JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Xun He,Jingsong Liu,Yugang Gong,Wei Lu,Xiaowei Sha,Chang Cao,Yanqun Li,Jiawei Wang
Background Evidence has demonstrated that Chinese medicine formula Xuefu Zhuyu decoction can markedly promote the formation of new hair in patients and mice with alopecia areata (AA). Amygdalin is one of the active components of Xuefu Zhuyu decoction, but its therapeutic effects and the underlying mechanisms on AA remains largely unrevealed. Purpose Therefore, this study aims to investigate the therapeutic effects and to probe its molecular mechanisms of inflammation and immune regulation on AA model of C3H/HeJ mice. Study design The C3H/HeJ female mice were divided into control, AA, rusolitinib (60 mg/kg), and amygdalin groups (60, 90, and 120 mg/kg, 0.2 ml/10 g, i.g.). Methods The optical microscope was used to observe the feature of the local skin, and the number of lanugo and terminal hair. H&E staining was performed to determine the degree of pathological damage to the skin. ELISA was performed to detect levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in mice serum. Flow cytometry was carried out to analyze the CD4 + CD25 + FOXP3 + , CD4 + and CD8 + of skin tissue. And the levels of CD4 + and CD8 + , p-JAK/JAK2, p-STAT3/STAT, and SOCS3 were detected by immunohistochemistry. Western blot and qRT-PCR were employed to examine the expression levels of IL-6, TNF-α, IFN-γ, JAK2, p-JAK, STAT, p-STAT3 and SOCS3 proteins and genes in skin tissues. Results Compared with AA group, amygdalin immensely increased the number of vellus hairs and decreased the number of terminal hairs determined by skin microscopy and H&E staining. ELISA, Western blot and qRT-PCR data showed that the levels of IL-6, TNF-α and IFN-γ in serum and skin tissues of AA mice were significantly increased, while amygdalin administration dramatically restrained the contents of the three pro-inflammatory factors. Flow cytometry and immunohistochemistry hinted that amygdalin observably enhanced the number of CD4 + CD25 + FOXP3 + and CD4 + cells, while inhibited the number of CD8 + positive cells in mice with AA. Moreover, amygdalin signally reduced JAK2/STAT3 pathway-related protein and gene levels in AA mice. Conclusion Amygdalin could inhibit inflammatory response and improve immune function in the treatment of AA. The underlying molecular mechanism may be related to inhibition of JAK2/STAT3 pathway.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 45
·2406236
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IF 18.5
Hao-Yu Zhao,Xin Wang,Jing Wu,Chao Shu,Fu-Lin Gao,Changjun Li,Xiao-Hang Lu,Yan Zhang,Qianlong Wang,Xiaofeng Li,Zhong-Zhen Yu
To alleviate resource shortage and environmental pollution, solar energy can be converted into thermal energy stored in phase change materials and in turn generate electrical energy. To enhance the solar energy utilization efficiency of solar-thermal-electrical conversion devices and prevent the heat loss to the environment at night, an intelligent solar-responsive phase-change system is innovatively designed consisting of a graphene aerogel film/paraffin wax stamen with an ultra-high thermal conductivity of 46.7 W m −1 K −1 , and thermally preserving aerogel film/liquid crystal elastomer bilayer petals that can bend solar-responsively by the synergistic effect of solar-thermal energy conversion and heat-induced contraction. The solar-responsive phase-change system achieves daytime blooming for solar-thermal conversion with simultaneous energy storage and nighttime closing for minimizing heat loss to the environment, exhibiting a high solar-thermal conversion and energy storage efficiency of 89.4% and delaying its temperature drop by the thermal preservation effect of the petals. The assembled solar-responsive solar-thermal-electric generator can reach an output voltage of 1033.8 mV at a light intensity of 500 mW cm −2 and continue to generate electrical energy during nighttime, holding tremendous promise in efficient solar energy conversion, storage, and utilization.
