RSC Advances
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2018
·Vol. 8
·期 13
·6798-6804
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IF 2.936
Junhuai Xu,Rui Yan,Haibo Wang,Zongliang Du,Jun Gu,Xu Cheng,Junjie Xiong
In this work, a novel and stable zwitterionic polymer (TPE-CB PUs) was prepared to realize a cellular imaging system. TPE was conjugated into the backbone of zwitterionic polyurethane, which could be well dispersed in aqueous solution and emitted strong blue fluorescence because the TPE segment was aggregated in the core of TPE-CB PUs micelles. More importantly, the TPE-CB PUs micelles showed significant stability in a large pH window and with different storage times. In addition, the micelles exhibited low cytotoxicity in HeLa cells and mainly distributed in the cytoplasm after being incubated with cells. The outstanding properties of TPE-CB PUs combining the merits of AIE and a zwitterionic segment highlight its potential for use as a cell imaging material with remarkable capability.
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ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 14
·1703369
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IF 13.325
Youchen Gu,Heping Shen,Chen Ye,Xuezeng Dai,Qian Cui,Jianbao Li,Feng Hao,Xiaojing Hao,Hong Lin
The thin-film photovoltaic material Cu 2 ZnSnS 4 (CZTS) has drawn worldwide attention in recent years due to its earth-abundant, nontoxic element constitution, and remarkable photovoltaic performance. Although state-of-the-art power conversion efficiency is achieved by hydrazine-based methods, effort to fabricate such devices in a high throughput, environmental-friendly way is still highlydesired. Here a hydrazine-free all-solution-processed CZTS solar cell with Na 2 S self-depleted back contact modification layer for the first time is demonstrated, using a ball-milled CZTS as light absorber, low-temperature solution-processed ZnO electron-transport layer as well as silver-nanowire transparent electrode. The inserting of Na 2 S self-depleted layer is proven to effectively stabilize the CZTS/Mo interface by eliminating a detrimental phase segregation reaction between CZTS and Mo-coated soda lime glass, thus leading to a better crystallinity of CZTS light absorbing layer, enhanced carrier transportation at CZTS/Mo interface as well as a smaller series resistance. Furthermore, the self-depletion feature of the Na 2 S modification layer also averts hole-transportation barrier within the devices. The results show the vital importance of interfacial engineering for these CZST devices and the Na 2 S interface layer can be extended to other optoelectronic devices using Mo contact.
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CHINESE JOURNAL OF CATALYSIS
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2024
·
IF 15.7
Xu Zhang,Wen-Jing Zhang,Yan-Cheng Hu,Zhi-Guang Zhang,Jing-Pei Cao
High-energy-density (HED) fuels (e.g. JP-10) are of great importance in safeguarding territorial air security, since they can increase the flight range and payload of military aircrafts. To reduce the reliance on limited petroleum source, the production of HED fuel with renewable biomass feedstocks is highly appealing. But currently, most of the synthetic biofuels, due to their intrinsic ring structure, are incapable of competing with JP-10 in terms of energy density and freezing point. By emulating the structural characteristic of JP-10, we herein design and prepare a special C 16 fused tetracyclic biofuel using renewable cyclopentanone and benzoquinone as feedstocks. Key to success depends on selective dehydration of vicinal diol (dimer of cyclopentanone) over Amberlyst-15 in [Hmim]Cl. The Amberlyst-15/[Hmim]Cl system effectively suppresses the dominant pinacol-type rearrangement pathway and also exhibits good reusability for the dehydration. The hydrogen-bonding interaction between vicinal diol and imidazolium ring, as well as electrostatic force between carbocation intermediate and chloride anion contribute to the high diene selectivity. The compact ring framework gives rise to a density of 0.966 g/mL, combustion heat of 43.1 MJ/L, freezing point of ‒67 °C, and kinematic viscosity of 12.4 cSt, which are comparable to the properties of JP-10. It is expected that this as-prepared HED biofuel may potentially serve as a renewable alternative to petroleum fuel JP-10.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
·
IF 5.6
