CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Yunyou Lv,Chunfeng Zhang,Yu Lu,Ting Wang,Peiyao Wu,Jie Liu
Sclerotinia sclerotiorum threatens crop production worldwide. Conventional prochloraz (Pro) suffers from photolysis, low utilization, and pollution. We developed a pH-responsive nanopesticide, Pro@ZnS@CMCS (PZC), using mesoporous ZnS to load Pro and coating it with carboxymethyl chitosan (CMCS). In the acidic microenvironment (pH ≈ 3) formed during fungal infection, the CMCS shell protonates and decomposes, enabling precise Pro release. Concurrently, the decomposition process consumes H + to modulate the pH of the infection microenvironment and disrupts the homeostasis of fungal oxalate metabolism. The exposed ZnS and residual CMCS synergistically enhance antibacterial activity, resulting in a triple mechanism of drug release, pH regulation, and multi-component action. PZC released 3.7-fold more Pro at pH 3 than pH 7. It improved leaf adhesion and rainfastness, with higher retention than free Pro. PZC exhibited an inhibition rate of 98.16% against Sclerotinia sclerotiorum , which was significantly higher than that of free Pro (30.23%). Transcriptomic analysis revealed that PZC treatment inhibits Sclerotinia sclerotiorum by inducing a “synergistic multiple stress” mechanism. This mechanism involves the simultaneous activation of stress responses, including catabolism, and the systemic inhibition of fundamental growth functions such as ribosome biogenesis, ultimately resulting in the collapse of its metabolic homeostasis. PZC also exhibited excellent biocompatibility with non-target organisms. This work offers a strategy for intelligent nanopesticides enabling targeted delivery, reduced dosage, higher efficacy, and environmental compatibility.
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高影响因子
Small
·
2026
·
IF 12.1
Xianming Gao,Ting Wu,Xinyi Dong,Qibo Wang,Hao Liu,Yu Zhang
The treatment of infected bone defects remains a significant clinical challenge, necessitating rigorous infection control alongside effective bone reconstruction. To address this, we develop a pH-responsive, zeolitic imidazolate framework-8 (ZIF-8)-based delivery system for targeted psoralen (PSO) delivery, which provides dual functionalities: antibacterial activity and osteogenic modulation. These nanoparticles (NPs) are further functionalized with a polydopamine (PDA) coating, designated as PSO/ZIF-8@PDA NPs (PZP NPs), to achieve synergistically enhanced therapeutic efficacy through photothermal activity. Exploiting rapid degradation in the acidic microenvironment of infected bone defects and slow degradation in the neutral microenvironment, these PZP NPs undergo spatiotemporal transformation, enabling sequential antibacterial and osteogenic modulation at the defect sites through the concentration-dependent effects of PSO. In vitro optimisation of PSO loading establishes a balance between osteogenic potency, antimicrobial efficacy, and biocompatibility, defining an optimal therapeutic platform for nanocarrier performance. In vivo evaluation in polymicrobial ( Staphylococcus aureus and Escherichia coli )-infected rat calvarial defect models demonstrates effective pathogen eradication and enhanced osteogenic differentiation. This dual-functional nanoplatform represents a promising strategy for the clinical management of infected bone defects and broadens the potential of nanomedicine in regenerative applications for infected tissues.
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PubMed
高影响因子
Nanoscale
·
2026
·
IF 5.1
Xiaofang Ma,Yuhao Cai,Yang Gao,Hairong Zhao,Xiaxia Liu,Yuanyuan Tian,He Xiao
The design and fabrication of highly active hydrogen evolution reaction (HER) electrocatalysts that can outperform Pt/C are extremely desirable but remain challenging. Herein, the fabrication of S-doped hollow mesoporous carbon anchored Ru nanoclusters (Ru NCs/S-HMCs) is reported as a novel and highly active HER electrocatalyst through modified Stöber process and subsequent hydrothermal treatment, in which Ru NCs (1.64 nm in size) are uniformly anchored into S-HMCs channels. Benefiting from the unique electronic structure induced by S doping and the spatial confinement effect of the mesoporous carbon, the Ru NCs/S-HMCs catalyst exhibits excellent pH-universal HER activity, requiring only 3.5, 61.0, and 63.5 mV of overpotential to achieve a current density of 10 mA cm-2 in alkaline, neutral, and acidic electrolytes, respectively. In 1 M KOH, 0.5 M H2SO4, and 0.5 M PBS solutions, Ru NCs/S0.5-HMCs exhibits high mass activities of 21542, 2998 and 7088 mA mgRu−1 at an overpotential of -50 mV, respectively. The excellent activity stems from: (1) the pore confinement effect, which promotes the formation of ultrasmall Ru NCs (1.64 nm) and suppresses metal leaching; (2) S doping, which modulates the electronic structure of Ru and reduces the water dissociation barrier; and (3) the hollow mesoporous architecture, which accelerates mass and electron transport. This work provides insights for designing high-efficiency pH-universal electrocatalysts.
