ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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2017
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IF 2.313
Hui Zhang,Xiaoxing Wu,Khalid Mehmood,Zhenyu Chang,Kun Li,Xiong Jiang,Fazul Nabi,Muhammad Ijaz,Mujeeb Ur Rehman,Muhammad Tariq Javed,Donghai Zhou
The nano copper has been widely used in modern clinical medicine practice. However, it has been noticed that nano copper particles induce cell injury and toxicity. The present study was designed to determine the effect of nano copper particles on cell injury of intestinal epithelial cells (IECs) in piglets. The IECs were treated with different doses of nano copper (5, 10, 20 and 40 μg/ml) for 24–48 h to observe cell injury and toxicity. Cell injury was measured based on morphological and other changes including oxidative stress and genes expression. The oxidative stress markers were assayed by differential expression levels of SOD, MDA and Metallothionein (MT) in addition to CTR1, SOD1, COX17, MT and ATOX1 genes expression. Cellular morphology showed an increasing growth of cells without nano copper treatment and nano copper showed significant damage to IECs with higher dose as compared to low dose. Higher doses of copper nanoparticles (10, 20 and 40 μg/ml) have membrane damaging effect on the intestinal epithelial cells, whereas MDA contents and MT value were significantly increased, and SOD activity was decreased with the increase in concentration of nanoparticles. Nano copper up-regulated the CTR1 and SOD1 genes and down-regulated the relative expression of COX17, MT and ATOX1 genes significantly in a dose-dependent manner. The findings of the current study provide important insights that nano copper plays an important role in intestinal epithelial cell injury and oxidative stress.
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MicrobiologyOpen
·
2017
·Vol. 6
·期 4
·e00485
·
IF 2.747
Xin Feng,Jian Xu,Yu Liang,Guo-Li Chen,Xian-Wei Fan,You-Zhi Li
Graphical Our work not only provides the potential protein biomarkers indicating the Cu pollution, target metabolic steps for engineering the Cu-tolerant fungi during bioremediation, but also presents clues for insight into heavy metal tolerance mechanisms of other eukaryotes. Filamentous fungi-copper (Cu) interactions are very important in the formation of natural ecosystems and the bioremediation of heavy metal pollution. However, important issues at the proteome level remain unclear. We compared six proteomes from Cu-resistant wild-type (WT) Penicillium janthinellum strain GXCR and a Cu-sensitive mutant (EC-6) under 0, 0.5, and 3 mmol/L Cu treatments using iTRAQ. A total of 495 known proteins were identified, and the following conclusions were drawn from the results: Cu tolerance depends on ATP generation and supply, which is relevant to glycolysis pathway activity; oxidative phosphorylation, the TCA cycle, gluconeogenesis, fatty acid synthesis, and metabolism are also affected by Cu; high Cu sensitivity is primarily due to an ATP energy deficit; among ATP generation pathways, Cu-sensitive and Cu-insensitive metabolic steps exist; gluconeogenesis pathway is crucial to the survival of fungi in Cu-containing and sugar-scarce environments; fungi change their proteomes via two routes (from ATP, ATP-dependent RNA helicases (ADRHs), and ribosome biogenesis to proteasomes and from ATP, ADRHs to spliceosomes and/or stress-adapted RNA degradosomes) to cope with changes in Cu concentrations; and unique routes exist through which fungi respond to high environmental Cu. Further, a general diagram of Cu-responsive paths and a model theory of high Cu are proposed at the proteome level. Our work not only provides the potential protein biomarkers that indicate Cu pollution and targets metabolic steps for engineering Cu-tolerant fungi during bioremediation but also presents clues for further insight into the heavy metal tolerance mechanisms of other eukaryotes.
