JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Yongmei Zhao,Jianwu Lv,Hongli Yu,Kang Huang,Zhihan Du,Wen Luo
A novel series of dictamnine derivatives were synthesized and evaluated as dual inhibitors for cholinesterase and β-amyloid aggregation. These molecules exhibited potent acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities at the micromolar to sub-micromolar levels. Compound 7k exhibited the strongest inhibitory activity for both AChE and BChE, with IC 50 values of 0.40 μM and 0.63 μM, respectively, improving results from its precursor dictamnine and the commercial inhibitor galanthamine. Kinetic analyses and molecular modeling results indicated a mixed-type inhibition of AChE by compound 7k . In addition, some of the derivatives revealed potent inhibitory activity of AChE induced β-amyloid (Aβ) aggregation. Moreover, 7k did not show toxicity against SH-SY5Y and HL-7702 cells at the tested concentration. Therefore, these dictamnine derivatives, and especially 7k , are suitable candidates for the treatment of Alzheimer's disease and should be further studied.
研究领域:
药物化学
·
神经生物学
·
有机合成
✓ 已验证
DOI
高影响因子
ORGANOMETALLICS
·
2020
·
IF 3.804
Liangwei Zhang,Long Liu,Tianzeng Huang,Qizhi Dong,Tieqiao Chen
A palladium-catalyzed cyclobutanation of aryl sulfonates with strained alkenes has been developed. The methodology is featured to achieve the cleavage of both C–O and C–H bonds of phenol derivatives in one pot. Under the reaction conditions, in addition to reactive triflates, the relatively inactive tosylates and mesylates can also be transformed into the corresponding benzocyclobutanes in high yields. This reaction can be carried out in gram-scale experiments with a low loading of the palladium catalyst and is applicable to the cyclobutanative modification of bioactive molecules, highlighting its synthetic value in organic synthesis.
研究领域:
有机化学
·
催化化学
·
合成化学
✓ 已验证
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2025
·
IF 2.8
Wang Guoqiang,Wang Jianyu,Wang Yueying,Wei Deyu,Hui Yunfeng,Yu Yiheng,Zhang Mengke,Shi Longqing,Hu Hongliang,Jin Yujie
In this work, two high-molecular-weight polyesters poly(1,12-dodecylene terephthalate) (PDT) and poly(1,12-dodecylene thiophenedicarboxylate) (PDTD) were synthesized using geometrically distinct aromatic monomers: dimethyl terephthalate (DMT, 180° bond angle) or 2,5-thiophenedicarboxylic acid (TDCA, 148° bond angle), coupled with 1,12-dodecanediol (DD). Comprehensive characterization (chemical/thermal/crystalline/tensile/dynamicmechanical/rheological properties) revealed unique structure–property relationships governed by TDCA’s nonlinear geometry. The weight-average molecular weights of poly (1,12-dodecylene terephthalate) (PDT) and poly (1,12-dodecylene thiophenedicarboxylate) (PDTD) were 119,700 and 110,700 g/mol, respectively. Both polyesters were identified as semi-crystalline polymers by differential scanning calorimetry (DSC) and wide-angle X-ray diffraction (WAXD). PDTD exhibited dual melting peaks (103.9 °C/94.3 °C), attributed to chain-folding constraints from TDCA’s angular distortion causing defective crystals, while PDT showed a single peak (124.1 °C). At the same time, the melting temperature of PDT is higher than that of PDTD, because the benzene ring is more conducive to the folding of the molecular chain. The decomposition temperatures at 5% weight loss of PDT and PDTD are 378 and 365 °C, respectively. PDT is more thermally stable than PDTD, because the benzene ring is more stable than the thiophene ring. PDT demonstrated polyethylene-like tensile strength (17.7 MPa) and melting temperature (124 °C). The results reported in this work provide deeper insights into the relationship between structures and properties of polyesters with long-chain diols, facilitating the design and synthesis of high-performance polyesters in the future. Graphical abstract
研究领域:
高分子化学
·
材料科学
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高分子合成
·
热分析
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聚合物表征
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Lin Chen,Di Wang
A tunable cascade reaction of ureidomalonates and alkenyl azlactones was disclosed, which gave rise to the construction of N-aroyl α-amino acid ester and imide-functionalized hydantoins in moderate to good yields and with excellent diastereoselectivities. The reaction pathway was precisely manipulated by organocatalysis and phase-transfer/sunlight relay catalysis, respectively, to realize the divergent synthesis. The successful gram-scale preparation of representative products exhibited the application potential of this protocol. Mechanistic studies indicated that the exchange and phase transfer of ethoxy anion played a key role in altering the reaction pathway, and sunlight might accelerate the oxidation process at the late stage of the reaction triggered by phase-transfer catalysis.