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PubMed
高影响因子
Applied Materials Today
·
2026
·
IF 6.9
Zimo Zhang,Yeyang Wu,Mingyu Xing,Mingshuang Zhang,Saima Sadaf,Ya Wang
Localized neoadjuvant chemotherapy (NACT) is a widely utilized strategy for breast cancer treatment, aimed at reducing tumor size before surgery and improving rates of pathological complete response (pCR), a critical indicator of favorable long-term outcomes. However, the therapeutic efficacy of NACT is often limited by conventional drug delivery systems, which fail to achieve sufficient drug concentrations within the crucial early treatment window due to slow and nonspecific drug release. To address this challenge, we have fabricated an injectable, pH and thermal dual sensitive microgel by the copolymerization of N-isopropylacrylamide (NIPAM), N-isopropylmethacrylamide (NIPMAM), and methacrylic acid (MAA). These microgels are specifically designed to respond to the acidic and hyperthermic conditions of the breast tumor microenvironment (TME), enabling a tumor-specific burst release of encapsulated drug doxorubicin (DOX). Under simulated TME conditions (pH 5.0, 42°C), the microgels achieve a significant initial burst release of 58.99 % DOX within 4 h, compared to only 21.00 % under physiological conditions (pH 7.4, 37°C). In vitro studies further demonstrate that DOX-loaded microgels could reduce the viability of MCF-7 breast cancer cells to 39.36 % after 48 h at a DOX-equivalent concentration of 4.0 µg/mL. Furthermore, the microgels could effectively mitigate the cytotoxic effects of high concentration DOX on normal cells, preserving greater cell viability compared to free DOX. These findings highlight the potential of this dualsensitive microgel system as an innovative platform for localized NACT, offering enhanced therapeutic efficacy, improved pCR rates, and reduced systemic toxicity.
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高影响因子
Biomaterials Advances
·
2026
·
IF 6
Yahong Li,Xinyuan Wang,Meina Wu,Jieying Ren,Yanan Wang,Chaochao Wen,Xia Sen,Qingjun Tian,Yijie Wang,Yumeng Guo,Jian Xue,Yajian Duan,Tao Gong,Baofeng Yu
Corneal neovascularization (CNV) is a sight-threatening pathological process that poses the challenge of controlling inflammation, preventing infection, and thereby inhibiting angiogenesis. To address this, we developed a novel pH-responsive smart micelle-integrated hydrogel, termed LEV@DG-HPMC. This system is composed of a three-dimensional network formed by dipotassium glycyrrhizinate (DG) and hydroxypropyl methylcellulose (HPMC) for the delivery of levofloxacin (LEV). The hydrogel network is formed by physical cross-linking. Within this system, LEV provides potent antibacterial activity, while DG contributes inherent anti-inflammatory properties. The LEV@DG-HPMC hydrogel demonstrated excellent biocompatibility and significantly prolonged ocular surface retention. Its unique pH-responsive drug release profile closely matched the temporal pH changes in the pathological microenvironment post-alkali injury. Crucially, the hydrogel exhibited synergistic therapeutic effects, combining potent antibacterial activity with the ability to significantly downregulate key inflammatory cytokines and suppress pro-angiogenic factors, such as such as interleukin-1β, Il-6, tumor necrosis factor-α, nuclear factor-κB, vascular endothelial growth factor A, matrix metalloproteinase-9. Consequently, it effectively inhibited CNV progression, reduced corneal opacity, and promoted corneal repair. This multifunctional smart hydrogel represents a highly promising strategy for the treatment of CNV.
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PubMed
高影响因子
Current Research in Food Science
·
2026
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IF 7
Yating Liu,Na Gan,Peiran Liu,Junjie Xu,Fang Geng,Di Wu
Unraveling the interaction mechanism between the food azo dye tartrazine (Tz) and β -lactoglobulin ( β -LG) under varying pH conditions is crucial for understanding their safe application in food systems. Molecular docking indicated that Tz primarily bound to the β -hydrophobic barrel of β -LG. The protonation of lysine residues diminished with increasing pH, which reduced hydrogen bond formation. The binding energy decreased from 8.77 kcal/mol (pH 2.0) to 8.43 kcal/mol (pH 7.4). Molecular dynamics simulations indicated that Tz bound exerts the greatest structural influence on β -LG at pH 2.0. Fluorescence and thermodynamic analyses confirmed that Tz quenched β -LG fluorescence through a static mechanism, through their interaction was a spontaneous process driven mainly by hydrophobic forces. The protonation level of β -LG gradually decreased with increasing pH, and electrostatic repulsion between β -LG and Tz was observed at pH 7.4. As a result, the binding constant between Tz and β -LG decreased from 6.669 × 10 5 L/mol (pH 2.0) to 3.596 × 10 5 L/mol (pH 5.2) and 0.956 × 10 5 L/mol (pH 7.4), respectively. Furthermore, Tz induced changes in the secondary structure content of β -LG and reduced its surface hydrophobicity under all pH conditions.