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Journal of Energy Chemistry
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2025
·
IF 14.9
Wenhui Fu,Yuxuan Tian,Chao Sui,Xiaorui Wang,Zhi Wang,Qiushi Chen,Junhao Liu,Xuzhong Gong
Polymer binders possess significant potential in alleviating the volume expansion issues of silicon-based anodes, yet remain challenging due to insufficient interfacial interactions with individual components (Si, C, and Cu) of the anode. Herein, we report the synthesis of a stable three-dimensional network structure of the PAA-PEA (polyacrylic acid-polyether amines) polymer binder through intermolecular physicochemical dual cross-linking. By incorporating polar functional groups, the binder molecules not only form strong C–O–Si, N–Si, O=C–O–C, and O=C–O–Cu covalent bonds but also enhance non-covalent interactions with Si, C, and Cu, thereby improving adhesion between the binder and each interface of the anode. Furthermore, weak hydrogen bonds, acting as “sacrificial bonds”, dissipate energy and disperse accumulated stress, improving the material flexibility. Due to the high mechanical stability of the framework, which combines both rigidity and flexibility and the coupling effect at the three interfaces, the movement and separation of electrode components are effectively restrained, significantly enhancing the cycling stability of silicon-graphite anodes. The PAA-PEA 2000 electrode exhibits a capacity retention of 78% after 500 cycles at a current density of 0.2 A g −1 . This work provides insights into the mechanism of binders and guides the design of polymer binders for high-performance Si-based electrodes.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
·
IF 20.2
Jingyu Zhang,Yan Wang,Mei Hong,Bin Peng,Yicheng Jiang,Shaobin Wen,Weishuo Li,Qiang Zhang
Fenton catalyst plays a significant role in Fenton-reaction mediated water treatment. Herein, three ferrocene-containing polymers have been prepared as smart Fenton catalysts capable of switching between homogeneous and heterogeneous phases for degrading complex water pollutants. Specifically, at 25℃, the smart catalyst is hydrophilic and parallels the catalytic behavior of correspondingly homogeneous one. While at 50℃, the smart catalyst aligns with the performance of heterogeneous one, showing a catalytic preference towards hydrophobic pollutants. The catalytic mechanism of all three catalysts are based on generated superoxide radicals and singlet oxygen, of which generation is not affected by temperatures. Notably, the polymeric Fenton-catalyst displayed a super tolerance towards salts. Our study provides a possibility of degrading complex water pollutants with one smart catalyst.
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Journal of Water Process Engineering
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2025
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IF 6.7
Peng Xu,Na Li,Pengfei Zhu,Ruoxi Wu
The use of the zero-valent copper activated peroxysulphate system (Cu(0)/PS system) has been widely studied for pollutant degradation. However, the presence of Cu(I) in the Cu(0)/PS system was limited due to the interaction of Cu(I) with O 2 and the occurrence of disproportionation reaction, which greatly reduced the effectiveness of the Cu(0)/PS system. To solve this problem, chloride ion (Cl − ) were introduced into the Cu(0)/PS system (Cl − /Cu(0)/PS system). When 10 mM Cl − was added to the Cu(0)/PS system, the degradation rate of tetracycline (TC) was enhanced from 48.5 % to 81.0 % within 8 min, while the reaction rate was also increased by about 2.5 times. The results indicated that the presence of Cl − significantly restricted the disproportionation and ineffective oxidation of Cu(I) by forming a stable Cu Cl complex with Cu(I). This ultimately enhanced the utilization of Cu(I). Furthermore, Cl − facilitated the reaction between Cu(0) and Cu(II) to produce CuCl, thereby establishing the Cu(II)/Cu(I) cycle, which was more conducive to the production of Cu(I). The main reactive species in the Cl − /Cu(0)/PS system were sulfate radicals (SO 4 − ), hydroxyl radicals ( OH), and reactive chlorine species (RCS). Overall, Cl − incorporation is a viable facilitator for the Cu(0)/PS system.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2024
·Vol. 171
·期 2
·027515
·
IF 3.1
Xinqin Zhang,Rui Cao,Zehua Chen,Liling Zhou,Peipei Li,Hui Zhang,Ju Wu