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APPLIED SURFACE SCIENCE
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2012
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IF 2.103
Xinjie Zhang,Chunmei Gao,Mingzhu Liu,Yinjuan Huang,Xiyong Yu,Enyong Ding
An easy, comprehensive and inexpensive method is demonstrated to produce asymmetric polymer/inorganic nanocomposites in a large quantity. With the aid of Pickering emulsion, unmodified particles aggregate on the surface of emulsion droplets and are fixed in place when the wax solidifies. The exposed surfaces of immobilized SiO 2 particles are modified chemically by 2-(dimethylamino) ethylmethacrylate (DMAEMA). With the removal of wax, the exposed side of particles can be further modified chemically by N-isopropylacrylamide (NIPAAm). Based on these procedures, dual responsive asymmetric nanocomposite particles are achieved with both pH and temperature sensitivities. Due to their dual-stimuli and asymmetric structure, these particles have potential applications in molecule targeting, drug delivery and as building blocks for the assembly of complex nanostructure.
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Materials Science & Engineering C-Materials for Biological Applications
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2012
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IF 2.686
Qingchun Zhang,Ke Tan,Zhaoyang Ye,Yan Zhang,Wensong Tan,Meidong Lang
Common hydrogel, composed of synthetic polymers or natural polysaccharides could not support the adhesion of anchorage-dependent cells due to the lack of cell affinitive interface and high cell constraint. The use of porous polyester microspheres as cell-carriers and introduction of cell-loaded microspheres into the hydrogel system might overcome the problem. However, the preparation of the open porous microsphere especially using polycaprolactone (PCL) has been rarely reported. Here, the open porous PCL microspheres were fabricated via the combined emulsion/solvent evaporation and particle leaching method. The microspheres exhibited porous surface and inter-connective pore structure. Additionally, the pore structure could be easily controlled by adjusting the processing parameters. The surface pore size could be altered from 20 μm to 80 μm and the internal porosities were varied from 30% to 70%. The obtained microspheres were evaluated to delivery mesenchymal stem cells (MSCs) and showed the improved cell adhesion and growth when compared with the non-porous microspheres. Then, the MSCs loaded microspheres were introduced into agarose hydrogel. MSCs remained alive and sustained proliferation in microsphere/agarose composite in 5-day incubation while a decrement of MSCs viabilities was found in agarose hydrogel without microspheres. The results indicated that the microsphere/hydrogel composite had a great potential in cell therapy and injectable system for tissue regeneration.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Huayang Zhang,Guopeng Chen,Shangzhen Xie,Ye Fu,Guangyi Tian,Jianyong Zheng,Biao Wang,Zhiguang Guo
Fog harvest has emerged as a direct and efficient water harvesting technology to relieve the intense pressure of freshwater scarcity worldwide. With the vagaries of climate and increasing amount of energy consumption, high-efficiency fog harvest devices focus on the fast water droplet capture and transportation are highly desired. In this study, a novel harp structure is developed using cross-twisted copper filaments arranged in a spatial triangular pattern to enhance water droplet capture and transportation. Inspired by the natural differences in Laplace pressure observed in cactus and spider silks, this design accelerates the movement of water bridges. Besides, drawing on the fruit waxes on the surface of hogweed and blueberries, a paraffin wax coating is applied on the copper sheet frame to create a solid slip frame, improving the synergy between filament capture and frame transportation. The monolithic fog collector (MFC) thus achieves a significant increase in fog harvest efficiency and demonstrates excellent durability. Integration of the MFCs into a 3D high-efficiency fog harvest system results in a harvest rate of 0.5027 g cm −2 min −1 , showing promise for practical applications due to its durability, simplicity, and environmental friendliness.
