with microneedles improved the survival of P. gingivalis -infected macrophages and inhibited periodontal tissue destruction. These findings highlight Zbp1 as a potential therapeutic target for P. gingivalis -induced periodontitis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·
IF 15.7
Su Keying,Yang Shan,Liang Yujia,Sun Dongmei,Gong Mingxing,Tang Yawen,Qiu Xiaoyu
Single-atom catalysts are highly active for specific reactions; however, their sinter-resistance and clean surfaces make it difficult to impart them with a “smart” property. Herein we design a thermosensitive single-atom Rh 1 -Pd nanosheets (NSs) by employing amino functionalized poly( N -isopropylacrylamide) as thermal responsive gate for the “open”/“closed” control of electro-catalytic activity. Using formic acid electro-oxidation as model reaction, the thermosensitive Rh 1 -Pd NSs exhibit high mass activity (2.29 A mg PGM -1 ), strong poisoning resistance, and reversible thermo-responsibility at a lower critical solution temperature (LCST) of 35 o C. In-situ spectroscopy and theoretical investigations reveal that the d-electron deficient Rh 1 -Pd NSs favor the direct formate pathway and weaken the binding of self-poisonous species, contributing to the high activity and anti-self-poisoning talent. Most importantly, for the direct formic acid fuel cells (DFAFCs), the thermosensitive Rh 1 -Pd NSs exhibit a high power density operated below the LCST, while the power drops sharply once above the LCST, realizing the intelligent battery thermal protection for DFAFCs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·
IF 15.7
Qiu Liang,Yao Lin,Wang Ping,Jiang Zhiwei,Li Jinglin,Li Ying,Li Yixin,Wu Zhaosong,Nasir Muhammad Salman,Wang Ding,Wang Xinqiang,Huang Zhen,Zhou Baowen
Hydrogen extraction from liquid hydrogen carriers is a promising strategy to address hydrogen storage and transportation challenges for a hydrogen economy. We report a novel heterogeneous catalytic architecture, Ni(Mn)-O-P/GaN nanowires, for efficient, selective, and ultra-stable hydrogen evolution from formic acid (FA). The catalyst achieves a high activity of 29.92 mol H 2 ·g cat −1 ·h −1 with nearly 100% selectivity and a high turnover frequency (TOF) of 31,019.2 h −1 at 150 °C. It exhibits exceptional stability over 4000 hours under fluctuated temperatures (55-75 °C) with a turnover numbers (TONs) of 5,023,060, integrable with low-grade industrial waste heat. In-situ characterizations, isotope experiments, and density functional theory calculations collectively reveal that the synergy between Ni(Mn)-O-P and GaN are favorable for the O-H dissociation of FA with an interesting H-exchange mechanism with H 2 O while inhibiting the undesired FA dehydration and coking formation. An industrial prototype test validates practical on-demand hydrogen production using waste heat.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2022
·Vol. 33
·期 10
·1-11
·
IF 4.727
Wei Li,Qin Shuai,Ye Yulin,Hu Jiawei,Luo Danyang,Li Yusi,Gao Yiming,Jiang Liting,Zhou Qi,Xie Xianfei,Li Ning
Cartilage is an alymphatic, avascular and non-innervated tissue. Lack of potential regenerative capacity to reconstruct chondral defect has accelerated investigation and development of new strategy for cartilage repair. We prepared a manganese ion-incorporated natupolymer-based scaffold with chitosan-gelatin by freeze-drying procedure. The scaffold was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, energy dispersive spectroscopy, compressive testing, and analysis of porosity and flexibility. Live/dead assay confirmed the good cytocompatibility of prepared scaffold on rat articular chondrocytes after 10 days and 4 weeks of culture. The manganese-loaded composite scaffold upregulated the expression of chondrogenic-related markers (Sox9, integrin, and Col II) in chondrocytes. Western blot analysis of proteins extracted from chondrocytes grown on scaffolds indicated the signaling pathways of p-Akt and p-ERK1/2 played a key role. Histological analysis following implantation of current composite scaffold loaded with chondrocytes into a rat articular cartilage defect model showed that the scaffolds promoted the formation of collagen II and cartilage repair. These findings suggested the potential of manganese-loaded scaffold to promote new cartilage formation and a promising strategy for articular cartilage engineering application.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）