Chloramphenicol (CAP), a broad-spectrum antibiotic, has severely impacted human health and the ecological environment, which brings an increasing demand for an efficient monitoring technology for rapid and sensitive antibiotic residue detection. Herein, a highly sensitive and selective electrochemical sensor was developed for detecting CAP, based on the synergistic effect of β-cyclodextrin (β-CD) and CuO-nanomaterials modifying glassy carbon electrode (GCE). Scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD) spectrometry were used for morphological characterization. β-CD/CuO/GCE sensor with high-specific surface area and cavity structure was prepared by modifying GCE for further electrochemical testing. Experimental parameters were optimized using square wave stripping voltammetry. The developed sensor obtains an ultra-wide linear range from 1.0 × 10−7 mol l−1 to 5.0 × 10−4 mol l−1and the limit of detection is 0.5 × 10−7 mol l−1. The sensor displays high sensitivity, remarkable stability, and reproducibility; particularly more convenient than the Liquid chromatography-mass spectrometry (LC-MS) verification method. Furthermore, the applicability of the developed β-CD/CuO/GCE sensor was demonstrated by detecting CAP in food samples.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Feng Feng,Jiaying Zhang,Lu Yu,Haixin Wang,Heda Ding,Jifan Cheng,Miaolan Wang,Fangfang Chen,Jiahui Zhang,Lingling Guo,Chunshan Lu,Qunfeng Zhang,Xiaonian Li
In order to develop an efficient and environmentally friendly method for the recovery of precious metals, a functionalized ionic liquid containing free radicals (1-methyl-3-(2-oxo-2-(2,2,6,6-tetramethyl-1-oxo-4-piperidinoxy) butyl) imidazole trichloro-1-bromoaluminium salt) was designed and synthesized. This was achieved by combining 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), which possesses oxidizing properties, with halide ions that exhibit complexing abilities. Notably, under optimal conditions, a maximum gold dissolution rate of 100 % was attained. X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and Raman spectroscopy analyses were conducted to elucidate the dissolution mechanism. Ultimately, these functionalized ionic liquids can be utilized for the dissolution of precious metals in CPU pins and waste catalysts. This study presents an effective approach for the recovery of precious metals.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Luya Shen,Haoyang Li,Xi Yang,Shaoyuan Li,Yuelong Yu,Jijun Lu,Fengshuo Xi,Wenhui Ma,Rong Deng
The environmentally friendly recycling of end-of-life (EoL) photovoltaic modules is a crucial pathway to achieving “carbon neutrality.” However, currently, most efforts are primarily focused on the recovery of valuable metals, neglecting the utilization of TPT (Tedlar/PET/Tedlar) plastic backsheet. This work develops a two-stage pyrolysis process for TPT decomposition and which can convert into high-value nanocarbon materials and hydrogen under the catalysis of Ni and Fe nanometal particles. The pyrolysis behavior of TPT backplates was systematically investigated, the gas chromatography results reveal that the pyrolysis products primarily consisted of CO 2 , CO, CH 4 , CH 3 CHO, and other small molecules, alongside sizeable residual compounds under the catalytic degradation process. The resulting hydrocarbons play an important role as carbon sources in the formation of carbon nanomaterials and hydrogen generation. The study thoroughly discusses the effects of different catalyst on pyrolysis gas species and components, fixed carbon content, and nanocarbon morphology. Molecular dynamics simulations based on the reactive force field (ReaxFF) was performed to analyze the pyrolysis products. Finally, a gas–liquid-solid physical model was proposed to interpret the growth process of the carbon nanomaterials under Ni-Fe nanometallic catalysis.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Jingbo Wang,Xinyue Li,Yushan Lan,Hanyu Wang,Xiulan Ma,Hongbin Wang,Haoyu Xu,Huiqing Liu
The recontamination of farming wastewater with antibiotics and metal ions has emerged as a considerable concern in recent years. In this study, fly ash (FA) served as the adsorbent material, and its modified form (AFA) was developed via response surface optimization. The study involved an analysis of the structure and chemical composition of the fly ash before and after modification, both pre- and post-modification, through the use of scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR) analyses. These analyses were aimed at exploring the adsorption mechanism of ciprofloxacin (CIP) in the presence of copper ion (Cu 2+ ) in livestock and poultry wastewater. The study indicates that the optimal modification parameters for AFA include an alkali-to-ash ratio of 1.5, a calcination temperature of 400 °C, and a 3-hour calcination period. At pH 6, AFA exhibited a markedly superior adsorption capacity for CIP in comparison to FA, with AFA achieving 19.32 mg/g and FA only 9.61 mg/g. The adsorption process conforms to the quasi-second-order kinetic model and Langmuir isothermal model.The adsorption capacity for CIP increases at low concentrations, specifically when Cu 2+ levels are below 100 mg/L. Nevertheless, elevated CIP concentrations impede the adsorption process. The adsorption of AFA for CIP is observed to decrease with rising temperature, in contrast to the adsorption of Cu 2+ , which increases as the temperature rises. The adsorption mechanism of AFA is primarily comprised of pore filling, ion exchange, electrostatic interaction, π bond coordination, complexation, and other similar processes.