Huixing Li,Xiong Shuai,Yanyan Chen,Jiaxing Xiong,Zhongxing Zou,Shuping Peng,Fangwei Qi,Cijun Shuai
Electrical stimulation displayed tremendous potential in promoting nerve regeneration. However, the current electrical stimulation therapy required complex traversing wires and external power sources, which significantly limited its practical application. Herein, a self-powered nerve scaffold based on primary battery principle was gradient printed by laser additive manufacturing technique. Specifically, poly-L-lactide (PLLA) containing Ag 2 O and Zn nanoparticles was prepared as the positive and negative electrode of the scaffold respectively, and PLLA/PPy was prepared as the middle conductive segment. In simulated body fluid, the negative electrode underwent oxidation to lose electrons and become positively charged. The lost electrons were transferred to the positive segment in a directed and orderly manner via the middle conductive segment, causing the positive electrode to be enriched electrons and become negatively charged. Subsequently, two segments can generate a potential difference to form an electric field, further generating current. Not merely, the redox process can release Ag + and Zn 2+ to endow the scaffold with antibacterial properties. Results showed that the scaffold could generate a current of up to 17.2 μA, which promoted a 14-fold increase in calcium ion influx and increased the mRNA expression of neuronal markers MAP2 by 24-fold. Moreover, the antibacterial rates of the scaffold against E. coli and S. aureus could reach 92.6 % and 91.9 %, respectively.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Qilong Wan,Hongqiu Zhu,Fei Cheng,Jianqiang Yuan,Chunhua Yang,Can Zhou
Cobalt ion is an impurity that has a negative effect in zinc hydrometallurgy, resulting in lower zinc yield and quality. Currently, the zinc hydrometallurgy industry typically uses manual sampling followed by manual sample preparation, and single-wavelength spectral analysis to detect cobalt ions in zinc solution, which is inefficient and lacks accuracy. Therefore, a new automatic detection system for cobalt ions concentration is developed. The system effectively overcomes challenges of pipeline blockage and corrosion by innovatively implementing negative pressure extraction, volume quantification, and split pipeline structure. Compared with manual detection, the system has higher detection repeatability and efficiency, specifically reducing reagent consumption by 70 %, and improving the detection speed by 8 times. In addition, to solve the spectral drift and noise problems, a spectral preprocessing algorithm by forced contraction of long-wavelength region spectra and Gaussian filtering is proposed. This algorithm not only improves the local linearity and regression accuracy of the spectrum, but also improves the detection repeatability of the system. Finally, five full-wavelength modeling methods are applied to the system. The best root mean square error for low concentration (0.1 to 1 mg/L) and high concentration (1 to 20 mg/L) cobalt zinc solution is only 0.0027 mg/L and 0.071 mg/L, respectively.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Jiankang Li,Liuquan Lin,Sen Zhou,Xiaoming Yang
Room-temperature phosphorescence carbon dots (CDs) show the highlighted advantages in chemical sensing and bioimaging owing to its long lifetime, however, acquiring the efficient phosphorescence of carbon dots is still encountering difficulty due to the spin prohibition. Here, we synthesized one type of CDs through one-step hydrothermal method. To be specific, the CDs displayed the blue fluorescence in aqueous, and emitted the bright green phosphorescence when being coated on the filter paper. Importantly, introducing coumarin to the CDs resulted in the distinct quenching of both its fluorescence and phosphorescence. Based on this phenomenon, we successfully established a dual-channel detection of coumarin. The fluorescence detection channel exhibited a linear range of 5–350 μM with a detection limit of 0.196 μM, while the phosphorescence detection channel achieved a linear range of 50–1000 μM with a detection limit of 0.268 μM. The further investigation revealed that IFE and SQE were mainly responsible for the fluorescence quenching of CDs, while the phosphorescence quenching was originated from the increased energy gap between the singlet and triplet states (ΔE ST ) of CDs, thus obstructing the ISC process. Moreover, we employed the CDs as the phosphorescent ink for anti-counterfeiting.