研究领域:
有机化学
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合成化学
·
催化
✓ 已验证
DOI
高影响因子
Letters in Drug Design & Discovery
·
2020
·Vol. 17
·期 3
·300-311
·
IF 1.169
Bao Longzhu,Wang Shuangshuang,Song Di,Wang Jingjing,Yue Xiali,Cao Xiufang
Background: Due to the extensive use of a single fungicide to control crop diseases, the increase of resistant individuals leads to control failures. The search for molecules with fungicidal activity is still ongoing. Strobilurin is one of the most popularly used fungicides in the agrochemical
field. A large number of strobilurin derivatives with both high activity and low toxicity have been developed. Methods: In the present study, a series of novel ortho-substituted benzyl carboxylates were efficiently synthesized by the reaction of (E)-methyl 2-(2-(bromom-ethyl)phenyl)-2-methox-yiminoaceta
with various carboxylic acids. Their structures were confirmed and characterized by 1H NMR, 13C NMR, and ESI-MS analysis. Their fungicidal activities against common phytopathogenic fungi from six major cash crops were screened based on the pesticides guidelines for the laboratory bioactivity
tests. Results: The primary fungicidal activity test results indicate that all compounds showed a certain inhibitory effect on the growth of 13 plants pathogenic fungi at a concentration of 100 ppm, and Compd. 3 has the most obvious inhibitory effect on all fungi. Further fungicidal activity
studies indicate that some of these novel strobilurin derivatives containing carboxylate unit exhibited potential in vitro fungicidal activities at the dosage of 6.25 mg/L-1. Conclusion: A series of the ortho-substituted benzyl carboxylates derivatives containing β- methoxyacrylate
moiety were designed and synthesized by modifying the side chain of traditional strobilurin fungicide. Compd. 3, Compd. 2 and Compd. 16 were identified as the most promising candidates for further study.
研究领域:
植物保护学
·
农药化学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Bo Yang,Wenjing Wang,Zhenzhong Hu,Boxiong Shen,Sheng-Qi Guo
Developing new photocatalysts to achieve efficient removal of phthalate esters (PAEs) in water is an important research task in environmental science. However, existing modification strategies for photocatalysts often focus on enhancing the efficiency of material photogenerated charge separation, neglecting the degradation characteristics of PAEs. In this work, we proposed an effective strategy for the photodegradation process of PAEs: introducing vacancy pair defects. We developed a BiOBr photocatalyst containing “Bi-Br” vacancy pairs, and confirmed that it has an excellent photocatalytic activity in removing phthalate esters (PAEs). Through a combination of experimental and theoretical calculations, it is proved that “Bi-Br” vacancy pairs can not only improve the charge separation efficiency, but also alter the adsorption configuration of O 2 , thus accelerating the formation and transformation of reactive oxygen species . Moreover, “Bi-Br” vacancy pairs can effectively improve the adsorption and activation of PAEs on the surface of samples, surpassing the effect of O vacancies. This work enriches the design concept of constructing highly active photocatalysts based on defect engineering, and provides a new idea for the treatment of PAEs in water.
研究领域:
环境科学
·
材料科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2021
·
IF 1.751
Le Guo,Yan-Peng Gao,Yan-Hua Lv,Li Wang,Yu Han,Fei Chang
We report the synthesis, crystal structures, and magnetic properties of a series of two-dimensional (2-D) and three-dimensional (3-D) coordination polymers (CPs). A solvothermal reaction of manganese metal salts with 4,4′-oxydibenzoic acid (H2oba), 4,4′-methylenebis(oxy) dibenzoic acid (H2mba), 4,4′-(propane-1,3-diylbis (oxy))dibenzoic acid (H2pba) or 1,4-bis (1H-imidazol-1-yl)-butane (bib) gives five new non-interpenetrating CPs, [Mn2(oba)2(CH3OH)(H2O)] (1), [Mn6(oba)6(bib)(DMF)2(H2O)4] · (DMF)2(CH3OH) (2), [Mn4(mba)4(bib)(CH3OH)] (3), [Mn7(pba)7 (bib)(H2O)4] · (H2O)3(DMA)(CH3OH)0.5 (4), and [Mn7(pba)7(H2O)6](DMA)3 (5). The X-ray crystal structural analyses revealed that 1, 4, and 5 are 2-D layers, whereas 2 and 3 are 3-D frameworks with 1-D Mn-carboxylate chains. In 1, 2, 4, and 5, the 1-D Mn-carboxylate chains are formed by flexible carboxylate ligands and Mn ions; these were then linked by organic ligands in different directions, leading to the formation of 2-D and 3-D frameworks. Furthermore, IR, PXRD, elemental analysis, TGA, and magnetic properties have been investigated.