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CHINESE JOURNAL OF CATALYSIS
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2025
·
IF 17.7
Xianlong Lu,Lili Wang,Xueyang Zhao,Binbin Pan,Zhendong Li,Xiangfei Du,Shihan Zhang,Fan Dong,Bangwei Deng
Copper (Cu)-based catalysts show significant potential for producing high value-added C 2+ products in electrocatalytic CO 2 /CO reduction reactions (CO (2) RR). However, the structural reconfiguration during operation poses substantial challenges in identifying the intrinsic catalytic active site, especially under similar mass transport conditions. Herein, three typical and commercial Cu-based catalysts (Cu, CuO, and Cu 2 O) are chosen as representatives to elucidate the structure-activity relationship of CORR in the membrane electrode assembly electrolyzer. Notably, only the Cu catalyst demonstrates the most suppression of hydrogen evolution reaction, thus achieving the highest FE of 86.7% for C 2+ products at a current density of 500 mA cm –2 and maintaining a stable electrolysis over 110 h at a current of 200 mA cm –2 . The influence of chemical valence state of Cu, electrochemical surface area, and local pH were firstly investigated and ruled out for the significant FE differences. Finally, based on the structure analysis from high resolution transmission electron microscope, OH – adsorption, in situ infrared spectroscopy and density functional theory calculations, it is suggested that the asymmetric C-C coupling ( via *CHO and *CO) is the most probable reaction pathway for forming C 2+ products, with Cu (100)-dominant grain boundaries (GBs) being the most favorable active sites. These findings provide deeper insights into the synergistic relationship between crystal facets and GBs in electrocatalytic systems.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Liu Shaojia,Deng Jingjing,Zhao Hewei,Wang Tianbai,Lu Junfeng,Ding Baosen,Guo Tianqi,Ritchie Robert O.,Guo Lin
Stiffness-damping balance, high specific mechanical performance, and corrosion resistance are demanded for metals. Here, we developed an enamel-inspired ceramic (EIC) coating strategy involving hydrothermal growth of a tooth enamel-like ZrO₂ nanorods on Zr foil and amorphous ZrO₂ intergranular phase formation via controlled hydrolysis. The EIC coated Zr foil (Zr-EIC) achieved a high viscoelastic figure of merit (4.6 GPa); as well as excellent specific stiffness and hardness owing to the lightweight of ceramics, surpassing the values of Zr and previously reported Zr-based alloys or Zr-based composites. This was due to the vertically oriented stiff nanorods and unique energy dissipation derived from deformation at the crystalline/amorphous interfaces. It demonstrated exceptional NaCl corrosion resistance. This approach showed universality across Ti, Zn, and Cu substrates, enhancing both mechanical properties and corrosion resistance. By constructing an enamel-like hierarchical structure on the metal surface, the strategy overcomes traditional metal limitations without causing an increase in density.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Bingxin Sun,Shuping Peng,Zihao Zhang,Weifan Dai,Jiaxiang Wu,Guoyong Wang,Cijun Shuai
Postoperative management of tumorous bone defects remains a formidable clinical challenge due to the persistence of residual malignant cells and substantial bone loss following tumor resection. To overcome this critical issue, an intelligent bifunctional scaffold was engineered through the strategic integration of SrCuSi 4 O 10 nanosheets (SC NSs) into 3D-printed poly (L-lactic acid) (PLLA) scaffold via selective laser sintering technology. This PLLA/SC scaffold achieves a sequential therapeutic mode that coordinates residual tumor eradication with subsequent bone regeneration through stage-specific mechanisms. During the primary therapeutic phase, the integrated SC NSs demonstrate exceptional photothermal conversion efficiency (η = 27.7%), enabling precise hyperthermia-mediated apoptosis of residual tumor cells under near infrared light II region irradiation. Following oncological clearance, the scaffold transitions to osteogenic promotion through sustained ion release kinetics, where strontium and silicate ions synergistically enhance osteoblast differentiation while copper (Cu 2+ ) ions stimulate angiogenic factor secretion. This sequential therapeutic strategy achieved remarkable tumor suppression coupled with substantial bone matrix deposition in Vitro models. This work presents a promising approach for reconstructing tumorous bone defects through multifunctional bio-scaffold engineering.
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