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Materials Today Physics
·
2024
·
IF 10
Yunsong Pang,Junhong Li,Zhibin Wen,Ting Liang,Shan Gao,Min Yang,Dezhao Huang,Jianbin Xu,Tengfei Luo,Xiaoliang Zeng,Rong Sun
The controlling of heat flow direction stands as a prominent methodological approach within the domain of thermal management, and this can be accomplished through the utilization of thermal diodes. However, if the thermal diode lacks mechanical compliance, hindering its intimate contact with heat source/sink surfaces, the thermal rectification performance is limited. In this work, we propose a method to solve the mechanical compliance problem that is introducing phase change material (PCM) consisting of dual alkanes (hexadecane and paraffine wax) and polyurethane to fabricate the heterojunction thermal diode. The fabricated thermal diode exhibits an ultra-soft mechanical feature, with a low elastic modulus of 0.4 KPa and >300 % elongation until failure – the best values reported to date for thermal diodes. The measured thermal rectification factor is as high as 1.42 – in line with the theoretical model prediction. Molecular dynamic simulations reveal that the thermal rectification mechanism of the PCM-based thermal diode originates from the crystal-amorphous phase transition of the hexadecane terminal as the temperature bias flips. Therefore, the heat flow in the forward direction is greater than the flux in the reverse direction. A series of experiments and finite element analyses are employed to verify the feasibility of thermal diodes for applications in real contexts like the civil engineering.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Chuhang Liu,Xinyue Liu,Xiaojie Shi,Guoqiang Zhou,Chaozheng Liu,Changtong Mei,Mei-Chun Li
The rapid global increase in the consumption of fossil energy had led to urgent environmental issues, thereby prompting vigorous efforts towards the development and application of renewable energy. The effective encapsulation of phase change materials (PCMs) is crucial and indispensable for achieving high-performance solar-thermal energy harvesting and storage. However, challenges persist in the manufacturing of PCMs encapsulations with customizable and intricate structures to meet diverse scenarios. Herein, a PCMs Pickering emulsion gel ink, based on lignocellulosic nanofibers (LCNFs)/graphene oxide (GO) nanosheets stabilized paraffin, has been prepared to fabricate customized PCMs using 3D printing techniques for solar-thermal-electric conversion applications. The micro-nano matrix consisting of LCNFs and GO nanosheets provides a stable oil/water (O/W) interface, limits movements and deformability of paraffin microsphere, thereby increasing the viscosity and stiffness of the PCMs Pickering emulsion gel ink to ensure its excellent rheological property. Moreover, the LCNFs enhance printability and shape fidelity of the ink as interfacial stabilizer and viscosity modifier, which facilitates the manufacture of various 3D geometries. As a result, the designed concave PCMs solar harvester not only exhibits exceptional solar-to-thermal conversion efficiency, but also effectively mitigates heat loss and enables efficient heat storage for electricity generation. Our work demonstrates a new way toward utilization of LCNFs as PCMs emulsion stabilizers and encapsulants in PCMs and the fabrication customized PCMs architectures for solar-thermal-electric conversion applications using 3D printing techniques.
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COMPOSITES SCIENCE AND TECHNOLOGY
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2024
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IF 8.3
Siyuan Qiu,Yajiao Li,Yi An,Wenhao Wang,Yuanmin Chen,Ke Chen,Daming Wu,Jingyao Sun
Phase change composites (PCCs) have attracted much attention in the fields of thermal management due to their high latent heat. However, their risk of leakage and poor shape designability greatly limit their industrial applications. Therefore, there is an urgent need to develop leakage-proof and customizable PCCs to meet the emerging requirements of thermal management applications. Some scholars have proposed the concept of preparing PCCs by 3D printing technology, aiming to meet customized thermal management requirements of various electronic devices. Nevertheless, the phase change material leaking of PCCs under high temperature is still a tough problem to solve. In this study, expanded graphite (EG) is used as the carrier for paraffin wax (PW), which names as EP can tightly enveloping PW in its porous structure. Then, an innovative carbomer gel ink is prepared for 3D printing using EP and short carbon fiber (SCF) as thermal conductive fillers. Freeze-drying and polydimethylsiloxane (PDMS) infiltrating procedures are furtherly performed to ensure the flexibility of final PCCs samples. A maximum thermal conductivity of 2.89 W/(m·K) is obtained when the content of SCF/EP filler is 10 wt%. Importantly, the flexible PCCs prepared through this method effectively prevent the PW leaking during thermal management applications, thereby avoiding the consequent safety risks and enhancing the lifespan of electronic devices. This work opens up a promising pathway for the rapid fabrication of leakage-proof, customizable and flexible PCCs.