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高影响因子
Journal of Molecular and Engineering Materials
·
2021
·
IF 0
Lili Feng,Pengyu Wang,Hansen Yang,Zhuo Chen,Shuhui Bo
A charge transfer dye with the D– π –A structure was synthesized by Pd catalyzed Hartwig–Buchwald coupling and Knoevenagel condensation reaction, using N, N-dihexylbenzo[b]thiophen-6-amine as donor and 2-(3-cyano-4, 5, 5-trimethylfuran-2 (5H)-ylidene)malononitrile (TCF) as acceptor. The solvatochromic and pH switch properties of the as-synthesized dye were investigated through UV-vis absorption and fluorescence emission spectra. A positive solvatochromism of the dye in different polar solvents was observed along with a visible color change of the solution. By adding acid/base into the DMSO solution of the dye, the color as well as the absorption and emission spectra of the solution exhibited outstanding characteristics of pH switch.
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BIOSENSORS & BIOELECTRONICS
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2018
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IF 8.173
Chao Liu,Juying Hou,Geoffrey I.N. Waterhouse,Lin Cui,Jing Dong,Shiyun Ai
A novel pH-responsive sandwich-type electrochemiluminescence immunosensor was successfully developed for the detection of avian leukosis virus subgroup J (ALV-J). The immunosensor consisted of graphene oxide functionalized with tannic acid (rGO-TA) and primary antibodies (Ab 1 ) as the main ALV-J sensing platform. For signal amplification , pH-responsive hollow MnO 2 (hMnO 2 ) nanospheres encapsulating Ru(bpy) 3 Cl 2 and carrying secondary antibodies (Ab 2 ) were employed. Under optimal conditions, the immunosensor exhibited a wide ALV-J detection range of 10 1.80 to 10 4.30 TCID 50 /mL (TCID 50 : 50% tissue culture infective dose) and a low detection limit of 10 1.71 TCID 50 /mL (S/N = 3). Importantly, the immunosensor showed high sensitivity, good reproducibility and excellent operational stability. Finally, the immunosensor was evaluated using a real avian serum sample containing ALV-J, with excellent results being achieved.
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高影响因子
RSC Advances
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2013
·Vol. 3
·期 35
·15085-15093
·
IF 2.562
Jiucun Chen,Mingzhu Liu,Chunmei Gao,Shaoyu Lü,Xinyu Zhang,Zhen Liu
A multi-responsive hydrophilic ABCBA-type pentablock copolymer, consisting of poly(ethylene glycol), poly(N-isopropylacrylamide), and poly(2-(diethylamino)ethyl methacrylate), PDEA-b-PNIPAM-b-PEG-b-PNIPAM-b-PDEA, was synthesized by consecutive reversible addition–fragmentation chain transfer (RAFT) polymerization. The polymerization showed all of the expected features of living radical polymerization and allowed the synthesis of copolymers with controlled lengths of the PNIPAM and PDEA blocks. Due to the multi-component and multi-functional nature of the pentablock copolymer, the solution properties can be manipulated by the changing of parameters such as temperature, pH etc. For example, the copolymer could be dissolved in acidic aqueous solution at room temperature, since the pH was below the pKa of the PDEA block, and the temperature was below the lower critical solution temperature (LCST) of the PNIPAM block. While in alkaline solution at room temperature, the copolymer self-assembled into core–shell–corona micelles, with the hydrophobic PDEA block as the core, the thermoresponsive PNIPAM block as the shell and the hydrophilic PEG block as the corona. At elevated temperatures in acidic media, the copolymer self-assembled into PNIPAM-core micelles with mixed hydrophilic PEG and pH-responsive PDEA coronas. Moreover, the self-assembly behavior of the pentablock copolymers in aqueous solution was investigated by varying the length of PDEA blocks.