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ANALYTICAL CHEMISTRY
·
2017
·
IF 6.32
Huixia Di,Huiqiao Liu,Mingmin Li,Jin Li,Dingbin Liu
Precise profiling of the sialic acid (SA) expression on the membrane of cancer cells is critical for early identification of cancers and assessment of cancer metastasis. However, the complex physiological environments often result in false positives with currently available imaging technologies. Herein, we have established a background-free surface-enhanced Raman scattering (SERS) imaging platform that allows high-precision profiling of SA expression in cancer cells and differentiation of clinically relevant cancer tissues with various metastasis degrees. Three-dimensional Raman imaging technique provided a deeper insight into visualizing the probe distribution and thus the SA expression at the single-cell level, without destructing the cells. This noninvasive, high-precision imaging technique could favor early diagnosis, staging, and monitoring therapeutic responses of cancers that are highly essential in clinical settings.
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Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 36
·7538-7546
·
IF 4.543
Peilian Liu,Bowen Li,Chenyue Zhan,Fang Zeng,Shuizhu Wu
A light-activated cleavage strategy for the concomitant release of active drugs and generation of fluorescence changes is highly desirable. Herein a molecular prodrug featuring real-time monitoring of drug localization and release by manipulating fluorophores has been created by constructing a cleavable structure which comprises a photoremovable coumarinyl, an anticancer drug camptothecin, a cleavable linker and a near infrared fluorescent dye dicyanomethylene-4H-pyran (DCM). The fluorescence of coumarinyl and CPT is completely quenched by the DCM moiety via fluorescence resonance energy transfer (FRET). The internalization of the prodrug by cells and its subsequent intracellular location can be tracked by collecting the red fluorescence of DCM; while the release of active CPT as a result of one- or two-photon irradiation can be monitored by observing the newly emerged fluorescence of CPT under one- or two-photon excitation. The prodrug also shows highly controllable cytotoxicity toward HeLa cells and A549 cells, with low IC50 values of 4.01 and 2.53 μM, respectively, upon light irradiation and with much higher IC50 values (>40 μM) without light irradiation. This strategy may provide an approach for the development of light-activatable theranostic anticancer therapeutics.
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SENSORS AND ACTUATORS B-CHEMICAL
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2024
·
IF 8
Siyi Li,Kexin Li,Xianfeng Gong,Pengfei Yan,Shaoping Sun
Multifunctional polymeric micelles, which possess capabilities for tracking, bioimaging, stimuli-responsive drug release and tumor targeting, are essential in facilitating the effective delivery of anticancer drugs. Hence, a novel copolymer (CD-CS-Bio-TPAA, CCBT) was synthesized with biotin and hydroxypropyl-β-cyclodextrin conjugated chitosan as the hydrophilic segment and aggregation-induced emission (AIE) featured tetraphenylethene derivative (TPAA) as the hydrophobic segment. Interestingly, under acidic conditions, CCBT exhibited color-tunable AIE behavior as a result of the cleavage of benzoic imine bonds in TPAA molecules, transitioning from red to yellow. Furthermore, CCBT could also self-assemble into polymeric micelles and be used as drug carriers to encapsulate paclitaxel (PTX) (PTX/CCBT PMs) for self-indicating cancer therapy. In vitro release experiments demonstrated that PTX/CCBT PMs could release drugs specifically under acidic conditions. Fluorescence imaging experiments demonstrated that CCBT PMs exhibited excellent cell imaging capabilities and could be tracked due to their unique color-changing behavior. Moreover, PTX/CCBT PMs exhibited notable cytotoxic effects on MCF-7 cells and showed selective internalization by MCF-7 cells through biotin receptor-mediated active targeting. In vivo antitumor experiments confirmed that PTX/CCBT PMs possessed remarkable tumor-inhibiting effects and low systemic toxicity. This work suggested that PTX/CCBT PMs provided new ideas for self-indicating breast cancer treatment.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Liu Shaojia,Deng Jingjing,Zhao Hewei,Wang Tianbai,Lu Junfeng,Ding Baosen,Guo Tianqi,Ritchie Robert O.,Guo Lin