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Materials Horizons
·
2025
·
IF 10.7
Minghan Wu,Yu Li,Gang Huang,Ruiqi Xu,Xiaochun Yin,Guizhen Zhang
Passive daytime radiative cooling offers a promising approach to address energy, environmental, and safety issues caused by global warming. However, the contradiction between high radiative cooling performance and long-lasting ultraviolet (UV) durability is a primary limitation at the current stage. Here, inspired by the ability of epidermal cells and palisade cells on the leaf surface to protect internal leaf structures (such as chloroplasts and nuclei) under drought and high-temperature conditions, a double-layer passive radiative cooling (PRC) porous membrane, which consists of an upper protective layer densely packed with highly ultraviolet-reflective inorganic particles and a bottom cooling layer doped with a variety of optically characterized inorganic particles, was developed to overcome these challenges. This special leaf-like structure and the synergistic effect of the inorganic particles ensure that the PRC membrane has a high solar reflectivity of 99.3% and a high mid-infrared (MIR) emissivity of ∼95%. In addition, the membrane still maintains excellent optical and mechanical performance after ultraviolet radiation treatment with a total radiation dose of 7000 MJ m−2. Therefore, the unique structural design and excellent comprehensive performance of the membrane can greatly promote the practical applications of the PRC technology.
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高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Shuai Chen,Haifeng Chen,Lindan Tan,Vahid Serpooshan
Adhesive tissue engineering scaffold (ATES) devices can be secured on tissues by relying on their intrinsic adhesive properties, hence, avoiding the complications such as host tissue/scaffold damages that are associated with conventional scaffold fixation methods like suturing or bioglue. This study introduces a new generation of three-dimensional (3D) bioprinted ATES systems for use as cardiac patches to regenerate the adult human heart. Tyramine-modified methacrylated hyaluronic acid (HAMA-tyr), gelatin methacrylate (GelMA), and gelatin were used to create the hybrid bioink formulation with self-adhesive properties. ATESs were bioprinted and further modified to improve the adhesion properties. In-depth characterization of printing fidelity, pore size, mechanical properties, swelling behavior, as well as biocompatibility was used to create ATESs with optimal biological function. Following in vitro testing, the ATESs were tested in a mouse model of myocardial infarction to study the scaffold adhesive strength in biological milieu. The method developed in this study can be used to manufacture off-the-shelf ATESs with complex cellular and extracellular architecture, with robust potential for clinical translation into a variety of personalized tissue engineering and regenerative medicine applications.
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高影响因子
LANGMUIR
·
2024
·
IF 3.7
Chuanqi Wei,Oleg Gendelman,Youhua Jiang
The inefficacy of repelling water droplets laden with macromolecules (complex droplets or diluted polymer solution) is a long-standing shortcoming of superhydrophobic surfaces, which severely limits their reliability in practical applications. Here, we design a surface termed the superhydrophobicity–slipperiness switchable surface (3S surface), which demonstrates superhydrophobicity at room temperature and slipperiness when heated. The 3S surface is composed of magneto-responsive wires coated with superhydrophobic nanoparticles and impregnated with thermoresponsive paraffin, exhibiting lotus leaf-inspired passive water repellency and respiratory cilia-inspired active water repellency at room temperature. When heated, the impregnated paraffin melts and forms a lubricant layer atop the surface structures, exhibiting the pitcher-plant-inspired removal of complex droplets that remain pinned on conventional superhydrophobic surfaces. The counterintuitive integration of superhydrophobicity (a liquid–solid–gas composite system) and slipperiness (a liquid–lubricant–gas system) into a surface and the on-demand switch between them are not only important to the applicability of self-cleaning surfaces to real-world environments, where complex liquids are inevitable, but also provide insights into various interface-related applications.
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高影响因子
CERAMICS INTERNATIONAL
·
2017
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IF 2.986
Yue Qian,Huawei Wei,Jidong Dong,Yunzhe Du,Xiaojiao Fang,Wenhui Zheng,Yutong Sun,Zaixing Jiang
The recently developed two-dimensional transition metal carbides (such as MXene) have shown amazing electrical properties. MXene and derivative two dimensional (2D) materials are widely used in electron devices, and have large potential application in electromagnetic (EM) absorber. Herein we describe a mild method to prepare an urchin-like ZnO-MXene Ti 3 C 2 T x nanocomposite through a coprecipitation process. The nanocomposite delivers a substantially enhanced EM absorbing performance with an optimum reflection loss of −26.30 dB, which is significantly better than that of primitive Ti 3 C 2 T x (−6.70 dB), owing to the construction of unique semiconductive networks and larger interfaces. The EM absorption performance can be effectively controlled in the range of 14.0–18.0 bands by changing the growth time of ZnO. Considering the large amount of members in MXene , this study demonstrates a new strategy applicable in maximizing their applications in EM absorbing materials.
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高影响因子
危险品化学品经营许可证（带存储）