研究领域:
无机化学
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材料科学
·
固体化学
✓ 已验证
DOI
高影响因子
CLINICAL BIOCHEMISTRY
·
2020
·
IF 2.573
Tianhua Zhang,Xiaoyu Tang,Ling Mao,Jin Chen,Jie Kuang,Xin Guo,Danyan Xu,Daoquan Peng,Bilian Yu
Background The mechanism for an abnormal pattern of triglyceride (TG) metabolism in response to a meal still needs further investigation. Extensive pieces of evidence have shown that apolipoprotein CIII (apoCIII) is a critical modulator of plasma TG metabolism mostly by inhibiting the hydrolysis of TG. Little is known about the role of apoCIII contained in high density lipoprotein (HDL) in plasma TG metabolism after a meal. Methods Fasting and 4-hour postprandial peripheral venous blood were collected in 91 subjects selected from our hospital. Serum lipid parameters, apoCIII levels and HDL subcomponents were tested by standard laboratory procedures, ELISA, and nuclear magnetic resonance (NMR), respectively. The t -test, and Non-parametric tests were performed to examine differences between groups, Pearson’s correlation and multiple regression analysis were used to assess the correlations between apoCIII (HDL-associated or nonHDL-associated) and postprandial TG. Results There was a significant increase in TG after a meal compared to fasting status [155.40(96.70–251.07) mg/dl .vs. 118.53(83.38–173.29)mg/dl, p < 0.001]. However, the total apoCIII levels were unchanged before (11.56(7.89–16.22) mg/dl) and after a meal (11.66(7.75–16.02)mg/dl, p = 0.124), while a significant increase in HDL-associated apoCIII (HDL-apoCIII) was observed from fasting (5.25(3.92–7.83)mg/dl) to post-meal (6.46(4.57–8.76)mg/dl, p = 0.001). Unlike nonHDL-apoCIII, HDL-apoCIII was positively correlated with both fasting and postprandial plasma TG in subjects with baseline plasma TG > 118.53 mg/dl (R = 0.503, p < 0.001 for fasting, R = 0.584, p < 0.001 for postprandial). Besides, in the subjects who had an abnormal TG response to a meal, which was defined as postprandial plasma TG increase of>30% compared to baseline TG levels, postprandial HDL-apoCIII was also increased significantly [5.37(3.52–7.02)mg/dl .vs. 6.64(4.61–8.86)mg/dl, p = 0.001]. The enrichment of apoCIII in HDL led to changes of TG, cholesterol, free cholesterol, phospholipid and apoAII contents in HDL particles defined by NMR. Conclusion Enrichment of apoCIII in HDL particles potentially plays an independent role in postprandial hypertriglyceridemia.