Stiffness-damping balance, high specific mechanical performance, and corrosion resistance are demanded for metals. Here, we developed an enamel-inspired ceramic (EIC) coating strategy involving hydrothermal growth of a tooth enamel-like ZrO₂ nanorods on Zr foil and amorphous ZrO₂ intergranular phase formation via controlled hydrolysis. The EIC coated Zr foil (Zr-EIC) achieved a high viscoelastic figure of merit (4.6 GPa); as well as excellent specific stiffness and hardness owing to the lightweight of ceramics, surpassing the values of Zr and previously reported Zr-based alloys or Zr-based composites. This was due to the vertically oriented stiff nanorods and unique energy dissipation derived from deformation at the crystalline/amorphous interfaces. It demonstrated exceptional NaCl corrosion resistance. This approach showed universality across Ti, Zn, and Cu substrates, enhancing both mechanical properties and corrosion resistance. By constructing an enamel-like hierarchical structure on the metal surface, the strategy overcomes traditional metal limitations without causing an increase in density.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Tingting Hu,Haimei Zeng,Hao Peng,Guanchao Yin,Jihong Zhang,Jun Xie,Yang Jiang
With the increasing discharge of pollutants into air, water, and soil, the rapid and sensitive detection and treatment of chemical pollutants, including toxic organic dyes and heavy metal ions, have become critical for minimizing potential threats to the ecological cycle and human health. In the current research, an in-situ degradation approach for toxic substances is proposed, combined with surface-enhanced Raman scattering (SERS). Fiber probes based on a silver nanoparticles/ silver phosphate tetrapod (Ag/ Ag 3 PO 4 ) composite were fabricated using a sequence of ion exchange, chemical reduction, and subsequent coating processes. The fiber probes were deployed for ultra-sensitive SERS detection and in situ photocatalytic degradation of dyes (specifically crystal violet (CV)) and heavy metal ions (particularly Hg 2+ ). The probes were functionalized with 4-mercaptopyridine (4-MPY) to facilitate the detection of Hg 2+ . Notably, the probes demonstrated detection limits as low as 10 −14 M for crystal violet (CV) and 4-aminothiophenol (PATP), and 10 −12 M of Hg 2+ . Under light exposure, the substrate degraded 93.2 % of CV and 98.0 % of PATP within 60 min, and 82.3 % of Hg 2+ within 30 min, as monitored in situs. Finite element method analysis suggested that the high electromagnetic field intensity generated by Ag/ Ag 3 PO 4 resulted from the close packing of Ag nanoparticles. Furthermore, the SERS fiber probes exhibited outstanding stability, selectivity, and reusability. This research suggest that the recyclable Ag/ Ag 3 PO 4 fiber probes hold significant potential for the detection and in situ monitoring of the degradation of trace environmental contaminants.
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APPLIED RADIATION AND ISOTOPES
·
2025
·
IF 1.8
Tao Gao,Xiang Gong,Jiali Liu,Sheng Hu,Wei Yu,Yuhong Liu,Jiwei Liang
A method for regulating the rutile and anatase ratio of TiO 2 products by adding tartaric acid is reported. By this method, TiO 2 with a specific anatase/rutile ratio exhibited excellent selective adsorption performance of 68 Ge and 68 Ga. Experiment shows that Tartaric acid assist synthesized TiO 2 enabled strong 68 Ge adsorption but negligible adsorption of 68 Ga. Meanwhile, the TiO 2 adsorption exhibited significant acid resistance, with minimal Ti 4+ leaching. In addition, the 68 Ga elution efficiency and 68 Ge breakthrough of radioactivity experiments demonstrated that synthesized TiO 2 achieved an initial 68 Ga elution efficiency of 75%, which remained about 65% after 200 elution cycles. Furthermore, over the four-month observation period, the 68 Ge breakthrough of the TiO 2 adsorbent did not exhibit a significant increase, remaining below 1×10 -5 . Generally, the synthesized TiO 2 adsorbent exhibits potential as a 68 Ge/ 68 Ga generator column adsorbent with outstanding acid-resistant, radiation-resistant, efficient 68 Ga elution and low 68 Ge breakthrough for long-term.
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