研究领域:
高分子化学
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材料科学
·
响应性高分子
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纳米材料
·
自组装
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高影响因子
ACS Applied Materials & Interfaces
·
2017
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IF 7.504
Lu-Nan Zhang,Si-Heng Li,Hua-Qiao Tan,Shifa Ullah Khan,Yuan-Yuan Ma,Hong-Ying Zang,Yong-Hui Wang,Yang-Guang Li
During the exploration of highly efficient noble-metal-free electrocatalysts for the hydrogen evolution reaction (HER), a promising and challenging strategy is to fabricate composite nanocatalysts by finely tuning metal and/or nonmetal element components. Herein, we report a new HER electrocatalyst, which is composed of molybdenum phosphide and molybdenum carbide composite nanoparticles (NPs) coated by few-layer N-doped graphitic carbon shells (denoted as MoP/Mo2C@C). Such a new combination mode of electrocatalysts is realized by a one-step annealing route with the mixture of a Mo/P-based polyoxometalate (POM) and dicyandiamide. On the basis of this method, the simultaneous phosphorization and carbonization in a nanoscale confined space can be easily achieved by the use of POM as the molecular-element-regulating platform. MoP/Mo2C@C exhibits more remarkable HER performance over the whole pH range than those of MoP, Mo2C, and the physical mixture of MoP and Mo2C. The low overpotentials of 89, 136, and 75 mV were obtained at a current density of 10 mA cm–2 in the media of pH = 0, 7, and 14, respectively. Furthermore, MoP/Mo2C@C shows a long-term durability for 14 h over the entire pH range (0–14). Because of the protection of carbon shells, such composite electrocatalyst also possesses better transition-metal tolerance exemplified by Fe2+, Co2+, and Ni2+ than that of 20% commercial Pt/C. This work demonstrates the advantage of POM precursors in adjusting the component and properties of nanoscale composite electrocatalysts for HER, which may suggest new options for the fabrication of highly efficient composite electrocatalysts.
研究领域:
电化学
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材料科学
·
催化
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能量转换
·
纳米材料
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DOI
高影响因子
MATERIALS & DESIGN
·
2026
·
IF 7.9
XinYu Mao,ShangNong Wu,MengHui Zhang,Peng Shen,XiaoZhong Yang,HongGang Wang
Colorectal cancer (CRC), a leading cause of cancer-related mortality, remains challenging due to drug resistance, insufficient targeting, and systemic toxicity. We engineered a pH/glucose dual-responsive zeolitic imidazolate framework-8 (ZIF-8) nanocarrier for the co-delivery of berberine (BBR) and glucose oxidase (GO X ). BBR and GO X were encapsulated into ZIF-8 nanoparticles via one-pot synthesis and subsequent surface modification with polyethylene glycol–folic acid (PEG–FA), yielding BBR@GO X @ZIF-8–FA (BGZF). At pH 5.4, BBR and GO X release was approximately 74% and 69%, respectively. Cellular uptake and JC-1 assays revealed that the delocalized positive charge of the nanoparticles enhanced mitochondrial targeting, synergizing with GO X -mediated glucose depletion for amplified starvation therapy. Reactive oxygen species (ROS) quantification showed that BBR and GO X synergistically exacerbated oxidative stress, resulting in higher levels of ROS than those observed with monotherapy. Mechanistically, BGZF induced apoptosis through dual pathways: endogenous mitochondrial dysfunction and exogenous ROS overproduction. BGZF’s tumor-specific targeting capabilities were validated in vivo , demonstrating FA-mediated active homing and prolonged biosafety with negligible systemic toxicity. This research pioneers a dual-responsive nanoplatform that integrates mitochondrial targeting and cascade catalytic amplification to achieve synergistic antitumor effects between BBR and GO X , offering a novel paradigm for CRC treatment.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Gerui Ren,Zhuge Caixin,Ying Zhu,Ruiqi Hu,Yiting Jiang,Xin Song,Wentao Wu,Miaomiao Wang,Junmei Zhou,Min Huang,Hujun Xie,Kejun Cheng
This study reports a novel pH-tuned double-network hydrogel via an entirely physical crosslinking strategy. The hydrogel consists of a first network formed between ferulic acid and ε-polylysine via hydrogen bonding and electrostatic interaction, while a second polyvinyl alcohol network established through freeze-thaw cycles. The former network confers biological activities, while the combination of the two networks ensures mechanical strength. The hydrogels exhibit pH-tuned behavior, with significant differences in mechanical performance, swelling characteristics, and antioxidant/antibacterial activities among hydrogels prepared under different pH. Specifically, the hydrogel formed at pH 3 demonstrates 3.5-fold higher energy dissipation than that at pH 9, while the equilibrium swelling ratio reaches 235% at pH 1 versus 102% at pH 9. pH serves as a switch, modulating intermolecular forces by altering hydrogel component protonation states, thereby optimizing synergy within the double network. Such multifunctional hydrogels show promise for applications like active food packaging materials.
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高影响因子
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