研究领域:
心脏病学
·
脂质代谢
·
临床生物化学
✓ 已验证
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2016
·
IF 3.698
Yiqun Chen,Pinya Deng,Pengchao Xie,Ran Shang,Zongping Wang,Songlin Wang
We evaluated the degradation of methylparaben (MeP) and ethylparaben (EtP), two representative parabens, using the heat-activated persulfate system in a laboratory. Both sulfate and hydroxyl radicals contributed to the removal of the two parabens. The degradations of both MeP and EtP were improved by increasing the heating temperature or persulfate dose in accordance with a pseudo-first-order reaction model. The oxidation efficiency of parabens was found to be pH-dependent; decreasing in the order pH 5.0 > 7.0 > 9.0. The presence of chloride, bicarbonate , or humic acid was found to inhibit the degradation of the two parabens to some extent because of competition for the reactive radicals, with humic acid having the most serious effect. Dealkylation of the methyl unit, decarboxylation of the carboxylic group, and subsequent hydrolysis are proposed to be involved in the degradation pathway of MeP. The results suggest that the heat-activated persulfate system might be efficiently applied in the treatment of paraben-containing water samples. This was also supported by the results of applying this system to treat a real water sample containing both MeP and EtP.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
COMPOSITE INTERFACES
·
2021
·
IF 2.952
Haicun Yang,Zinan Cai,Runfei Li,Wenzhong Ma,Zheng cao,Fanghong Gong,Guoliang Tao,Chunlin Liu
In this work, the thiolized attapulgite (ATP-MTS) particles were prepared by the dealcoholation between hydroxyl and γ-mercaptopropyltrimethoxysilane (MTS). Then, based on the ‘grafting from’ mechanism, the surface-initiated graft polymerization was carried out to give ATP grafted with polymethyl methacrylate hybrid particles (ATP@PMMA). The grafting process was characterized in detail by FTIR, TGA, XRD, XPS, TEM and elemental analysis. The effects of the main polymerization conditions on the grafting ratio were investigated in detail. Finally, polycarbonate (PC) was modified with ATP@PMMA to investigate the effects of hybrid particles on the processability of nanocomposites. The results showed that ATP@PMMA particles with a maximum graft ratio of 23.3% were prepared successfully within 5 h. The optimum polymerization temperature was 60°C, and the ratio of MMA/SH/AIBN was 500/2/1. The surface tailoring improved the dispersion of ATP@PMMA in the matrix. Compared with the pristine PC, the incorporation of ATP@PMMA enhanced the melt flow index (MFI), while reduced the glass transition temperature (Tg) and complex viscosity of nanocomposites.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Xiaolong Li,Limin Guo,Jing Li,Erkang Wang,Tianfu Liu,Guoxiong Wang,Ke Sun,Chuntai Liu,Zhangquan Peng
As one of the greatest inventions in the history of electrochemistry, the lithium-ion battery (LIB) has radically transformed human beings’ daily life by powering portable electronics and electric vehicles. When we look back upon the long and arduous effort devoted to the development of the LIB technology, it is found that the birth of LIBs could have been even earlier if reversible cycling of the graphite electrode had been realized in the propylene carbonate (PC) electrolyte, one of the few dominating electrolytes extensively used in nonaqueous electrochemistry long before the concept of LIBs. In this work, a functional electrolyte additive, that is, ethyl isothiocyanate, has been identified to enable the reversible Li+ ion intercalation/de-intercalation into/out of the graphite electrode in PC electrolyte by forming a high-quality solid electrolyte interphase (SEI) on the graphite electrode. A wide range of advanced in situ and ex situ spectroscopic characterization techniques coupled with theoretical calculations have been employed to understand the SEI formation mechanism. The results reported here rejuvenate the promise of PC as the primary electrolyte solvent for LIBs by artificially rectifying the interfacial electrochemical processes.
研究领域:
电化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Taishun Yang,Qingming Fan,Hao He,Chuang Gao,Zixu Yang,Jing Xu
Closed-loop chemical recycling offers a promising solution to the end-of-life challenges of plastic waste. However, efficiently cleaving bonds to generate value-added products and develop chemically recyclable polymers remains a considerable challenge. We have developed a closed-loop upcycling strategy that depolymerizes poly(ethylene terephthalate) (PET) into bis(2-hydroxyethyl) terephthalate (BHET), followed by polycondensation to produce recycled PET (rPET). A series of xMn/Zn (x = 0, 0.5, 1, 2) catalysts, where x represents the molar ratio of Mn and Zn, were synthesized and employed to depolymerize PET plastic into the BHET monomer. The efficient PET glycolysis approach, utilizing the high surface area and weak acid sites of the 1Mn/Zn catalyst, achieved complete depolymerization of PET plastic with a BHET yield of 93.6 %. The recovered monomers can be utilized to remanufacture rPET, which exhibits competitive molecular weight, thermal stability, and rheological properties. The energy efficiency and techno-economic feasibility of the strategy for recycling PET waste plastic were assessed by constructing a lab-scale 5.0 g-grade process and simulating a 1-ton-grade process. This work introduces a closed-loop “PET-BHET-rPET” process, addressing end-of-use challenges, offering a cost-effective method, and providing a sustainable solution for upcycling plastic waste.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）